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| TissGeneSummary for GRM2 |
 Gene summary |
| Basic gene information | Gene symbol | GRM2 |
| Gene name | glutamate receptor, metabotropic 2 | |
| Synonyms | GLUR2|GPRC1B|MGLUR2|mGlu2 | |
| Cytomap | UCSC genome browser: 3p21.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_000839.3, NM_001130063.1, | |
| Description | glutamate metabotropic receptor 2glutamate receptor homologmetabotropic glutamate receptor 2 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 604099 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000164082 | ||
| HPRD : 04977 | ||
| Vega : OTTHUMG00000156902 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_GRM2 | |
| BioGPS: 2912 | ||
| Pathway | NCI Pathway Interaction Database: GRM2 | |
| KEGG: GRM2 | ||
| REACTOME: GRM2 | ||
| Pathway Commons: GRM2 | ||
| Context | iHOP: GRM2 | |
| ligand binding site mutation search in PubMed: GRM2 | ||
| UCL Cancer Institute: GRM2 | ||
| Assigned class in TissGDB* | A | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | BrainTestis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGGTGCT | |
| Reference showing the relevant tissue of GRM2 | Putative genes mediating the effects of orexins in the posterior paraventricular thalamus on neuroendocrine and behavioral adaptations to repeated stress. Heydendael W, Sengupta A, Bhatnagar S. Brain Res Bull. 2012 Dec 1;89(5-6):203-10. doi: 10.1016/j.brainresbull.2012.09.002. Epub 2012 Sep 13. (pmid:22982687) go to article | |
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for GRM2 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| STAD | 0.217909436 | -1.072496814 | 1.29040625 | 3.16E-07 | 6.58E-06 |
| KICH | 0.344613311 | -0.838658689 | 1.183272 | 0.00188 | 0.003886979 |
| LIHC | -0.562094689 | -1.631644689 | 1.06955 | 5.91E-05 | 0.000215182 |
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| TissGene-miRNA for GRM2 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for GRM2 |
| TissGeneSNV for GRM2 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E136K | COAD | 2 |
| p.E218K | STAD | 2 |
| p.L199I | UCEC | 2 |
| p.R346H | COAD | 1 |
| p.R200H | STAD | 1 |
| p.S3L | UCEC | 1 |
| p.S678P | LUAD | 1 |
| p.S489L | LUAD | 1 |
| p.W344R | SKCM | 1 |
| p.C553F | LUAD | 1 |
| p.E94K | COAD | 1 |
| p.P524L | SKCM | 1 |
| p.P753H | PRAD | 1 |
| p.E754K | SKCM | 1 |
| p.E347* | BLCA | 1 |
| p.R247H | STAD | 1 |
| p.F327C | LGG | 1 |
| p.A275V | KIRP | 1 |
| p.P496R | BRCA | 1 |
| p.G802S | SKCM | 1 |
| p.W487C | SKCM | 1 |
| p.R636C | UCEC | 1 |
| p.G242C | HNSC | 1 |
| p.A68V | COAD | 1 |
| p.S212Y | LUAD | 1 |
| p.D131E | SKCM | 1 |
| p.K240N | SKCM | 1 |
| p.L155F | BLCA | 1 |
| p.R255Q | HNSC | 1 |
| p.V804M | STAD | 1 |
| p.D436N | SKCM | 1 |
| p.G802D | SKCM | 1 |
| p.R636H | STAD | 1 |
| p.R465C | STAD | 1 |
| p.D436V | LUAD | 1 |
| p.V178M | COAD | 1 |
| p.E312K | BLCA | 1 |
| p.E559K | HNSC | 1 |
| p.E218K | SKCM | 1 |
| p.A50T | COAD | 1 |
| p.A196T | UCEC | 1 |
| p.E534K | SKCM | 1 |
| p.W337* | SKCM | 1 |
| p.S145G | STAD | 1 |
| p.E701K | STAD | 1 |
| p.W487* | SKCM | 1 |
| p.K599E | SKCM | 1 |
| p.E308K | BLCA | 1 |
| p.R255Q | BRCA | 1 |
| p.R635W | STAD | 1 |
| p.P703A | STAD | 1 |
| p.R452H | STAD | 1 |
| p.R284C | STAD | 1 |
| p.H119Y | SKCM | 1 |
| p.A127V | PAAD | 1 |
| p.T479I | SKCM | 1 |
| p.C742* | UCEC | 1 |
| p.L738F | KIRP | 1 |
| p.P39S | LUAD | 1 |
| p.E604X | LIHC | 1 |
| p.L577P | PRAD | 1 |
| p.R417C | UCEC | 1 |
| p.S164G | SKCM | 1 |
| p.T743M | STAD | 1 |
| p.R341W | STAD | 1 |
| p.R71H | HNSC | 1 |
| p.R271C | STAD | 1 |
| p.F854C | SKCM | 1 |
| p.P431S | SKCM | 1 |
| p.A681D | SKCM | 1 |
| p.R442H | STAD | 1 |
| p.P161S | SKCM | 1 |
| p.S3L | SKCM | 1 |
| p.A9T | PAAD | 1 |
| p.T551I | COAD | 1 |
| p.P431L | SKCM | 1 |
| p.S797L | CESC | 1 |
| p.R71H | BLCA | 1 |
| p.V699E | KIRC | 1 |
| p.R659H | UCEC | 1 |
| p.R243H | STAD | 1 |
| p.R659H | ESCA | 1 |
| p.R346H | HNSC | 1 |
| p.G578S | STAD | 1 |
| p.R38H | COAD | 1 |
| p.F353L | BRCA | 1 |
| p.F269I | LIHC | 1 |
| p.W487X | SKCM | 1 |
| p.R243C | STAD | 1 |
| p.S176P | COAD | 1 |
| p.R562C | COAD | 1 |
| p.R368L | SKCM | 1 |
| p.A280T | SKCM | 1 |
| p.R659L | ESCA | 1 |
| p.A696T | LIHC | 1 |
| p.R659H | LUSC | 1 |
| p.A702T | BLCA | 1 |
| p.W337X | SKCM | 1 |
| p.R467C | SKCM | 1 |
| p.R83C | UCEC | 1 |
| p.N286K | STAD | 1 |
| p.A127V | READ | 1 |
| p.R750H | STAD | 1 |
| p.R71H | PAAD | 1 |
| p.S844F | BLCA | 1 |
| p.E529Q | HNSC | 1 |
| p.R276L | CESC | 1 |
| p.R74H | STAD | 1 |
| p.T482P | KIRP | 1 |
| p.A248V | STAD | 1 |
| p.A114T | PAAD | 1 |
| p.R635W | LGG | 1 |
| p.F236L | COAD | 1 |
| p.V585M | LUAD | 1 |
| p.R231H | READ | 1 |
| p.A102V | COAD | 1 |
| p.G564V | DLBC | 1 |
| p.V370A | LUSC | 1 |
| p.L459M | LGG | 1 |
| p.R183H | BLCA | 1 |
| p.R445C | ESCA | 1 |
| p.D786N | BLCA | 1 |
| p.E350D | STAD | 1 |
| p.M245I | BLCA | 1 |
| p.E239K | BLCA | 1 |
| p.S325G | STAD | 1 |
| p.D215Y | THCA | 1 |
| p.R411W | PRAD | 1 |
| p.R656S | LUSC | 1 |
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| TissGeneCNV for GRM2 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for GRM2 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for GRM2 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| GRM2, GNAQ, GNA15, RGS12, GRASP (tumor) | GRM2, GNAQ, GNA15, RGS12, GRASP (normal) |
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| COAD (tumor) | COAD (normal) |
| GRM2, GNAQ, GNA15, RGS12, GRASP (tumor) | GRM2, GNAQ, GNA15, RGS12, GRASP (normal) |
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| HNSC (tumor) | HNSC (normal) |
| GRM2, GNAQ, GNA15, RGS12, GRASP (tumor) | GRM2, GNAQ, GNA15, RGS12, GRASP (normal) |
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| KICH (tumor) | KICH (normal) |
| GRM2, GNAQ, GNA15, RGS12, GRASP (tumor) | GRM2, GNAQ, GNA15, RGS12, GRASP (normal) |
 |  |
| KIRC (tumor) | KIRC (normal) |
| GRM2, GNAQ, GNA15, RGS12, GRASP (tumor) | GRM2, GNAQ, GNA15, RGS12, GRASP (normal) |
 |  |
| KIRP (tumor) | KIRP (normal) |
| GRM2, GNAQ, GNA15, RGS12, GRASP (tumor) | GRM2, GNAQ, GNA15, RGS12, GRASP (normal) |
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| LIHC (tumor) | LIHC (normal) |
| GRM2, GNAQ, GNA15, RGS12, GRASP (tumor) | GRM2, GNAQ, GNA15, RGS12, GRASP (normal) |
 |  |
| LUAD (tumor) | LUAD (normal) |
| GRM2, GNAQ, GNA15, RGS12, GRASP (tumor) | GRM2, GNAQ, GNA15, RGS12, GRASP (normal) |
 |  |
| LUSC (tumor) | LUSC (normal) |
| GRM2, GNAQ, GNA15, RGS12, GRASP (tumor) | GRM2, GNAQ, GNA15, RGS12, GRASP (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| GRM2, GNAQ, GNA15, RGS12, GRASP (tumor) | GRM2, GNAQ, GNA15, RGS12, GRASP (normal) |
 |  |
| STAD (tumor) | STAD (normal) |
| GRM2, GNAQ, GNA15, RGS12, GRASP (tumor) | GRM2, GNAQ, GNA15, RGS12, GRASP (normal) |
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| THCA (tumor) | THCA (normal) |
| GRM2, GNAQ, GNA15, RGS12, GRASP (tumor) | GRM2, GNAQ, GNA15, RGS12, GRASP (normal) |
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| TissGeneProg for GRM2 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for GRM2 |
| TissGeneDrug for GRM2 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for GRM2 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0036341 | Schizophrenia | 14 | BeFree,CTD_human,GAD,LHGDN |
| umls:C0002736 | Amyotrophic Lateral Sclerosis | 9 | BeFree,LHGDN |
| umls:C0014544 | Epilepsy | 5 | BeFree |
| umls:C1862941 | Amyotrophic Lateral Sclerosis, Sporadic | 3 | BeFree |
| umls:C0011570 | Mental Depression | 2 | BeFree |
| umls:C0011581 | Depressive disorder | 2 | BeFree |
| umls:C0014556 | Epilepsy, Temporal Lobe | 2 | BeFree,CTD_human |
| umls:C0033975 | Psychotic Disorders | 2 | BeFree |
| umls:C0038454 | Cerebrovascular accident | 2 | BeFree |
| umls:C0349204 | Nonorganic psychosis | 2 | BeFree |
| umls:C0002395 | Alzheimer's Disease | 1 | BeFree |
| umls:C0011847 | Diabetes | 1 | BeFree |
| umls:C0011849 | Diabetes Mellitus | 1 | BeFree |
| umls:C0017636 | Glioblastoma | 1 | BeFree |
| umls:C0017638 | Glioma | 1 | BeFree |
| umls:C0027796 | Neuralgia | 1 | BeFree |
| umls:C0033941 | Psychoses, Substance-Induced | 1 | CTD_human |
| umls:C0036572 | Seizures | 1 | BeFree |
| umls:C0036939 | Shared Paranoid Disorder | 1 | BeFree |
| umls:C0041696 | Unipolar Depression | 1 | BeFree |
| umls:C0043094 | Weight Gain | 1 | GAD |
| umls:C0154682 | Lateral Sclerosis | 1 | BeFree |
| umls:C0236733 | Amphetamine-Related Disorders | 1 | CTD_human |
| umls:C0338656 | Impaired cognition | 1 | BeFree |
| umls:C0344307 | Absence of pain sensation | 1 | BeFree |
| umls:C0443306 | Spastic | 1 | BeFree |
| umls:C0525041 | Neurobehavioral Manifestations | 1 | BeFree |
| umls:C0525045 | Mood Disorders | 1 | BeFree,GAD |
| umls:C0746408 | mass lesion | 1 | BeFree |
| umls:C0948008 | Ischemic stroke | 1 | BeFree |
| umls:C1269683 | Major Depressive Disorder | 1 | BeFree |
| umls:C2911647 | Weight Gain Adverse Event | 1 | GAD |
| umls:C3272363 | Ischemic Cerebrovascular Accident | 1 | BeFree |
| umls:C3532942 | Mixed dementia | 1 | BeFree |
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