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| TissGeneSummary for KIF4B |
 Gene summary |
| Basic gene information | Gene symbol | KIF4B |
| Gene name | kinesin family member 4B | |
| Synonyms | - | |
| Cytomap | UCSC genome browser: 5q33.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001099293.1, | |
| Description | chromokinesin-Bchromosome-associated kinesin KIF4B | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 609184 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000226650 | ||
| Vega : OTTHUMG00000164143 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_KIF4B | |
| BioGPS: 285643 | ||
| Pathway | NCI Pathway Interaction Database: KIF4B | |
| KEGG: KIF4B | ||
| REACTOME: KIF4B | ||
| Pathway Commons: KIF4B | ||
| Context | iHOP: KIF4B | |
| ligand binding site mutation search in PubMed: KIF4B | ||
| UCL Cancer Institute: KIF4B | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
| Reference showing the relevant tissue of KIF4B | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for KIF4B |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| BLCA | -0.560156562 | -2.119430246 | 1.559273684 | 2.91E-06 | 7.61E-05 |
| KIRC | -1.60016219 | -2.670930246 | 1.070768056 | 1.31E-14 | 6.40E-14 |
| STAD | 0.116935379 | -1.358942746 | 1.475878125 | 3.64E-06 | 4.87E-05 |
| LUSC | -0.327475344 | -2.590371422 | 2.262896078 | 5.66E-32 | 3.54E-30 |
| COAD | -0.074457169 | -1.4533264 | 1.378869231 | 3.87E-08 | 2.99E-07 |
| LUAD | -0.606468177 | -2.249066453 | 1.642598276 | 2.73E-14 | 2.57E-13 |
| BRCA | -1.015345158 | -2.609008316 | 1.593663158 | 1.40E-27 | 1.59E-26 |
| HNSC | 1.89073487 | 0.101130219 | 1.789604651 | 2.61E-13 | 1.17E-11 |
| ESCA | 0.501433391 | -2.383821155 | 2.885254545 | 4.34E-06 | 0.000804347 |
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| TissGene-miRNA for KIF4B |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for KIF4B |
| TissGeneSNV for KIF4B |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.S48F | SKCM | 2 |
| p.S387F | SKCM | 2 |
| p.E400K | SKCM | 2 |
| p.H369Y | SKCM | 2 |
| p.P1147S | SKCM | 2 |
| p.W641* | SKCM | 2 |
| p.A86T | STAD | 2 |
| p.D52N | SKCM | 2 |
| p.C1088F | THYM | 1 |
| p.P167L | SKCM | 1 |
| p.K665E | PAAD | 1 |
| p.R256H | COAD | 1 |
| p.K946T | CHOL | 1 |
| p.P792L | SKCM | 1 |
| p.L934V | LUAD | 1 |
| p.S822I | SARC | 1 |
| p.L959P | LUSC | 1 |
| p.K22I | SKCM | 1 |
| p.R713Q | LGG | 1 |
| p.Q998L | LUAD | 1 |
| p.E855K | BRCA | 1 |
| p.R17C | THCA | 1 |
| p.V527A | STAD | 1 |
| p.F49L | GBM | 1 |
| p.Q957H | UCEC | 1 |
| p.D166N | SKCM | 1 |
| p.Q1134R | HNSC | 1 |
| p.P1208S | SKCM | 1 |
| p.E911G | BRCA | 1 |
| p.C1114F | HNSC | 1 |
| p.T323A | LUAD | 1 |
| p.N590S | LIHC | 1 |
| p.Q222K | LUAD | 1 |
| p.R419K | LUAD | 1 |
| p.R974* | SARC | 1 |
| p.R419S | LUSC | 1 |
| p.E455K | SKCM | 1 |
| p.A410D | HNSC | 1 |
| p.R156H | PAAD | 1 |
| p.R404C | LGG | 1 |
| p.W641X | SKCM | 1 |
| p.V35M | HNSC | 1 |
| p.E493K | SKCM | 1 |
| p.G735E | SKCM | 1 |
| p.S1113C | HNSC | 1 |
| p.E125X | COAD | 1 |
| p.R713L | OV | 1 |
| p.L327F | SKCM | 1 |
| p.P71L | STAD | 1 |
| p.E253K | SKCM | 1 |
| p.R631H | STAD | 1 |
| p.A1000S | LUAD | 1 |
| p.R680C | LUAD | 1 |
| p.A432T | STAD | 1 |
| p.D1107N | UCEC | 1 |
| p.L517F | SKCM | 1 |
| p.L72H | STAD | 1 |
| p.A516V | SKCM | 1 |
| p.T1135N | GBM | 1 |
| p.G1140S | SKCM | 1 |
| p.M654I | SKCM | 1 |
| p.Q838L | LGG | 1 |
| p.P9S | SKCM | 1 |
| p.Q393L | HNSC | 1 |
| p.S189F | SKCM | 1 |
| p.T1010I | SKCM | 1 |
| p.Q1037R | SKCM | 1 |
| p.H306D | HNSC | 1 |
| p.E847K | SKCM | 1 |
| p.M1039I | LUAD | 1 |
| p.G1109D | UCEC | 1 |
| p.Q471L | LUAD | 1 |
| p.M901L | LUAD | 1 |
| p.K715N | UCEC | 1 |
| p.R211Q | SKCM | 1 |
| p.K1181N | BLCA | 1 |
| p.A184S | SARC | 1 |
| p.I220T | HNSC | 1 |
| p.T423A | BLCA | 1 |
| p.S1051C | BLCA | 1 |
| p.E1176D | LUAD | 1 |
| p.R233C | SKCM | 1 |
| p.V313A | COAD | 1 |
| p.S887R | LUSC | 1 |
| p.I995T | HNSC | 1 |
| p.S305N | STAD | 1 |
| p.R652H | GBM | 1 |
| p.N692I | LUAD | 1 |
| p.S507Y | UCEC | 1 |
| p.L994R | ESCA | 1 |
| p.E1139K | SKCM | 1 |
| p.M651V | BLCA | 1 |
| p.D611Y | LUAD | 1 |
| p.P1007H | STAD | 1 |
| p.V441L | THYM | 1 |
| p.R419M | KIRC | 1 |
| p.R156L | LUSC | 1 |
| p.L182I | LUAD | 1 |
| p.A510T | THYM | 1 |
| p.H908N | UCEC | 1 |
| p.E1230K | SKCM | 1 |
| p.T250P | LIHC | 1 |
| p.R419K | SKCM | 1 |
| p.D489G | LUAD | 1 |
| p.G27D | SKCM | 1 |
| p.R1120Q | COAD | 1 |
| p.R830S | ESCA | 1 |
| p.D52N | PAAD | 1 |
| p.E919* | HNSC | 1 |
| p.D836G | COAD | 1 |
| p.A414S | SARC | 1 |
| p.K562N | COAD | 1 |
| p.G371S | SKCM | 1 |
| p.R682S | LUSC | 1 |
| p.T294N | LUAD | 1 |
| p.V342L | LUAD | 1 |
| p.E245Q | LUAD | 1 |
| p.D131G | UCEC | 1 |
| p.Q556K | HNSC | 1 |
| p.L623R | ESCA | 1 |
| p.L1216V | BLCA | 1 |
| p.G1153E | SKCM | 1 |
| p.I1021V | HNSC | 1 |
| p.G1062C | LUAD | 1 |
| p.R233C | BLCA | 1 |
| p.E38K | SKCM | 1 |
| p.Q776H | CESC | 1 |
| p.E565A | SKCM | 1 |
| p.R652H | STAD | 1 |
| p.D446Y | CESC | 1 |
| p.H1234Y | LUAD | 1 |
| p.L388M | UCEC | 1 |
| p.S1141F | SKCM | 1 |
| p.R722L | UCEC | 1 |
| p.S33F | SKCM | 1 |
| p.H213Y | THCA | 1 |
| p.D716Y | BLCA | 1 |
| p.H806Y | HNSC | 1 |
| p.D836N | THCA | 1 |
| p.R15H | ESCA | 1 |
| p.S1138F | SKCM | 1 |
| p.E26K | HNSC | 1 |
| p.H515Y | UCEC | 1 |
| p.A201T | UCS | 1 |
| p.R652L | LUAD | 1 |
| p.T584K | OV | 1 |
| p.Q208H | THYM | 1 |
| p.E750K | SKCM | 1 |
| p.A409T | COAD | 1 |
| p.I989T | STAD | 1 |
| p.E783X | READ | 1 |
| p.S941R | LIHC | 1 |
| p.A538V | THYM | 1 |
| p.R762H | UCEC | 1 |
| p.R713X | COAD | 1 |
| p.M1172L | LUAD | 1 |
| p.A710V | BRCA | 1 |
| p.Q780K | UCEC | 1 |
| p.G100D | LUAD | 1 |
| p.Q985R | HNSC | 1 |
| p.F800L | UCEC | 1 |
| p.P167S | SKCM | 1 |
| p.L718F | HNSC | 1 |
| p.R404C | SKCM | 1 |
| p.R156H | COAD | 1 |
| p.N1219S | SKCM | 1 |
| p.E730X | KIRP | 1 |
| p.A1186D | GBM | 1 |
| p.K715N | LUAD | 1 |
| p.L602F | SKCM | 1 |
| p.G1100E | LUAD | 1 |
| p.A1186V | STAD | 1 |
| p.L837Q | BLCA | 1 |
| p.S1224C | CESC | 1 |
| p.K946N | STAD | 1 |
| p.G807D | COAD | 1 |
| p.D186Y | BLCA | 1 |
| p.N431I | LUAD | 1 |
| p.C1173F | LUAD | 1 |
| p.S130G | BRCA | 1 |
| p.Q519K | STAD | 1 |
| p.Q551L | LUAD | 1 |
| p.G872R | SKCM | 1 |
| p.G283C | OV | 1 |
| p.T490I | SKCM | 1 |
| p.E915X | COAD | 1 |
| p.E383D | UCEC | 1 |
| p.R1122H | COAD | 1 |
| p.R404S | UCEC | 1 |
| p.G1060V | KIRC | 1 |
| p.E1201Q | HNSC | 1 |
| p.M389I | SKCM | 1 |
| p.K179T | UCEC | 1 |
| p.P1014A | BLCA | 1 |
| p.L578F | LUAD | 1 |
| p.C153* | HNSC | 1 |
| p.Q608E | OV | 1 |
| p.E769K | SKCM | 1 |
| p.E1019K | GBM | 1 |
| p.L430R | COAD | 1 |
| p.L768F | LUSC | 1 |
| p.P792A | HNSC | 1 |
| p.A70V | UCEC | 1 |
| p.P1208L | LUSC | 1 |
| p.L297P | STAD | 1 |
| p.R652H | LUAD | 1 |
| p.R233H | OV | 1 |
| p.L151I | UCEC | 1 |
| p.S234Y | BRCA | 1 |
| p.R652H | UVM | 1 |
| p.D290H | LUAD | 1 |
| p.R788Q | GBM | 1 |
| p.E574K | SKCM | 1 |
| p.R728W | STAD | 1 |
| p.L121R | STAD | 1 |
| p.G1100W | LUAD | 1 |
| p.R652H | READ | 1 |
| p.R598C | COAD | 1 |
| p.K715T | ESCA | 1 |
| p.R680C | SKCM | 1 |
| p.Q964K | HNSC | 1 |
| p.Q89H | LUAD | 1 |
| p.E968K | SKCM | 1 |
| p.R796W | DLBC | 1 |
| p.R722* | LGG | 1 |
| p.S207F | SKCM | 1 |
| p.E169K | SKCM | 1 |
| p.L19M | LUAD | 1 |
| p.S1195L | LUAD | 1 |
| p.N1008K | HNSC | 1 |
| p.D766A | PAAD | 1 |
| p.R580L | COAD | 1 |
| p.R256C | SKCM | 1 |
| p.G1100V | LUAD | 1 |
| p.V724F | UCEC | 1 |
| p.S403G | SKCM | 1 |
| p.R691K | SKCM | 1 |
| p.C269Y | HNSC | 1 |
| p.A491V | HNSC | 1 |
| p.A510T | LIHC | 1 |
| p.R652H | SARC | 1 |
| p.A918T | READ | 1 |
| p.T704M | HNSC | 1 |
| p.E321K | SKCM | 1 |
| p.R647Q | BRCA | 1 |
| p.A1162S | UCEC | 1 |
| p.E3K | CESC | 1 |
| p.R256H | PAAD | 1 |
| p.R223K | SKCM | 1 |
| p.E824K | ESCA | 1 |
| p.Q298H | COAD | 1 |
| p.S48F | KIRC | 1 |
| p.G302E | SKCM | 1 |
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| TissGeneCNV for KIF4B |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for KIF4B |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | TopHat-Fusion | UCEC | TCGA-5B-A90C-01A | KIF4B-KIF4A | In-Frame | chr5:154395656 | chrX:69607114 |
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| TissGeneNet for KIF4B |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| KIF4B, SUMO2 (tumor) | KIF4B, SUMO2 (normal) |
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| COAD (tumor) | COAD (normal) |
| KIF4B, SUMO2 (tumor) | KIF4B, SUMO2 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| KIF4B, SUMO2 (tumor) | KIF4B, SUMO2 (normal) |
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| KICH (tumor) | KICH (normal) |
| KIF4B, SUMO2 (tumor) | KIF4B, SUMO2 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| KIF4B, SUMO2 (tumor) | KIF4B, SUMO2 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| KIF4B, SUMO2 (tumor) | KIF4B, SUMO2 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| KIF4B, SUMO2 (tumor) | KIF4B, SUMO2 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| KIF4B, SUMO2 (tumor) | KIF4B, SUMO2 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| KIF4B, SUMO2 (tumor) | KIF4B, SUMO2 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| KIF4B, SUMO2 (tumor) | KIF4B, SUMO2 (normal) |
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| STAD (tumor) | STAD (normal) |
| KIF4B, SUMO2 (tumor) | KIF4B, SUMO2 (normal) |
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| THCA (tumor) | THCA (normal) |
| KIF4B, SUMO2 (tumor) | KIF4B, SUMO2 (normal) |
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| TissGeneProg for KIF4B |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for KIF4B |
| TissGeneDrug for KIF4B |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for KIF4B |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
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