TissGeneSummary for GPT |
Gene summary |
Basic gene information | Gene symbol | GPT |
Gene name | glutamic-pyruvate transaminase (alanine aminotransferase) | |
Synonyms | AAT1|ALT1|GPT1 | |
Cytomap | UCSC genome browser: 8q24.3 | |
Type of gene | protein-coding | |
RefGenes | NM_005309.2, | |
Description | GPT 1alanine aminotransferase 1glutamate pyruvate transaminase 1glutamic--alanine transaminase 1glutamic--pyruvic transaminase 1glutamic-alanine transaminase 1 | |
Modification date | 20141218 | |
dbXrefs | MIM : 138200 | |
HGNC : HGNC | ||
Ensembl : ENSG00000167701 | ||
HPRD : 00689 | ||
Vega : OTTHUMG00000165176 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_GPT | |
BioGPS: 2875 | ||
Pathway | NCI Pathway Interaction Database: GPT | |
KEGG: GPT | ||
REACTOME: GPT | ||
Pathway Commons: GPT | ||
Context | iHOP: GPT | |
ligand binding site mutation search in PubMed: GPT | ||
UCL Cancer Institute: GPT | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | KidneyLiver | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICHLIHC | |
Reference showing the relevant tissue of GPT | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
Top |
TissGeneExp for GPT |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
COAD | -0.197638269 | 4.242250192 | -4.439888462 | 1.94E-14 | 7.87E-13 |
HNSC | -2.25524623 | 1.515925863 | -3.771172093 | 3.41E-17 | 6.98E-15 |
BRCA | -1.47127275 | 0.728106198 | -2.199378947 | 5.07E-16 | 2.84E-15 |
THCA | -0.819172363 | -2.528102872 | 1.708930508 | 3.32E-12 | 2.69E-11 |
KIRP | 0.165657404 | 3.237463654 | -3.07180625 | 2.11E-07 | 1.21E-06 |
KICH | 0.186008654 | 2.069484654 | -1.883476 | 0.000511 | 0.001164678 |
LIHC | 5.022270654 | 6.161770654 | -1.1395 | 0.000218 | 0.000692672 |
Top |
TissGene-miRNA for GPT |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
Top |
TissGeneMut for GPT |
TissGeneSNV for GPT |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.H14N | COAD | 2 |
p.N398S | THCA | 1 |
p.A411V | COAD | 1 |
p.X497R | KIRP | 1 |
p.S313P | SKCM | 1 |
p.D103N | BLCA | 1 |
p.E175K | BRCA | 1 |
p.T195M | ESCA | 1 |
p.R107G | KIRC | 1 |
p.G145R | UCEC | 1 |
p.L225P | KIRP | 1 |
p.P401H | COAD | 1 |
p.R107G | THYM | 1 |
p.G448S | LUSC | 1 |
p.R143H | HNSC | 1 |
p.G410D | SKCM | 1 |
p.D277G | UCS | 1 |
p.V418M | READ | 1 |
p.A45S | PAAD | 1 |
p.S97N | BLCA | 1 |
p.R478P | UCEC | 1 |
p.Q355H | COAD | 1 |
p.V452M | STAD | 1 |
p.G410S | SKCM | 1 |
p.A281V | STAD | 1 |
p.S127C | BRCA | 1 |
p.G302R | SKCM | 1 |
p.V408A | LIHC | 1 |
p.R478W | ESCA | 1 |
p.A173S | ACC | 1 |
p.D93V | LIHC | 1 |
p.R8W | BRCA | 1 |
p.A71T | STAD | 1 |
p.D135E | COAD | 1 |
p.P101H | PRAD | 1 |
p.L88I | STAD | 1 |
Top |
TissGeneCNV for GPT |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
Top |
TissGeneFusions for GPT |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | FusionScan | UCS | TCGA-NA-A4QW-01A | GPT2-GPT | In-Frame | chr16:46950619 | chr8:145731377 |
Top |
TissGeneNet for GPT |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
Top |
TissGeneProg for GPT |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Top |
TissGeneClin for GPT |
TissGeneDrug for GPT |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
DB00780 | Phenelzine | Inhibitor | Small molecule | Approved |
Top |
TissGeneDisease for GPT |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0015695 | Fatty Liver | 5 | CTD_human,LHGDN |
umls:C0023895 | Liver diseases | 4 | CTD_human,LHGDN |
umls:C2239176 | Liver carcinoma | 4 | BeFree,LHGDN |
umls:C0023903 | Liver neoplasms | 3 | BeFree |
umls:C0019196 | Hepatitis C | 2 | BeFree,LHGDN |
umls:C0023418 | leukemia | 2 | BeFree |
umls:C0235946 | Cerebral atrophy | 2 | BeFree |
umls:C0860207 | Drug-Induced Liver Injury | 2 | CTD_human |
umls:C0011175 | Dehydration | 1 | BeFree |
umls:C0015672 | Fatigue | 1 | BeFree |
umls:C0016085 | Filariasis | 1 | BeFree |
umls:C0022116 | Ischemia | 1 | LHGDN |
umls:C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
umls:C0027627 | Neoplasm Metastasis | 1 | BeFree |
umls:C0035126 | Reperfusion Injury | 1 | CTD_human |
umls:C0035412 | Rhabdomyosarcoma | 1 | BeFree |
umls:C0153594 | Malignant neoplasm of testis | 1 | BeFree |
umls:C0220611 | childhood rhabdomyosarcoma | 1 | BeFree |
umls:C0238644 | Anemia, severe | 1 | BeFree |
umls:C0271650 | Impaired glucose tolerance | 1 | LHGDN |
umls:C0339510 | Vitelliform Macular Dystrophy | 1 | BeFree |
umls:C0520679 | Sleep Apnea, Obstructive | 1 | LHGDN |
umls:C1175175 | Severe Acute Respiratory Syndrome | 1 | LHGDN |