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| TissGeneSummary for GALT |
 Gene summary |
| Basic gene information | Gene symbol | GALT |
| Gene name | galactose-1-phosphate uridylyltransferase | |
| Synonyms | - | |
| Cytomap | UCSC genome browser: 9p13 | |
| Type of gene | protein-coding | |
| RefGenes | NM_000155.3, NM_001258332.1, | |
| Description | UDP-glucose--hexose-1-phosphate uridylyltransferasegal-1-P uridylyltransferasegalactose-1-phosphate uridyl transferase | |
| Modification date | 20141219 | |
| dbXrefs | MIM : 606999 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000213930 | ||
| HPRD : 06106 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_GALT | |
| BioGPS: 2592 | ||
| Pathway | NCI Pathway Interaction Database: GALT | |
| KEGG: GALT | ||
| REACTOME: GALT | ||
| Pathway Commons: GALT | ||
| Context | iHOP: GALT | |
| ligand binding site mutation search in PubMed: GALT | ||
| UCL Cancer Institute: GALT | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Bone marrowLiver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LAMLLIHC | |
| Reference showing the relevant tissue of GALT | ||
| Description by TissGene annotations | Cancer gene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for GALT |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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| TissGene-miRNA for GALT |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for GALT |
| TissGeneSNV for GALT |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E16Q | CESC | 1 |
| p.V332A | LIHC | 1 |
| p.R201H | UCEC | 1 |
| p.D98Y | LUAD | 1 |
| p.P244L | SKCM | 1 |
| p.E16Q | HNSC | 1 |
| p.R25Q | STAD | 1 |
| p.E237Q | BRCA | 1 |
| p.R262W | COAD | 1 |
| p.R223L | ESCA | 1 |
| p.L326I | COAD | 1 |
| p.A155T | UCEC | 1 |
| p.R231C | STAD | 1 |
| p.C75F | LUAD | 1 |
| p.R263W | LUAD | 1 |
| p.H114Y | BLCA | 1 |
| p.E352* | CESC | 1 |
| p.E340K | UCEC | 1 |
| p.R123P | HNSC | 1 |
| p.R201C | THYM | 1 |
| p.S277F | SKCM | 1 |
| p.R201H | SKCM | 1 |
| p.R272C | STAD | 1 |
| p.P325S | THCA | 1 |
| p.Q169H | COAD | 1 |
| p.R67H | LUSC | 1 |
| p.A163T | THCA | 1 |
| p.N182D | OV | 1 |
| p.R258H | PRAD | 1 |
| p.P362S | KIRC | 1 |
| p.A78V | THYM | 1 |
| p.M341T | KIRC | 1 |
| p.D152V | LUAD | 1 |
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| TissGeneCNV for GALT |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for GALT |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BF593407 | GALT-CENPF | chr9:34650571 | chr1:214786559 | |
| Chimerdb3.0 | ChiTaRs | NA | CV351576 | SNRNP70-GALT | chr19:49611448 | chr9:34648372 |
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| TissGeneNet for GALT |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| GALT, TRIP13 (tumor) | GALT, TRIP13 (normal) |
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| COAD (tumor) | COAD (normal) |
| GALT, TRIP13 (tumor) | GALT, TRIP13 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| GALT, TRIP13 (tumor) | GALT, TRIP13 (normal) |
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| KICH (tumor) | KICH (normal) |
| GALT, TRIP13 (tumor) | GALT, TRIP13 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| GALT, TRIP13 (tumor) | GALT, TRIP13 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| GALT, TRIP13 (tumor) | GALT, TRIP13 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| GALT, TRIP13 (tumor) | GALT, TRIP13 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| GALT, TRIP13 (tumor) | GALT, TRIP13 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| GALT, TRIP13 (tumor) | GALT, TRIP13 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| GALT, TRIP13 (tumor) | GALT, TRIP13 (normal) |
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| STAD (tumor) | STAD (normal) |
| GALT, TRIP13 (tumor) | GALT, TRIP13 (normal) |
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| THCA (tumor) | THCA (normal) |
| GALT, TRIP13 (tumor) | GALT, TRIP13 (normal) |
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| TissGeneProg for GALT |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for GALT |
| TissGeneDrug for GALT |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for GALT |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0268151 | Classical galactosemia | 70 | BeFree,CLINVAR,ORPHANET,UNIPROT |
| umls:C0016952 | Galactosemias | 50 | BeFree,CTD_human,GAD,LHGDN |
| umls:C0014175 | Endometriosis | 9 | BeFree,GAD |
| umls:C1140680 | Malignant neoplasm of ovary | 7 | BeFree,GAD |
| umls:C0029925 | Ovarian Carcinoma | 6 | BeFree |
| umls:C0019693 | HIV Infections | 4 | BeFree |
| umls:C0025322 | Premature Menopause | 3 | BeFree |
| umls:C0025517 | Metabolic Diseases | 3 | BeFree |
| umls:C0085215 | Ovarian Failure, Premature | 3 | BeFree,GAD,LHGDN |
| umls:C0154971 | Presenile cataract | 3 | BeFree,GAD |
| umls:C0677886 | Epithelial ovarian cancer | 3 | BeFree |
| umls:C0025521 | Inborn Errors of Metabolism | 2 | BeFree |
| umls:C0041107 | Trisomy | 2 | BeFree |
| umls:C0086543 | Cataract | 2 | BeFree,GAD |
| umls:C1698581 | Rokitansky Kuster Hauser syndrome | 2 | BeFree |
| umls:C0006840 | Candidiasis | 1 | BeFree |
| umls:C0011849 | Diabetes Mellitus | 1 | GAD |
| umls:C0015230 | Exanthema | 1 | BeFree |
| umls:C0021390 | Inflammatory Bowel Diseases | 1 | BeFree |
| umls:C0026106 | Mild Mental Retardation | 1 | BeFree |
| umls:C0026827 | Muscle hypotonia | 1 | BeFree |
| umls:C0154208 | Disorder of endocrine ovary | 1 | BeFree |
| umls:C0162429 | Malnutrition | 1 | BeFree |
| umls:C0276088 | Escherichia coli septicemia | 1 | BeFree |
| umls:C0521707 | Bilateral cataracts (disorder) | 1 | BeFree |
| umls:C0750927 | Apraxia, Developmental Verbal | 1 | BeFree |
| umls:C0751435 | Hyperphenylalaninaemia | 1 | GAD |
| umls:C0848332 | Spots on skin | 1 | BeFree |
| umls:C0919267 | ovarian neoplasm | 1 | LHGDN |
| umls:C0268152 | Classical galactosemia, homozygous Duarte-type | 0 | CLINVAR |
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