TissGeneSummary for POM121L12 |
Gene summary |
Basic gene information | Gene symbol | POM121L12 |
Gene name | POM121 transmembrane nucleoporin-like 12 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 7p12.1 | |
Type of gene | protein-coding | |
RefGenes | NM_182595.3, | |
Description | POM121 membrane glycoprotein-like 12POM121-like protein 12 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000221900 | ||
HPRD : 13212 | ||
Vega : OTTHUMG00000155995 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_POM121L12 | |
BioGPS: 285877 | ||
Pathway | NCI Pathway Interaction Database: POM121L12 | |
KEGG: POM121L12 | ||
REACTOME: POM121L12 | ||
Pathway Commons: POM121L12 | ||
Context | iHOP: POM121L12 | |
ligand binding site mutation search in PubMed: POM121L12 | ||
UCL Cancer Institute: POM121L12 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of POM121L12 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for POM121L12 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for POM121L12 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for POM121L12 |
TissGeneSNV for POM121L12 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.G188E | SKCM | 5 |
p.E79K | SKCM | 3 |
p.G140R | SKCM | 3 |
p.S274F | SKCM | 3 |
p.A158T | SKCM | 2 |
p.P238S | SKCM | 2 |
p.R208Q | SKCM | 2 |
p.P144S | COAD | 2 |
p.A270V | UCEC | 2 |
p.M120I | SKCM | 2 |
p.G69R | SKCM | 2 |
p.P293H | LUAD | 2 |
p.R132Q | SKCM | 2 |
p.E176K | SKCM | 2 |
p.P231T | LUAD | 2 |
p.S228F | SKCM | 2 |
p.G109W | LIHC | 1 |
p.G241S | STAD | 1 |
p.I78M | HNSC | 1 |
p.P160H | STAD | 1 |
p.A30K | HNSC | 1 |
p.V287F | BRCA | 1 |
p.P195R | LIHC | 1 |
p.L55M | SKCM | 1 |
p.G162D | LIHC | 1 |
p.R159C | LUAD | 1 |
p.R81W | BLCA | 1 |
p.G140W | UCEC | 1 |
p.R157T | LUAD | 1 |
p.A5S | LUAD | 1 |
p.R81W | STAD | 1 |
p.A270V | HNSC | 1 |
p.R70C | PRAD | 1 |
p.V281F | LUAD | 1 |
p.S254F | SKCM | 1 |
p.W265L | SKCM | 1 |
p.V230L | LUAD | 1 |
p.G2S | SKCM | 1 |
p.C125* | STAD | 1 |
p.C278* | HNSC | 1 |
p.R152K | SKCM | 1 |
p.G205D | SKCM | 1 |
p.V93I | SKCM | 1 |
p.Q167* | BLCA | 1 |
p.I139M | LUAD | 1 |
p.C248G | HNSC | 1 |
p.D202N | SKCM | 1 |
p.P54S | LUAD | 1 |
p.W151C | LUAD | 1 |
p.A30T | HNSC | 1 |
p.E168D | THCA | 1 |
p.R207K | ACC | 1 |
p.N129S | BLCA | 1 |
p.A30E | STAD | 1 |
p.A291S | PAAD | 1 |
p.C173F | HNSC | 1 |
p.L23P | LUAD | 1 |
p.G241V | LGG | 1 |
p.A166T | READ | 1 |
p.R175Q | SKCM | 1 |
p.P54S | LIHC | 1 |
p.P46L | SKCM | 1 |
p.F283L | LUSC | 1 |
p.S239C | LUAD | 1 |
p.P136T | BLCA | 1 |
p.D250N | BRCA | 1 |
p.C248R | LUAD | 1 |
p.S296P | STAD | 1 |
p.R208W | STAD | 1 |
p.P89L | GBM | 1 |
p.T43M | HNSC | 1 |
p.F283V | SKCM | 1 |
p.P238L | PAAD | 1 |
p.A142V | HNSC | 1 |
p.Q258H | HNSC | 1 |
p.R175Q | ESCA | 1 |
p.W151* | SKCM | 1 |
p.R208W | COAD | 1 |
p.W68R | LUSC | 1 |
p.R207S | HNSC | 1 |
p.G241C | LUAD | 1 |
p.P219S | HNSC | 1 |
p.R126H | GBM | 1 |
p.A251T | STAD | 1 |
p.P89S | SKCM | 1 |
p.T106I | SKCM | 1 |
p.P235S | THCA | 1 |
p.G104R | GBM | 1 |
p.T59S | BRCA | 1 |
p.P37L | LUSC | 1 |
p.P212H | LUSC | 1 |
p.P235S | BLCA | 1 |
p.P195S | LIHC | 1 |
p.E145* | HNSC | 1 |
p.R110Q | CESC | 1 |
p.P261Q | LUAD | 1 |
p.P89L | SKCM | 1 |
p.A165V | SKCM | 1 |
p.A3S | PCPG | 1 |
p.L178V | HNSC | 1 |
p.C114W | HNSC | 1 |
p.G234V | LUAD | 1 |
p.E168K | SKCM | 1 |
p.R159C | LGG | 1 |
p.G162D | SKCM | 1 |
p.R146H | UCEC | 1 |
p.L256Q | LUAD | 1 |
p.R159H | ESCA | 1 |
p.E95Q | BLCA | 1 |
p.A270V | GBM | 1 |
p.A166T | GBM | 1 |
p.A31S | LUAD | 1 |
p.R146H | HNSC | 1 |
p.C125X | STAD | 1 |
p.A87T | PRAD | 1 |
p.L182I | PRAD | 1 |
p.Q184H | LUAD | 1 |
p.P154S | BLCA | 1 |
p.P242H | LUAD | 1 |
p.P144S | READ | 1 |
p.P73S | SKCM | 1 |
p.R159C | SKCM | 1 |
p.P186T | STAD | 1 |
p.V93A | STAD | 1 |
p.Q64E | COAD | 1 |
p.A260T | UCEC | 1 |
p.A142T | UCS | 1 |
p.S113F | SKCM | 1 |
p.A101V | SKCM | 1 |
p.D111Y | UCEC | 1 |
p.R208Q | HNSC | 1 |
p.P253H | STAD | 1 |
p.D85A | KIRP | 1 |
p.L77R | STAD | 1 |
p.Q184L | GBM | 1 |
p.G188R | SKCM | 1 |
p.P130Q | LUAD | 1 |
p.A260T | PRAD | 1 |
p.Q156K | LUAD | 1 |
p.S149N | SKCM | 1 |
p.G48D | SKCM | 1 |
p.W97* | SKCM | 1 |
p.A115D | HNSC | 1 |
p.V72L | LGG | 1 |
p.A165S | LUAD | 1 |
p.K187N | HNSC | 1 |
p.E79D | LUAD | 1 |
p.D250V | HNSC | 1 |
p.A31T | LUAD | 1 |
p.S221I | STAD | 1 |
p.P54L | MESO | 1 |
p.L58P | STAD | 1 |
p.S38R | UCEC | 1 |
p.R159H | PRAD | 1 |
p.P46S | SKCM | 1 |
p.R81W | UCEC | 1 |
p.E286K | LUAD | 1 |
p.A30E | HNSC | 1 |
p.L169P | STAD | 1 |
p.G180E | LUAD | 1 |
p.P40L | SKCM | 1 |
p.A260T | STAD | 1 |
p.A263T | PRAD | 1 |
p.R159H | BRCA | 1 |
p.N223S | LUAD | 1 |
p.S203N | PAAD | 1 |
p.R159H | LAML | 1 |
p.R110L | ACC | 1 |
p.W197* | HNSC | 1 |
p.A190S | ESCA | 1 |
p.P164S | CESC | 1 |
p.W97X | SKCM | 1 |
p.R99C | STAD | 1 |
p.S189R | ESCA | 1 |
p.R159H | LUSC | 1 |
p.A181S | LUAD | 1 |
p.P100A | SKCM | 1 |
p.S9F | SKCM | 1 |
p.Q41* | LUAD | 1 |
p.P46T | LUAD | 1 |
p.P186L | SKCM | 1 |
p.P32H | LUAD | 1 |
p.A227S | LUAD | 1 |
p.P82L | SKCM | 1 |
p.L29M | LUAD | 1 |
p.Q67X | SKCM | 1 |
p.R146C | HNSC | 1 |
p.R213W | DLBC | 1 |
p.R213G | HNSC | 1 |
p.A165T | UCEC | 1 |
p.A227S | GBM | 1 |
p.R99H | UCEC | 1 |
p.T75N | LUAD | 1 |
p.W197L | HNSC | 1 |
p.A166V | SKCM | 1 |
p.W252C | COAD | 1 |
p.W268X | SKCM | 1 |
p.P238S | STAD | 1 |
p.T59S | DLBC | 1 |
p.A263T | GBM | 1 |
p.I141N | STAD | 1 |
p.R146H | PAAD | 1 |
p.S262F | LUAD | 1 |
p.Q60K | LUAD | 1 |
p.G104E | SKCM | 1 |
p.L236V | LUAD | 1 |
p.T272M | COAD | 1 |
p.W268* | SKCM | 1 |
p.G140R | LUAD | 1 |
p.A260T | LIHC | 1 |
p.P103S | SKCM | 1 |
p.P164H | LUAD | 1 |
p.L77H | LUAD | 1 |
p.G123W | LUAD | 1 |
p.R126L | STAD | 1 |
p.E286D | LUAD | 1 |
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TissGeneCNV for POM121L12 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for POM121L12 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | AK097768 | BCOR-POM121L12 | chrX:39922198 | chr7:53103335 |
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TissGeneNet for POM121L12 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for POM121L12 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for POM121L12 |
TissGeneDrug for POM121L12 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for POM121L12 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |