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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for DHDH
check button Gene summary
Basic gene informationGene symbolDHDH
Gene namedihydrodiol dehydrogenase (dimeric)
Synonyms2DD|HUM2DD
CytomapUCSC genome browser: 19q13.3
Type of geneprotein-coding
RefGenesNM_014475.3,
Description3-deoxyglucosone reductaseD-xylose 1-dehydrogenaseD-xylose-NADP dehydrogenasetrans-1,2-dihydrobenzene-1,2-diol dehydrogenase
Modification date20141207
dbXrefs MIM : 606377
HGNC : HGNC
Ensembl : ENSG00000104808
HPRD : 08399
Vega : OTTHUMG00000165029
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_DHDH
BioGPS: 27294
PathwayNCI Pathway Interaction Database: DHDH
KEGG: DHDH
REACTOME: DHDH
Pathway Commons: DHDH
ContextiHOP: DHDH
ligand binding site mutation search in PubMed: DHDH
UCL Cancer Institute: DHDH
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Kidney
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)KIRC,KIRP,KICH
Reference showing the relevant tissue of DHDH
Description by TissGene annotationsFused withOncogene
Fused withTSGene
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


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TissGeneExp for DHDH

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
KICH-1.6594743362.861457664-4.5209325.92E-103.92E-09
BRCA-0.138117389-1.1710515991.0329342111.06E-083.48E-08
LUSC0.6542869971.752355624-1.0980686271.39E-063.42E-06
THCA0.769636715-1.9729276922.7425644078.68E-192.53E-17
COAD0.33485751-0.767792491.102650.005470.012928554
KIRP2.6767880394.312294289-1.635506250.001350.003586137
LIHC-0.831212336-2.0255623361.194359.32E-050.000323939


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TissGene-miRNA for DHDH

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for DHDH
TissGeneSNV for DHDH

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.S66NPCPG4
p.A324VSKCM2
p.A173GLIHC2
p.V240MUCEC1
p.A103TSTAD1
p.V200LLIHC1
p.S309LSTAD1
p.G73SLUAD1
p.E133KSARC1
p.Q192XSTAD1
p.V247ACOAD1
p.G155ESKCM1
p.D38NSKCM1
p.R37LLUAD1
p.Q22RBLCA1
p.Q192*STAD1
p.D166HTGCT1
p.S132FSKCM1
p.V240MCOAD1
p.P307LSKCM1
p.G282ESKCM1
p.D38NCESC1
p.R116QKIRC1
p.P130SSKCM1
p.S66NBRCA1
p.F279VKIRP1
p.S66NCOAD1
p.W5CTHYM1
p.S309LSKCM1
p.P269LUCEC1
p.P65LKIRP1
p.R297HLUAD1
p.G224VUCEC1
p.P194ABLCA1
p.R107CCOAD1
p.S286CSTAD1
p.Q47HUCEC1
p.C181YSTAD1
p.L215FBLCA1
p.A2PCOAD1
p.E258XCHOL1
p.A62TSKCM1
p.Y287NKIRP1
p.E59DTHYM1
p.S66NUVM1


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TissGeneCNV for DHDH

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for DHDH

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0FusionScanBRCATCGA-A2-A25D-01AAP2A1-DHDHOut-of-Framechr19:50270457chr19:49442705
TCGAfusionPortalPRADABRCATCGA-A2-A25D-01AAP2A1-DHDHOut-of-frameChr19:50270457Chr19:49442706
TCGAfusionPortalPRADABRCATCGA-EW-A2FS-01ABAX-DHDHIn-frameChr19:49459590Chr19:49438257


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TissGeneNet for DHDH

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)


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TissGeneProg for DHDH

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for DHDH
TissGeneDrug for DHDH

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for DHDH

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0005684Malignant neoplasm of urinary bladder1GAD
umls:C0010054Coronary Arteriosclerosis1BeFree
umls:C0010068Coronary heart disease1BeFree
umls:C0023488Leukemia, Radiation-Induced1BeFree
umls:C0023890Liver Cirrhosis1BeFree
umls:C0024117Chronic Obstructive Airway Disease1GAD
umls:C0033578Prostatic Neoplasms1CTD_human
umls:C0038356Stomach Neoplasms1LHGDN
umls:C0155773Portal vein thrombosis1BeFree
umls:C0242379Malignant neoplasm of lung1GAD