TissGeneSummary for GK2 |
Gene summary |
Basic gene information | Gene symbol | GK2 |
Gene name | glycerol kinase 2 | |
Synonyms | GKP2|GKTA | |
Cytomap | UCSC genome browser: 4q13 | |
Type of gene | protein-coding | |
RefGenes | NM_033214.2, | |
Description | ATP:glycerol 3-phosphotransferase 2glycerokinase 2glycerol kinase pseudogene 2glycerol kinase testis specific 2glycerol kinase, testis specific 2 | |
Modification date | 20141207 | |
dbXrefs | MIM : 600148 | |
HGNC : HGNC | ||
Ensembl : ENSG00000196475 | ||
HPRD : 15966 | ||
Vega : OTTHUMG00000130199 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_GK2 | |
BioGPS: 2712 | ||
Pathway | NCI Pathway Interaction Database: GK2 | |
KEGG: GK2 | ||
REACTOME: GK2 | ||
Pathway Commons: GK2 | ||
Context | iHOP: GK2 | |
ligand binding site mutation search in PubMed: GK2 | ||
UCL Cancer Institute: GK2 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of GK2 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for GK2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for GK2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for GK2 |
TissGeneSNV for GK2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R330C | SKCM | 5 |
p.G273E | SKCM | 2 |
p.R155C | SKCM | 2 |
p.M508I | SKCM | 2 |
p.D259N | SKCM | 2 |
p.G533E | SKCM | 2 |
p.E77K | UCEC | 2 |
p.E77K | SKCM | 2 |
p.R420C | SKCM | 2 |
p.H443Y | SKCM | 2 |
p.I60S | UCEC | 2 |
p.E319A | LUAD | 1 |
p.R155C | HNSC | 1 |
p.A33G | UCEC | 1 |
p.G427R | SKCM | 1 |
p.P531L | LIHC | 1 |
p.D344G | BLCA | 1 |
p.C283F | OV | 1 |
p.S480L | SKCM | 1 |
p.F364Y | SKCM | 1 |
p.Q165X | SKCM | 1 |
p.V164I | UCEC | 1 |
p.R155C | UCEC | 1 |
p.S355F | SKCM | 1 |
p.K129N | TGCT | 1 |
p.D440Y | UCEC | 1 |
p.I183M | HNSC | 1 |
p.A69V | STAD | 1 |
p.E50K | SKCM | 1 |
p.E238K | SKCM | 1 |
p.Q274H | LUSC | 1 |
p.E42A | STAD | 1 |
p.E346A | READ | 1 |
p.A314V | UCEC | 1 |
p.E124K | ACC | 1 |
p.W100* | SKCM | 1 |
p.S473R | COAD | 1 |
p.G458R | SKCM | 1 |
p.G353E | SKCM | 1 |
p.Q165* | SKCM | 1 |
p.G382D | LUSC | 1 |
p.G378E | SKCM | 1 |
p.S236F | SKCM | 1 |
p.W114X | SKCM | 1 |
p.A305S | KICH | 1 |
p.N84I | COAD | 1 |
p.L543I | LUAD | 1 |
p.R377T | BLCA | 1 |
p.R347I | UCEC | 1 |
p.S146N | STAD | 1 |
p.T429N | HNSC | 1 |
p.Y359* | MESO | 1 |
p.E169K | SKCM | 1 |
p.E95K | SKCM | 1 |
p.S496R | UCEC | 1 |
p.Y109* | BRCA | 1 |
p.R172I | SKCM | 1 |
p.L474I | LGG | 1 |
p.Y306X | THYM | 1 |
p.L108I | UCEC | 1 |
p.D101E | COAD | 1 |
p.V164I | STAD | 1 |
p.A167D | UCEC | 1 |
p.L108I | CHOL | 1 |
p.M227I | BLCA | 1 |
p.G258E | LUAD | 1 |
p.E66K | UCEC | 1 |
p.K49R | SKCM | 1 |
p.W114* | SKCM | 1 |
p.F223S | HNSC | 1 |
p.R499C | SKCM | 1 |
p.M540I | COAD | 1 |
p.G51E | SKCM | 1 |
p.R204M | PAAD | 1 |
p.D259N | BLCA | 1 |
p.M484T | LGG | 1 |
p.E406D | CESC | 1 |
p.P226S | SKCM | 1 |
p.W52L | COAD | 1 |
p.V446A | LUSC | 1 |
p.G14R | SKCM | 1 |
p.N79S | LUAD | 1 |
p.S355F | LUSC | 1 |
p.G343E | SKCM | 1 |
p.A506D | SKCM | 1 |
p.V541I | KICH | 1 |
p.T197A | SARC | 1 |
p.A33V | ESCA | 1 |
p.E59X | COAD | 1 |
p.D198Y | UCEC | 1 |
p.E59* | UCEC | 1 |
p.A33V | STAD | 1 |
p.L300F | SKCM | 1 |
p.Y240C | LGG | 1 |
p.A8V | SKCM | 1 |
p.P226L | LUSC | 1 |
p.T341I | SKCM | 1 |
p.P226S | LUAD | 1 |
p.S510L | HNSC | 1 |
p.W100X | SKCM | 1 |
p.V481I | LIHC | 1 |
p.R310T | ESCA | 1 |
p.R547T | BRCA | 1 |
p.A546E | LUAD | 1 |
p.L103X | COAD | 1 |
p.E311D | UCEC | 1 |
p.R24H | UCEC | 1 |
p.R486Q | SKCM | 1 |
p.L219F | COAD | 1 |
p.S236C | PAAD | 1 |
p.G280E | SKCM | 1 |
p.S127N | LGG | 1 |
p.K140Q | COAD | 1 |
p.A33V | BLCA | 1 |
p.V190I | PAAD | 1 |
p.K102R | LUAD | 1 |
p.E272K | SKCM | 1 |
p.E406G | STAD | 1 |
p.R420C | STAD | 1 |
p.L35I | LUSC | 1 |
p.G533R | SKCM | 1 |
p.L12S | ESCA | 1 |
p.Q492* | SKCM | 1 |
p.G266E | SKCM | 1 |
p.W503X | SKCM | 1 |
p.F149V | STAD | 1 |
p.W156C | THCA | 1 |
p.E398K | BRCA | 1 |
p.A460S | ESCA | 1 |
p.R499C | HNSC | 1 |
p.E495K | SKCM | 1 |
p.E214V | LUAD | 1 |
p.E351D | SARC | 1 |
p.R155L | GBM | 1 |
p.L207I | UCEC | 1 |
p.F534L | UCEC | 1 |
p.G192R | SKCM | 1 |
p.R420C | READ | 1 |
p.W503* | SKCM | 1 |
p.V361A | HNSC | 1 |
p.A314S | LUAD | 1 |
p.E373K | SKCM | 1 |
p.N277T | SKCM | 1 |
p.V137D | BLCA | 1 |
p.R291C | SKCM | 1 |
p.R330C | UCEC | 1 |
p.P11L | PAAD | 1 |
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TissGeneCNV for GK2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for GK2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for GK2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for GK2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for GK2 |
TissGeneDrug for GK2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for GK2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |