TissGeneSummary for FBXO43 |
Gene summary |
Basic gene information | Gene symbol | FBXO43 |
Gene name | F-box protein 43 | |
Synonyms | EMI2|ERP1|FBX43 | |
Cytomap | UCSC genome browser: 8q22.2 | |
Type of gene | protein-coding | |
RefGenes | NM_001077528.1, NM_001029860.3,NR_036491.1, | |
Description | F-box only protein 43early mitotic inhibitor 2endogenous meiotic inhibitor 2 | |
Modification date | 20141207 | |
dbXrefs | MIM : 609110 | |
HGNC : HGNC | ||
Ensembl : ENSG00000156509 | ||
HPRD : 18777 | ||
Vega : OTTHUMG00000164803 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_FBXO43 | |
BioGPS: 286151 | ||
Pathway | NCI Pathway Interaction Database: FBXO43 | |
KEGG: FBXO43 | ||
REACTOME: FBXO43 | ||
Pathway Commons: FBXO43 | ||
Context | iHOP: FBXO43 | |
ligand binding site mutation search in PubMed: FBXO43 | ||
UCL Cancer Institute: FBXO43 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of FBXO43 | ||
Description by TissGene annotations | Cancer gene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for FBXO43 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
BRCA | -0.371132844 | -2.107123195 | 1.735990351 | 5.17E-34 | 8.76E-33 |
LUSC | 0.253006269 | -2.47386628 | 2.726872549 | 3.76E-23 | 6.51E-22 |
STAD | -1.207500716 | -2.762110091 | 1.554609375 | 3.56E-06 | 4.79E-05 |
LUAD | -0.744135415 | -2.518399208 | 1.774263793 | 2.98E-16 | 3.41E-15 |
LIHC | -0.125147966 | -2.971073966 | 2.845926 | 5.46E-18 | 2.89E-16 |
HNSC | -1.11381685 | -2.165712199 | 1.051895349 | 4.04E-06 | 2.59E-05 |
ESCA | -0.273454694 | -2.038900148 | 1.765445455 | 0.00339 | 0.031045224 |
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TissGene-miRNA for FBXO43 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for FBXO43 |
TissGeneSNV for FBXO43 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E342D | UCEC | 2 |
p.L341* | HNSC | 1 |
p.E565G | SKCM | 1 |
p.R504I | UCEC | 1 |
p.L510F | ESCA | 1 |
p.S612C | BLCA | 1 |
p.S121F | CESC | 1 |
p.I550F | LUAD | 1 |
p.E679Q | LUAD | 1 |
p.T18S | KIRC | 1 |
p.K22R | SKCM | 1 |
p.D66N | UCEC | 1 |
p.D496H | KIRP | 1 |
p.Q390L | SKCM | 1 |
p.P320H | SKCM | 1 |
p.D406G | STAD | 1 |
p.L609P | COAD | 1 |
p.R38W | BLCA | 1 |
p.M512I | SKCM | 1 |
p.D370Y | LUSC | 1 |
p.S83C | BLCA | 1 |
p.S261C | BLCA | 1 |
p.R455M | LGG | 1 |
p.R655S | LUSC | 1 |
p.R457I | COAD | 1 |
p.T123A | ESCA | 1 |
p.S161C | LUAD | 1 |
p.E680* | UCEC | 1 |
p.L223X | COAD | 1 |
p.P601S | SKCM | 1 |
p.Q356* | PAAD | 1 |
p.L657M | STAD | 1 |
p.E397A | LIHC | 1 |
p.P696L | LUSC | 1 |
p.D429Y | UCEC | 1 |
p.S344L | SKCM | 1 |
p.T633S | COAD | 1 |
p.S391C | SKCM | 1 |
p.R155H | UCEC | 1 |
p.T102P | THYM | 1 |
p.T290R | KIRC | 1 |
p.A686T | PAAD | 1 |
p.E215* | BLCA | 1 |
p.R9I | UCEC | 1 |
p.E679K | BLCA | 1 |
p.R703Q | UCEC | 1 |
p.A47V | STAD | 1 |
p.P651S | PRAD | 1 |
p.L609P | BLCA | 1 |
p.G100R | LUAD | 1 |
p.E296G | SKCM | 1 |
p.E187* | UCEC | 1 |
p.S220C | LUAD | 1 |
p.G491D | KIRC | 1 |
p.R65I | LUSC | 1 |
p.S347F | SKCM | 1 |
p.D295H | BLCA | 1 |
p.V627A | SKCM | 1 |
p.Q356X | PAAD | 1 |
p.Q538E | BLCA | 1 |
p.Y652S | UCEC | 1 |
p.P441L | SKCM | 1 |
p.V160A | ESCA | 1 |
p.S407Y | LGG | 1 |
p.L510V | LUAD | 1 |
p.N88K | SKCM | 1 |
p.P696S | SKCM | 1 |
p.R570W | LUAD | 1 |
p.Q479* | LIHC | 1 |
p.S53F | BLCA | 1 |
p.R155H | PRAD | 1 |
p.Q469K | BLCA | 1 |
p.L657P | STAD | 1 |
p.I56N | LUAD | 1 |
p.G603V | LUSC | 1 |
p.R703Q | ESCA | 1 |
p.Q356* | SKCM | 1 |
p.E140K | COAD | 1 |
p.V207L | LUAD | 1 |
p.F466L | BLCA | 1 |
p.R570Q | STAD | 1 |
p.Q479X | LIHC | 1 |
p.E92K | KIRC | 1 |
p.R544W | STAD | 1 |
p.E332K | BRCA | 1 |
p.R388W | HNSC | 1 |
p.K374N | UCEC | 1 |
p.S269I | UCEC | 1 |
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TissGeneCNV for FBXO43 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for FBXO43 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for FBXO43 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for FBXO43 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for FBXO43 |
TissGeneDrug for FBXO43 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for FBXO43 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |