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| TissGeneSummary for GRIN2A |
 Gene summary |
| Basic gene information | Gene symbol | GRIN2A |
| Gene name | glutamate receptor, ionotropic, N-methyl D-aspartate 2A | |
| Synonyms | EPND|FESD|GluN2A|LKS|NMDAR2A|NR2A | |
| Cytomap | UCSC genome browser: 16p13.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_000833.4, NM_001134407.2,NM_001134408.2, | |
| Description | N-methyl D-aspartate receptor subtype 2AN-methyl-D-aspartate receptor channel, subunit epsilon-1N-methyl-D-aspartate receptor subunit 2Aglutamate receptor ionotropic, NMDA 2A | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 138253 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000183454 | ||
| HPRD : 00698 | ||
| Vega : OTTHUMG00000129721 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_GRIN2A | |
| BioGPS: 2903 | ||
| Pathway | NCI Pathway Interaction Database: GRIN2A | |
| KEGG: GRIN2A | ||
| REACTOME: GRIN2A | ||
| Pathway Commons: GRIN2A | ||
| Context | iHOP: GRIN2A | |
| ligand binding site mutation search in PubMed: GRIN2A | ||
| UCL Cancer Institute: GRIN2A | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,TiGER | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Brain | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGG | |
| Reference showing the relevant tissue of GRIN2A | ||
| Description by TissGene annotations | Cancer gene Fused withTSGene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0045471 | response to ethanol | 18445116 | GO:0045471 | response to ethanol | 18445116 |
| Top |
| TissGeneExp for GRIN2A |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRP | -0.611847619 | 2.186996131 | -2.79884375 | 7.82E-09 | 6.09E-08 |
| BRCA | 0.683782425 | 2.119683302 | -1.435900877 | 1.09E-12 | 4.87E-12 |
| COAD | -2.066158196 | 0.931714881 | -2.997873077 | 1.36E-13 | 4.45E-12 |
| STAD | 1.238380506 | 3.807883631 | -2.569503125 | 8.09E-07 | 1.37E-05 |
| KICH | 0.177762881 | 1.523222881 | -1.34546 | 0.0198 | 0.033491328 |
| LIHC | -0.688159119 | -1.968451119 | 1.280292 | 0.0057 | 0.012931256 |
| ESCA | -0.00939421 | 3.668923972 | -3.678318182 | 0.000793 | 0.012508028 |
| PRAD | -0.123963965 | 0.989697573 | -1.113661538 | 3.16E-05 | 0.000151965 |
| BLCA | -1.989474593 | 0.933656986 | -2.923131579 | 5.76E-06 | 0.000125591 |
| Top |
| TissGene-miRNA for GRIN2A |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| LUAD | hsa-miR-27b-3p | MIMAT0000419 | 0.034 | -0.28 | 60 |
| UVM | hsa-miR-30b-5p | MIMAT0000420 | 0.012 | -0.28 | 80 |
| ACC | hsa-miR-373-3p | MIMAT0000726 | 0.0099 | -0.29 | 78 |
| ACC | hsa-miR-373-3p | MIMAT0000726 | 0.0099 | -0.29 | 78 |
| Top |
| TissGeneMut for GRIN2A |
| TissGeneSNV for GRIN2A |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
 |
| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.G1322E | SKCM | 7 |
| p.E962K | SKCM | 3 |
| p.R1067W | SKCM | 3 |
| p.D1153N | SKCM | 3 |
| p.G688E | SKCM | 3 |
| p.G20D | SKCM | 2 |
| p.E1175K | SKCM | 2 |
| p.R1022C | LUAD | 2 |
| p.R1067Q | SKCM | 2 |
| p.D105N | SKCM | 2 |
| p.R1376C | BLCA | 2 |
| p.D1315N | SKCM | 2 |
| p.S1447F | SKCM | 2 |
| p.P699S | SKCM | 2 |
| p.E806K | SKCM | 2 |
| p.D1024N | SKCM | 2 |
| p.D344N | SKCM | 2 |
| p.E657K | SKCM | 2 |
| p.E1156K | SKCM | 2 |
| p.P1132L | SKCM | 2 |
| p.E743K | SKCM | 2 |
| p.P273S | SKCM | 2 |
| p.E1125K | SKCM | 2 |
| p.E1073K | SKCM | 2 |
| p.H1129Y | SKCM | 2 |
| p.D731N | SKCM | 1 |
| p.R370Q | SKCM | 1 |
| p.R1241Q | LUSC | 1 |
| p.D78N | UCS | 1 |
| p.M817I | STAD | 1 |
| p.E1175X | CHOL | 1 |
| p.G101R | SKCM | 1 |
| p.A968P | LUAD | 1 |
| p.N946S | SKCM | 1 |
| p.Q1278K | KIRC | 1 |
| p.A302T | COAD | 1 |
| p.P401Q | LUAD | 1 |
| p.G1127C | BLCA | 1 |
| p.R970W | UCEC | 1 |
| p.D234N | SKCM | 1 |
| p.H381Y | SKCM | 1 |
| p.A643S | HNSC | 1 |
| p.D1195E | HNSC | 1 |
| p.V568F | LUAD | 1 |
| p.N490Y | LGG | 1 |
| p.M133I | SKCM | 1 |
| p.G873E | HNSC | 1 |
| p.A638T | COAD | 1 |
| p.A921T | LGG | 1 |
| p.S1403L | SKCM | 1 |
| p.V633A | BLCA | 1 |
| p.S1045F | SKCM | 1 |
| p.E743Q | HNSC | 1 |
| p.T1441N | LUAD | 1 |
| p.S1004Y | LUAD | 1 |
| p.Y700N | CESC | 1 |
| p.R1276H | DLBC | 1 |
| p.V526A | BRCA | 1 |
| p.Q163R | LUAD | 1 |
| p.C231S | LUAD | 1 |
| p.G610D | THYM | 1 |
| p.A33T | PRAD | 1 |
| p.D1270H | SKCM | 1 |
| p.E1175* | CHOL | 1 |
| p.R1376C | STAD | 1 |
| p.F849L | BLCA | 1 |
| p.D1162N | SKCM | 1 |
| p.V617L | THCA | 1 |
| p.Y1105* | LUAD | 1 |
| p.S225F | SKCM | 1 |
| p.S117F | LUAD | 1 |
| p.D1251N | PAAD | 1 |
| p.L1357F | SKCM | 1 |
| p.D252N | SKCM | 1 |
| p.Q710* | SKCM | 1 |
| p.A1006V | PRAD | 1 |
| p.N264S | SKCM | 1 |
| p.P1010R | LUAD | 1 |
| p.R681X | SKCM | 1 |
| p.F473I | PRAD | 1 |
| p.Q59K | HNSC | 1 |
| p.H1213Q | SKCM | 1 |
| p.R1402W | SKCM | 1 |
| p.E1426X | THYM | 1 |
| p.K453N | READ | 1 |
| p.R692T | BLCA | 1 |
| p.R1011L | SKCM | 1 |
| p.A61T | UCEC | 1 |
| p.H332R | UCEC | 1 |
| p.G873V | LIHC | 1 |
| p.E997K | SKCM | 1 |
| p.V409I | GBM | 1 |
| p.H872Q | UCEC | 1 |
| p.S991P | SKCM | 1 |
| p.P314S | SKCM | 1 |
| p.E838K | SKCM | 1 |
| p.T1164K | LUAD | 1 |
| p.G483V | UCS | 1 |
| p.W372* | SKCM | 1 |
| p.V1090A | COAD | 1 |
| p.R52Q | SKCM | 1 |
| p.R1022C | LIHC | 1 |
| p.A1395V | HNSC | 1 |
| p.V1444I | SKCM | 1 |
| p.S1330N | PAAD | 1 |
| p.M653I | SKCM | 1 |
| p.D1364N | SKCM | 1 |
| p.A33T | COAD | 1 |
| p.R1159H | STAD | 1 |
| p.R846C | STAD | 1 |
| p.M564I | KIRC | 1 |
| p.L72Q | LUAD | 1 |
| p.A1409V | HNSC | 1 |
| p.K881T | BLCA | 1 |
| p.E1123X | PRAD | 1 |
| p.M915I | SKCM | 1 |
| p.R291G | LUSC | 1 |
| p.I222M | BRCA | 1 |
| p.P435S | ESCA | 1 |
| p.G1226D | STAD | 1 |
| p.P770L | HNSC | 1 |
| p.G1326D | SKCM | 1 |
| p.T84M | STAD | 1 |
| p.R695Q | DLBC | 1 |
| p.R681X | READ | 1 |
| p.T888M | STAD | 1 |
| p.T1104N | SKCM | 1 |
| p.T474A | READ | 1 |
| p.R1022H | READ | 1 |
| p.R1316K | SKCM | 1 |
| p.W343* | BLCA | 1 |
| p.G250R | PRAD | 1 |
| p.S905F | SKCM | 1 |
| p.R586I | COAD | 1 |
| p.A643S | LUAD | 1 |
| p.N587Y | SKCM | 1 |
| p.S890Y | SKCM | 1 |
| p.H128D | KIRP | 1 |
| p.M74I | SKCM | 1 |
| p.R1452C | GBM | 1 |
| p.A26V | LUAD | 1 |
| p.P1307L | SKCM | 1 |
| p.R19C | LUAD | 1 |
| p.K707T | STAD | 1 |
| p.R1276C | SKCM | 1 |
| p.N1244S | SKCM | 1 |
| p.V419M | HNSC | 1 |
| p.L608P | SKCM | 1 |
| p.T1069M | LUAD | 1 |
| p.L51V | HNSC | 1 |
| p.D398N | SKCM | 1 |
| p.P1148S | SKCM | 1 |
| p.R1206* | OV | 1 |
| p.F637L | SKCM | 1 |
| p.D973Y | PRAD | 1 |
| p.L1313F | STAD | 1 |
| p.E50K | READ | 1 |
| p.V187I | STAD | 1 |
| p.K346T | UCEC | 1 |
| p.T759N | LUSC | 1 |
| p.D114N | SKCM | 1 |
| p.L565M | UCEC | 1 |
| p.L411M | STAD | 1 |
| p.D1350N | SKCM | 1 |
| p.E235K | HNSC | 1 |
| p.S511L | SKCM | 1 |
| p.P581L | SKCM | 1 |
| p.P622S | SKCM | 1 |
| p.G1161R | SKCM | 1 |
| p.P140L | GBM | 1 |
| p.V1000M | LUAD | 1 |
| p.G1338R | SKCM | 1 |
| p.E877K | THCA | 1 |
| p.G583R | SKCM | 1 |
| p.D88N | READ | 1 |
| p.R504W | GBM | 1 |
| p.C87F | LUAD | 1 |
| p.K721Q | SKCM | 1 |
| p.D78N | SKCM | 1 |
| p.V417I | KIRC | 1 |
| p.D294N | SKCM | 1 |
| p.Q218K | LUSC | 1 |
| p.G1243V | BLCA | 1 |
| p.S1308P | STAD | 1 |
| p.E400K | SKCM | 1 |
| p.S209F | SKCM | 1 |
| p.T1069M | GBM | 1 |
| p.V440I | HNSC | 1 |
| p.R1318Q | GBM | 1 |
| p.S1393F | SKCM | 1 |
| p.G712E | SKCM | 1 |
| p.P1142T | LUAD | 1 |
| p.I1286S | UCEC | 1 |
| p.G498D | SKCM | 1 |
| p.D347Y | UCEC | 1 |
| p.R1022H | UCEC | 1 |
| p.E315D | STAD | 1 |
| p.R1114T | BLCA | 1 |
| p.M450I | HNSC | 1 |
| p.D855H | LUSC | 1 |
| p.G56V | LIHC | 1 |
| p.L248F | SKCM | 1 |
| p.T995M | UCEC | 1 |
| p.P401L | GBM | 1 |
| p.L794M | PAAD | 1 |
| p.W1014L | LUAD | 1 |
| p.E962K | COAD | 1 |
| p.T8N | KIRP | 1 |
| p.F524V | STAD | 1 |
| p.E656V | LUAD | 1 |
| p.M910I | SKCM | 1 |
| p.S468F | SKCM | 1 |
| p.P435S | LUAD | 1 |
| p.E182K | SKCM | 1 |
| p.S580C | LUAD | 1 |
| p.G596E | SKCM | 1 |
| p.V529L | BRCA | 1 |
| p.D207N | SKCM | 1 |
| p.S1025L | SKCM | 1 |
| p.V109I | PRAD | 1 |
| p.S1425W | HNSC | 1 |
| p.P1199L | SKCM | 1 |
| p.A727T | LUSC | 1 |
| p.E1123* | PRAD | 1 |
| p.R1159C | UCEC | 1 |
| p.P1150H | LUAD | 1 |
| p.L246I | LUAD | 1 |
| p.G322W | BRCA | 1 |
| p.D937N | SKCM | 1 |
| p.P1113L | LUAD | 1 |
| p.R1288H | COAD | 1 |
| p.A388T | UCEC | 1 |
| p.S556F | SKCM | 1 |
| p.F524L | BRCA | 1 |
| p.E289K | SKCM | 1 |
| p.K1189N | LUAD | 1 |
| p.P1132S | SKCM | 1 |
| p.P401L | SKCM | 1 |
| p.P1074S | UCEC | 1 |
| p.R1022L | PRAD | 1 |
| p.W609R | LUAD | 1 |
| p.S1110L | LGG | 1 |
| p.M1457I | SKCM | 1 |
| p.S1410L | SKCM | 1 |
| p.R1169W | THYM | 1 |
| p.T1064M | GBM | 1 |
| p.E1461K | SKCM | 1 |
| p.T1262S | PRAD | 1 |
| p.Q1289H | SKCM | 1 |
| p.S1425L | UCEC | 1 |
| p.S1027F | SKCM | 1 |
| p.Q1394L | LUAD | 1 |
| p.M932I | SKCM | 1 |
| p.L1052I | LUAD | 1 |
| p.R504L | LIHC | 1 |
| p.S395T | LUAD | 1 |
| p.E1125* | LUAD | 1 |
| p.L796H | GBM | 1 |
| p.R1067W | LUSC | 1 |
| p.C1236* | UCEC | 1 |
| p.V617G | LUAD | 1 |
| p.Y1411D | SKCM | 1 |
| p.W372R | COAD | 1 |
| p.D103N | SKCM | 1 |
| p.R1169Q | UCEC | 1 |
| p.P31S | SKCM | 1 |
| p.M705I | BLCA | 1 |
| p.P1392L | SKCM | 1 |
| p.N491K | LUAD | 1 |
| p.R1067W | BRCA | 1 |
| p.Q811L | LUSC | 1 |
| p.G602E | SKCM | 1 |
| p.S1390L | SKCM | 1 |
| p.R1009K | SKCM | 1 |
| p.D139N | SKCM | 1 |
| p.R1452H | COAD | 1 |
| p.R1288C | COAD | 1 |
| p.E953Q | SKCM | 1 |
| p.L464P | STAD | 1 |
| p.R1114T | LUAD | 1 |
| p.P1442S | SKCM | 1 |
| p.A414T | LUAD | 1 |
| p.A643G | LUAD | 1 |
| p.K1107E | CESC | 1 |
| p.W843X | SKCM | 1 |
| p.S1425L | SKCM | 1 |
| p.D776N | UCEC | 1 |
| p.I605V | COAD | 1 |
| p.G532E | OV | 1 |
| p.R1159C | LUAD | 1 |
| p.N1294K | LUSC | 1 |
| p.D855N | UCEC | 1 |
| p.D105E | BRCA | 1 |
| p.E962K | LUSC | 1 |
| p.W843* | SKCM | 1 |
| p.Q106* | SKCM | 1 |
| p.P1095H | BRCA | 1 |
| p.G297V | LUSC | 1 |
| p.A638T | UCEC | 1 |
| p.K488* | SKCM | 1 |
| p.A1039E | HNSC | 1 |
| p.G723W | LUAD | 1 |
| p.P273L | SKCM | 1 |
| p.V1145M | BLCA | 1 |
| p.L1343I | UCEC | 1 |
| p.R181M | KIRP | 1 |
| p.M331I | LUAD | 1 |
| p.L512F | LUAD | 1 |
| p.E373K | SKCM | 1 |
| p.K309N | PRAD | 1 |
| p.A643T | LUAD | 1 |
| p.Q503P | LGG | 1 |
| p.L1391V | COAD | 1 |
| p.R1241Q | COAD | 1 |
| p.R1309Q | CESC | 1 |
| p.S677F | SKCM | 1 |
| p.L477F | SKCM | 1 |
| p.E58K | COAD | 1 |
| p.W634R | SKCM | 1 |
| p.S511L | READ | 1 |
| p.V46M | DLBC | 1 |
| p.R1376S | LUAD | 1 |
| p.D776Y | COAD | 1 |
| p.A1037T | COAD | 1 |
| p.Q163K | LUAD | 1 |
| p.V419M | STAD | 1 |
| p.G624A | HNSC | 1 |
| p.G20C | LUAD | 1 |
| p.R1353K | SKCM | 1 |
| p.E1040D | PRAD | 1 |
| p.G939V | COAD | 1 |
| p.K309T | LUAD | 1 |
| p.S1425L | CESC | 1 |
| p.R1452H | LUAD | 1 |
| p.S1020Y | BLCA | 1 |
| p.A1037T | ESCA | 1 |
| p.V70L | LUAD | 1 |
| p.D462N | SKCM | 1 |
| p.P79S | SKCM | 1 |
| p.V109I | SARC | 1 |
| p.K1005N | PAAD | 1 |
| p.A37V | PAAD | 1 |
| p.R1042K | SKCM | 1 |
| p.R856W | PAAD | 1 |
| p.R1022C | UCEC | 1 |
| p.F841L | LIHC | 1 |
| p.I442M | HNSC | 1 |
| p.K488X | SKCM | 1 |
| p.G591R | SKCM | 1 |
| p.S666G | UCEC | 1 |
| p.D1237N | SKCM | 1 |
| p.E448K | HNSC | 1 |
| p.L307V | BLCA | 1 |
| p.T1408M | LGG | 1 |
| p.V506F | LUSC | 1 |
| p.K484M | SKCM | 1 |
| p.Q971R | KIRP | 1 |
| p.R681* | SKCM | 1 |
| p.D933N | SKCM | 1 |
| p.F439I | SKCM | 1 |
| p.Q671K | SARC | 1 |
| p.N709I | SKCM | 1 |
| p.A1261V | ESCA | 1 |
| p.L1052F | SKCM | 1 |
| p.R1022C | HNSC | 1 |
| p.H1278Y | SKCM | 1 |
| p.E1175K | BRCA | 1 |
| p.T850M | STAD | 1 |
| p.R1402W | READ | 1 |
| p.R1206* | UCEC | 1 |
| p.E427K | SKCM | 1 |
| p.N68H | STAD | 1 |
| p.Y943C | STAD | 1 |
| p.I461F | LUSC | 1 |
| p.S43N | UCEC | 1 |
| p.R1306M | HNSC | 1 |
| p.S616F | SKCM | 1 |
| p.Y1439* | LUSC | 1 |
| p.P883S | SKCM | 1 |
| p.V430A | LUAD | 1 |
| p.E1055K | SKCM | 1 |
| p.A1276V | UCEC | 1 |
| p.T1212K | LUSC | 1 |
| p.R586K | SKCM | 1 |
| p.P1171S | SKCM | 1 |
| p.N380D | UCEC | 1 |
| p.K1083T | SKCM | 1 |
| p.N992T | OV | 1 |
| p.P1279S | SKCM | 1 |
| p.K1078T | ESCA | 1 |
| p.R695W | SKCM | 1 |
| p.W606* | BRCA | 1 |
| p.H1200Q | LUAD | 1 |
| p.D78N | READ | 1 |
| p.R846H | UCEC | 1 |
| p.E371D | UCEC | 1 |
| p.M560I | SKCM | 1 |
| p.D1297N | LGG | 1 |
| p.L735M | SKCM | 1 |
| p.D916N | SKCM | 1 |
| p.M1221I | LUAD | 1 |
| p.R846S | LUSC | 1 |
| p.L845V | STAD | 1 |
| p.R1288H | SKCM | 1 |
| p.K394N | UVM | 1 |
| p.R1288H | GBM | 1 |
| p.A733T | LIHC | 1 |
| Top |
| TissGeneCNV for GRIN2A |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| Top |
| TissGeneFusions for GRIN2A |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BP251842 | GRIN2A-GRIN2A | chr16:9857658 | chr16:10032166 | |
| TCGAfusionPortal | PRADA | BLCA | TCGA-DK-A3IN-01A | CABIN1-GRIN2A | Out-of-frame | Chr22:24515665 | Chr16:9984957 |
| TCGAfusionPortal | PRADA | BRCA | TCGA-BH-A5J0-01A | MOBKL1B-GRIN2A | Out-of-frame | Chr2:74405788 | Chr16:9928087 |
| TCGAfusionPortal | PRADA | LGG | TCGA-CS-5397-01A | SHB-GRIN2A | Out-of-frame | Chr9:37955880 | Chr16:9943818 |
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| TissGeneNet for GRIN2A |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| GRIN2A, SRC, DLG2, DLG4, GRIN1, FYN, PTK2B, DLGAP1, IL16, DLG1, PTPN4, DLG3, GRIN3B (tumor) | GRIN2A, SRC, DLG2, DLG4, GRIN1, FYN, PTK2B, DLGAP1, IL16, DLG1, PTPN4, DLG3, GRIN3B (normal) |
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| COAD (tumor) | COAD (normal) |
| GRIN2A, SRC, DLG2, DLG4, GRIN1, FYN, PTK2B, DLGAP1, IL16, DLG1, PTPN4, DLG3, GRIN3B (tumor) | GRIN2A, SRC, DLG2, DLG4, GRIN1, FYN, PTK2B, DLGAP1, IL16, DLG1, PTPN4, DLG3, GRIN3B (normal) |
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| HNSC (tumor) | HNSC (normal) |
| GRIN2A, SRC, DLG2, DLG4, GRIN1, FYN, PTK2B, DLGAP1, IL16, DLG1, PTPN4, DLG3, GRIN3B (tumor) | GRIN2A, SRC, DLG2, DLG4, GRIN1, FYN, PTK2B, DLGAP1, IL16, DLG1, PTPN4, DLG3, GRIN3B (normal) |
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| KICH (tumor) | KICH (normal) |
| GRIN2A, SRC, DLG2, DLG4, GRIN1, FYN, PTK2B, DLGAP1, IL16, DLG1, PTPN4, DLG3, GRIN3B (tumor) | GRIN2A, SRC, DLG2, DLG4, GRIN1, FYN, PTK2B, DLGAP1, IL16, DLG1, PTPN4, DLG3, GRIN3B (normal) |
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| KIRC (tumor) | KIRC (normal) |
| GRIN2A, SRC, DLG2, DLG4, GRIN1, FYN, PTK2B, DLGAP1, IL16, DLG1, PTPN4, DLG3, GRIN3B (tumor) | GRIN2A, SRC, DLG2, DLG4, GRIN1, FYN, PTK2B, DLGAP1, IL16, DLG1, PTPN4, DLG3, GRIN3B (normal) |
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| KIRP (tumor) | KIRP (normal) |
| GRIN2A, SRC, DLG2, DLG4, GRIN1, FYN, PTK2B, DLGAP1, IL16, DLG1, PTPN4, DLG3, GRIN3B (tumor) | GRIN2A, SRC, DLG2, DLG4, GRIN1, FYN, PTK2B, DLGAP1, IL16, DLG1, PTPN4, DLG3, GRIN3B (normal) |
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| LIHC (tumor) | LIHC (normal) |
| GRIN2A, SRC, DLG2, DLG4, GRIN1, FYN, PTK2B, DLGAP1, IL16, DLG1, PTPN4, DLG3, GRIN3B (tumor) | GRIN2A, SRC, DLG2, DLG4, GRIN1, FYN, PTK2B, DLGAP1, IL16, DLG1, PTPN4, DLG3, GRIN3B (normal) |
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| LUAD (tumor) | LUAD (normal) |
| GRIN2A, SRC, DLG2, DLG4, GRIN1, FYN, PTK2B, DLGAP1, IL16, DLG1, PTPN4, DLG3, GRIN3B (tumor) | GRIN2A, SRC, DLG2, DLG4, GRIN1, FYN, PTK2B, DLGAP1, IL16, DLG1, PTPN4, DLG3, GRIN3B (normal) |
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| LUSC (tumor) | LUSC (normal) |
| GRIN2A, SRC, DLG2, DLG4, GRIN1, FYN, PTK2B, DLGAP1, IL16, DLG1, PTPN4, DLG3, GRIN3B (tumor) | GRIN2A, SRC, DLG2, DLG4, GRIN1, FYN, PTK2B, DLGAP1, IL16, DLG1, PTPN4, DLG3, GRIN3B (normal) |
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| PRAD (tumor) | PRAD (normal) |
| GRIN2A, SRC, DLG2, DLG4, GRIN1, FYN, PTK2B, DLGAP1, IL16, DLG1, PTPN4, DLG3, GRIN3B (tumor) | GRIN2A, SRC, DLG2, DLG4, GRIN1, FYN, PTK2B, DLGAP1, IL16, DLG1, PTPN4, DLG3, GRIN3B (normal) |
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| STAD (tumor) | STAD (normal) |
| GRIN2A, SRC, DLG2, DLG4, GRIN1, FYN, PTK2B, DLGAP1, IL16, DLG1, PTPN4, DLG3, GRIN3B (tumor) | GRIN2A, SRC, DLG2, DLG4, GRIN1, FYN, PTK2B, DLGAP1, IL16, DLG1, PTPN4, DLG3, GRIN3B (normal) |
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| THCA (tumor) | THCA (normal) |
| GRIN2A, SRC, DLG2, DLG4, GRIN1, FYN, PTK2B, DLGAP1, IL16, DLG1, PTPN4, DLG3, GRIN3B (tumor) | GRIN2A, SRC, DLG2, DLG4, GRIN1, FYN, PTK2B, DLGAP1, IL16, DLG1, PTPN4, DLG3, GRIN3B (normal) |
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| TissGeneProg for GRIN2A |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for GRIN2A |
| TissGeneDrug for GRIN2A |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| DB00454 | Pethidine | Antagonist | Small molecule | Approved |
| DB00949 | Felbamate | Antagonist | Small molecule | Approved |
| DB06151 | Acetylcysteine | Activator | Small molecule | Approved |
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| TissGeneDisease for GRIN2A |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0036341 | Schizophrenia | 18 | BeFree,GAD,GWASCAT,LHGDN |
| umls:C0014544 | Epilepsy | 12 | BeFree,CTD_human |
| umls:C0005586 | Bipolar Disorder | 9 | BeFree,GAD |
| umls:C3806402 | EPILEPSY, FOCAL, WITH SPEECH DISORDER AND WITH OR WITHOUT MENTAL RETARDATION | 7 | ORPHANET,UNIPROT |
| umls:C1263846 | Attention deficit hyperactivity disorder | 5 | BeFree,GAD |
| umls:C0041696 | Unipolar Depression | 4 | BeFree |
| umls:C0376532 | Epilepsy, Rolandic | 4 | BeFree,CTD_human |
| umls:C1096063 | Drug Resistant Epilepsy | 4 | BeFree |
| umls:C1269683 | Major Depressive Disorder | 4 | BeFree |
| umls:C0001973 | Alcoholic Intoxication, Chronic | 3 | BeFree,GAD |
| umls:C0020179 | Huntington Disease | 3 | BeFree,GAD,LHGDN |
| umls:C0002395 | Alzheimer's Disease | 2 | BeFree,LHGDN |
| umls:C0002736 | Amyotrophic Lateral Sclerosis | 2 | BeFree,GAD |
| umls:C0004936 | Mental disorders | 2 | BeFree,GAD |
| umls:C0014547 | Epilepsies, Partial | 2 | BeFree |
| umls:C0019337 | Heroin Dependence | 2 | BeFree |
| umls:C0023890 | Liver Cirrhosis | 2 | BeFree |
| umls:C0025202 | melanoma | 2 | BeFree,CTD_human |
| umls:C0085584 | Encephalopathies | 2 | BeFree |
| umls:C0525045 | Mood Disorders | 2 | BeFree |
| umls:C0751495 | Seizures, Focal | 2 | BeFree |
| umls:C1623038 | Cirrhosis | 2 | BeFree |
| umls:C3714756 | Intellectual Disability | 2 | BeFree |
| umls:C3806403 | CONTINUOUS SPIKE AND WAVES DURING SLOW-WAVE SLEEP SYNDROME | 2 | BeFree |
| umls:C0003537 | Aphasia | 1 | BeFree |
| umls:C0003635 | Apraxias | 1 | BeFree |
| umls:C0004352 | Autistic Disorder | 1 | BeFree,CTD_human |
| umls:C0007102 | Malignant tumor of colon | 1 | BeFree |
| umls:C0009402 | Colorectal Carcinoma | 1 | BeFree |
| umls:C0009404 | Colorectal Neoplasms | 1 | CTD_human,LHGDN |
| umls:C0011570 | Mental Depression | 1 | BeFree |
| umls:C0011581 | Depressive disorder | 1 | BeFree |
| umls:C0013170 | Drug habituation | 1 | BeFree |
| umls:C0013362 | Dysarthria | 1 | BeFree |
| umls:C0014556 | Epilepsy, Temporal Lobe | 1 | BeFree |
| umls:C0015934 | Fetal Growth Retardation | 1 | RGD |
| umls:C0018817 | Atrial Septal Defects | 1 | BeFree |
| umls:C0019163 | Hepatitis B | 1 | BeFree,GAD,GWASCAT |
| umls:C0022116 | Ischemia | 1 | BeFree |
| umls:C0023014 | Language Development Disorders | 1 | CTD_human |
| umls:C0025362 | Mental Retardation | 1 | BeFree |
| umls:C0026552 | Morphine Dependence | 1 | CTD_human |
| umls:C0027404 | Narcolepsy | 1 | GAD |
| umls:C0032051 | Placental Insufficiency | 1 | RGD |
| umls:C0033975 | Psychotic Disorders | 1 | BeFree |
| umls:C0035126 | Reperfusion Injury | 1 | RGD |
| umls:C0036572 | Seizures | 1 | BeFree |
| umls:C0037769 | West Syndrome | 1 | BeFree |
| umls:C0037822 | Speech Disorders | 1 | CTD_human |
| umls:C0038220 | Status Epilepticus | 1 | BeFree |
| umls:C0038454 | Cerebrovascular accident | 1 | BeFree |
| umls:C0038587 | Substance Withdrawal Syndrome | 1 | CTD_human |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
| umls:C0041107 | Trisomy | 1 | BeFree |
| umls:C0043094 | Weight Gain | 1 | GAD |
| umls:C0085400 | Neurofibrillary degeneration (morphologic abnormality) | 1 | BeFree |
| umls:C0206716 | Ganglioglioma | 1 | BeFree |
| umls:C0233715 | Speech impairment | 1 | BeFree |
| umls:C0234516 | Speech dysfunction | 1 | BeFree |
| umls:C0243026 | Sepsis | 1 | RGD |
| umls:C0282512 | Landau-Kleffner Syndrome | 1 | BeFree,CTD_human,ORPHANET |
| umls:C0348165 | Central Nervous System Viral Diseases | 1 | RGD |
| umls:C0349204 | Nonorganic psychosis | 1 | BeFree |
| umls:C0424605 | Developmental delay (disorder) | 1 | BeFree |
| umls:C0524662 | Opiate Addiction | 1 | BeFree |
| umls:C0678356 | alcohol effect | 1 | BeFree |
| umls:C0699790 | Colon Carcinoma | 1 | BeFree |
| umls:C0752308 | Hypoxia-Ischemia, Brain | 1 | RGD |
| umls:C1504404 | Hippocampal sclerosis | 1 | BeFree |
| umls:C1868677 | PHOTOPAROXYSMAL RESPONSE 1 | 1 | BeFree |
| umls:C2911647 | Weight Gain Adverse Event | 1 | GAD |
| umls:C1832814 | Rolandic Epilepsy, Mental Retardation, And Speech Dyspraxia, Autosomal Dominant | 0 | CLINVAR |
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