TissGDB
Tissglogo

Home

Download

 Statistics

 Landscape

Help

Contact

Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

bullet point

TissGeneSummary

bullet point

TissGeneExp

bullet point

TissGene-miRNA

bullet point

TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

bullet point

TissGeneNet

bullet point

TissGeneProg

bullet point

TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for AMH
check button Gene summary
Basic gene informationGene symbolAMH
Gene nameanti-Mullerian hormone
SynonymsMIF|MIS
CytomapUCSC genome browser: 19p13.3
Type of geneprotein-coding
RefGenesNM_000479.3,
DescriptionMullerian inhibiting factorMullerian inhibiting substanceanti-Muellerian hormonemuellerian-inhibiting factormuellerian-inhibiting substance
Modification date20141222
dbXrefs MIM : 600957
HGNC : HGNC
Ensembl : ENSG00000104899
HPRD : 02979
Vega : OTTHUMG00000180415
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_AMH
BioGPS: 268
PathwayNCI Pathway Interaction Database: AMH
KEGG: AMH
REACTOME: AMH
Pathway Commons: AMH
ContextiHOP: AMH
ligand binding site mutation search in PubMed: AMH
UCL Cancer Institute: AMH
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesHPA,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Testis
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)TGCT
Reference showing the relevant tissue of AMH
Description by TissGene annotationsCancer gene
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID
GO:0001880Mullerian duct regression14695376
GO:0001880Mullerian duct regression14695376


Top
TissGeneExp for AMH

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
BRCA-1.816283907-2.9742207491.1579368424.13E-091.41E-08
KIRP-1.859368885-3.035428261.1760593750.003880.00935372
ESCA1.666874865-1.1649978622.8318727271.77E-050.001157788
KICH-1.136585135-2.8676811351.7310960.0004520.001044243
LUSC-1.766968272-2.8563447421.0893764710.000130.000265422
BLCA-0.116535661-2.7114409242.5949052631.30E-050.000236984
COAD-1.107305904-2.9975482121.8902423085.71E-050.000222609
STAD0.41671549-1.916828262.333543751.22E-050.000137189


Top
TissGene-miRNA for AMH

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


Top
TissGeneMut for AMH
TissGeneSNV for AMH

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
bullet point


check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.V515ACOAD5
p.P398LKIRP1
p.S226RPAAD1
p.V57MCOAD1
p.P480SLUAD1
p.G36VTHYM1
p.P170HCOAD1
p.Q496*BLCA1
p.G65SSTAD1
p.A519VACC1
p.A75VPAAD1
p.G157DTHYM1
p.E41KBLCA1
p.R116WCOAD1
p.G74WKIRP1
p.G119VLIHC1
p.E556KHNSC1


Top
TissGeneCNV for AMH

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


Top
TissGeneFusions for AMH

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP


Top
TissGeneNet for AMH

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
AMH, COPS5, EGFR, PCSK5, NR5A1, SOX9, AMHR2, ARL8B, ZMAT2, ETV5 (tumor)AMH, COPS5, EGFR, PCSK5, NR5A1, SOX9, AMHR2, ARL8B, ZMAT2, ETV5 (normal)
bullet pointbullet point
COAD (tumor)COAD (normal)
AMH, COPS5, EGFR, PCSK5, NR5A1, SOX9, AMHR2, ARL8B, ZMAT2, ETV5 (tumor)AMH, COPS5, EGFR, PCSK5, NR5A1, SOX9, AMHR2, ARL8B, ZMAT2, ETV5 (normal)
bullet pointbullet point
HNSC (tumor)HNSC (normal)
AMH, COPS5, EGFR, PCSK5, NR5A1, SOX9, AMHR2, ARL8B, ZMAT2, ETV5 (tumor)AMH, COPS5, EGFR, PCSK5, NR5A1, SOX9, AMHR2, ARL8B, ZMAT2, ETV5 (normal)
bullet pointbullet point
KICH (tumor)KICH (normal)
AMH, COPS5, EGFR, PCSK5, NR5A1, SOX9, AMHR2, ARL8B, ZMAT2, ETV5 (tumor)AMH, COPS5, EGFR, PCSK5, NR5A1, SOX9, AMHR2, ARL8B, ZMAT2, ETV5 (normal)
bullet pointbullet point
KIRC (tumor)KIRC (normal)
AMH, COPS5, EGFR, PCSK5, NR5A1, SOX9, AMHR2, ARL8B, ZMAT2, ETV5 (tumor)AMH, COPS5, EGFR, PCSK5, NR5A1, SOX9, AMHR2, ARL8B, ZMAT2, ETV5 (normal)
bullet pointbullet point
KIRP (tumor)KIRP (normal)
AMH, COPS5, EGFR, PCSK5, NR5A1, SOX9, AMHR2, ARL8B, ZMAT2, ETV5 (tumor)AMH, COPS5, EGFR, PCSK5, NR5A1, SOX9, AMHR2, ARL8B, ZMAT2, ETV5 (normal)
bullet pointbullet point
LIHC (tumor)LIHC (normal)
AMH, COPS5, EGFR, PCSK5, NR5A1, SOX9, AMHR2, ARL8B, ZMAT2, ETV5 (tumor)AMH, COPS5, EGFR, PCSK5, NR5A1, SOX9, AMHR2, ARL8B, ZMAT2, ETV5 (normal)
bullet pointbullet point
LUAD (tumor)LUAD (normal)
AMH, COPS5, EGFR, PCSK5, NR5A1, SOX9, AMHR2, ARL8B, ZMAT2, ETV5 (tumor)AMH, COPS5, EGFR, PCSK5, NR5A1, SOX9, AMHR2, ARL8B, ZMAT2, ETV5 (normal)
bullet pointbullet point
LUSC (tumor)LUSC (normal)
AMH, COPS5, EGFR, PCSK5, NR5A1, SOX9, AMHR2, ARL8B, ZMAT2, ETV5 (tumor)AMH, COPS5, EGFR, PCSK5, NR5A1, SOX9, AMHR2, ARL8B, ZMAT2, ETV5 (normal)
bullet pointbullet point
PRAD (tumor)PRAD (normal)
AMH, COPS5, EGFR, PCSK5, NR5A1, SOX9, AMHR2, ARL8B, ZMAT2, ETV5 (tumor)AMH, COPS5, EGFR, PCSK5, NR5A1, SOX9, AMHR2, ARL8B, ZMAT2, ETV5 (normal)
bullet pointbullet point
STAD (tumor)STAD (normal)
AMH, COPS5, EGFR, PCSK5, NR5A1, SOX9, AMHR2, ARL8B, ZMAT2, ETV5 (tumor)AMH, COPS5, EGFR, PCSK5, NR5A1, SOX9, AMHR2, ARL8B, ZMAT2, ETV5 (normal)
bullet pointbullet point
THCA (tumor)THCA (normal)
AMH, COPS5, EGFR, PCSK5, NR5A1, SOX9, AMHR2, ARL8B, ZMAT2, ETV5 (tumor)AMH, COPS5, EGFR, PCSK5, NR5A1, SOX9, AMHR2, ARL8B, ZMAT2, ETV5 (normal)
bullet pointbullet point


Top
TissGeneProg for AMH

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

Top
TissGeneClin for AMH
TissGeneDrug for AMH

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


Top
TissGeneDisease for AMH

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C1849930Persistent Mullerian duct syndrome23BeFree,CTD_human,ORPHANET,UNIPROT
umls:C0032460Polycystic Ovary Syndrome17BeFree,GAD,LHGDN
umls:C0029928Ovarian Diseases9BeFree
umls:C0003873Rheumatoid Arthritis8BeFree
umls:C0041408Turner Syndrome8BeFree
umls:C0029925Ovarian Carcinoma7BeFree
umls:C1140680Malignant neoplasm of ovary7BeFree
umls:C0085215Ovarian Failure, Premature6BeFree,GAD,LHGDN
umls:C0009324Ulcerative Colitis5BeFree
umls:C0018051Gonadal Dysgenesis5BeFree
umls:C0028754Obesity5BeFree
umls:C0376358Malignant neoplasm of prostate5BeFree
umls:C0600139Prostate carcinoma5BeFree
umls:C0919267ovarian neoplasm5BeFree,LHGDN,RGD
umls:C0006142Malignant neoplasm of breast4BeFree
umls:C0678222Breast Carcinoma4BeFree
umls:C3714757Juvenile rheumatoid arthritis4BeFree
umls:C0003850Arteriosclerosis3BeFree
umls:C0004153Atherosclerosis3BeFree
umls:C0004364Autoimmune Diseases3BeFree
umls:C0007847Malignant tumor of cervix3BeFree
umls:C0014175Endometriosis3BeFree,LHGDN
umls:C0018206granulosa cell tumor3BeFree,LHGDN
umls:C0021390Inflammatory Bowel Diseases3BeFree
umls:C0022735Klinefelter Syndrome3BeFree
umls:C0024141Lupus Erythematosus, Systemic3BeFree
umls:C0024530Malaria3BeFree
umls:C0024623Malignant neoplasm of stomach3BeFree
umls:C0026769Multiple Sclerosis3BeFree
umls:C0027708Nephroblastoma3BeFree
umls:C0036202Sarcoidosis3BeFree
umls:C0038454Cerebrovascular accident3BeFree
umls:C0042755Virilism3BeFree
umls:C0302592Cervix carcinoma3BeFree
umls:C0374997Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site3BeFree
umls:C0596263Carcinogenesis3BeFree
umls:C0699791Stomach Carcinoma3BeFree
umls:C1261504Congenital absence of both testes3BeFree
umls:C3495559Juvenile arthritis3BeFree
umls:C3839507Diminished ovarian reserve3BeFree
umls:C0010417Cryptorchidism2BeFree
umls:C0011854Diabetes Mellitus, Insulin-Dependent2BeFree
umls:C0011860Diabetes Mellitus, Non-Insulin-Dependent2BeFree
umls:C0017152Gastritis2BeFree
umls:C0017636Glioblastoma2BeFree
umls:C0025202melanoma2BeFree
umls:C0025286Meningioma2BeFree
umls:C0027051Myocardial Infarction2BeFree
umls:C0027726Nephrotic Syndrome2BeFree
umls:C0032002Pituitary Diseases2BeFree
umls:C0033578Prostatic Neoplasms2BeFree,LHGDN
umls:C0033860Psoriasis2BeFree
umls:C0039585Androgen-Insensitivity Syndrome2BeFree
umls:C0085083Ovarian Hyperstimulation Syndrome2BeFree
umls:C0162809Kallmann Syndrome2BeFree
umls:C0238395Male Pseudohermaphroditism2BeFree
umls:C0266360Streak gonad2BeFree
umls:C0268301Reifenstein Syndrome2BeFree
umls:C0271623Hypogonadotropic hypogonadism2BeFree
umls:C0429468Anovulatory2BeFree
umls:C0476089Endometrial Carcinoma2BeFree
umls:C0677886Epithelial ovarian cancer2BeFree,GAD
umls:C0850666Helicobacter pylori infection2BeFree
umls:C0936016Testicular Feminization2BeFree
umls:C0000768Congenital Abnormality1BeFree
umls:C0001430Adenoma1BeFree
umls:C0001623Adrenal gland hypofunction1BeFree
umls:C0003128Anovulation1BeFree
umls:C0004943Behcet Syndrome1BeFree
umls:C0004997Benign Ovarian Neoplasm1BeFree
umls:C0005411Biliary Atresia1BeFree
umls:C0005684Malignant neoplasm of urinary bladder1BeFree
umls:C0006012Borderline Personality Disorder1BeFree
umls:C0006118Brain Neoplasms1BeFree
umls:C0006287Bronchopulmonary Dysplasia1BeFree
umls:C0007103Malignant neoplasm of endometrium1BeFree
umls:C0007131Non-Small Cell Lung Carcinoma1BeFree
umls:C0007570Celiac Disease1BeFree
umls:C0008312Primary biliary cirrhosis1BeFree
umls:C0008352Cholemia1BeFree
umls:C0008690Chronic anterior uveitis1BeFree
umls:C0009319Colitis1BeFree
umls:C0010054Coronary Arteriosclerosis1BeFree
umls:C0010068Coronary heart disease1BeFree
umls:C0010674Cystic Fibrosis1BeFree
umls:C0010823Cytomegalovirus Infections1BeFree
umls:C0011847Diabetes1BeFree
umls:C0011849Diabetes Mellitus1BeFree
umls:C0011881Diabetic Nephropathy1BeFree
umls:C0014072Experimental Autoimmune Encephalomyelitis1BeFree
umls:C0018213Graves Disease1BeFree
umls:C0019270Hernia1BeFree
umls:C0020619Hypogonadism1LHGDN
umls:C0021361Female infertility1GAD
umls:C0022116Ischemia1BeFree
umls:C0023434Chronic Lymphocytic Leukemia1BeFree
umls:C0023467Leukemia, Myelocytic, Acute1BeFree
umls:C0024117Chronic Obstructive Airway Disease1BeFree
umls:C0024299Lymphoma1BeFree
umls:C0024535Malaria, Falciparum1BeFree
umls:C0025268Multiple Endocrine Neoplasia Type 2a1BeFree
umls:C0025303Meningococcal Infections1BeFree
umls:C0025362Mental Retardation1BeFree
umls:C0026269Mitral Valve Stenosis1BeFree
umls:C0026691Mucocutaneous Lymph Node Syndrome1BeFree
umls:C0027126Myotonic Dystrophy1BeFree
umls:C0027819Neuroblastoma1BeFree
umls:C0030354Papilloma1BeFree
umls:C0032285Pneumonia1BeFree
umls:C0033027Preleukemia1BeFree
umls:C0033804Pseudohermaphroditism1BeFree
umls:C0033817Pseudomonas Infections1BeFree
umls:C0034013Precocious Puberty1BeFree
umls:C0034152Henoch-Schoenlein Purpura1BeFree
umls:C0035222Respiratory Distress Syndrome, Adult1BeFree
umls:C0036341Schizophrenia1BeFree
umls:C0036421Systemic Scleroderma1BeFree
umls:C0036690Septicemia1BeFree
umls:C0039483Giant Cell Arteritis1BeFree
umls:C0039590Testicular Neoplasms1BeFree
umls:C0041107Trisomy1BeFree
umls:C0041296Tuberculosis1BeFree
umls:C0042075Urologic Diseases1BeFree
umls:C0042170Uveomeningoencephalitic Syndrome1BeFree
umls:C0151436Vasculitis, Leukocytoclastic, Cutaneous1BeFree
umls:C0151721Testicular hypogonadism1BeFree
umls:C0151744Myocardial Ischemia1BeFree
umls:C0153676Secondary malignant neoplasm of lung1BeFree
umls:C0155626Acute myocardial infarction1BeFree
umls:C0162872Aortic Aneurysm, Thoracic1BeFree
umls:C0205748Dysplastic Nevus1BeFree
umls:C0205851Germ cell tumor1BeFree
umls:C0206661Gonadoblastoma1BeFree
umls:C0206701Cystadenocarcinoma, Serous1BeFree
umls:C0241910Hepatitis, Autoimmune1BeFree
umls:C0243026Sepsis1BeFree
umls:C0262988Vasculitis of the skin1BeFree
umls:C0266361True Hermaphroditism (disorder)1BeFree
umls:C0266362Ambiguous Genitalia1BeFree
umls:C0266435Congenital hypoplasia of penis1BeFree
umls:C0267375Chronic colitis1BeFree
umls:C0268151Classical galactosemia1BeFree
umls:C0271528Isosexual precocious puberty1BeFree
umls:C0278704Malignant Childhood Neoplasm1BeFree
umls:C0280220stage, ovarian epithelial cancer1BeFree
umls:C0342510Ovarian dysgenesis1BeFree
umls:C0406317Chronic small plaque psoriasis1BeFree
umls:C0410226Congenital Myotonic Dystrophy1BeFree
umls:C0432474Klinefelter's syndrome - male with more than two X chromosomes1BeFree
umls:C0520463Chronic active hepatitis1BeFree
umls:C0524851Neurodegenerative Disorders1BeFree
umls:C0699885Carcinoma of bladder1BeFree
umls:C0700095Central neuroblastoma1BeFree
umls:C0747102Ovarian failure1BeFree
umls:C0848558Hypospadias1BeFree
umls:C0948896Primary hypogonadism1BeFree
umls:C1384582Primary testicular failure1BeFree
umls:C1384583Congenital absence of germinal epithelium of testes1BeFree
umls:C1387005Penis agenesis1BeFree
umls:C1401084Ovarian Insufficiency1BeFree
umls:C1458155Mammary Neoplasms1BeFree
umls:C1559271Non-Malignant Ascites Adverse Event1BeFree
umls:C1691215Penile hypospadias1BeFree
umls:C1692871Inflammatory polyarthritis1BeFree
umls:C1720887Female Urogenital Diseases1CTD_human
umls:C1883486Uterine Corpus Cancer1BeFree
umls:C2930618Intersex Conditions1BeFree
umls:C2931822Nasopharyngeal carcinoma1BeFree
umls:C3463824MYELODYSPLASTIC SYNDROME1BeFree