TissGeneSummary for ACTL9 |
Gene summary |
Basic gene information | Gene symbol | ACTL9 |
Gene name | actin-like 9 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 19p13.2 | |
Type of gene | protein-coding | |
RefGenes | NM_178525.4, | |
Description | actin-like protein 9 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000181786 | ||
HPRD : 14562 | ||
Vega : OTTHUMG00000182194 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ACTL9 | |
BioGPS: 284382 | ||
Pathway | NCI Pathway Interaction Database: ACTL9 | |
KEGG: ACTL9 | ||
REACTOME: ACTL9 | ||
Pathway Commons: ACTL9 | ||
Context | iHOP: ACTL9 | |
ligand binding site mutation search in PubMed: ACTL9 | ||
UCL Cancer Institute: ACTL9 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of ACTL9 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for ACTL9 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for ACTL9 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for ACTL9 |
TissGeneSNV for ACTL9 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.H227N | COAD | 6 |
p.D136N | SKCM | 2 |
p.E404K | SKCM | 2 |
p.S345L | SKCM | 2 |
p.E357D | LUAD | 1 |
p.F97L | SKCM | 1 |
p.R159H | LUAD | 1 |
p.G240S | BLCA | 1 |
p.R391H | PAAD | 1 |
p.A233V | PAAD | 1 |
p.S389T | LIHC | 1 |
p.E357K | STAD | 1 |
p.E404K | COAD | 1 |
p.R391C | ESCA | 1 |
p.R220H | LUSC | 1 |
p.H216Y | SKCM | 1 |
p.E365D | SARC | 1 |
p.Y204C | LUSC | 1 |
p.W122* | LUAD | 1 |
p.G240D | SKCM | 1 |
p.G384S | KIRC | 1 |
p.A239V | PAAD | 1 |
p.G117S | STAD | 1 |
p.T109M | HNSC | 1 |
p.A156G | BRCA | 1 |
p.T218M | PAAD | 1 |
p.T279S | LUAD | 1 |
p.F97S | BLCA | 1 |
p.T60I | STAD | 1 |
p.E160K | COAD | 1 |
p.V411M | GBM | 1 |
p.D249H | SKCM | 1 |
p.D284N | STAD | 1 |
p.V53D | STAD | 1 |
p.R271Q | COAD | 1 |
p.P272T | SARC | 1 |
p.A187T | COAD | 1 |
p.S92T | MESO | 1 |
p.V104M | ESCA | 1 |
p.G211D | LGG | 1 |
p.V313I | PAAD | 1 |
p.P242S | LUAD | 1 |
p.R286C | COAD | 1 |
p.H227N | READ | 1 |
p.A319D | BRCA | 1 |
p.H367Q | PAAD | 1 |
p.R278Q | SKCM | 1 |
p.T74I | SKCM | 1 |
p.V185L | BRCA | 1 |
p.V380I | GBM | 1 |
p.C81S | LIHC | 1 |
p.G384S | SKCM | 1 |
p.G384D | SKCM | 1 |
p.G93E | SKCM | 1 |
p.L334V | ESCA | 1 |
p.R286H | COAD | 1 |
p.Q210R | BLCA | 1 |
p.V208I | GBM | 1 |
p.P308S | SKCM | 1 |
p.G309W | LUAD | 1 |
p.M40V | COAD | 1 |
p.G383V | LUAD | 1 |
p.F378L | UCEC | 1 |
p.V261M | ESCA | 1 |
p.L132M | SKCM | 1 |
p.A364S | LUAD | 1 |
p.V208I | PAAD | 1 |
p.V195M | SKCM | 1 |
p.T96M | STAD | 1 |
p.V411M | STAD | 1 |
p.S184F | THCA | 1 |
p.P26L | LUSC | 1 |
p.R130C | HNSC | 1 |
p.E401K | SKCM | 1 |
p.V41G | ESCA | 1 |
p.A372D | UCEC | 1 |
p.A233T | SKCM | 1 |
p.R391C | SARC | 1 |
p.G39S | COAD | 1 |
p.R353H | ACC | 1 |
p.H135N | UCEC | 1 |
p.E351K | STAD | 1 |
p.S154N | SKCM | 1 |
p.G349S | HNSC | 1 |
p.S9L | COAD | 1 |
p.P374S | KIRC | 1 |
p.K62N | HNSC | 1 |
p.A224V | PAAD | 1 |
p.V261L | LUAD | 1 |
p.T317N | ESCA | 1 |
p.R355Q | UCS | 1 |
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TissGeneCNV for ACTL9 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for ACTL9 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for ACTL9 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for ACTL9 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for ACTL9 |
TissGeneDrug for ACTL9 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for ACTL9 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0011615 | Dermatitis, Atopic | 3 | BeFree,CTD_human |
umls:C0013595 | Eczema | 2 | BeFree |