TissGeneSummary for FBXO24 |
Gene summary |
Basic gene information | Gene symbol | FBXO24 |
Gene name | F-box protein 24 | |
Synonyms | FBX24 | |
Cytomap | UCSC genome browser: 7q22 | |
Type of gene | protein-coding | |
RefGenes | NM_001163499.1, NM_012172.4,NM_033506.2, | |
Description | F-box only protein 24F-box protein Fbx24 | |
Modification date | 20141207 | |
dbXrefs | MIM : 609097 | |
HGNC : HGNC | ||
Ensembl : ENSG00000106336 | ||
HPRD : 16438 | ||
Vega : OTTHUMG00000159543 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_FBXO24 | |
BioGPS: 26261 | ||
Pathway | NCI Pathway Interaction Database: FBXO24 | |
KEGG: FBXO24 | ||
REACTOME: FBXO24 | ||
Pathway Commons: FBXO24 | ||
Context | iHOP: FBXO24 | |
ligand binding site mutation search in PubMed: FBXO24 | ||
UCL Cancer Institute: FBXO24 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of FBXO24 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for FBXO24 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for FBXO24 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for FBXO24 |
TissGeneSNV for FBXO24 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.P7S | SKCM | 4 |
p.M515V | HNSC | 2 |
p.P19S | SKCM | 2 |
p.R495K | SKCM | 2 |
p.R127C | GBM | 1 |
p.D190G | PAAD | 1 |
p.P535S | COAD | 1 |
p.R127C | UCS | 1 |
p.V316I | STAD | 1 |
p.R442H | UCEC | 1 |
p.V2G | SKCM | 1 |
p.K306N | CESC | 1 |
p.S38F | SKCM | 1 |
p.A469D | STAD | 1 |
p.G2S | SKCM | 1 |
p.R377Q | SKCM | 1 |
p.P209S | SKCM | 1 |
p.R9L | BRCA | 1 |
p.E59K | READ | 1 |
p.R84H | UCEC | 1 |
p.R207Q | UCEC | 1 |
p.G502R | SKCM | 1 |
p.R214H | UCEC | 1 |
p.K293R | LIHC | 1 |
p.C223Y | LUAD | 1 |
p.R442P | OV | 1 |
p.D144N | SKCM | 1 |
p.E211D | STAD | 1 |
p.R523H | KICH | 1 |
p.Q40R | BLCA | 1 |
p.R182H | PAAD | 1 |
p.M553V | GBM | 1 |
p.K185N | LUAD | 1 |
p.A518T | CHOL | 1 |
p.V274A | STAD | 1 |
p.K331R | LIHC | 1 |
p.L272S | THCA | 1 |
p.S52L | CESC | 1 |
p.T328I | SKCM | 1 |
p.K268N | UCEC | 1 |
p.R89C | UCS | 1 |
p.V97F | LUAD | 1 |
p.R176C | SKCM | 1 |
p.A556T | CHOL | 1 |
p.P74L | STAD | 1 |
p.R173W | UCEC | 1 |
p.V226I | LGG | 1 |
p.E558K | SKCM | 1 |
p.G398R | SKCM | 1 |
p.P388S | STAD | 1 |
p.R373K | READ | 1 |
p.W310* | STAD | 1 |
p.I82V | STAD | 1 |
p.S164F | BRCA | 1 |
p.V275I | SKCM | 1 |
p.G386R | SKCM | 1 |
p.G514R | SKCM | 1 |
p.R45G | SKCM | 1 |
p.R9Q | LIHC | 1 |
p.S52* | UCEC | 1 |
p.L400M | COAD | 1 |
p.N383T | UCEC | 1 |
p.W79* | SKCM | 1 |
p.T316I | SKCM | 1 |
p.M349I | UCEC | 1 |
p.A341S | UCEC | 1 |
p.N309K | HNSC | 1 |
p.P209L | LUAD | 1 |
p.Q40P | KIRP | 1 |
p.D334N | UCEC | 1 |
p.G51S | COAD | 1 |
p.R84H | PAAD | 1 |
p.R121H | LUAD | 1 |
p.D431N | STAD | 1 |
p.T256N | STAD | 1 |
p.V60A | LUAD | 1 |
p.S227L | CESC | 1 |
p.R245Q | UCEC | 1 |
p.H288R | SKCM | 1 |
p.X619Y | PAAD | 1 |
p.E3A | SKCM | 1 |
p.D228G | PAAD | 1 |
p.E249D | STAD | 1 |
p.R122H | PAAD | 1 |
p.W557* | SKCM | 1 |
p.G386E | SKCM | 1 |
p.H300R | SKCM | 1 |
p.I476T | SKCM | 1 |
p.Q533L | LUAD | 1 |
p.G330E | SKCM | 1 |
p.A220V | SKCM | 1 |
p.R573H | KICH | 1 |
p.Q525H | STAD | 1 |
p.R122Q | HNSC | 1 |
p.W67X | SKCM | 1 |
p.R365Q | SKCM | 1 |
p.V341M | CESC | 1 |
p.V250M | OV | 1 |
p.Q93H | OV | 1 |
p.A208V | SKCM | 1 |
p.S218Y | READ | 1 |
p.R333C | SKCM | 1 |
p.V312A | STAD | 1 |
p.G398E | SKCM | 1 |
p.G375W | THYM | 1 |
p.V287I | SKCM | 1 |
p.D58N | UCEC | 1 |
p.R176H | UCEC | 1 |
p.D393N | STAD | 1 |
p.R211W | UCEC | 1 |
p.P350S | STAD | 1 |
p.R9W | UCEC | 1 |
p.E293D | LIHC | 1 |
p.G320E | LGG | 1 |
p.G453S | DLBC | 1 |
p.R57G | SKCM | 1 |
p.R220H | PAAD | 1 |
p.T294N | STAD | 1 |
p.R9Q | BRCA | 1 |
p.S21G | LIHC | 1 |
p.G403D | STAD | 1 |
p.S26F | SKCM | 1 |
p.Q78P | KIRP | 1 |
p.I464T | SKCM | 1 |
p.A507D | STAD | 1 |
p.R234W | LUAD | 1 |
p.Q563H | STAD | 1 |
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TissGeneCNV for FBXO24 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for FBXO24 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BF753854 | FBXO24-RBFOX2 | chr7:100198351 | chr22:36205827 |
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TissGeneNet for FBXO24 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for FBXO24 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for FBXO24 |
TissGeneDrug for FBXO24 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for FBXO24 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |