TissGeneSummary for TMEM59L |
Gene summary |
Basic gene information | Gene symbol | TMEM59L |
Gene name | transmembrane protein 59-like | |
Synonyms | BSMAP|C19orf4 | |
Cytomap | UCSC genome browser: 19p12 | |
Type of gene | protein-coding | |
RefGenes | NM_012109.2, | |
Description | brain-specific membrane-anchored protein | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000105696 | ||
HPRD : 12709 | ||
Vega : OTTHUMG00000183113 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_TMEM59L | |
BioGPS: 25789 | ||
Pathway | NCI Pathway Interaction Database: TMEM59L | |
KEGG: TMEM59L | ||
REACTOME: TMEM59L | ||
Pathway Commons: TMEM59L | ||
Context | iHOP: TMEM59L | |
ligand binding site mutation search in PubMed: TMEM59L | ||
UCL Cancer Institute: TMEM59L | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,TiGER | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Brain | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGG | |
Reference showing the relevant tissue of TMEM59L | ||
Description by TissGene annotations | Protective TissGene in OS Protective TissGene in RFS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for TMEM59L |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
THCA | 0.962522094 | -1.185072821 | 2.147594915 | 1.61E-07 | 6.79E-07 |
KIRC | -2.361125034 | -0.688145868 | -1.672979167 | 1.68E-10 | 5.76E-10 |
COAD | -1.938081231 | 1.302484154 | -3.240565385 | 2.67E-11 | 4.50E-10 |
LUAD | 1.732816249 | -0.63509582 | 2.367912069 | 5.90E-08 | 2.39E-07 |
KICH | -3.082198923 | -0.321498923 | -2.7607 | 1.86E-10 | 1.35E-09 |
STAD | -1.149195173 | 0.791789202 | -1.940984375 | 0.000237 | 0.001605461 |
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TissGene-miRNA for TMEM59L |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for TMEM59L |
TissGeneSNV for TMEM59L |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.T288I | SKCM | 1 |
p.E134* | LUAD | 1 |
p.G196S | SKCM | 1 |
p.T173I | STAD | 1 |
p.D315N | BRCA | 1 |
p.W316* | SKCM | 1 |
p.V139F | BRCA | 1 |
p.R137I | UCEC | 1 |
p.Q306K | LUAD | 1 |
p.S148F | SKCM | 1 |
p.P223L | THYM | 1 |
p.S75R | SARC | 1 |
p.P214T | OV | 1 |
p.E65K | PAAD | 1 |
p.A91T | UCEC | 1 |
p.C272Y | THYM | 1 |
p.I191V | LUAD | 1 |
p.N253S | SARC | 1 |
p.S247F | BRCA | 1 |
p.R201H | LUAD | 1 |
p.G145V | LUSC | 1 |
p.S260F | PRAD | 1 |
p.R204C | LUAD | 1 |
p.G166V | ESCA | 1 |
p.V221L | LUAD | 1 |
p.A71T | PAAD | 1 |
p.P332T | LUAD | 1 |
p.V207M | SKCM | 1 |
p.S277P | HNSC | 1 |
p.A98V | GBM | 1 |
p.R82H | COAD | 1 |
p.V139I | THYM | 1 |
p.S126R | BLCA | 1 |
p.I191L | SKCM | 1 |
p.W316* | LIHC | 1 |
p.Q300* | SKCM | 1 |
p.A292P | HNSC | 1 |
p.R204C | STAD | 1 |
p.A106P | KIRC | 1 |
p.S240N | COAD | 1 |
p.R201H | COAD | 1 |
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TissGeneCNV for TMEM59L |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for TMEM59L |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BG700433 | NOL6-TMEM59L | chr9:33473892 | chr19:18729254 | |
Chimerdb3.0 | ChiTaRs | NA | AK308714 | TMEM59L-SYNGR1 | chr19:18724750 | chr22:39779377 | |
Chimerdb3.0 | TopHat-Fusion | BRCA | TCGA-AN-A0FD-01A | KXD1-TMEM59L | In-Frame | chr19:18675830 | chr19:18726111 |
TCGAfusionPortal | PRADA | LUAD | TCGA-55-6981-01A | COPE-TMEM59L | In-frame | Chr19:19030032 | Chr19:18724682 |
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TissGeneNet for TMEM59L |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for TMEM59L |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for TMEM59L |
TissGeneDrug for TMEM59L |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for TMEM59L |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0029927 | Ovarian Cysts | 1 | CTD_human |