TissGeneSummary for CNNM1 |
Gene summary |
Basic gene information | Gene symbol | CNNM1 |
Gene name | cyclin and CBS domain divalent metal cation transport mediator 1 | |
Synonyms | ACDP1|CLP-1 | |
Cytomap | UCSC genome browser: 10q24.2 | |
Type of gene | protein-coding | |
RefGenes | NM_020348.2, | |
Description | ancient conserved domain protein 1ancient conserved domain-containing protein 1cyclin M1cyclin-M1metal transporter CNNM1 | |
Modification date | 20141207 | |
dbXrefs | MIM : 607802 | |
HGNC : HGNC | ||
Ensembl : ENSG00000119946 | ||
HPRD : 07417 | ||
Vega : OTTHUMG00000018881 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CNNM1 | |
BioGPS: 26507 | ||
Pathway | NCI Pathway Interaction Database: CNNM1 | |
KEGG: CNNM1 | ||
REACTOME: CNNM1 | ||
Pathway Commons: CNNM1 | ||
Context | iHOP: CNNM1 | |
ligand binding site mutation search in PubMed: CNNM1 | ||
UCL Cancer Institute: CNNM1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of CNNM1 | ||
Description by TissGene annotations | Risk TissGene in RFS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for CNNM1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
THCA | -4.199132688 | -2.846373366 | -1.352759322 | 1.42E-08 | 6.96E-08 |
BRCA | -2.440782673 | -0.540366884 | -1.900415789 | 7.85E-16 | 4.33E-15 |
KICH | -4.780102112 | 1.125393888 | -5.905496 | 4.05E-18 | 1.98E-16 |
LUSC | 0.396018359 | -2.048973798 | 2.444992157 | 3.17E-11 | 1.26E-10 |
ESCA | 1.660887343 | 0.056523707 | 1.604363636 | 0.00202 | 0.02291736 |
HNSC | -2.112465088 | -0.577704623 | -1.534760465 | 0.00177 | 0.005562151 |
COAD | -2.591227342 | -1.22866965 | -1.362557692 | 0.000621 | 0.001876705 |
BLCA | -2.311889691 | 0.310883994 | -2.622773684 | 0.000168 | 0.001653239 |
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TissGene-miRNA for CNNM1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for CNNM1 |
TissGeneSNV for CNNM1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.V330M | SKCM | 1 |
p.Q676H | LUAD | 1 |
p.Y757* | LUAD | 1 |
p.V535E | HNSC | 1 |
p.T613I | HNSC | 1 |
p.P948S | PAAD | 1 |
p.V681G | TGCT | 1 |
p.N692S | LGG | 1 |
p.E680G | MESO | 1 |
p.Y628C | STAD | 1 |
p.V713M | LGG | 1 |
p.G313R | DLBC | 1 |
p.P934L | BLCA | 1 |
p.Q676* | LUAD | 1 |
p.R819W | BLCA | 1 |
p.P657L | COAD | 1 |
p.R458L | LUAD | 1 |
p.R738L | SKCM | 1 |
p.S444* | HNSC | 1 |
p.R378H | COAD | 1 |
p.E853K | SKCM | 1 |
p.E468D | COAD | 1 |
p.L661F | SKCM | 1 |
p.E691K | HNSC | 1 |
p.R584W | STAD | 1 |
p.A226S | LUSC | 1 |
p.K523N | THCA | 1 |
p.R819Q | COAD | 1 |
p.G313V | UCEC | 1 |
p.Y807C | UCEC | 1 |
p.S758G | LUAD | 1 |
p.L566M | ESCA | 1 |
p.N537K | SKCM | 1 |
p.A368T | DLBC | 1 |
p.C793S | LUAD | 1 |
p.H507Y | COAD | 1 |
p.P909H | LUSC | 1 |
p.P822S | STAD | 1 |
p.I475N | HNSC | 1 |
p.L26P | ESCA | 1 |
p.Y786C | UCEC | 1 |
p.R394W | STAD | 1 |
p.F440S | BLCA | 1 |
p.P582Q | PRAD | 1 |
p.E853K | STAD | 1 |
p.A830T | SARC | 1 |
p.S597L | UCEC | 1 |
p.T904R | BRCA | 1 |
p.V681G | ACC | 1 |
p.E520Q | CESC | 1 |
p.V466L | BRCA | 1 |
p.C842X | STAD | 1 |
p.R443L | LUAD | 1 |
p.P543S | SKCM | 1 |
p.V681G | STAD | 1 |
p.L627M | UCEC | 1 |
p.R602W | STAD | 1 |
p.F594L | LIHC | 1 |
p.E66K | LUAD | 1 |
p.D574H | HNSC | 1 |
p.P884S | SKCM | 1 |
p.P657R | STAD | 1 |
p.T924P | SKCM | 1 |
p.L27F | CESC | 1 |
p.E559D | UCEC | 1 |
p.I475V | LUSC | 1 |
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TissGeneCNV for CNNM1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for CNNM1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for CNNM1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for CNNM1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for CNNM1 |
TissGeneDrug for CNNM1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for CNNM1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0002395 | Alzheimer's Disease | 1 | GAD |
umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | BeFree |
umls:C0025202 | melanoma | 1 | CTD_human |
umls:C0026848 | Myopathy | 1 | BeFree |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
umls:C0234958 | Muscle degeneration | 1 | BeFree |