TissGeneSummary for MYO1H |
Gene summary |
Basic gene information | Gene symbol | MYO1H |
Gene name | myosin IH | |
Synonyms | - | |
Cytomap | UCSC genome browser: 12q24.11 | |
Type of gene | protein-coding | |
RefGenes | NM_001101421.3, NM_173597.1, | |
Description | myosin-1Hmyosin-Ihunconventional myosin-Ih | |
Modification date | 20141207 | |
dbXrefs | MIM : 614636 | |
HGNC : HGNC | ||
Ensembl : ENSG00000174527 | ||
HPRD : 08227 | ||
Vega : OTTHUMG00000169252 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_MYO1H | |
BioGPS: 283446 | ||
Pathway | NCI Pathway Interaction Database: MYO1H | |
KEGG: MYO1H | ||
REACTOME: MYO1H | ||
Pathway Commons: MYO1H | ||
Context | iHOP: MYO1H | |
ligand binding site mutation search in PubMed: MYO1H | ||
UCL Cancer Institute: MYO1H | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of MYO1H | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for MYO1H |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KICH | 3.500249231 | 0.107961231 | 3.392288 | 1.94E-06 | 6.99E-06 |
BRCA | 0.266637477 | 2.37984888 | -2.113211404 | 5.85E-27 | 6.34E-26 |
THCA | 0.640692621 | 1.959763808 | -1.319071186 | 5.21E-14 | 5.57E-13 |
KIRP | -0.841176394 | 0.221245481 | -1.062421875 | 2.56E-06 | 1.18E-05 |
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TissGene-miRNA for MYO1H |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for MYO1H |
TissGeneSNV for MYO1H |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.T485_splice | LUSC | 2 |
p.R688C | UCEC | 2 |
p.V910M | SKCM | 2 |
p.E629K | ESCA | 1 |
p.S462Y | UCEC | 1 |
p.S26Y | SARC | 1 |
p.E267Q | BLCA | 1 |
p.R353* | STAD | 1 |
p.E285Q | CESC | 1 |
p.P177T | LIHC | 1 |
p.C708F | SARC | 1 |
p.A620V | COAD | 1 |
p.N368D | SARC | 1 |
p.R616Q | UCEC | 1 |
p.R156Q | BRCA | 1 |
p.R734Q | LIHC | 1 |
p.A731T | THYM | 1 |
p.F518L | READ | 1 |
p.A4V | THYM | 1 |
p.I576M | HNSC | 1 |
p.Q738R | HNSC | 1 |
p.G59R | BRCA | 1 |
p.M92I | LUSC | 1 |
p.R156Q | LGG | 1 |
p.E687K | STAD | 1 |
p.E687K | LUAD | 1 |
p.E316X | ESCA | 1 |
p.H181Y | LUAD | 1 |
p.A803T | READ | 1 |
p.T692N | UCEC | 1 |
p.L314F | SKCM | 1 |
p.R773W | COAD | 1 |
p.G753E | SKCM | 1 |
p.E147K | SARC | 1 |
p.V953I | KICH | 1 |
p.V1018F | ESCA | 1 |
p.K516M | LUAD | 1 |
p.K305E | UCEC | 1 |
p.P894L | UCEC | 1 |
p.R616Q | STAD | 1 |
p.Y69D | UCEC | 1 |
p.H793Y | CESC | 1 |
p.E444K | SKCM | 1 |
p.L683M | READ | 1 |
p.R343T | BLCA | 1 |
p.S928C | SKCM | 1 |
p.T62I | ESCA | 1 |
p.C332S | BLCA | 1 |
p.L102V | PRAD | 1 |
p.Q696* | BLCA | 1 |
p.A549D | LUAD | 1 |
p.E199Q | HNSC | 1 |
p.E992K | SKCM | 1 |
p.P491L | LIHC | 1 |
p.S142P | LIHC | 1 |
p.G610W | LUAD | 1 |
p.M91R | UCEC | 1 |
p.G864V | THYM | 1 |
p.L40F | SKCM | 1 |
p.I323S | STAD | 1 |
p.R712T | PRAD | 1 |
p.R748K | BLCA | 1 |
p.E544K | SKCM | 1 |
p.R200W | CESC | 1 |
p.L102F | KIRP | 1 |
p.E510* | LUAD | 1 |
p.D15N | SKCM | 1 |
p.D344N | SKCM | 1 |
p.I323T | LUAD | 1 |
p.R783W | OV | 1 |
p.V770M | STAD | 1 |
p.R321K | SKCM | 1 |
p.E697* | CESC | 1 |
p.D590N | SARC | 1 |
p.G798V | CHOL | 1 |
p.A21V | UCEC | 1 |
p.K887* | SKCM | 1 |
p.R745Q | SKCM | 1 |
p.P868L | LUSC | 1 |
p.A342V | UCEC | 1 |
p.V330A | HNSC | 1 |
p.K965N | HNSC | 1 |
p.F393C | COAD | 1 |
p.G490D | LIHC | 1 |
p.K887X | SKCM | 1 |
p.Q833X | LIHC | 1 |
p.A292D | BRCA | 1 |
p.T154M | UCEC | 1 |
p.P333L | SKCM | 1 |
p.E120K | CESC | 1 |
p.D288N | LUAD | 1 |
p.D599Y | LUAD | 1 |
p.S160F | SKCM | 1 |
p.E801K | READ | 1 |
p.Q833* | LIHC | 1 |
p.A304V | KIRP | 1 |
p.R755Q | UCEC | 1 |
p.R353X | STAD | 1 |
p.R626Q | UCEC | 1 |
p.P226S | UCEC | 1 |
p.K531N | KIRP | 1 |
p.A481T | PRAD | 1 |
p.G847D | SKCM | 1 |
p.D248Y | LUAD | 1 |
p.G493S | SKCM | 1 |
p.L379F | UCEC | 1 |
p.R603K | SKCM | 1 |
p.D137G | LIHC | 1 |
p.R729H | STAD | 1 |
p.R711K | SKCM | 1 |
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TissGeneCNV for MYO1H |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for MYO1H |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
TCGAfusionPortal | PRADA | LGG | TCGA-HW-A5KL-01A | SFSWAP-MYO1H | In-frame | Chr12:132250853 | Chr12:109845599 |
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TissGeneNet for MYO1H |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for MYO1H |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for MYO1H |
TissGeneDrug for MYO1H |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for MYO1H |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |