 |
| |
| |
| |
| |
| |
| |
|
| TissGeneSummary for GRIA1 |
 Gene summary |
| Basic gene information | Gene symbol | GRIA1 |
| Gene name | glutamate receptor, ionotropic, AMPA 1 | |
| Synonyms | GLUH1|GLUR1|GLURA|GluA1|HBGR1 | |
| Cytomap | UCSC genome browser: 5q31.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_000827.3, NM_001114183.1,NM_001258019.1,NM_001258020.1,NM_001258021.1, NM_001258022.1,NM_001258023.1,NR_047578.1, | |
| Description | AMPA 1AMPA-selective glutamate receptor 1gluR-1gluR-AgluR-K1glutamate receptor 1 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 138248 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000155511 | ||
| HPRD : 00695 | ||
| Vega : OTTHUMG00000130148 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_GRIA1 | |
| BioGPS: 2890 | ||
| Pathway | NCI Pathway Interaction Database: GRIA1 | |
| KEGG: GRIA1 | ||
| REACTOME: GRIA1 | ||
| Pathway Commons: GRIA1 | ||
| Context | iHOP: GRIA1 | |
| ligand binding site mutation search in PubMed: GRIA1 | ||
| UCL Cancer Institute: GRIA1 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,TiGER | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Brain | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGG | |
| Reference showing the relevant tissue of GRIA1 | ||
| Description by TissGene annotations | Protective TissGene in RFS Cancer gene Have significant anti-correlated miRNA TissgsKTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0035235 | ionotropic glutamate receptor signaling pathway | 20805473 | GO:0035235 | ionotropic glutamate receptor signaling pathway | 20805473 |
| Top |
| TissGeneExp for GRIA1 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
 |
| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
 |
| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUAD | -0.537132539 | 4.45123815 | -4.98837069 | 1.05E-28 | 8.41E-27 |
| BRCA | -2.081897784 | 0.975216251 | -3.057114035 | 6.11E-25 | 6.07E-24 |
| COAD | -2.910009728 | -0.893675112 | -2.016334615 | 5.72E-09 | 5.50E-08 |
| HNSC | -3.26082869 | -1.762875202 | -1.497953488 | 6.39E-07 | 5.08E-06 |
| LUSC | -1.077000829 | 4.449140348 | -5.526141176 | 1.72E-25 | 4.08E-24 |
| BLCA | -3.826879363 | -1.28808989 | -2.538789474 | 4.19E-12 | 3.11E-09 |
| THCA | -3.760302557 | -1.434195777 | -2.32610678 | 1.69E-24 | 2.20E-22 |
| ESCA | -2.770036301 | -1.038345392 | -1.731690909 | 0.0056 | 0.042652055 |
| STAD | -2.157341699 | -0.791754199 | -1.3655875 | 0.00156 | 0.007528841 |
| Top |
| TissGene-miRNA for GRIA1 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| LUSC | hsa-miR-182-5p | MIMAT0000259 | 0.0028 | -0.26 | 128 |
| UVM | hsa-miR-96-5p | MIMAT0000095 | 0.0069 | -0.32 | 80 |
| Top |
| TissGeneMut for GRIA1 |
| TissGeneSNV for GRIA1 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
 |
 |
| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
 |
| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.D400N | SKCM | 5 |
| p.D783N | SKCM | 5 |
| p.E852K | SKCM | 3 |
| p.R706* | SKCM | 2 |
| p.M704I | SKCM | 2 |
| p.R455H | PRAD | 2 |
| p.T71A | STAD | 2 |
| p.D331N | SKCM | 2 |
| p.E783K | SKCM | 2 |
| p.M635I | SKCM | 2 |
| p.W270* | SKCM | 2 |
| p.T81A | STAD | 2 |
| p.S857L | SKCM | 2 |
| p.P492S | SKCM | 2 |
| p.G115E | SKCM | 2 |
| p.V764I | SKCM | 2 |
| p.R855W | PRAD | 2 |
| p.G184E | SKCM | 2 |
| p.T110M | UCEC | 2 |
| p.A491V | UCEC | 1 |
| p.F595Y | ESCA | 1 |
| p.L762M | BLCA | 1 |
| p.G223S | SKCM | 1 |
| p.L104F | HNSC | 1 |
| p.S629L | SKCM | 1 |
| p.R455H | BLCA | 1 |
| p.T721I | SKCM | 1 |
| p.M517I | SKCM | 1 |
| p.T110M | ESCA | 1 |
| p.S904C | STAD | 1 |
| p.A161T | THYM | 1 |
| p.S530F | HNSC | 1 |
| p.M714T | LIHC | 1 |
| p.A903V | SKCM | 1 |
| p.A447V | COAD | 1 |
| p.P521L | SKCM | 1 |
| p.R613C | SKCM | 1 |
| p.N427H | LUAD | 1 |
| p.P42L | READ | 1 |
| p.E183G | COAD | 1 |
| p.S10F | SKCM | 1 |
| p.V809M | BLCA | 1 |
| p.S606Y | UCEC | 1 |
| p.G14D | SKCM | 1 |
| p.G828V | CESC | 1 |
| p.E136K | SKCM | 1 |
| p.G399C | LUAD | 1 |
| p.L813R | UCEC | 1 |
| p.G533E | SKCM | 1 |
| p.A483S | KIRP | 1 |
| p.R808W | COAD | 1 |
| p.M527I | STAD | 1 |
| p.M887V | HNSC | 1 |
| p.G772D | SKCM | 1 |
| p.E500A | SKCM | 1 |
| p.R387X | LIHC | 1 |
| p.W341C | LUSC | 1 |
| p.P111L | HNSC | 1 |
| p.N416K | KIRC | 1 |
| p.V550M | SKCM | 1 |
| p.K665R | LIHC | 1 |
| p.G905R | SARC | 1 |
| p.S894C | STAD | 1 |
| p.E701K | SKCM | 1 |
| p.V17A | STAD | 1 |
| p.G883V | STAD | 1 |
| p.V618I | PRAD | 1 |
| p.E431A | SKCM | 1 |
| p.T120M | ESCA | 1 |
| p.R386H | LGG | 1 |
| p.R126H | THCA | 1 |
| p.Q310H | BLCA | 1 |
| p.K535X | LIHC | 1 |
| p.D295N | SKCM | 1 |
| p.V737M | BRCA | 1 |
| p.R559C | STAD | 1 |
| p.E658Q | BLCA | 1 |
| p.S79F | SKCM | 1 |
| p.W38X | SKCM | 1 |
| p.N862K | SARC | 1 |
| p.Y452C | LUAD | 1 |
| p.K284N | BLCA | 1 |
| p.E568K | SKCM | 1 |
| p.R698W | STAD | 1 |
| p.E515K | SKCM | 1 |
| p.G583E | STAD | 1 |
| p.R136C | UCEC | 1 |
| p.P791S | SKCM | 1 |
| p.S137L | SKCM | 1 |
| p.Y661* | BLCA | 1 |
| p.G738E | SKCM | 1 |
| p.E584K | SKCM | 1 |
| p.R377Q | BRCA | 1 |
| p.S889L | UCEC | 1 |
| p.K586N | COAD | 1 |
| p.S606F | SKCM | 1 |
| p.G12R | SKCM | 1 |
| p.V747M | UCS | 1 |
| p.M517I | STAD | 1 |
| p.M684L | HNSC | 1 |
| p.R311K | BLCA | 1 |
| p.R838Q | UCEC | 1 |
| p.S886F | SKCM | 1 |
| p.E658K | SKCM | 1 |
| p.W341R | CESC | 1 |
| p.R642K | SKCM | 1 |
| p.E384K | SKCM | 1 |
| p.G602E | SKCM | 1 |
| p.Q888K | HNSC | 1 |
| p.P127S | SKCM | 1 |
| p.R316C | SKCM | 1 |
| p.M704I | LIHC | 1 |
| p.P194L | COAD | 1 |
| p.R434H | UCEC | 1 |
| p.T127I | STAD | 1 |
| p.A567T | COAD | 1 |
| p.D688N | COAD | 1 |
| p.R316H | MESO | 1 |
| p.A301T | UCEC | 1 |
| p.G409S | STAD | 1 |
| p.Y687H | LGG | 1 |
| p.E837A | ESCA | 1 |
| p.R208C | STAD | 1 |
| p.E302* | HNSC | 1 |
| p.F8L | LUAD | 1 |
| p.E167Q | LUAD | 1 |
| p.A636D | PRAD | 1 |
| p.I71T | ESCA | 1 |
| p.A211G | LUAD | 1 |
| p.G549V | HNSC | 1 |
| p.S788L | SKCM | 1 |
| p.S525F | SKCM | 1 |
| p.T120M | UCEC | 1 |
| p.S710F | SKCM | 1 |
| p.A45P | SKCM | 1 |
| p.A867S | STAD | 1 |
| p.E827A | ESCA | 1 |
| p.G441D | ESCA | 1 |
| p.R861H | KIRC | 1 |
| p.K529X | STAD | 1 |
| p.G252E | SKCM | 1 |
| p.G669E | SKCM | 1 |
| p.F529V | SKCM | 1 |
| p.F598V | SKCM | 1 |
| p.R444H | UCEC | 1 |
| p.L133V | BRCA | 1 |
| p.R629W | COAD | 1 |
| p.A303P | HNSC | 1 |
| p.T41M | READ | 1 |
| p.A691E | UCS | 1 |
| p.R706Q | SKCM | 1 |
| p.H139Y | SKCM | 1 |
| p.R455H | LGG | 1 |
| p.I229F | LIHC | 1 |
| p.G81R | SKCM | 1 |
| p.K519* | STAD | 1 |
| p.H70Y | SKCM | 1 |
| p.I212V | COAD | 1 |
| p.E724* | LUAD | 1 |
| p.A447P | KIRP | 1 |
| p.Y830C | LUAD | 1 |
| p.R706Q | HNSC | 1 |
| p.T669A | STAD | 1 |
| p.T657K | PRAD | 1 |
| p.R57H | THCA | 1 |
| p.R559H | STAD | 1 |
| p.E648Q | LUAD | 1 |
| p.K244R | COAD | 1 |
| p.R377* | LUAD | 1 |
| p.R280W | PAAD | 1 |
| p.P465L | SKCM | 1 |
| p.G262S | LIHC | 1 |
| p.T686A | BRCA | 1 |
| p.G905E | SKCM | 1 |
| p.L497F | LUAD | 1 |
| p.L255Q | LUAD | 1 |
| p.R887G | ESCA | 1 |
| p.G29E | UCEC | 1 |
| p.R467L | SKCM | 1 |
| p.G331R | LUSC | 1 |
| p.G836E | SKCM | 1 |
| p.E796K | UVM | 1 |
| p.P860S | SKCM | 1 |
| p.D116N | SKCM | 1 |
| p.G334E | LGG | 1 |
| p.F603L | COAD | 1 |
| p.P349S | SKCM | 1 |
| p.G321E | SKCM | 1 |
| p.L463F | SKCM | 1 |
| p.R569C | STAD | 1 |
| p.M897I | ESCA | 1 |
| p.R608K | HNSC | 1 |
| p.T93P | BLCA | 1 |
| p.V772F | LUAD | 1 |
| p.R207Q | READ | 1 |
| p.Q225_splice | LUSC | 1 |
| p.P759S | SKCM | 1 |
| p.R877G | LUAD | 1 |
| p.A636T | STAD | 1 |
| p.P646L | SKCM | 1 |
| p.M839I | BLCA | 1 |
| p.R477Q | LUSC | 1 |
| p.V628I | PRAD | 1 |
| p.E682Q | BLCA | 1 |
| p.G465E | STAD | 1 |
| p.K775I | PRAD | 1 |
| p.H449Q | KIRP | 1 |
| p.R208W | GBM | 1 |
| p.R208W | LIHC | 1 |
| p.R377* | LIHC | 1 |
| p.K520N | SKCM | 1 |
| p.K687T | STAD | 1 |
| p.G399S | STAD | 1 |
| p.G753R | SKCM | 1 |
| p.A457P | KIRP | 1 |
| p.H227Q | PAAD | 1 |
| p.D213N | SKCM | 1 |
| p.G788R | SKCM | 1 |
| p.G573E | STAD | 1 |
| p.D47N | SKCM | 1 |
| p.C9Y | ESCA | 1 |
| p.S720T | LUSC | 1 |
| p.R729Q | HNSC | 1 |
| p.S206L | SKCM | 1 |
| p.R465H | PRAD | 1 |
| p.V37I | LGG | 1 |
| p.R218C | ESCA | 1 |
| p.N220D | STAD | 1 |
| p.S594F | SKCM | 1 |
| p.C101F | BLCA | 1 |
| p.S99A | ESCA | 1 |
| p.G905R | SKCM | 1 |
| p.L188M | LUSC | 1 |
| p.R276Q | SKCM | 1 |
| p.G876* | LUSC | 1 |
| p.I495N | SKCM | 1 |
| p.S651F | SKCM | 1 |
| p.M887I | BRCA | 1 |
| p.D282N | SKCM | 1 |
| p.N406K | KIRC | 1 |
| p.T71I | PAAD | 1 |
| p.Y782H | LGG | 1 |
| p.T117I | STAD | 1 |
| p.D191N | SKCM | 1 |
| p.I736F | KIRC | 1 |
| p.S609F | SKCM | 1 |
| p.D122N | SKCM | 1 |
| p.R208C | ESCA | 1 |
| p.D688N | SKCM | 1 |
| p.P562L | SKCM | 1 |
| p.N210D | STAD | 1 |
| p.E347Q | BRCA | 1 |
| p.P534L | SKCM | 1 |
| p.G871S | PRAD | 1 |
| p.G265E | LGG | 1 |
| p.N172S | COAD | 1 |
| p.P759T | UCEC | 1 |
| p.L341M | HNSC | 1 |
| p.R848Q | UCEC | 1 |
| p.T192S | SKCM | 1 |
| p.L664Q | BLCA | 1 |
| p.V669I | SKCM | 1 |
| p.H459Q | KIRP | 1 |
| p.S832F | SKCM | 1 |
| p.T652I | SKCM | 1 |
| p.N176K | LUAD | 1 |
| p.D374N | SKCM | 1 |
| p.M893I | SKCM | 1 |
| p.G873E | SKCM | 1 |
| p.V411F | LUAD | 1 |
| p.P891S | SKCM | 1 |
| p.R434H | SARC | 1 |
| p.G871V | PRAD | 1 |
| p.I64T | STAD | 1 |
| p.Y782C | STAD | 1 |
| p.I726F | KIRC | 1 |
| p.I61T | ESCA | 1 |
| p.P769T | UCEC | 1 |
| p.G475E | STAD | 1 |
| p.S763F | SKCM | 1 |
| p.E786K | UVM | 1 |
| p.R218C | STAD | 1 |
| p.H49R | KIRC | 1 |
| p.Q68H | LUSC | 1 |
| p.A765P | LUSC | 1 |
| p.A751T | COAD | 1 |
| p.T699S | PRAD | 1 |
| p.L591F | BLCA | 1 |
| p.R339K | SKCM | 1 |
| p.R569H | STAD | 1 |
| p.T835M | COAD | 1 |
| p.Y547C | UCEC | 1 |
| p.V106I | LGG | 1 |
| p.K677T | STAD | 1 |
| p.G282E | SKCM | 1 |
| p.I239F | LIHC | 1 |
| p.A877S | STAD | 1 |
| p.T667K | PRAD | 1 |
| p.G351E | SKCM | 1 |
| p.F145C | UCEC | 1 |
| p.K231N | ESCA | 1 |
| p.M704T | LIHC | 1 |
| p.G873V | STAD | 1 |
| p.R708Q | GBM | 1 |
| p.S899L | UCEC | 1 |
| p.S530F | SKCM | 1 |
| p.Q656H | BRCA | 1 |
| p.R739Q | TGCT | 1 |
| p.H39R | KIRC | 1 |
| p.E205K | STAD | 1 |
| p.S76Y | HNSC | 1 |
| p.N425S | COAD | 1 |
| p.P418S | SKCM | 1 |
| p.R729Q | TGCT | 1 |
| p.R360H | PRAD | 1 |
| p.R887Q | LIHC | 1 |
| p.S109A | ESCA | 1 |
| p.D783N | BLCA | 1 |
| p.L532F | SKCM | 1 |
| p.W201X | SKCM | 1 |
| p.S720F | SKCM | 1 |
| p.K221N | ESCA | 1 |
| p.X917Y | ESCA | 1 |
| p.V737M | UCS | 1 |
| p.T914M | CESC | 1 |
| p.T261S | SKCM | 1 |
| p.E205K | SKCM | 1 |
| p.M714I | LIHC | 1 |
| p.L773S | LUAD | 1 |
| p.D443N | CESC | 1 |
| Top |
| TissGeneCNV for GRIA1 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
 |
| Top |
| TissGeneFusions for GRIA1 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | AW895009 | GRIA1-GRIA1 | chr5:153178819 | chr5:153179066 | |
| TCGAfusionPortal | PRADA | LUAD | TCGA-95-A4VK-01A | SQSTM1-GRIA1 | 5UTR-CDS | Chr5:179233591 | Chr5:153077604 |
| Top |
| TissGeneNet for GRIA1 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| GRIA1, SQSTM1, PPP1CA, CASP8, PRKCA, PRKACA, GRIA4, PICK1, ANAPC2, EPB41L1, FZR1, DLG1, GRIP1, TRPC1, SDCBP, CXCR2, HOMER1, GRIK2, GRID2, GRIPAP1, EPB41L2 (tumor) | GRIA1, PPP1CA, CASP8, PRKCA, NEDD4, GRIA4, PICK1, CANX, ANAPC2, EPB41L1, FZR1, DLG1, GRIP1, SDCBP, CXCR2, HOMER1, GRIK2, GRIA2, CACNG2, GRID2, GRIPAP1 (normal) |
 |  |
| COAD (tumor) | COAD (normal) |
| GRIA1, PPP1CA, CASP8, PRKCA, NEDD4, TANC1, CAMK2G, GRIA4, PICK1, EPB41L1, FZR1, DLG1, GRIP1, TRPC1, HOMER1, GRIK2, GRIA2, CACNG2, GRID2, GRIPAP1, EPB41L2 (tumor) | GRIA1, PPP1CA, CASP8, PRKCA, NEDD4, PRKACA, TANC1, CAMK2G, GRIA4, PICK1, HSPA5, EPB41L1, GRIP1, TRPC1, CXCR2, GRIK2, GRIA2, CACNG2, GRID2, GRIPAP1, EPB41L2 (normal) |
 |  |
| HNSC (tumor) | HNSC (normal) |
| GRIA1, PPP1CA, CASP8, NEDD4, PRKACA, TANC1, CAMK2G, GRIA4, HSPA5, CANX, ANAPC2, EPB41L1, FZR1, TRPC1, SDCBP, HOMER1, GRIK2, GRIA2, CACNG2, GRID2, EPB41L2 (tumor) | GRIA1, PPP1CA, UBC, CASP8, PRKCA, PRKACA, GRIA4, PICK1, HSPA5, CANX, EPB41L1, FZR1, DLG1, GRIP1, TRPC1, CXCR2, GRIK2, GRIA2, CACNG2, GRID2, EPB41L2 (normal) |
 |  |
| KICH (tumor) | KICH (normal) |
| GRIA1, SQSTM1, PPP1CA, CASP8, PRKCA, NEDD4, PRKACA, TANC1, CAMK2G, GRIA4, PICK1, HSPA5, EPB41L1, DLG1, GRIP1, TRPC1, SDCBP, CXCR2, HOMER1, GRIA2, EPB41L2 (tumor) | GRIA1, SQSTM1, PPP1CA, UBC, CASP8, NEDD4, CAMK2G, GRIA4, PICK1, HSPA5, ANAPC2, FZR1, DLG1, GRIP1, TRPC1, CXCR2, HOMER1, GRIK2, GRIA2, CACNG2, GRID2 (normal) |
 |  |
| KIRC (tumor) | KIRC (normal) |
| GRIA1, PPP1CA, CASP8, PRKCA, NEDD4, PRKACA, TANC1, CAMK2G, PICK1, CANX, EPB41L1, DLG1, TRPC1, CXCR2, HOMER1, GRIK2, GRIA2, CACNG2, GRID2, GRIPAP1, EPB41L2 (tumor) | GRIA1, SQSTM1, PPP1CA, UBC, PRKCA, NEDD4, PRKACA, TANC1, CAMK2G, PICK1, HSPA5, DLG1, GRIP1, TRPC1, CXCR2, HOMER1, GRIK2, GRIA2, CACNG2, GRID2, EPB41L2 (normal) |
 |  |
| KIRP (tumor) | KIRP (normal) |
| GRIA1, UBC, PRKCA, NEDD4, PRKACA, CAMK2G, PICK1, HSPA5, CANX, ANAPC2, EPB41L1, FZR1, DLG1, GRIP1, SDCBP, CXCR2, HOMER1, GRIK2, GRIA2, GRID2, GRIPAP1 (tumor) | GRIA1, SQSTM1, PPP1CA, UBC, CASP8, NEDD4, TANC1, CAMK2G, PICK1, HSPA5, CANX, ANAPC2, EPB41L1, FZR1, GRIP1, SDCBP, CXCR2, HOMER1, GRIK2, GRIA2, EPB41L2 (normal) |
 |  |
| LIHC (tumor) | LIHC (normal) |
| GRIA1, SQSTM1, PPP1CA, UBC, NEDD4, TANC1, CAMK2G, GRIA4, PICK1, CANX, ANAPC2, EPB41L1, DLG1, GRIP1, TRPC1, CXCR2, HOMER1, GRIK2, GRIA2, GRID2, EPB41L2 (tumor) | GRIA1, PPP1CA, PRKCA, NEDD4, TANC1, CAMK2G, GRIA4, HSPA5, CANX, ANAPC2, DLG1, GRIP1, TRPC1, SDCBP, CXCR2, HOMER1, GRIK2, GRIA2, CACNG2, GRID2, EPB41L2 (normal) |
 |  |
| LUAD (tumor) | LUAD (normal) |
| GRIA1, SQSTM1, PPP1CA, CASP8, PRKCA, NEDD4, PRKACA, TANC1, CAMK2G, PICK1, HSPA5, CANX, DLG1, GRIP1, TRPC1, SDCBP, CXCR2, HOMER1, GRIK2, GRID2, EPB41L2 (tumor) | GRIA1, PPP1CA, UBC, PRKCA, NEDD4, PRKACA, TANC1, CAMK2G, GRIA4, HSPA5, CANX, EPB41L1, FZR1, TRPC1, SDCBP, CXCR2, HOMER1, GRIK2, CACNG2, GRID2, EPB41L2 (normal) |
 |  |
| LUSC (tumor) | LUSC (normal) |
| GRIA1, SQSTM1, PPP1CA, PRKCA, NEDD4, TANC1, CAMK2G, GRIA4, PICK1, HSPA5, ANAPC2, EPB41L1, FZR1, DLG1, GRIP1, TRPC1, HOMER1, GRIK2, GRID2, GRIPAP1, EPB41L2 (tumor) | GRIA1, SQSTM1, PPP1CA, UBC, PRKCA, NEDD4, CAMK2G, GRIA4, HSPA5, ANAPC2, FZR1, DLG1, GRIP1, TRPC1, SDCBP, CXCR2, GRIK2, GRIA2, GRID2, GRIPAP1, EPB41L2 (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| GRIA1, SQSTM1, PPP1CA, PRKCA, NEDD4, PRKACA, TANC1, CAMK2G, GRIA4, PICK1, HSPA5, EPB41L1, FZR1, DLG1, GRIP1, TRPC1, CXCR2, HOMER1, GRIA2, CACNG2, EPB41L2 (tumor) | GRIA1, SQSTM1, PPP1CA, PRKCA, NEDD4, PRKACA, CAMK2G, GRIA4, PICK1, HSPA5, CANX, ANAPC2, EPB41L1, TRPC1, SDCBP, CXCR2, GRIK2, GRIA2, CACNG2, GRIPAP1, EPB41L2 (normal) |
 |  |
| STAD (tumor) | STAD (normal) |
| GRIA1, PPP1CA, UBC, CASP8, PRKCA, NEDD4, PRKACA, TANC1, CAMK2G, PICK1, HSPA5, CANX, GRIP1, TRPC1, HOMER1, GRIK2, GRIA2, CACNG2, GRID2, GRIPAP1, EPB41L2 (tumor) | GRIA1, PPP1CA, CASP8, PRKCA, NEDD4, PRKACA, TANC1, CAMK2G, GRIA4, PICK1, HSPA5, CANX, ANAPC2, FZR1, GRIP1, TRPC1, GRIK2, GRIA2, CACNG2, GRID2, EPB41L2 (normal) |
 |  |
| THCA (tumor) | THCA (normal) |
| GRIA1, SQSTM1, PPP1CA, NEDD4, PRKACA, TANC1, CAMK2G, GRIA4, PICK1, HSPA5, CANX, EPB41L1, DLG1, GRIP1, TRPC1, CXCR2, HOMER1, GRIA2, GRID2, GRIPAP1, EPB41L2 (tumor) | GRIA1, SQSTM1, PPP1CA, UBC, CASP8, PRKCA, NEDD4, CAMK2G, GRIA4, PICK1, HSPA5, CANX, ANAPC2, EPB41L1, FZR1, TRPC1, CXCR2, GRIK2, CACNG2, GRID2, EPB41L2 (normal) |
 |  |
| Top |
| TissGeneProg for GRIA1 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
 |
| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Top |
| TissGeneClin for GRIA1 |
| TissGeneDrug for GRIA1 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| DB01189 | Desflurane | Antagonist | Small molecule | Approved |
| DB08883 | Perampanel | Antagonist | Small molecule | Approved |
| DB00228 | Enflurane | Antagonist | Small molecule | Approved|Vet_approved |
| DB00753 | Isoflurane | Antagonist | Small molecule | Approved|Vet_approved |
| DB01028 | Methoxyflurane | Antagonist | Small molecule | Approved|Vet_approved |
| DB01236 | Sevoflurane | Antagonist | Small molecule | Approved|Vet_approved |
| Top |
| TissGeneDisease for GRIA1 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0036341 | Schizophrenia | 8 | BeFree,GAD,LHGDN |
| umls:C0236736 | Cocaine-Related Disorders | 5 | CTD_human |
| umls:C0005586 | Bipolar Disorder | 4 | BeFree,GAD |
| umls:C0014544 | Epilepsy | 4 | BeFree,RGD |
| umls:C0013170 | Drug habituation | 3 | BeFree |
| umls:C0017636 | Glioblastoma | 3 | BeFree |
| umls:C0036572 | Seizures | 3 | BeFree,RGD |
| umls:C0038587 | Substance Withdrawal Syndrome | 3 | BeFree,CTD_human |
| umls:C0002736 | Amyotrophic Lateral Sclerosis | 2 | BeFree,LHGDN |
| umls:C0004936 | Mental disorders | 2 | BeFree,GAD |
| umls:C0011570 | Mental Depression | 2 | BeFree |
| umls:C0011581 | Depressive disorder | 2 | BeFree |
| umls:C0017638 | Glioma | 2 | BeFree,LHGDN |
| umls:C0041696 | Unipolar Depression | 2 | BeFree |
| umls:C0149931 | Migraine Disorders | 2 | BeFree,GAD |
| umls:C0424295 | Hyperactive behavior | 2 | CTD_human |
| umls:C1269683 | Major Depressive Disorder | 2 | BeFree |
| umls:C0002395 | Alzheimer's Disease | 1 | LHGDN |
| umls:C0003469 | Anxiety Disorders | 1 | BeFree |
| umls:C0004352 | Autistic Disorder | 1 | CTD_human |
| umls:C0005911 | Body Weight Changes | 1 | GAD |
| umls:C0011124 | Decreased Libido | 1 | BeFree |
| umls:C0013182 | Drug Allergy | 1 | GAD |
| umls:C0014556 | Epilepsy, Temporal Lobe | 1 | LHGDN |
| umls:C0015934 | Fetal Growth Retardation | 1 | RGD |
| umls:C0017650 | Globus Hystericus | 1 | BeFree |
| umls:C0019151 | Hepatic Encephalopathy | 1 | RGD |
| umls:C0019693 | HIV Infections | 1 | BeFree |
| umls:C0020649 | Hypotension | 1 | CTD_human |
| umls:C0023186 | Learning Disorders | 1 | CTD_human |
| umls:C0026552 | Morphine Dependence | 1 | CTD_human |
| umls:C0026838 | Muscle Spasticity | 1 | BeFree |
| umls:C0033953 | Psychosexual Disorders | 1 | CTD_human |
| umls:C0033975 | Psychotic Disorders | 1 | BeFree |
| umls:C0035126 | Reperfusion Injury | 1 | RGD |
| umls:C0036877 | organic sexual dysfunction | 1 | BeFree |
| umls:C0038220 | Status Epilepticus | 1 | RGD |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
| umls:C0043094 | Weight Gain | 1 | GAD |
| umls:C0085298 | Sudden Cardiac Death | 1 | GAD |
| umls:C0152128 | Drug withdrawal syndrome | 1 | BeFree |
| umls:C0159020 | Convulsions in the newborn | 1 | BeFree |
| umls:C0206725 | Subependymal Glioma | 1 | BeFree |
| umls:C0334579 | Anaplastic astrocytoma | 1 | BeFree |
| umls:C0348165 | Central Nervous System Viral Diseases | 1 | RGD |
| umls:C0443306 | Spastic | 1 | BeFree |
| umls:C0525045 | Mood Disorders | 1 | BeFree |
| umls:C0549622 | Sexual Dysfunction | 1 | BeFree |
| umls:C0746408 | mass lesion | 1 | BeFree |
| umls:C1720824 | Sudden Cardiac Arrest | 1 | GWASCAT |
| umls:C1961099 | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | 1 | GAD |
| umls:C2911647 | Weight Gain Adverse Event | 1 | GAD |
| umls:C3539909 | Allergic disposition | 1 | BeFree |
Copyright 2016-Present - The University of Texas Health Science Center at Houston (UTHealth) Web File Viewing | How to Report, Fraud, Waste and Abuse | State of Texas | Statewide Search | Texas Homeland Security | Site Policies |