TissGeneSummary for TTLL6 |
Gene summary |
Basic gene information | Gene symbol | TTLL6 |
Gene name | tubulin tyrosine ligase-like family, member 6 | |
Synonyms | TTL.6 | |
Cytomap | UCSC genome browser: 17q21.32 | |
Type of gene | protein-coding | |
RefGenes | NM_001130918.1, NM_173623.3, | |
Description | tubulin polyglutamylase TTLL6tubulin--tyrosine ligase-like protein 6 | |
Modification date | 20141207 | |
dbXrefs | MIM : 610849 | |
HGNC : HGNC | ||
Ensembl : ENSG00000170703 | ||
HPRD : 08763 | ||
Vega : OTTHUMG00000156978 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_TTLL6 | |
BioGPS: 284076 | ||
Pathway | NCI Pathway Interaction Database: TTLL6 | |
KEGG: TTLL6 | ||
REACTOME: TTLL6 | ||
Pathway Commons: TTLL6 | ||
Context | iHOP: TTLL6 | |
ligand binding site mutation search in PubMed: TTLL6 | ||
UCL Cancer Institute: TTLL6 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of TTLL6 | ||
Description by TissGene annotations | Cancer gene Fused withOncogene Fused withTSGene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for TTLL6 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUAD | -1.238824015 | 0.480457019 | -1.719281034 | 3.16E-06 | 9.76E-06 |
LUSC | -2.781930641 | 0.199857594 | -2.981788235 | 1.06E-15 | 7.30E-15 |
COAD | 0.414028107 | 3.119443491 | -2.705415385 | 3.99E-10 | 4.84E-09 |
THCA | -3.913406248 | -2.872040146 | -1.041366102 | 3.30E-14 | 3.65E-13 |
STAD | 1.135914886 | -0.980956989 | 2.116871875 | 0.0022 | 0.009758974 |
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TissGene-miRNA for TTLL6 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for TTLL6 |
TissGeneSNV for TTLL6 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R525W | SKCM | 2 |
p.S419C | CESC | 1 |
p.K668N | UCEC | 1 |
p.A667P | LUAD | 1 |
p.R152W | COAD | 1 |
p.V425L | LUAD | 1 |
p.K742E | DLBC | 1 |
p.A203V | COAD | 1 |
p.I352T | PAAD | 1 |
p.A626T | THYM | 1 |
p.M740I | READ | 1 |
p.D422N | HNSC | 1 |
p.A476V | UCEC | 1 |
p.N649H | KIRP | 1 |
p.S502L | UCEC | 1 |
p.P591T | CHOL | 1 |
p.M547I | SKCM | 1 |
p.D247N | UCEC | 1 |
p.L93I | UCEC | 1 |
p.R193H | ACC | 1 |
p.T482N | LGG | 1 |
p.E64K | BRCA | 1 |
p.T718K | THYM | 1 |
p.G129S | BRCA | 1 |
p.L763I | LUSC | 1 |
p.A524D | BLCA | 1 |
p.E712D | COAD | 1 |
p.N801D | LUSC | 1 |
p.G784E | SKCM | 1 |
p.S818R | CESC | 1 |
p.Q729* | UCS | 1 |
p.E889D | BRCA | 1 |
p.V153E | LIHC | 1 |
p.R867K | LUAD | 1 |
p.S275F | UCEC | 1 |
p.E24K | BLCA | 1 |
p.E620* | BLCA | 1 |
p.R606T | HNSC | 1 |
p.L786F | SKCM | 1 |
p.T582I | PRAD | 1 |
p.D614N | BLCA | 1 |
p.R193C | COAD | 1 |
p.A626D | BRCA | 1 |
p.K586I | CESC | 1 |
p.D719N | SKCM | 1 |
p.T236N | THYM | 1 |
p.P643L | SKCM | 1 |
p.E486K | BLCA | 1 |
p.S774F | SKCM | 1 |
p.S691F | UCS | 1 |
p.Q729X | UCS | 1 |
p.T396M | OV | 1 |
p.A876T | READ | 1 |
p.E56X | ESCA | 1 |
p.E821K | SKCM | 1 |
p.R420W | COAD | 1 |
p.C490Y | COAD | 1 |
p.S787F | PCPG | 1 |
p.S743Y | UCEC | 1 |
p.A876T | BLCA | 1 |
p.I391M | LUAD | 1 |
p.A584T | BLCA | 1 |
p.L93P | KICH | 1 |
p.E620D | STAD | 1 |
p.T841N | ACC | 1 |
p.E449K | SKCM | 1 |
p.G2X | ESCA | 1 |
p.A529V | KIRP | 1 |
p.R890M | UCEC | 1 |
p.R183L | SARC | 1 |
p.K543T | LUSC | 1 |
p.K610I | SKCM | 1 |
p.W20G | PRAD | 1 |
p.N801H | SKCM | 1 |
p.V685I | BLCA | 1 |
p.G887E | SKCM | 1 |
p.G4D | PRAD | 1 |
p.S235L | OV | 1 |
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TissGeneCNV for TTLL6 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for TTLL6 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | FusionScan | ESCA | TCGA-L5-A4OW-01A | JUP-TTLL6 | In-Frame | chr17:39925220 | chr17:46865361 |
Chimerdb3.0 | FusionScan | ESCA | TCGA-L5-A4OW-01A | TTLL6-NOS2 | Out-of-Frame | chr17:46862284 | chr17:26116714 |
TCGAfusionPortal | PRADA | LUAD | TCGA-50-5930-01A | TOB1-TTLL6 | 5UTR-5UTR | Chr17:48943419 | Chr17:46882353 |
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TissGeneNet for TTLL6 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for TTLL6 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for TTLL6 |
TissGeneDrug for TTLL6 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for TTLL6 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |