TissGeneSummary for NKPD1 |
Gene summary |
Basic gene information | Gene symbol | NKPD1 |
Gene name | NTPase, KAP family P-loop domain containing 1 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 19q13.32 | |
Type of gene | protein-coding | |
RefGenes | NM_198478.3, | |
Description | NTPase KAP family P-loop domain-containing protein 1 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000179846 | ||
HPRD : 11393 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_NKPD1 | |
BioGPS: 284353 | ||
Pathway | NCI Pathway Interaction Database: NKPD1 | |
KEGG: NKPD1 | ||
REACTOME: NKPD1 | ||
Pathway Commons: NKPD1 | ||
Context | iHOP: NKPD1 | |
ligand binding site mutation search in PubMed: NKPD1 | ||
UCL Cancer Institute: NKPD1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Skin | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | SKCM | |
Reference showing the relevant tissue of NKPD1 | ||
Description by TissGene annotations | Have significant anti-correlated miRNA |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for NKPD1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUAD | -2.110444932 | -3.571181139 | 1.460736207 | 1.06E-10 | 6.29E-10 |
COAD | -1.238240821 | -3.283856205 | 2.045615385 | 5.92E-08 | 4.38E-07 |
KIRP | -2.534038898 | -3.739042023 | 1.205003125 | 7.87E-06 | 3.35E-05 |
LUSC | -0.123364878 | -3.443047231 | 3.319682353 | 2.10E-21 | 2.99E-20 |
KIRC | -2.85761112 | -3.984516676 | 1.126905556 | 3.21E-12 | 1.32E-11 |
BRCA | -1.3675946 | -0.03527267 | -1.33232193 | 3.00E-09 | 1.04E-08 |
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TissGene-miRNA for NKPD1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
ACC | hsa-miR-370-5p | MIMAT0026483 | 0.0028 | -0.34 | 78 |
ACC | hsa-miR-370-5p | MIMAT0026483 | 0.0028 | -0.34 | 78 |
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TissGeneMut for NKPD1 |
TissGeneSNV for NKPD1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E599D | STAD | 1 |
p.D644N | SKCM | 1 |
p.R558C | BLCA | 1 |
p.S361X | ESCA | 1 |
p.R624C | ESCA | 1 |
p.D494E | ESCA | 1 |
p.S361* | ESCA | 1 |
p.E231K | CESC | 1 |
p.F276L | BLCA | 1 |
p.R752Q | COAD | 1 |
p.P829L | SKCM | 1 |
p.D513Y | LIHC | 1 |
p.R753H | STAD | 1 |
p.S375N | STAD | 1 |
p.R552C | UCEC | 1 |
p.A544V | ESCA | 1 |
p.G812V | LUSC | 1 |
p.A727T | ACC | 1 |
p.A190T | THYM | 1 |
p.D543N | THYM | 1 |
p.A762T | SARC | 1 |
p.V760I | COAD | 1 |
p.R566G | BRCA | 1 |
p.R753S | KIRP | 1 |
p.V633M | HNSC | 1 |
p.A500T | UCEC | 1 |
p.S422N | COAD | 1 |
p.E569K | CESC | 1 |
p.R413W | KIRP | 1 |
p.R753C | STAD | 1 |
p.R608H | STAD | 1 |
p.E685Q | LUAD | 1 |
p.S481C | BLCA | 1 |
p.D543N | COAD | 1 |
p.T703A | HNSC | 1 |
p.P684H | LUAD | 1 |
p.T511M | PRAD | 1 |
p.A683E | COAD | 1 |
p.L636Q | STAD | 1 |
p.R97Q | PRAD | 1 |
p.D591A | HNSC | 1 |
p.R608C | STAD | 1 |
p.A278T | UCEC | 1 |
p.A575V | UCS | 1 |
p.L150V | ESCA | 1 |
p.P560S | COAD | 1 |
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TissGeneCNV for NKPD1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for NKPD1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for NKPD1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for NKPD1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for NKPD1 |
TissGeneDrug for NKPD1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for NKPD1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |