TissGeneSummary for TPRX1 |
Gene summary |
Basic gene information | Gene symbol | TPRX1 |
Gene name | tetra-peptide repeat homeobox 1 | |
Synonyms | TPRX | |
Cytomap | UCSC genome browser: 19q13.33 | |
Type of gene | protein-coding | |
RefGenes | NM_198479.2, | |
Description | CRX like homeobox 2tetra-peptide repeat homeobox protein 1 | |
Modification date | 20141207 | |
dbXrefs | MIM : 611166 | |
HGNC : HGNC | ||
Ensembl : ENSG00000178928 | ||
HPRD : 13447 | ||
Vega : OTTHUMG00000170628 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_TPRX1 | |
BioGPS: 284355 | ||
Pathway | NCI Pathway Interaction Database: TPRX1 | |
KEGG: TPRX1 | ||
REACTOME: TPRX1 | ||
Pathway Commons: TPRX1 | ||
Context | iHOP: TPRX1 | |
ligand binding site mutation search in PubMed: TPRX1 | ||
UCL Cancer Institute: TPRX1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of TPRX1 | ||
Description by TissGene annotations | TissgsKTS CNV lost TissGeneKTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for TPRX1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for TPRX1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for TPRX1 |
TissGeneSNV for TPRX1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.P208S | COAD | 7 |
p.P208S | KIRC | 3 |
p.P206L | KIRP | 2 |
p.S200P | BRCA | 2 |
p.S313P | TGCT | 2 |
p.S297P | TGCT | 2 |
p.P208S | READ | 2 |
p.S316L | STAD | 1 |
p.Q433* | HNSC | 1 |
p.V201G | BRCA | 1 |
p.S216P | BRCA | 1 |
p.L250P | LIHC | 1 |
p.P448S | LUAD | 1 |
p.G205D | KIRP | 1 |
p.G383D | THYM | 1 |
p.P222L | PAAD | 1 |
p.P222L | KIRP | 1 |
p.P319L | LUAD | 1 |
p.S192P | BRCA | 1 |
p.G410D | SKCM | 1 |
p.P415R | LIHC | 1 |
p.I135T | LIHC | 1 |
p.I157M | READ | 1 |
p.I215N | LIHC | 1 |
p.H449D | BLCA | 1 |
p.G364S | SKCM | 1 |
p.P240S | COAD | 1 |
p.S309P | MESO | 1 |
p.G374D | HNSC | 1 |
p.P319L | PRAD | 1 |
p.G233V | LIHC | 1 |
p.P130L | COAD | 1 |
p.D443G | SARC | 1 |
p.S297P | MESO | 1 |
p.R503K | SKCM | 1 |
p.G267S | SKCM | 1 |
p.S192P | KIRC | 1 |
p.R406K | SKCM | 1 |
p.A258V | LIHC | 1 |
p.R150P | KIRP | 1 |
p.P230Q | ESCA | 1 |
p.P367S | SKCM | 1 |
p.D342Y | LUAD | 1 |
p.P351T | LUSC | 1 |
p.N183I | UCEC | 1 |
p.G388V | ESCA | 1 |
p.D507N | SKCM | 1 |
p.D476N | LGG | 1 |
p.Q471H | LGG | 1 |
p.G147S | LIHC | 1 |
p.T69M | STAD | 1 |
p.N183I | LIHC | 1 |
p.A141V | KIRC | 1 |
p.G205D | SKCM | 1 |
p.P256S | STAD | 1 |
p.E393Q | BLCA | 1 |
p.P351S | SKCM | 1 |
p.N219I | UCEC | 1 |
p.P290T | STAD | 1 |
p.P351S | LUAD | 1 |
p.G132R | BLCA | 1 |
p.G277D | HNSC | 1 |
p.P417L | SKCM | 1 |
p.R292L | HNSC | 1 |
p.S297P | LIHC | 1 |
p.P448S | SKCM | 1 |
p.F13L | LUSC | 1 |
p.S313P | ACC | 1 |
p.L160F | SKCM | 1 |
p.R32H | READ | 1 |
p.P387T | STAD | 1 |
p.D439Y | LUAD | 1 |
p.P335L | TGCT | 1 |
p.P204S | LIHC | 1 |
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TissGeneCNV for TPRX1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for TPRX1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | TopHat-Fusion | UCEC | TCGA-KP-A3VZ-01A | HNRNPL-TPRX1 | In-Frame | chr19:39331739 | chr19:48306026 |
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TissGeneNet for TPRX1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for TPRX1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for TPRX1 |
TissGeneDrug for TPRX1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for TPRX1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |