TissGeneSummary for DCAF4L1 |
Gene summary |
Basic gene information | Gene symbol | DCAF4L1 |
Gene name | DDB1 and CUL4 associated factor 4-like 1 | |
Synonyms | WDR21B | |
Cytomap | UCSC genome browser: 4p13 | |
Type of gene | protein-coding | |
RefGenes | NM_001029955.3, | |
Description | DDB1- and CUL4-associated factor 4-like protein 1WD repeat domain 21BWD repeat-containing protein 21B | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000182308 | ||
HPRD : 18775 | ||
Vega : OTTHUMG00000160527 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_DCAF4L1 | |
BioGPS: 285429 | ||
Pathway | NCI Pathway Interaction Database: DCAF4L1 | |
KEGG: DCAF4L1 | ||
REACTOME: DCAF4L1 | ||
Pathway Commons: DCAF4L1 | ||
Context | iHOP: DCAF4L1 | |
ligand binding site mutation search in PubMed: DCAF4L1 | ||
UCL Cancer Institute: DCAF4L1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of DCAF4L1 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for DCAF4L1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KICH | 1.01959381 | -0.32140219 | 1.340996 | 4.58E-08 | 2.23E-07 |
LIHC | 0.29793181 | -0.97376419 | 1.271696 | 1.57E-07 | 1.05E-06 |
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TissGene-miRNA for DCAF4L1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for DCAF4L1 |
TissGeneSNV for DCAF4L1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.V39I | UCEC | 2 |
p.T235M | ESCA | 2 |
p.A196S | SARC | 1 |
p.P394L | SKCM | 1 |
p.A70V | COAD | 1 |
p.F240L | LUSC | 1 |
p.P66S | SKCM | 1 |
p.L267P | COAD | 1 |
p.S354F | SKCM | 1 |
p.A316T | CESC | 1 |
p.A161V | PRAD | 1 |
p.A189V | STAD | 1 |
p.C155Y | LUAD | 1 |
p.I101M | BLCA | 1 |
p.V332M | UCEC | 1 |
p.A79T | COAD | 1 |
p.P110S | SKCM | 1 |
p.E4K | SKCM | 1 |
p.R73Q | COAD | 1 |
p.W262* | SKCM | 1 |
p.E95K | SKCM | 1 |
p.R244H | UCEC | 1 |
p.A287T | PAAD | 1 |
p.L349F | ESCA | 1 |
p.T235M | LUAD | 1 |
p.E93K | THCA | 1 |
p.A70V | LIHC | 1 |
p.V39F | THYM | 1 |
p.D72Y | LIHC | 1 |
p.Q206* | BLCA | 1 |
p.Q206X | SKCM | 1 |
p.F221C | STAD | 1 |
p.R163W | UCEC | 1 |
p.L299M | ESCA | 1 |
p.A79T | UCEC | 1 |
p.E325K | DLBC | 1 |
p.T40P | KIRC | 1 |
p.S220* | BLCA | 1 |
p.W132* | SKCM | 1 |
p.H347Y | LUAD | 1 |
p.A316T | COAD | 1 |
p.V116M | STAD | 1 |
p.E10K | COAD | 1 |
p.R387Q | LUAD | 1 |
p.R163W | PAAD | 1 |
p.L64F | HNSC | 1 |
p.D72N | COAD | 1 |
p.S225R | SKCM | 1 |
p.R7* | UCEC | 1 |
p.D84V | LIHC | 1 |
p.R105Q | UCEC | 1 |
p.V213M | LUSC | 1 |
p.R105Q | SKCM | 1 |
p.R125Q | COAD | 1 |
p.E309K | UCS | 1 |
p.Q206R | CESC | 1 |
p.R50H | UCEC | 1 |
p.H141Q | LUAD | 1 |
p.E93K | STAD | 1 |
p.Q206* | SKCM | 1 |
p.V171A | STAD | 1 |
p.Q60H | COAD | 1 |
p.R62W | SKCM | 1 |
p.A189V | UCEC | 1 |
p.S134L | CESC | 1 |
p.S129P | HNSC | 1 |
p.G246R | COAD | 1 |
p.R125Q | BRCA | 1 |
p.E93K | UCEC | 1 |
p.A161V | STAD | 1 |
p.E95K | COAD | 1 |
p.A161E | LUAD | 1 |
p.R125Q | STAD | 1 |
p.G377* | LUAD | 1 |
p.K260N | UCEC | 1 |
p.R7Q | PRAD | 1 |
p.V114L | STAD | 1 |
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TissGeneCNV for DCAF4L1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for DCAF4L1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | AL122070 | DCAF4L1-LOC100268168 | chr4:41986489 | chr5:172381785 |
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TissGeneNet for DCAF4L1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for DCAF4L1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for DCAF4L1 |
TissGeneDrug for DCAF4L1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for DCAF4L1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |