TissGeneSummary for FETUB |
Gene summary |
Basic gene information | Gene symbol | FETUB |
Gene name | fetuin B | |
Synonyms | 16G2|Gugu|IRL685 | |
Cytomap | UCSC genome browser: 3q27 | |
Type of gene | protein-coding | |
RefGenes | NM_014375.2, | |
Description | fetuin-Bfetuin-like protein IRL685 | |
Modification date | 20141207 | |
dbXrefs | MIM : 605954 | |
HGNC : HGNC | ||
Ensembl : ENSG00000090512 | ||
HPRD : 09335 | ||
Vega : OTTHUMG00000156586 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_FETUB | |
BioGPS: 26998 | ||
Pathway | NCI Pathway Interaction Database: FETUB | |
KEGG: FETUB | ||
REACTOME: FETUB | ||
Pathway Commons: FETUB | ||
Context | iHOP: FETUB | |
ligand binding site mutation search in PubMed: FETUB | ||
UCL Cancer Institute: FETUB | ||
Assigned class in TissGDB* | A | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
Reference showing the relevant tissue of FETUB | Toxicogenomics and cross-species biomarker discovery: applications in drug discovery and safety assessment. Orr MS. Toxicol Mech Methods. 2006;16(2-3):79-87. doi: 10.1080/15376520600558317. (pmid:20021000) go to article | |
Description by TissGene annotations | Cancer gene TissgsKTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for FETUB |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LIHC | 6.979698996 | 9.838020996 | -2.858322 | 4.61E-08 | 3.51E-07 |
KIRC | -1.86723356 | -0.710714115 | -1.156519444 | 1.39E-06 | 3.51E-06 |
KICH | -2.551603004 | -0.574435004 | -1.977168 | 3.34E-07 | 1.37E-06 |
LUSC | 1.291755819 | -2.309510847 | 3.601266667 | 4.45E-08 | 1.30E-07 |
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TissGene-miRNA for FETUB |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for FETUB |
TissGeneSNV for FETUB |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.P300S | SKCM | 2 |
p.G336E | SKCM | 2 |
p.E337K | BLCA | 2 |
p.G336R | SKCM | 2 |
p.V95A | LUAD | 1 |
p.E337* | UCEC | 1 |
p.S214L | CESC | 1 |
p.H165Q | GBM | 1 |
p.E283* | SKCM | 1 |
p.C10X | COAD | 1 |
p.Q116E | LUAD | 1 |
p.I211F | LIHC | 1 |
p.V129A | STAD | 1 |
p.P290S | SKCM | 1 |
p.G302E | SKCM | 1 |
p.I341N | LUSC | 1 |
p.P381L | SARC | 1 |
p.G77V | ACC | 1 |
p.L139V | BLCA | 1 |
p.S143X | COAD | 1 |
p.A176G | PRAD | 1 |
p.R140H | STAD | 1 |
p.A176G | BRCA | 1 |
p.E181D | READ | 1 |
p.D58N | SKCM | 1 |
p.Y148F | SKCM | 1 |
p.E173* | LIHC | 1 |
p.S143X | ACC | 1 |
p.S225L | SKCM | 1 |
p.P21S | BLCA | 1 |
p.R364C | PAAD | 1 |
p.R66G | HNSC | 1 |
p.G17* | LUAD | 1 |
p.R364H | COAD | 1 |
p.P233S | UCEC | 1 |
p.E337K | SKCM | 1 |
p.E351V | STAD | 1 |
p.R140C | SKCM | 1 |
p.G59R | PAAD | 1 |
p.S33F | LUAD | 1 |
p.A375V | BLCA | 1 |
p.E213* | UCEC | 1 |
p.P308S | SKCM | 1 |
p.F82L | OV | 1 |
p.R75_splice | LUSC | 1 |
p.S219F | STAD | 1 |
p.T150M | LUSC | 1 |
p.E361K | SKCM | 1 |
p.K57N | COAD | 1 |
p.C36Y | COAD | 1 |
p.Q220R | ESCA | 1 |
p.E213X | COAD | 1 |
p.G302X | COAD | 1 |
p.D293N | SKCM | 1 |
p.P320T | BLCA | 1 |
p.S184F | SKCM | 1 |
p.R364C | COAD | 1 |
p.L31P | LIHC | 1 |
p.I147V | KIRP | 1 |
p.S196F | SKCM | 1 |
p.Y209C | HNSC | 1 |
p.P381Q | LUAD | 1 |
p.R243Q | COAD | 1 |
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TissGeneCNV for FETUB |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for FETUB |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for FETUB |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for FETUB |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for FETUB |
TissGeneDrug for FETUB |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for FETUB |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0000786 | Spontaneous abortion | 1 | CTD_human |
umls:C0155626 | Acute myocardial infarction | 1 | BeFree |
umls:C0340288 | Stable angina | 1 | BeFree |