TissGeneSummary for DHDH |
Gene summary |
Basic gene information | Gene symbol | DHDH |
Gene name | dihydrodiol dehydrogenase (dimeric) | |
Synonyms | 2DD|HUM2DD | |
Cytomap | UCSC genome browser: 19q13.3 | |
Type of gene | protein-coding | |
RefGenes | NM_014475.3, | |
Description | 3-deoxyglucosone reductaseD-xylose 1-dehydrogenaseD-xylose-NADP dehydrogenasetrans-1,2-dihydrobenzene-1,2-diol dehydrogenase | |
Modification date | 20141207 | |
dbXrefs | MIM : 606377 | |
HGNC : HGNC | ||
Ensembl : ENSG00000104808 | ||
HPRD : 08399 | ||
Vega : OTTHUMG00000165029 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_DHDH | |
BioGPS: 27294 | ||
Pathway | NCI Pathway Interaction Database: DHDH | |
KEGG: DHDH | ||
REACTOME: DHDH | ||
Pathway Commons: DHDH | ||
Context | iHOP: DHDH | |
ligand binding site mutation search in PubMed: DHDH | ||
UCL Cancer Institute: DHDH | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Kidney | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICH | |
Reference showing the relevant tissue of DHDH | ||
Description by TissGene annotations | Fused withOncogene Fused withTSGene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for DHDH |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KICH | -1.659474336 | 2.861457664 | -4.520932 | 5.92E-10 | 3.92E-09 |
BRCA | -0.138117389 | -1.171051599 | 1.032934211 | 1.06E-08 | 3.48E-08 |
LUSC | 0.654286997 | 1.752355624 | -1.098068627 | 1.39E-06 | 3.42E-06 |
THCA | 0.769636715 | -1.972927692 | 2.742564407 | 8.68E-19 | 2.53E-17 |
COAD | 0.33485751 | -0.76779249 | 1.10265 | 0.00547 | 0.012928554 |
KIRP | 2.676788039 | 4.312294289 | -1.63550625 | 0.00135 | 0.003586137 |
LIHC | -0.831212336 | -2.025562336 | 1.19435 | 9.32E-05 | 0.000323939 |
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TissGene-miRNA for DHDH |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for DHDH |
TissGeneSNV for DHDH |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.S66N | PCPG | 4 |
p.A324V | SKCM | 2 |
p.A173G | LIHC | 2 |
p.V240M | UCEC | 1 |
p.A103T | STAD | 1 |
p.V200L | LIHC | 1 |
p.S309L | STAD | 1 |
p.G73S | LUAD | 1 |
p.E133K | SARC | 1 |
p.Q192X | STAD | 1 |
p.V247A | COAD | 1 |
p.G155E | SKCM | 1 |
p.D38N | SKCM | 1 |
p.R37L | LUAD | 1 |
p.Q22R | BLCA | 1 |
p.Q192* | STAD | 1 |
p.D166H | TGCT | 1 |
p.S132F | SKCM | 1 |
p.V240M | COAD | 1 |
p.P307L | SKCM | 1 |
p.G282E | SKCM | 1 |
p.D38N | CESC | 1 |
p.R116Q | KIRC | 1 |
p.P130S | SKCM | 1 |
p.S66N | BRCA | 1 |
p.F279V | KIRP | 1 |
p.S66N | COAD | 1 |
p.W5C | THYM | 1 |
p.S309L | SKCM | 1 |
p.P269L | UCEC | 1 |
p.P65L | KIRP | 1 |
p.R297H | LUAD | 1 |
p.G224V | UCEC | 1 |
p.P194A | BLCA | 1 |
p.R107C | COAD | 1 |
p.S286C | STAD | 1 |
p.Q47H | UCEC | 1 |
p.C181Y | STAD | 1 |
p.L215F | BLCA | 1 |
p.A2P | COAD | 1 |
p.E258X | CHOL | 1 |
p.A62T | SKCM | 1 |
p.Y287N | KIRP | 1 |
p.E59D | THYM | 1 |
p.S66N | UVM | 1 |
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TissGeneCNV for DHDH |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for DHDH |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | FusionScan | BRCA | TCGA-A2-A25D-01A | AP2A1-DHDH | Out-of-Frame | chr19:50270457 | chr19:49442705 |
TCGAfusionPortal | PRADA | BRCA | TCGA-A2-A25D-01A | AP2A1-DHDH | Out-of-frame | Chr19:50270457 | Chr19:49442706 |
TCGAfusionPortal | PRADA | BRCA | TCGA-EW-A2FS-01A | BAX-DHDH | In-frame | Chr19:49459590 | Chr19:49438257 |
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TissGeneNet for DHDH |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for DHDH |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for DHDH |
TissGeneDrug for DHDH |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for DHDH |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0005684 | Malignant neoplasm of urinary bladder | 1 | GAD |
umls:C0010054 | Coronary Arteriosclerosis | 1 | BeFree |
umls:C0010068 | Coronary heart disease | 1 | BeFree |
umls:C0023488 | Leukemia, Radiation-Induced | 1 | BeFree |
umls:C0023890 | Liver Cirrhosis | 1 | BeFree |
umls:C0024117 | Chronic Obstructive Airway Disease | 1 | GAD |
umls:C0033578 | Prostatic Neoplasms | 1 | CTD_human |
umls:C0038356 | Stomach Neoplasms | 1 | LHGDN |
umls:C0155773 | Portal vein thrombosis | 1 | BeFree |
umls:C0242379 | Malignant neoplasm of lung | 1 | GAD |