TissGeneSummary for LRIT1 |
Gene summary |
Basic gene information | Gene symbol | LRIT1 |
Gene name | leucine-rich repeat, immunoglobulin-like and transmembrane domains 1 | |
Synonyms | FIGLER9|LRRC21|PAL | |
Cytomap | UCSC genome browser: 10q23 | |
Type of gene | protein-coding | |
RefGenes | NM_015613.2, | |
Description | fibronectin type III, immunoglobulin and leucine rich repeat domains 9leucine rich repeat containing 21leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1leucine-rich repeat-containing protein 21photoreceptor- | |
Modification date | 20141207 | |
dbXrefs | MIM : 616103 | |
HGNC : HGNC | ||
Ensembl : ENSG00000148602 | ||
HPRD : 14315 | ||
Vega : OTTHUMG00000018632 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_LRIT1 | |
BioGPS: 26103 | ||
Pathway | NCI Pathway Interaction Database: LRIT1 | |
KEGG: LRIT1 | ||
REACTOME: LRIT1 | ||
Pathway Commons: LRIT1 | ||
Context | iHOP: LRIT1 | |
ligand binding site mutation search in PubMed: LRIT1 | ||
UCL Cancer Institute: LRIT1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of LRIT1 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for LRIT1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for LRIT1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for LRIT1 |
TissGeneSNV for LRIT1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E370K | SKCM | 2 |
p.S397C | BLCA | 2 |
p.L109M | LUSC | 1 |
p.L11F | COAD | 1 |
p.R602H | LAML | 1 |
p.E404K | SKCM | 1 |
p.R557Q | UCEC | 1 |
p.P349T | HNSC | 1 |
p.A204E | STAD | 1 |
p.V434M | DLBC | 1 |
p.I57T | THCA | 1 |
p.L8I | CESC | 1 |
p.I57T | LIHC | 1 |
p.R194W | COAD | 1 |
p.G292C | LUAD | 1 |
p.R422Q | BLCA | 1 |
p.D47N | SKCM | 1 |
p.S177C | CESC | 1 |
p.A414D | UCEC | 1 |
p.V572I | STAD | 1 |
p.A126V | CESC | 1 |
p.R557Q | SKCM | 1 |
p.Y210C | LIHC | 1 |
p.Y326H | HNSC | 1 |
p.A390T | LUSC | 1 |
p.R72H | LGG | 1 |
p.G366C | COAD | 1 |
p.E227K | HNSC | 1 |
p.R134Q | ESCA | 1 |
p.G369E | SKCM | 1 |
p.R110L | LUAD | 1 |
p.T394A | THYM | 1 |
p.G83S | KIRP | 1 |
p.W15* | SKCM | 1 |
p.P387A | OV | 1 |
p.E67K | SKCM | 1 |
p.A373S | LUSC | 1 |
p.M34I | LIHC | 1 |
p.F22V | STAD | 1 |
p.R80M | PAAD | 1 |
p.P387L | SKCM | 1 |
p.W15* | STAD | 1 |
p.P254L | SKCM | 1 |
p.A12V | LGG | 1 |
p.M34V | LIHC | 1 |
p.T61I | BLCA | 1 |
p.R429Q | SKCM | 1 |
p.L489F | BLCA | 1 |
p.S62P | STAD | 1 |
p.P348L | LUAD | 1 |
p.L295V | BLCA | 1 |
p.R20W | STAD | 1 |
p.R104W | KIRP | 1 |
p.E594D | LUSC | 1 |
p.A70V | SKCM | 1 |
p.E581K | SKCM | 1 |
p.R274C | UCEC | 1 |
p.T278I | LUAD | 1 |
p.R249M | LUAD | 1 |
p.I71V | LIHC | 1 |
p.G6D | THYM | 1 |
p.A239T | COAD | 1 |
p.S400R | COAD | 1 |
p.A4T | SKCM | 1 |
p.R422Q | HNSC | 1 |
p.G314D | BLCA | 1 |
p.V476L | LUAD | 1 |
p.R555C | BLCA | 1 |
p.A360T | STAD | 1 |
p.E417X | READ | 1 |
p.P258S | LUSC | 1 |
p.T544M | STAD | 1 |
p.C548S | LIHC | 1 |
p.R68W | STAD | 1 |
p.W15X | SKCM | 1 |
p.G324E | BLCA | 1 |
p.R473Q | STAD | 1 |
p.E508K | SKCM | 1 |
p.V538I | PAAD | 1 |
p.P131T | SARC | 1 |
p.S603C | LUAD | 1 |
p.L154M | COAD | 1 |
p.S323F | SKCM | 1 |
p.Q608* | LUAD | 1 |
p.S357R | LIHC | 1 |
p.G259V | LUSC | 1 |
p.Q252K | ESCA | 1 |
p.F466V | LUAD | 1 |
p.R236H | STAD | 1 |
p.G611A | HNSC | 1 |
p.E97K | SKCM | 1 |
p.V495A | HNSC | 1 |
p.L407V | LUAD | 1 |
p.T456A | BRCA | 1 |
p.K507N | SKCM | 1 |
p.S397Y | LUAD | 1 |
p.Q553H | STAD | 1 |
p.I33M | UCS | 1 |
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TissGeneCNV for LRIT1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for LRIT1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for LRIT1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for LRIT1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for LRIT1 |
TissGeneDrug for LRIT1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for LRIT1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0014740 | Erythema Chronicum Migrans | 1 | BeFree |
umls:C0017677 | Glossitis, Benign Migratory | 1 | BeFree |
umls:C0018916 | Hemangioma | 1 | BeFree |
umls:C0024221 | Lymphangioma | 1 | BeFree |
umls:C0025202 | melanoma | 1 | BeFree |
umls:C0038013 | Ankylosing spondylitis | 1 | BeFree |
umls:C0178874 | Tumor Progression | 1 | BeFree |
umls:C0282607 | Vascular Neoplasms | 1 | BeFree |
umls:C0596263 | Carcinogenesis | 1 | BeFree |
umls:C0751435 | Hyperphenylalaninaemia | 1 | BeFree |
umls:C1261473 | Sarcoma | 1 | BeFree |
umls:C1384514 | Conn Syndrome | 1 | BeFree |