TissGeneSummary for PPIL6 |
Gene summary |
Basic gene information | Gene symbol | PPIL6 |
Gene name | peptidylprolyl isomerase (cyclophilin)-like 6 | |
Synonyms | PPIase|RSPH12|bA425D10.6|dJ919F19.1 | |
Cytomap | UCSC genome browser: 6q21 | |
Type of gene | protein-coding | |
RefGenes | NM_001111298.2, NM_001286360.1,NM_001286361.1,NM_173672.4,NR_104429.1, | |
Description | cyclophilin-like protein PPIL6peptidyl-prolyl cis-trans isomerase-like 6peptidyl-prolyl cis-trans isomerase-like variant aradial spoke 12 homologrotamase PPIL6 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000185250 | ||
HPRD : 15165 | ||
Vega : OTTHUMG00000036593 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_PPIL6 | |
BioGPS: 285755 | ||
Pathway | NCI Pathway Interaction Database: PPIL6 | |
KEGG: PPIL6 | ||
REACTOME: PPIL6 | ||
Pathway Commons: PPIL6 | ||
Context | iHOP: PPIL6 | |
ligand binding site mutation search in PubMed: PPIL6 | ||
UCL Cancer Institute: PPIL6 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of PPIL6 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for PPIL6 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUSC | -2.042059665 | 0.50857759 | -2.550637255 | 7.32E-20 | 8.45E-19 |
LUAD | -1.037252701 | 0.676990403 | -1.714243103 | 1.21E-11 | 8.35E-11 |
KICH | -1.852513391 | 0.590422609 | -2.442936 | 2.77E-11 | 2.41E-10 |
HNSC | -3.072350135 | -1.660491995 | -1.41185814 | 1.65E-07 | 1.53E-06 |
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TissGene-miRNA for PPIL6 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for PPIL6 |
TissGeneSNV for PPIL6 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R200* | UCEC | 2 |
p.P309H | UCEC | 1 |
p.F174C | UCEC | 1 |
p.E161K | SKCM | 1 |
p.A126T | GBM | 1 |
p.R200Q | UCEC | 1 |
p.I59V | LUSC | 1 |
p.R200* | STAD | 1 |
p.G188D | SKCM | 1 |
p.K119E | STAD | 1 |
p.F93C | UCS | 1 |
p.D142Y | LGG | 1 |
p.I298T | SARC | 1 |
p.R200X | STAD | 1 |
p.A126T | COAD | 1 |
p.S92Y | READ | 1 |
p.A126T | CESC | 1 |
p.Q97* | GBM | 1 |
p.G209R | SARC | 1 |
p.S152Y | UCEC | 1 |
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TissGeneCNV for PPIL6 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for PPIL6 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | FusionScan | BRCA | TCGA-E2-A155-01A | ZNF322-PPIL6 | 5'UTR-CDS | chr6:26658785 | chr6:109721373 |
TCGAfusionPortal | PRADA | BRCA | TCGA-E2-A155-01A | ZNF322-PPIL6 | 5UTR-CDS | Chr6:26658786 | Chr6:109721373 |
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TissGeneNet for PPIL6 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for PPIL6 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for PPIL6 |
TissGeneDrug for PPIL6 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for PPIL6 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0374997 | Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site | 1 | BeFree |