TissGeneSummary for KCNV1 |
Gene summary |
Basic gene information | Gene symbol | KCNV1 |
Gene name | potassium channel, subfamily V, member 1 | |
Synonyms | HNKA|KCNB3|KV2.3|KV8.1 | |
Cytomap | UCSC genome browser: 8q23.2 | |
Type of gene | protein-coding | |
RefGenes | NM_014379.2, | |
Description | neuronal potassium channel alpha subunit HNKApotassium channel Kv8.1potassium voltage-gated channel subfamily V member 1voltage-gated potassium channel subunit Kv8.1 | |
Modification date | 20141207 | |
dbXrefs | MIM : 608164 | |
HGNC : HGNC | ||
Ensembl : ENSG00000164794 | ||
HPRD : 16293 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_KCNV1 | |
BioGPS: 27012 | ||
Pathway | NCI Pathway Interaction Database: KCNV1 | |
KEGG: KCNV1 | ||
REACTOME: KCNV1 | ||
Pathway Commons: KCNV1 | ||
Context | iHOP: KCNV1 | |
ligand binding site mutation search in PubMed: KCNV1 | ||
UCL Cancer Institute: KCNV1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,TiGER | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Brain | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGG | |
Reference showing the relevant tissue of KCNV1 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for KCNV1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRP | 4.155081935 | 0.509663185 | 3.64541875 | 1.05E-09 | 9.81E-09 |
LUAD | 0.104181612 | -1.45754425 | 1.561725862 | 2.64E-06 | 8.25E-06 |
THCA | 2.31284184 | 1.256528281 | 1.056313559 | 1.02E-09 | 5.88E-09 |
KICH | -1.70820894 | 0.76172306 | -2.469932 | 6.04E-11 | 4.88E-10 |
COAD | 1.167469676 | 2.897392753 | -1.729923077 | 0.000505 | 0.00155183 |
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TissGene-miRNA for KCNV1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
LUSC | hsa-miR-758-3p | MIMAT0003879 | 0.0026 | -0.27 | 128 |
UCS | hsa-let-7f-5p | MIMAT0000067 | 0.035 | -0.29 | 56 |
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TissGeneMut for KCNV1 |
TissGeneSNV for KCNV1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.G187R | SKCM | 2 |
p.F436V | STAD | 2 |
p.G495R | SKCM | 2 |
p.L349P | LUAD | 1 |
p.E243K | SKCM | 1 |
p.Y365H | COAD | 1 |
p.R265W | LGG | 1 |
p.R315M | UCEC | 1 |
p.S146N | SKCM | 1 |
p.V214I | PRAD | 1 |
p.E449D | PRAD | 1 |
p.P85H | LUAD | 1 |
p.L229M | STAD | 1 |
p.G416E | SKCM | 1 |
p.V311F | SARC | 1 |
p.K456N | LUSC | 1 |
p.R260H | SKCM | 1 |
p.D92N | UCEC | 1 |
p.P96T | LUAD | 1 |
p.Q194K | LUAD | 1 |
p.G187A | SKCM | 1 |
p.W499R | LUAD | 1 |
p.E442K | SKCM | 1 |
p.R77L | READ | 1 |
p.V264L | BRCA | 1 |
p.A425P | LUAD | 1 |
p.W252C | LUSC | 1 |
p.S370R | STAD | 1 |
p.D401E | HNSC | 1 |
p.R333C | CESC | 1 |
p.V214I | PAAD | 1 |
p.V70L | KIRP | 1 |
p.R210H | SARC | 1 |
p.C189Y | GBM | 1 |
p.R267K | SKCM | 1 |
p.S180N | UCEC | 1 |
p.A386V | UCEC | 1 |
p.A459D | BLCA | 1 |
p.D183E | SKCM | 1 |
p.I339T | LUAD | 1 |
p.A319D | GBM | 1 |
p.V408E | LUAD | 1 |
p.I371V | COAD | 1 |
p.V220M | STAD | 1 |
p.S361L | SKCM | 1 |
p.I224L | STAD | 1 |
p.L418F | HNSC | 1 |
p.G187E | SKCM | 1 |
p.P380S | SKCM | 1 |
p.A209V | OV | 1 |
p.P85L | ESCA | 1 |
p.R446T | STAD | 1 |
p.Q240H | LUAD | 1 |
p.R481* | ESCA | 1 |
p.T375N | SARC | 1 |
p.Q186K | HNSC | 1 |
p.G204V | LUAD | 1 |
p.P190S | SKCM | 1 |
p.T301M | THYM | 1 |
p.E344K | SKCM | 1 |
p.C249Y | LUSC | 1 |
p.S361* | HNSC | 1 |
p.S354F | SKCM | 1 |
p.I244M | UVM | 1 |
p.S86R | TGCT | 1 |
p.R333S | LUSC | 1 |
p.P423S | STAD | 1 |
p.T300I | COAD | 1 |
p.R272I | BRCA | 1 |
p.C342W | UCEC | 1 |
p.G356* | CESC | 1 |
p.E163Q | BLCA | 1 |
p.C59S | HNSC | 1 |
p.R260H | PRAD | 1 |
p.W385* | CESC | 1 |
p.L320M | ESCA | 1 |
p.R481X | ESCA | 1 |
p.R309C | BLCA | 1 |
p.G356* | HNSC | 1 |
p.E233* | LUAD | 1 |
p.L418F | UCEC | 1 |
p.L131F | BLCA | 1 |
p.Y343C | STAD | 1 |
p.R121H | COAD | 1 |
p.R333H | STAD | 1 |
p.R260C | STAD | 1 |
p.F212V | STAD | 1 |
p.I211F | SKCM | 1 |
p.R76L | BRCA | 1 |
p.C342W | BLCA | 1 |
p.V311L | HNSC | 1 |
p.R491G | KICH | 1 |
p.P372S | SKCM | 1 |
p.G495E | SKCM | 1 |
p.E100K | CESC | 1 |
p.R265W | HNSC | 1 |
p.S370R | SARC | 1 |
p.R481* | PRAD | 1 |
p.M477I | SKCM | 1 |
p.V346F | LUAD | 1 |
p.A109V | STAD | 1 |
p.R321C | COAD | 1 |
p.N95S | ESCA | 1 |
p.S298I | HNSC | 1 |
p.R111Q | STAD | 1 |
p.G331X | COAD | 1 |
p.A386T | STAD | 1 |
p.R210L | BLCA | 1 |
p.E486K | BRCA | 1 |
p.R321C | STAD | 1 |
p.R272K | SKCM | 1 |
p.D497A | COAD | 1 |
p.I424N | STAD | 1 |
p.V393L | HNSC | 1 |
p.F253L | SKCM | 1 |
p.H328Y | OV | 1 |
p.D497N | BLCA | 1 |
p.S329F | SKCM | 1 |
p.M337I | HNSC | 1 |
p.E100K | SKCM | 1 |
p.I427T | LUSC | 1 |
p.R265W | PRAD | 1 |
p.Q240H | UCEC | 1 |
p.E179G | SKCM | 1 |
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TissGeneCNV for KCNV1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for KCNV1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for KCNV1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for KCNV1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for KCNV1 |
TissGeneDrug for KCNV1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for KCNV1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C1271104 | Blood pressure finding | 1 | GAD |
umls:C1272641 | Systemic arterial pressure | 1 | GAD |