TissGeneSummary for GRID2 |
Gene summary |
Basic gene information | Gene symbol | GRID2 |
Gene name | glutamate receptor, ionotropic, delta 2 | |
Synonyms | GluD2 | |
Cytomap | UCSC genome browser: 4q22 | |
Type of gene | protein-coding | |
RefGenes | NM_001286838.1, NM_001510.3, | |
Description | gluR delta-2 subunitglutamate receptor delta-2 subunitglutamate receptor ionotropic, delta-2 | |
Modification date | 20141207 | |
dbXrefs | MIM : 602368 | |
HGNC : HGNC | ||
Ensembl : ENSG00000152208 | ||
HPRD : 06781 | ||
Vega : OTTHUMG00000130975 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_GRID2 | |
BioGPS: 2895 | ||
Pathway | NCI Pathway Interaction Database: GRID2 | |
KEGG: GRID2 | ||
REACTOME: GRID2 | ||
Pathway Commons: GRID2 | ||
Context | iHOP: GRID2 | |
ligand binding site mutation search in PubMed: GRID2 | ||
UCL Cancer Institute: GRID2 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of GRID2 | ||
Description by TissGene annotations | Fused withOncogene Fused withTSGene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for GRID2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
STAD | -0.005022958 | 1.585852042 | -1.590875 | 0.000211 | 0.001446765 |
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TissGene-miRNA for GRID2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for GRID2 |
TissGeneSNV for GRID2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.D267N | SKCM | 3 |
p.E487K | SKCM | 3 |
p.G735E | SKCM | 2 |
p.S104F | SKCM | 2 |
p.R224Q | SKCM | 2 |
p.R222L | SARC | 2 |
p.E719K | SKCM | 2 |
p.E272K | SKCM | 2 |
p.G769E | SKCM | 2 |
p.R594X | COAD | 2 |
p.S664F | SKCM | 2 |
p.R345Q | SKCM | 2 |
p.R297Q | SKCM | 2 |
p.R710Q | STAD | 2 |
p.G427R | SKCM | 2 |
p.G520E | SKCM | 2 |
p.P698S | SKCM | 2 |
p.S295R | STAD | 2 |
p.P698L | SKCM | 2 |
p.F254V | SKCM | 1 |
p.S352R | ESCA | 1 |
p.S368F | SKCM | 1 |
p.R304* | BLCA | 1 |
p.L58I | COAD | 1 |
p.R942H | THYM | 1 |
p.K807N | BLCA | 1 |
p.R692S | STAD | 1 |
p.Y648H | SKCM | 1 |
p.P698S | SARC | 1 |
p.R1003Q | BLCA | 1 |
p.D41N | LUAD | 1 |
p.Q364H | LUSC | 1 |
p.R550Q | STAD | 1 |
p.K38Q | OV | 1 |
p.E201K | BRCA | 1 |
p.T853M | UCEC | 1 |
p.D311G | KIRP | 1 |
p.E219* | UCEC | 1 |
p.S1006Y | LUSC | 1 |
p.T925I | LGG | 1 |
p.E218Q | LUAD | 1 |
p.K313N | HNSC | 1 |
p.R439C | STAD | 1 |
p.A164V | SKCM | 1 |
p.R539H | PAAD | 1 |
p.D476N | LUAD | 1 |
p.D901N | SKCM | 1 |
p.E852K | SKCM | 1 |
p.E264K | SKCM | 1 |
p.E201D | SKCM | 1 |
p.D566V | LUAD | 1 |
p.A825T | SKCM | 1 |
p.P362S | UCEC | 1 |
p.R530C | SARC | 1 |
p.S122L | LUSC | 1 |
p.G410C | LUAD | 1 |
p.I900T | LUAD | 1 |
p.H153N | LUAD | 1 |
p.Y486N | LUAD | 1 |
p.D173Y | OV | 1 |
p.S715R | LUAD | 1 |
p.Q894H | LUAD | 1 |
p.K313Q | COAD | 1 |
p.P592L | SKCM | 1 |
p.A23V | COAD | 1 |
p.G546E | LUAD | 1 |
p.S983* | UCEC | 1 |
p.D194N | SKCM | 1 |
p.R539H | STAD | 1 |
p.T930S | KIRC | 1 |
p.D518N | OV | 1 |
p.D41N | SKCM | 1 |
p.P115L | LUAD | 1 |
p.G391E | SKCM | 1 |
p.T630N | LUAD | 1 |
p.E531K | BLCA | 1 |
p.R414* | UCEC | 1 |
p.M708K | SKCM | 1 |
p.R147C | COAD | 1 |
p.V268L | COAD | 1 |
p.L587F | HNSC | 1 |
p.D827N | SKCM | 1 |
p.L578F | SKCM | 1 |
p.G192R | SKCM | 1 |
p.R710W | UCEC | 1 |
p.Y489* | LUAD | 1 |
p.M193I | LUAD | 1 |
p.R530C | SKCM | 1 |
p.I356M | CESC | 1 |
p.R550Q | UCEC | 1 |
p.A641S | THYM | 1 |
p.G680V | COAD | 1 |
p.D887N | SKCM | 1 |
p.T537M | HNSC | 1 |
p.R45C | READ | 1 |
p.M711I | SKCM | 1 |
p.E700Q | BLCA | 1 |
p.R710Q | COAD | 1 |
p.R216K | LIHC | 1 |
p.T992I | ESCA | 1 |
p.R45C | SKCM | 1 |
p.P394S | SKCM | 1 |
p.H257N | LUAD | 1 |
p.R1003P | OV | 1 |
p.Q106E | LUAD | 1 |
p.S718L | SKCM | 1 |
p.P564T | LUAD | 1 |
p.S647T | SKCM | 1 |
p.I356T | SARC | 1 |
p.S277P | LUAD | 1 |
p.L671I | LUSC | 1 |
p.R550Q | SKCM | 1 |
p.T537M | KIRC | 1 |
p.P904L | SKCM | 1 |
p.Q988K | UCEC | 1 |
p.M541I | ESCA | 1 |
p.M438V | STAD | 1 |
p.P312A | BLCA | 1 |
p.R439C | UCEC | 1 |
p.L108F | KIRC | 1 |
p.E487K | UCS | 1 |
p.D889N | SKCM | 1 |
p.C418* | LUAD | 1 |
p.P315Q | SARC | 1 |
p.K554N | HNSC | 1 |
p.T100M | HNSC | 1 |
p.D314Y | PRAD | 1 |
p.T244S | HNSC | 1 |
p.A230V | STAD | 1 |
p.I114T | UCEC | 1 |
p.R539C | UCEC | 1 |
p.R781* | UCEC | 1 |
p.L905V | LUAD | 1 |
p.L671F | KIRP | 1 |
p.R550* | PAAD | 1 |
p.R710W | STAD | 1 |
p.P904A | HNSC | 1 |
p.D869G | BLCA | 1 |
p.F254L | ESCA | 1 |
p.X1008R | THCA | 1 |
p.S599L | SKCM | 1 |
p.V150L | STAD | 1 |
p.H926N | LUAD | 1 |
p.R942S | LUAD | 1 |
p.V9F | ESCA | 1 |
p.E719* | LUAD | 1 |
p.S104Y | LUSC | 1 |
p.P964L | SKCM | 1 |
p.L844I | UCEC | 1 |
p.C836* | SKCM | 1 |
p.D24N | LUAD | 1 |
p.E511K | PAAD | 1 |
p.A686V | THYM | 1 |
p.S189F | SKCM | 1 |
p.R768Q | UCEC | 1 |
p.M693T | STAD | 1 |
p.G192R | LUSC | 1 |
p.E871K | SKCM | 1 |
p.D50N | ESCA | 1 |
p.P911S | SKCM | 1 |
p.V474F | LUSC | 1 |
p.R550X | COAD | 1 |
p.R530C | UCEC | 1 |
p.V442L | KIRC | 1 |
p.R439C | PRAD | 1 |
p.S715N | LGG | 1 |
p.R414Q | BRCA | 1 |
p.R594L | LUSC | 1 |
p.P236S | STAD | 1 |
p.H802Y | KIRP | 1 |
p.I97V | PAAD | 1 |
p.G402E | SKCM | 1 |
p.H397Y | BRCA | 1 |
p.S107F | SKCM | 1 |
p.L409F | SKCM | 1 |
p.G103E | SKCM | 1 |
p.V765G | PAAD | 1 |
p.V490I | COAD | 1 |
p.A571T | UCEC | 1 |
p.G180V | LUAD | 1 |
p.A574V | LUAD | 1 |
p.C83F | LUSC | 1 |
p.V732I | SKCM | 1 |
p.A337D | LIHC | 1 |
p.R710Q | BLCA | 1 |
p.T649M | HNSC | 1 |
p.T214N | LUAD | 1 |
p.T100M | SARC | 1 |
p.T764N | PAAD | 1 |
p.T209N | LUAD | 1 |
p.F4Y | SKCM | 1 |
p.Q500P | LUSC | 1 |
p.L826M | LUAD | 1 |
p.D40N | SKCM | 1 |
p.T537M | PRAD | 1 |
p.D311N | SKCM | 1 |
p.R147G | BLCA | 1 |
p.R280G | SKCM | 1 |
p.P970R | LUAD | 1 |
p.R414X | READ | 1 |
p.R539H | DLBC | 1 |
p.H878Y | LIHC | 1 |
p.D670E | PAAD | 1 |
p.M193V | KIRC | 1 |
p.E487Q | LUSC | 1 |
p.L51H | LUAD | 1 |
p.G30R | STAD | 1 |
p.G440E | SKCM | 1 |
p.K947E | BLCA | 1 |
p.T423K | LUAD | 1 |
p.F4I | SKCM | 1 |
p.S845C | LUSC | 1 |
p.R222C | STAD | 1 |
p.A650T | GBM | 1 |
p.M708I | LUSC | 1 |
p.I90V | LUAD | 1 |
p.R16Q | STAD | 1 |
p.F831I | STAD | 1 |
p.L478F | LUAD | 1 |
p.R367H | SKCM | 1 |
p.P499S | THYM | 1 |
p.L211I | LUAD | 1 |
p.D493N | LUAD | 1 |
p.A686V | UCEC | 1 |
p.P236S | SKCM | 1 |
p.S568F | BRCA | 1 |
p.S830R | LUAD | 1 |
p.R976M | STAD | 1 |
p.G376C | ESCA | 1 |
p.L85H | COAD | 1 |
p.D827E | LUAD | 1 |
p.L482V | BLCA | 1 |
p.F242L | KIRP | 1 |
p.S664F | HNSC | 1 |
p.R714L | LUAD | 1 |
p.S25L | UCEC | 1 |
p.K822N | LUAD | 1 |
p.F44L | PAAD | 1 |
p.E343K | HNSC | 1 |
p.S66L | SKCM | 1 |
p.D702E | LUAD | 1 |
p.S718L | STAD | 1 |
p.V246I | SKCM | 1 |
p.T601M | BRCA | 1 |
p.T953S | LUAD | 1 |
p.R224X | SKCM | 1 |
p.E724Q | LUAD | 1 |
p.F536V | DLBC | 1 |
p.D518H | ESCA | 1 |
p.D753Y | LUAD | 1 |
p.V533M | LUSC | 1 |
p.L605V | HNSC | 1 |
p.R135Q | PAAD | 1 |
p.N882K | SKCM | 1 |
p.E35K | SKCM | 1 |
p.G695* | LUAD | 1 |
p.R121C | THYM | 1 |
p.R300C | LUAD | 1 |
p.Q53H | COAD | 1 |
p.A686V | BRCA | 1 |
p.Q191K | LUAD | 1 |
p.P394L | SKCM | 1 |
p.G462D | ESCA | 1 |
p.S145* | CESC | 1 |
p.H116Q | HNSC | 1 |
p.L381F | LUAD | 1 |
p.E747K | ACC | 1 |
p.G388V | HNSC | 1 |
p.T447S | STAD | 1 |
p.A230V | LGG | 1 |
p.V442I | SKCM | 1 |
p.N426K | GBM | 1 |
p.P148T | HNSC | 1 |
p.Y688C | LIHC | 1 |
p.V150F | UCEC | 1 |
p.E384K | LUSC | 1 |
p.Q88* | SKCM | 1 |
p.I170V | PRAD | 1 |
p.L668P | HNSC | 1 |
p.Q619H | HNSC | 1 |
p.Y625N | SKCM | 1 |
p.T447I | SKCM | 1 |
p.R224* | SKCM | 1 |
p.R539S | HNSC | 1 |
p.E245K | BLCA | 1 |
p.A571V | SKCM | 1 |
p.G279R | SKCM | 1 |
p.I751F | KIRC | 1 |
p.R942H | PRAD | 1 |
p.R439G | LUAD | 1 |
p.D889N | UCEC | 1 |
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TissGeneCNV for GRID2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for GRID2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BF972933 | GRID2-PRDX6 | chr4:94123026 | chr1:173455450 | |
Chimerdb3.0 | ChiTaRs | NA | BI042006 | RANGAP1-GRID2 | chr22:41642676 | chr4:94557598 | |
Chimerdb3.0 | FusionScan | ESCA | TCGA-LN-A4A1-01A | SMARCAD1-GRID2 | In-Frame | chr4:95174158 | chr4:94128554 |
Chimerdb3.0 | FusionScan | ESCA | TCGA-LN-A4A1-01A | SMARCAD1-GRID2 | In-Frame | chr4:95174822 | chr4:94128554 |
Chimerdb3.0 | TopHat-Fusion | LUAD | TCGA-69-7979-01A | PSMD1-GRID2 | Out-of-Frame | chr2:231951894 | chr4:93471851 |
Chimerdb3.0 | TopHat-Fusion | LAML | TCGA-AB-2819-03A | GRID2-GNB2L1 | Out-of-Frame | chr4:93743194 | chr5:180664039 |
Chimerdb3.0 | TopHat-Fusion | LAML | TCGA-AB-2832-03A | GRID2-GNB2L1 | Out-of-Frame | chr4:93743194 | chr5:180664039 |
Chimerdb3.0 | TopHat-Fusion | LAML | TCGA-AB-2844-03A | GRID2-GNB2L1 | Out-of-Frame | chr4:93743194 | chr5:180664039 |
Chimerdb3.0 | TopHat-Fusion | LAML | TCGA-AB-2845-03B | GRID2-GNB2L1 | Out-of-Frame | chr4:93743194 | chr5:180664039 |
Chimerdb3.0 | TopHat-Fusion | LAML | TCGA-AB-2847-03A | GRID2-GNB2L1 | Out-of-Frame | chr4:93743194 | chr5:180664039 |
Chimerdb3.0 | TopHat-Fusion | LAML | TCGA-AB-2862-03A | GRID2-GNB2L1 | Out-of-Frame | chr4:93743194 | chr5:180664039 |
Chimerdb3.0 | TopHat-Fusion | LAML | TCGA-AB-2881-03A | GRID2-GNB2L1 | Out-of-Frame | chr4:93743194 | chr5:180664039 |
Chimerdb3.0 | TopHat-Fusion | LAML | TCGA-AB-2887-03A | GRID2-GNB2L1 | Out-of-Frame | chr4:93743194 | chr5:180664039 |
Chimerdb3.0 | TopHat-Fusion | LAML | TCGA-AB-2919-03A | GRID2-GNB2L1 | Out-of-Frame | chr4:93743194 | chr5:180664039 |
Chimerdb3.0 | TopHat-Fusion | LAML | TCGA-AB-2928-03A | GRID2-GNB2L1 | Out-of-Frame | chr4:93743194 | chr5:180664039 |
Chimerdb3.0 | TopHat-Fusion | LAML | TCGA-AB-2949-03B | GRID2-GNB2L1 | Out-of-Frame | chr4:93743194 | chr5:180664039 |
Chimerdb3.0 | TopHat-Fusion | LAML | TCGA-AB-2964-03A | GRID2-GNB2L1 | Out-of-Frame | chr4:93743194 | chr5:180664039 |
Chimerdb3.0 | TopHat-Fusion | LAML | TCGA-AB-2969-03A | GRID2-GNB2L1 | Out-of-Frame | chr4:93743194 | chr5:180664039 |
Chimerdb3.0 | TopHat-Fusion | LAML | TCGA-AB-2986-03A | GRID2-GNB2L1 | Out-of-Frame | chr4:93743194 | chr5:180664039 |
Chimerdb3.0 | TopHat-Fusion | LAML | TCGA-AB-2999-03B | GRID2-GNB2L1 | Out-of-Frame | chr4:93743194 | chr5:180664039 |
Chimerdb3.0 | TopHat-Fusion | LAML | TCGA-AB-3000-03A | GRID2-GNB2L1 | Out-of-Frame | chr4:93743194 | chr5:180664039 |
Chimerdb3.0 | TopHat-Fusion | LAML | TCGA-AB-3007-03A | GRID2-GNB2L1 | Out-of-Frame | chr4:93743194 | chr5:180664039 |
Chimerdb3.0 | TopHat-Fusion | LAML | TCGA-AB-3012-03A | GRID2-GNB2L1 | Out-of-Frame | chr4:93743194 | chr5:180664039 |
Chimerdb3.0 | TopHat-Fusion | LAML | TCGA-AB-2806-03A | GRID2-GNB2L1 | Out-of-Frame | chr4:93743196 | chr5:180664041 |
Chimerdb3.0 | TopHat-Fusion | LAML | TCGA-AB-2924-03A | GRID2-GNB2L1 | Out-of-Frame | chr4:93743196 | chr5:180664041 |
TCGAfusionPortal | PRADA | BRCA | TCGA-AR-A2LR-01A | GNPDA2-GRID2 | 5UTR-CDS | Chr4:44728491 | Chr4:94316758 |
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TissGeneNet for GRID2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for GRID2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for GRID2 |
TissGeneDrug for GRID2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for GRID2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0007758 | Cerebellar Ataxia | 4 | BeFree |
umls:C0004134 | Ataxia | 1 | BeFree |
umls:C0017638 | Glioma | 1 | BeFree |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
umls:C0393525 | Progressive cerebellar ataxia | 1 | BeFree |
umls:C0520966 | Abnormal coordination | 1 | BeFree |
umls:C0740279 | Cerebellar atrophy | 1 | BeFree |
umls:C0852975 | Congenital cerebellar ataxia | 1 | BeFree |
umls:C0854723 | Retinal Dystrophies | 1 | BeFree |
umls:C4015505 | SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 18 | 1 | MGD,ORPHANET,UNIPROT |