TissGeneSummary for GAP43 |
Gene summary |
Basic gene information | Gene symbol | GAP43 |
Gene name | growth associated protein 43 | |
Synonyms | B-50|PP46 | |
Cytomap | UCSC genome browser: 3q13.31 | |
Type of gene | protein-coding | |
RefGenes | NM_001130064.1, NM_002045.3, | |
Description | axonal membrane protein GAP-43calmodulin-binding protein P-57growth-associated protein 43nerve growth-related peptide GAP43neural phosphoprotein B-50neuromodulinneuron growth-associated protein 43protein F1 | |
Modification date | 20141207 | |
dbXrefs | MIM : 162060 | |
HGNC : HGNC | ||
Ensembl : ENSG00000172020 | ||
HPRD : 01198 | ||
Vega : OTTHUMG00000133758 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_GAP43 | |
BioGPS: 2596 | ||
Pathway | NCI Pathway Interaction Database: GAP43 | |
KEGG: GAP43 | ||
REACTOME: GAP43 | ||
Pathway Commons: GAP43 | ||
Context | iHOP: GAP43 | |
ligand binding site mutation search in PubMed: GAP43 | ||
UCL Cancer Institute: GAP43 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,TiGER | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Brain | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGG | |
Reference showing the relevant tissue of GAP43 | ||
Description by TissGene annotations | Cancer gene TissgsKTS Fused withTSGene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0051489 | regulation of filopodium assembly | 14978216 | GO:0051489 | regulation of filopodium assembly | 14978216 |
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TissGeneExp for GAP43 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUAD | -1.800138267 | -3.41113137 | 1.610993103 | 1.90E-07 | 7.14E-07 |
THCA | 0.471253872 | -3.31070884 | 3.781962712 | 4.31E-12 | 3.44E-11 |
LUSC | -0.433064805 | -3.104684413 | 2.671619608 | 5.86E-11 | 2.26E-10 |
COAD | -1.705732829 | 1.662501786 | -3.368234615 | 1.09E-09 | 1.21E-08 |
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TissGene-miRNA for GAP43 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for GAP43 |
TissGeneSNV for GAP43 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.G141E | SKCM | 2 |
p.P144L | SKCM | 2 |
p.G236A | LUAD | 1 |
p.A66T | STAD | 1 |
p.E90K | SKCM | 1 |
p.E266K | SKCM | 1 |
p.E164K | CESC | 1 |
p.R258W | BRCA | 1 |
p.S190F | LUAD | 1 |
p.E115K | PAAD | 1 |
p.E199K | SKCM | 1 |
p.P188R | LUAD | 1 |
p.G236W | LUAD | 1 |
p.E142* | LUAD | 1 |
p.Q203K | LUSC | 1 |
p.G200S | LUAD | 1 |
p.R84K | SKCM | 1 |
p.S187L | SKCM | 1 |
p.G141* | LUAD | 1 |
p.G172S | SKCM | 1 |
p.E115A | UVM | 1 |
p.Q96* | SKCM | 1 |
p.P92L | HNSC | 1 |
p.K254N | UCEC | 1 |
p.C3Y | COAD | 1 |
p.A71T | PRAD | 1 |
p.E221Q | BLCA | 1 |
p.M1I | LUAD | 1 |
p.E200K | SKCM | 1 |
p.D53N | SKCM | 1 |
p.G172C | LUAD | 1 |
p.R84G | KIRC | 1 |
p.K19N | CESC | 1 |
p.T215I | OV | 1 |
p.G172A | LUAD | 1 |
p.D93H | LUSC | 1 |
p.E266D | LUSC | 1 |
p.A160T | SKCM | 1 |
p.G262C | COAD | 1 |
p.S154F | LUAD | 1 |
p.E83Q | HNSC | 1 |
p.G141V | LUAD | 1 |
p.E79K | PAAD | 1 |
p.R79C | COAD | 1 |
p.P207H | UCEC | 1 |
p.A229T | SKCM | 1 |
p.E243K | BLCA | 1 |
p.K55E | CESC | 1 |
p.A108V | UCEC | 1 |
p.E250K | SKCM | 1 |
p.S166F | SKCM | 1 |
p.A195V | KIRC | 1 |
p.E99K | LUSC | 1 |
p.E175D | UCEC | 1 |
p.R258W | SKCM | 1 |
p.P128L | HNSC | 1 |
p.G136A | LUAD | 1 |
p.A241T | SKCM | 1 |
p.D153N | LUSC | 1 |
p.D93N | SKCM | 1 |
p.D106N | UCEC | 1 |
p.C3F | ESCA | 1 |
p.M5V | COAD | 1 |
p.E193* | LUAD | 1 |
p.A111D | LUSC | 1 |
p.E119Q | HNSC | 1 |
p.G150V | BRCA | 1 |
p.A102T | STAD | 1 |
p.W43C | BRCA | 1 |
p.D205Y | LUSC | 1 |
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TissGeneCNV for GAP43 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for GAP43 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | AK123311 | LMNA-GAP43 | chr1:156086800 | chr3:115342509 | |
Chimerdb3.0 | ChiTaRs | NA | T07418 | SEZ6L-GAP43 | chr22:26702013 | chr3:115395138 | |
TCGAfusionPortal | PRADA | BRCA | TCGA-AR-A2LR-01A | LSAMP-GAP43 | Out-of-frame | Chr3:117716029 | Chr3:115394860 |
TCGAfusionPortal | PRADA | LUAD | TCGA-55-6985-01A | TMEM108-GAP43 | Out-of-frame | Chr3:132948195 | Chr3:115394860 |
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TissGeneNet for GAP43 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for GAP43 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for GAP43 |
TissGeneDrug for GAP43 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for GAP43 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0027819 | Neuroblastoma | 6 | BeFree |
umls:C0036341 | Schizophrenia | 6 | BeFree |
umls:C0700095 | Central neuroblastoma | 5 | BeFree |
umls:C0002736 | Amyotrophic Lateral Sclerosis | 3 | BeFree |
umls:C0011265 | Presenile dementia | 2 | BeFree |
umls:C0333463 | Senile Plaques | 2 | BeFree |
umls:C0497327 | Dementia | 2 | BeFree |
umls:C0007684 | Central Nervous System Infection | 1 | BeFree |
umls:C0009375 | Colonic Neoplasms | 1 | CTD_human |
umls:C0011570 | Mental Depression | 1 | BeFree |
umls:C0011581 | Depressive disorder | 1 | BeFree |
umls:C0013415 | Dysthymic Disorder | 1 | BeFree |
umls:C0018681 | Headache | 1 | BeFree |
umls:C0019196 | Hepatitis C | 1 | BeFree |
umls:C0026650 | Movement Disorders | 1 | BeFree |
umls:C0026769 | Multiple Sclerosis | 1 | BeFree |
umls:C0027765 | nervous system disorder | 1 | BeFree |
umls:C0027809 | Neurilemmoma | 1 | BeFree |
umls:C0027877 | Neuronal Ceroid-Lipofuscinoses | 1 | BeFree |
umls:C0031350 | Pharyngitis | 1 | BeFree |
umls:C0033845 | Pseudotumor Cerebri | 1 | BeFree |
umls:C0036572 | Seizures | 1 | RGD |
umls:C0038220 | Status Epilepticus | 1 | CTD_human |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
umls:C0085084 | Motor Neuron Disease | 1 | BeFree |
umls:C0236642 | Pick Disease of the Brain | 1 | BeFree |
umls:C0338451 | Frontotemporal dementia | 1 | BeFree |
umls:C0424605 | Developmental delay (disorder) | 1 | BeFree |
umls:C3811653 | Experimental Organism Basal Cell Carcinoma | 1 | BeFree |