TissGeneSummary for ODF3L2 |
Gene summary |
Basic gene information | Gene symbol | ODF3L2 |
Gene name | outer dense fiber of sperm tails 3-like 2 | |
Synonyms | C19orf19 | |
Cytomap | UCSC genome browser: 19p13.3 | |
Type of gene | protein-coding | |
RefGenes | NM_182577.2, | |
Description | outer dense fiber protein 3-like protein 2 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000181781 | ||
HPRD : 12700 | ||
Vega : OTTHUMG00000180547 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ODF3L2 | |
BioGPS: 284451 | ||
Pathway | NCI Pathway Interaction Database: ODF3L2 | |
KEGG: ODF3L2 | ||
REACTOME: ODF3L2 | ||
Pathway Commons: ODF3L2 | ||
Context | iHOP: ODF3L2 | |
ligand binding site mutation search in PubMed: ODF3L2 | ||
UCL Cancer Institute: ODF3L2 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of ODF3L2 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for ODF3L2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUSC | -1.6424681 | -0.502038688 | -1.140429412 | 9.22E-13 | 4.26E-12 |
LUAD | -1.684337944 | -0.597851737 | -1.086486207 | 3.36E-12 | 2.50E-11 |
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TissGene-miRNA for ODF3L2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for ODF3L2 |
TissGeneSNV for ODF3L2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.A212T | ACC | 3 |
p.V135A | KIRP | 2 |
p.P133L | READ | 1 |
p.T249I | READ | 1 |
p.P86A | SKCM | 1 |
p.E246* | LUAD | 1 |
p.P86L | SKCM | 1 |
p.T249I | SKCM | 1 |
p.V135A | UCS | 1 |
p.T22M | STAD | 1 |
p.S265L | BLCA | 1 |
p.R11W | STAD | 1 |
p.C35S | LUAD | 1 |
p.P81L | SKCM | 1 |
p.R188C | LIHC | 1 |
p.A242T | HNSC | 1 |
p.P233S | SKCM | 1 |
p.R148C | COAD | 1 |
p.A69T | ESCA | 1 |
p.V135A | STAD | 1 |
p.G239S | LGG | 1 |
p.R263S | LUAD | 1 |
p.R267Q | SKCM | 1 |
p.Q82H | UCEC | 1 |
p.A212T | KIRP | 1 |
p.R263H | STAD | 1 |
p.V250M | GBM | 1 |
p.G43C | CESC | 1 |
p.R193H | SARC | 1 |
p.A242T | BLCA | 1 |
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TissGeneCNV for ODF3L2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for ODF3L2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | TopHat-Fusion | BRCA | TCGA-LL-A5YN-01A | MED1-ODF3L2 | Out-of-Frame | chr17:37604050 | chr19:464363 |
Chimerdb3.0 | TopHat-Fusion | BRCA | TCGA-LL-A5YN-01A | MED1-ODF3L2 | Out-of-Frame | chr17:37604050 | chr19:467545 |
TCGAfusionPortal | PRADA | BRCA | TCGA-A7-A5ZV-01A | BCAR3-ODF3L2 | Out-of-frame | Chr1:94107860 | Chr19:467762 |
TCGAfusionPortal | PRADA | BRCA | TCGA-LL-A5YN-01A | MED1-ODF3L2 | Out-of-frame | Chr17:37604051 | Chr19:464364 |
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TissGeneNet for ODF3L2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for ODF3L2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for ODF3L2 |
TissGeneDrug for ODF3L2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for ODF3L2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |