TissGeneSummary for ZBTB32 |
Gene summary |
Basic gene information | Gene symbol | ZBTB32 |
Gene name | zinc finger and BTB domain containing 32 | |
Synonyms | FAXF|FAZF|Rog|TZFP|ZNF538 | |
Cytomap | UCSC genome browser: 19q13.1 | |
Type of gene | protein-coding | |
RefGenes | NM_014383.1, | |
Description | FANCC-interacting proteinfanconi anemia zinc finger proteinrepressor of GATAtestis zinc finger proteinzinc finger and BTB domain-containing protein 32zinc finger protein 538 | |
Modification date | 20141207 | |
dbXrefs | MIM : 605859 | |
HGNC : HGNC | ||
Ensembl : ENSG00000011590 | ||
HPRD : 12055 | ||
Vega : OTTHUMG00000048118 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ZBTB32 | |
BioGPS: 27033 | ||
Pathway | NCI Pathway Interaction Database: ZBTB32 | |
KEGG: ZBTB32 | ||
REACTOME: ZBTB32 | ||
Pathway Commons: ZBTB32 | ||
Context | iHOP: ZBTB32 | |
ligand binding site mutation search in PubMed: ZBTB32 | ||
UCL Cancer Institute: ZBTB32 | ||
Assigned class in TissGDB* | A | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of ZBTB32 | Tzfp represses the androgen receptor in mouse testis.PLoS One. 2013 Apr 25;8(4):e62314. (pmid:3634227) go to article | |
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for ZBTB32 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRC | -0.821504841 | -1.857010397 | 1.035505556 | 1.57E-11 | 6.02E-11 |
HNSC | 0.642443706 | -0.720312108 | 1.362755814 | 4.87E-07 | 4.03E-06 |
ESCA | 0.630384932 | -1.064242341 | 1.694627273 | 0.00512 | 0.040094648 |
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TissGene-miRNA for ZBTB32 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for ZBTB32 |
TissGeneSNV for ZBTB32 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.G284E | BLCA | 1 |
p.H43D | LUAD | 1 |
p.D206N | SKCM | 1 |
p.R113X | COAD | 1 |
p.R25W | STAD | 1 |
p.S248X | STAD | 1 |
p.P427S | BLCA | 1 |
p.T346A | STAD | 1 |
p.L420M | LUAD | 1 |
p.R195C | COAD | 1 |
p.E129K | KIRP | 1 |
p.G434W | BLCA | 1 |
p.E132D | UCEC | 1 |
p.D121N | HNSC | 1 |
p.R16W | SKCM | 1 |
p.E147* | PAAD | 1 |
p.R136K | SKCM | 1 |
p.S313F | UCEC | 1 |
p.E147X | PAAD | 1 |
p.P260H | PRAD | 1 |
p.A42T | LUAD | 1 |
p.P479T | LIHC | 1 |
p.Q387L | LIHC | 1 |
p.R136M | READ | 1 |
p.G273S | STAD | 1 |
p.S442F | SKCM | 1 |
p.E139K | BLCA | 1 |
p.A117T | UCEC | 1 |
p.G13D | SKCM | 1 |
p.A117V | KIRP | 1 |
p.S104F | SKCM | 1 |
p.S222F | KIRP | 1 |
p.R371L | ESCA | 1 |
p.P260T | LIHC | 1 |
p.P438T | OV | 1 |
p.K125T | BLCA | 1 |
p.S483F | BLCA | 1 |
p.G146R | SKCM | 1 |
p.A252S | SARC | 1 |
p.T422A | STAD | 1 |
p.S476L | HNSC | 1 |
p.C480G | SKCM | 1 |
p.Y428* | PRAD | 1 |
p.Q408L | BLCA | 1 |
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TissGeneCNV for ZBTB32 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for ZBTB32 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for ZBTB32 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for ZBTB32 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for ZBTB32 |
TissGeneDrug for ZBTB32 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for ZBTB32 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0015625 | Fanconi Anemia | 2 | BeFree,LHGDN |
umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
umls:C0023487 | Acute Promyelocytic Leukemia | 1 | BeFree |
umls:C0079744 | Diffuse Large B-Cell Lymphoma | 1 | BeFree |
umls:C0278996 | Cancer of Head and Neck | 1 | BeFree |
umls:C0678222 | Breast Carcinoma | 1 | BeFree |
umls:C1168401 | Squamous cell carcinoma of the head and neck | 1 | BeFree |
umls:C2349952 | Oropharyngeal Carcinoma | 1 | BeFree |
umls:C2745900 | Promyelocytic leukemia | 1 | BeFree |
umls:C3469521 | FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder) | 1 | BeFree |