TissGeneSummary for FAM71E2 |
Gene summary |
Basic gene information | Gene symbol | FAM71E2 |
Gene name | family with sequence similarity 71, member E2 | |
Synonyms | C19orf16 | |
Cytomap | UCSC genome browser: 19q13.42 | |
Type of gene | protein-coding | |
RefGenes | NM_001145402.1, | |
Description | protein FAM71E2putative protein FAM71E2 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000180043 | ||
Vega : OTTHUMG00000170357 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_FAM71E2 | |
BioGPS: 284418 | ||
Pathway | NCI Pathway Interaction Database: FAM71E2 | |
KEGG: FAM71E2 | ||
REACTOME: FAM71E2 | ||
Pathway Commons: FAM71E2 | ||
Context | iHOP: FAM71E2 | |
ligand binding site mutation search in PubMed: FAM71E2 | ||
UCL Cancer Institute: FAM71E2 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of FAM71E2 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for FAM71E2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUSC | 1.523723199 | -0.486568958 | 2.010292157 | 7.43E-07 | 1.89E-06 |
ESCA | 2.678669723 | -0.327693913 | 3.006363636 | 0.00319 | 0.030028692 |
COAD | 0.808010982 | -0.471631326 | 1.279642308 | 0.000836 | 0.002454623 |
HNSC | 1.124032091 | -0.35477256 | 1.478804651 | 4.61E-05 | 0.000224513 |
STAD | 1.024831655 | -0.604705845 | 1.6295375 | 1.59E-05 | 0.000167883 |
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TissGene-miRNA for FAM71E2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for FAM71E2 |
TissGeneSNV for FAM71E2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.L406P | PRAD | 2 |
p.E774K | ACC | 1 |
p.Q500P | MESO | 1 |
p.A920V | COAD | 1 |
p.T868I | CESC | 1 |
p.A171G | CESC | 1 |
p.D261N | ACC | 1 |
p.R39H | ESCA | 1 |
p.K766X | ESCA | 1 |
p.Q400H | UCEC | 1 |
p.P553L | TGCT | 1 |
p.L747F | KIRC | 1 |
p.L152F | KIRC | 1 |
p.Q758H | ESCA | 1 |
p.G682D | THYM | 1 |
p.E774K | KIRP | 1 |
p.L876I | COAD | 1 |
p.S377Y | LIHC | 1 |
p.E810K | SARC | 1 |
p.M734V | ESCA | 1 |
p.E774K | THYM | 1 |
p.P295S | COAD | 1 |
p.R39C | UCEC | 1 |
p.D563Y | BRCA | 1 |
p.R39H | COAD | 1 |
p.V58M | UCEC | 1 |
p.P727S | CESC | 1 |
p.P40L | UCEC | 1 |
p.K252N | UCEC | 1 |
p.R259H | READ | 1 |
p.P394L | UCEC | 1 |
p.K766* | ESCA | 1 |
p.R669Q | SARC | 1 |
p.P711R | SKCM | 1 |
p.E141Q | CESC | 1 |
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TissGeneCNV for FAM71E2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for FAM71E2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for FAM71E2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for FAM71E2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for FAM71E2 |
TissGeneDrug for FAM71E2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for FAM71E2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |