TissGeneSummary for SLC6A16 |
Gene summary |
Basic gene information | Gene symbol | SLC6A16 |
Gene name | solute carrier family 6, member 16 | |
Synonyms | NT5|NTT5 | |
Cytomap | UCSC genome browser: 19q13.33 | |
Type of gene | protein-coding | |
RefGenes | NM_014037.2, | |
Description | orphan sodium- and chloride-dependent neurotransmitter transporter NTT5solute carrier family 6 (neurotransmitter transporter), member 16 | |
Modification date | 20141207 | |
dbXrefs | MIM : 607972 | |
HGNC : HGNC | ||
Ensembl : ENSG00000063127 | ||
Vega : OTTHUMG00000183179 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_SLC6A16 | |
BioGPS: 28968 | ||
Pathway | NCI Pathway Interaction Database: SLC6A16 | |
KEGG: SLC6A16 | ||
REACTOME: SLC6A16 | ||
Pathway Commons: SLC6A16 | ||
Context | iHOP: SLC6A16 | |
ligand binding site mutation search in PubMed: SLC6A16 | ||
UCL Cancer Institute: SLC6A16 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of SLC6A16 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for SLC6A16 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
THCA | -2.083141683 | 0.267288825 | -2.350430508 | 1.79E-20 | 7.77E-19 |
LIHC | 0.710411774 | 2.241965774 | -1.531554 | 7.72E-09 | 6.89E-08 |
KIRC | -0.854919226 | 1.26666133 | -2.121580556 | 5.44E-15 | 2.73E-14 |
LUSC | -1.180878539 | 0.649523422 | -1.830401961 | 5.54E-13 | 2.64E-12 |
COAD | -3.484332687 | -1.606148072 | -1.878184615 | 2.54E-09 | 2.58E-08 |
LUAD | -1.184726984 | 0.589373016 | -1.7741 | 1.14E-15 | 1.24E-14 |
BRCA | -1.690920541 | 0.203775073 | -1.894695614 | 8.34E-29 | 1.03E-27 |
ESCA | -1.736276044 | 0.179814865 | -1.916090909 | 0.00308 | 0.029525517 |
BLCA | -2.173904752 | -0.107946857 | -2.065957895 | 6.28E-05 | 0.000771642 |
STAD | -1.761128601 | -0.136962976 | -1.624165625 | 2.94E-05 | 0.000276655 |
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TissGene-miRNA for SLC6A16 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for SLC6A16 |
TissGeneSNV for SLC6A16 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.S356F | SKCM | 1 |
p.A428V | READ | 1 |
p.P657S | SKCM | 1 |
p.P687T | KIRP | 1 |
p.E222D | BLCA | 1 |
p.L126I | READ | 1 |
p.V387A | UCEC | 1 |
p.F553Y | SKCM | 1 |
p.A400V | ACC | 1 |
p.E655* | LGG | 1 |
p.Y436* | LUSC | 1 |
p.G138S | READ | 1 |
p.S362F | SKCM | 1 |
p.P654T | ESCA | 1 |
p.G171V | STAD | 1 |
p.E316K | HNSC | 1 |
p.E4Q | LUAD | 1 |
p.G422V | LUAD | 1 |
p.M191V | UCEC | 1 |
p.G262E | STAD | 1 |
p.E96Q | BLCA | 1 |
p.W643* | LGG | 1 |
p.I304S | LUAD | 1 |
p.P365T | PAAD | 1 |
p.S243Y | ESCA | 1 |
p.C277G | SARC | 1 |
p.S41Y | STAD | 1 |
p.F528L | UCEC | 1 |
p.T599M | STAD | 1 |
p.L721I | UCEC | 1 |
p.W614C | LUSC | 1 |
p.A596T | LIHC | 1 |
p.P493S | SKCM | 1 |
p.M228L | HNSC | 1 |
p.R55W | LUAD | 1 |
p.V298L | LUSC | 1 |
p.R128H | SKCM | 1 |
p.G197C | LUAD | 1 |
p.P687S | BLCA | 1 |
p.T31M | PRAD | 1 |
p.P431L | STAD | 1 |
p.S736F | SKCM | 1 |
p.S230P | LIHC | 1 |
p.L347M | GBM | 1 |
p.V579I | LUAD | 1 |
p.S124Y | COAD | 1 |
p.P104L | BRCA | 1 |
p.L156V | BLCA | 1 |
p.L666P | STAD | 1 |
p.E409D | STAD | 1 |
p.V327A | COAD | 1 |
p.G693R | COAD | 1 |
p.L491R | SKCM | 1 |
p.R103S | LUAD | 1 |
p.E413D | UCEC | 1 |
p.Q345K | PRAD | 1 |
p.E718K | SKCM | 1 |
p.L458F | SKCM | 1 |
p.C125F | HNSC | 1 |
p.P711S | PRAD | 1 |
p.A318V | OV | 1 |
p.L538F | UCEC | 1 |
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TissGeneCNV for SLC6A16 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for SLC6A16 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for SLC6A16 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for SLC6A16 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for SLC6A16 |
TissGeneDrug for SLC6A16 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for SLC6A16 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |