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| TissGeneSummary for GRM5 |
 Gene summary |
| Basic gene information | Gene symbol | GRM5 |
| Gene name | glutamate receptor, metabotropic 5 | |
| Synonyms | GPRC1E|MGLUR5|PPP1R86|mGlu5 | |
| Cytomap | UCSC genome browser: 11q14.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_000842.4, NM_001143831.2, | |
| Description | metabotropic glutamate receptor 5protein phosphatase 1, regulatory subunit 86 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 604102 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000168959 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_GRM5 | |
| BioGPS: 2915 | ||
| Pathway | NCI Pathway Interaction Database: GRM5 | |
| KEGG: GRM5 | ||
| REACTOME: GRM5 | ||
| Pathway Commons: GRM5 | ||
| Context | iHOP: GRM5 | |
| ligand binding site mutation search in PubMed: GRM5 | ||
| UCL Cancer Institute: GRM5 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,TiGER | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Brain | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGG | |
| Reference showing the relevant tissue of GRM5 | ||
| Description by TissGene annotations | Cancer gene Have significant anti-correlated miRNA | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for GRM5 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| THCA | -1.38207452 | -2.885810113 | 1.503735593 | 1.04E-11 | 7.94E-11 |
| KICH | -1.307845164 | 1.027770836 | -2.335616 | 3.67E-09 | 2.08E-08 |
| KIRP | 2.096369336 | 0.681566211 | 1.414803125 | 0.0123 | 0.026338682 |
| LUAD | 0.562384422 | -0.614529371 | 1.176913793 | 0.00337 | 0.00665397 |
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| TissGene-miRNA for GRM5 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| ACC | hsa-miR-30b-5p | MIMAT0000420 | 0.018 | -0.27 | 78 |
| ACC | hsa-miR-30a-5p | MIMAT0000087 | 0.021 | -0.27 | 78 |
| ACC | hsa-miR-30b-5p | MIMAT0000420 | 0.018 | -0.27 | 78 |
| ACC | hsa-miR-30a-5p | MIMAT0000087 | 0.021 | -0.27 | 78 |
| ACC | hsa-miR-128-3p | MIMAT0000424 | 0.011 | -0.29 | 78 |
| ACC | hsa-miR-128-3p | MIMAT0000424 | 0.011 | -0.29 | 78 |
| ACC | hsa-miR-129-5p | MIMAT0000242 | 0.0058 | -0.31 | 78 |
| ACC | hsa-miR-129-5p | MIMAT0000242 | 0.0058 | -0.31 | 78 |
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| TissGeneMut for GRM5 |
| TissGeneSNV for GRM5 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R834C | STAD | 2 |
| p.R574* | UCEC | 2 |
| p.T906P | STAD | 2 |
| p.Y340C | HNSC | 2 |
| p.C803W | PAAD | 1 |
| p.S116F | SARC | 1 |
| p.G92C | LUSC | 1 |
| p.M907V | BLCA | 1 |
| p.E111V | LUAD | 1 |
| p.S509P | MESO | 1 |
| p.R435W | LUAD | 1 |
| p.A623S | KIRC | 1 |
| p.T1199I | BLCA | 1 |
| p.L744I | ESCA | 1 |
| p.D1171N | SKCM | 1 |
| p.I824N | LUAD | 1 |
| p.R844L | LUAD | 1 |
| p.A1140T | PCPG | 1 |
| p.T183A | HNSC | 1 |
| p.A710S | BLCA | 1 |
| p.A692V | BLCA | 1 |
| p.S1187P | HNSC | 1 |
| p.G897E | SKCM | 1 |
| p.A905P | STAD | 1 |
| p.R605H | STAD | 1 |
| p.D1139N | SKCM | 1 |
| p.S384Y | UCEC | 1 |
| p.R605S | LUAD | 1 |
| p.K851T | STAD | 1 |
| p.R200M | UCEC | 1 |
| p.V192L | PRAD | 1 |
| p.T75N | KIRC | 1 |
| p.P1119S | KIRP | 1 |
| p.E14K | SKCM | 1 |
| p.F112L | LUSC | 1 |
| p.A855T | LUAD | 1 |
| p.P193L | LUSC | 1 |
| p.Y405C | LUAD | 1 |
| p.D258N | LUAD | 1 |
| p.G369E | SKCM | 1 |
| p.A155V | BRCA | 1 |
| p.G464* | LUSC | 1 |
| p.A271T | BRCA | 1 |
| p.V1065I | UCEC | 1 |
| p.G526E | SKCM | 1 |
| p.S909I | HNSC | 1 |
| p.W575* | SKCM | 1 |
| p.H267N | BLCA | 1 |
| p.F804L | UCEC | 1 |
| p.G460R | SKCM | 1 |
| p.L862I | LUSC | 1 |
| p.L268M | LUAD | 1 |
| p.A836T | STAD | 1 |
| p.K207N | LIHC | 1 |
| p.Y478C | UCEC | 1 |
| p.G92D | BLCA | 1 |
| p.S840Y | COAD | 1 |
| p.D457Y | COAD | 1 |
| p.R727X | STAD | 1 |
| p.R292C | STAD | 1 |
| p.A174T | LUAD | 1 |
| p.C1190S | LUAD | 1 |
| p.A775T | PRAD | 1 |
| p.R128L | KIRC | 1 |
| p.A827D | STAD | 1 |
| p.F185L | BLCA | 1 |
| p.A963T | PAAD | 1 |
| p.S556F | SKCM | 1 |
| p.S1086C | LIHC | 1 |
| p.F633V | SARC | 1 |
| p.H391N | LUAD | 1 |
| p.T780M | LUAD | 1 |
| p.V585A | UCEC | 1 |
| p.S176R | UCEC | 1 |
| p.F698L | UCEC | 1 |
| p.M429I | READ | 1 |
| p.G421V | LUSC | 1 |
| p.D457N | STAD | 1 |
| p.D204G | THYM | 1 |
| p.S102L | STAD | 1 |
| p.A289V | SKCM | 1 |
| p.R727* | STAD | 1 |
| p.R319L | LUAD | 1 |
| p.S98Y | LUAD | 1 |
| p.I800T | COAD | 1 |
| p.L653V | HNSC | 1 |
| p.S1211L | STAD | 1 |
| p.L302P | LUAD | 1 |
| p.G526A | BLCA | 1 |
| p.E77K | SKCM | 1 |
| p.T924M | COAD | 1 |
| p.R834C | LUSC | 1 |
| p.R68I | UCEC | 1 |
| p.L1075H | HNSC | 1 |
| p.V334F | LUAD | 1 |
| p.T535I | STAD | 1 |
| p.E111A | KIRC | 1 |
| p.V52I | STAD | 1 |
| p.R292C | UCEC | 1 |
| p.M189I | LUSC | 1 |
| p.E541D | LUAD | 1 |
| p.R932C | LGG | 1 |
| p.E527K | SKCM | 1 |
| p.T1110M | STAD | 1 |
| p.P32L | LGG | 1 |
| p.A670V | THYM | 1 |
| p.V1089I | ESCA | 1 |
| p.S239Y | UCEC | 1 |
| p.R605C | COAD | 1 |
| p.R272Q | BLCA | 1 |
| p.L411I | LIHC | 1 |
| p.P558R | CHOL | 1 |
| p.Q197K | HNSC | 1 |
| p.D1174A | SKCM | 1 |
| p.E439G | ESCA | 1 |
| p.R727X | READ | 1 |
| p.E770K | SKCM | 1 |
| p.R668H | CESC | 1 |
| p.Q318H | HNSC | 1 |
| p.R524Q | BLCA | 1 |
| p.N166S | UCEC | 1 |
| p.R362H | COAD | 1 |
| p.D82G | LUAD | 1 |
| p.R345W | UCS | 1 |
| p.D394N | SKCM | 1 |
| p.S151P | STAD | 1 |
| p.M202V | UCEC | 1 |
| p.S109N | UCEC | 1 |
| p.T453M | DLBC | 1 |
| p.G410W | LUAD | 1 |
| p.S153Y | PAAD | 1 |
| p.V484I | LIHC | 1 |
| p.R435W | BLCA | 1 |
| p.P346T | LUAD | 1 |
| p.W307C | ACC | 1 |
| p.P765S | SKCM | 1 |
| p.R345Q | LUAD | 1 |
| p.M1I | UCEC | 1 |
| p.L344F | PAAD | 1 |
| p.G628C | LUAD | 1 |
| p.Q157* | BLCA | 1 |
| p.L573I | UCEC | 1 |
| p.R114I | LUAD | 1 |
| p.F112L | SKCM | 1 |
| p.I289T | LUAD | 1 |
| p.S151F | SKCM | 1 |
| p.I726F | ESCA | 1 |
| p.R671G | COAD | 1 |
| p.S406L | STAD | 1 |
| p.E516D | LUAD | 1 |
| p.R294S | BLCA | 1 |
| p.V43A | UCEC | 1 |
| p.S8* | STAD | 1 |
| p.H390Q | READ | 1 |
| p.W336C | LGG | 1 |
| p.I774N | STAD | 1 |
| p.V948I | STAD | 1 |
| p.V191A | UCEC | 1 |
| p.Q169H | UCEC | 1 |
| p.M290V | LUAD | 1 |
| p.S136Y | BLCA | 1 |
| p.D97N | HNSC | 1 |
| p.Q919H | BLCA | 1 |
| p.S613* | LUAD | 1 |
| p.V1161E | LIHC | 1 |
| p.D131N | LUAD | 1 |
| p.S8X | STAD | 1 |
| p.F596S | PAAD | 1 |
| p.C754* | LUAD | 1 |
| p.A1095T | COAD | 1 |
| p.E124K | CESC | 1 |
| p.E579K | BLCA | 1 |
| p.H267D | LUSC | 1 |
| p.R17C | LUSC | 1 |
| p.R128C | GBM | 1 |
| p.M237L | LIHC | 1 |
| p.G652C | BLCA | 1 |
| p.R844C | PRAD | 1 |
| p.G675V | STAD | 1 |
| p.S1172L | CESC | 1 |
| p.L268F | STAD | 1 |
| p.D204G | COAD | 1 |
| p.R351* | UCEC | 1 |
| p.K525N | COAD | 1 |
| p.G58R | SKCM | 1 |
| p.L455P | LUAD | 1 |
| p.Q255K | STAD | 1 |
| p.L744V | LUAD | 1 |
| p.M237K | LUAD | 1 |
| p.A623D | SARC | 1 |
| p.H45Q | LUSC | 1 |
| p.T780M | UCEC | 1 |
| p.L418P | STAD | 1 |
| p.S805L | SKCM | 1 |
| p.A408G | LUAD | 1 |
| p.D480A | KIRC | 1 |
| p.S8P | UCEC | 1 |
| p.P288T | HNSC | 1 |
| p.G92R | OV | 1 |
| p.A1098V | READ | 1 |
| p.P580T | LUAD | 1 |
| p.D1174N | SKCM | 1 |
| p.R292L | ESCA | 1 |
| p.K259E | HNSC | 1 |
| p.F893L | COAD | 1 |
| p.P353T | LUAD | 1 |
| p.K140* | LUAD | 1 |
| p.S840F | SKCM | 1 |
| p.F358C | UCEC | 1 |
| p.F277V | ESCA | 1 |
| p.Q647* | SKCM | 1 |
| p.G490E | SKCM | 1 |
| p.P346T | CESC | 1 |
| p.P1087L | COAD | 1 |
| p.P346S | STAD | 1 |
| p.E1074Q | GBM | 1 |
| p.S173* | BLCA | 1 |
| p.T348P | STAD | 1 |
| p.R524* | LGG | 1 |
| p.T326R | BLCA | 1 |
| p.T219I | STAD | 1 |
| p.A39S | LUAD | 1 |
| p.W785R | KIRP | 1 |
| p.D488E | LUAD | 1 |
| p.R138H | STAD | 1 |
| p.R366Q | COAD | 1 |
| p.S304R | HNSC | 1 |
| p.R61H | COAD | 1 |
| p.S805X | STAD | 1 |
| p.L627Q | LUAD | 1 |
| p.V334I | STAD | 1 |
| p.M714I | SKCM | 1 |
| p.C1062F | COAD | 1 |
| p.Y172H | STAD | 1 |
| p.N796K | LUAD | 1 |
| p.E298A | UCEC | 1 |
| p.S136F | SKCM | 1 |
| p.N88S | UCEC | 1 |
| p.V217M | STAD | 1 |
| p.T282M | PRAD | 1 |
| p.P580L | SKCM | 1 |
| p.A199S | STAD | 1 |
| p.S215L | SKCM | 1 |
| p.R858T | CESC | 1 |
| p.W557C | HNSC | 1 |
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| TissGeneCNV for GRM5 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for GRM5 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | DB175186 | GRM5-SF3A3 | chr11:88766533 | chr1:38449859 | |
| TCGAfusionPortal | PRADA | LUAD | TCGA-91-6831-01A | TTC33-GRM5 | 5UTR-CDS | Chr5:40755926 | Chr11:88242672 |
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| TissGeneNet for GRM5 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| GRM5, PRKCG, PRKCA, FLNA, EFNB2, CALM1, PRKCE, GPRASP1, PRKCZ, PRKCD, HOMER3, PRKCB, PRKCQ, RGS12, HOMER1, GRASP (tumor) | GRM5, PRKCG, PRKCA, FLNA, EFNB2, CALM1, PRKCE, GPRASP1, PRKCZ, PRKCD, HOMER3, PRKCB, PRKCQ, RGS12, HOMER1, GRASP (normal) |
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| COAD (tumor) | COAD (normal) |
| GRM5, PRKCG, PRKCA, FLNA, EFNB2, CALM1, PRKCE, GPRASP1, PRKCZ, PRKCD, HOMER3, PRKCB, PRKCQ, RGS12, HOMER1, GRASP (tumor) | GRM5, PRKCG, PRKCA, FLNA, EFNB2, CALM1, PRKCE, GPRASP1, PRKCZ, PRKCD, HOMER3, PRKCB, PRKCQ, RGS12, HOMER1, GRASP (normal) |
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| HNSC (tumor) | HNSC (normal) |
| GRM5, PRKCG, PRKCA, FLNA, EFNB2, CALM1, PRKCE, GPRASP1, PRKCZ, PRKCD, HOMER3, PRKCB, PRKCQ, RGS12, HOMER1, GRASP (tumor) | GRM5, PRKCG, PRKCA, FLNA, EFNB2, CALM1, PRKCE, GPRASP1, PRKCZ, PRKCD, HOMER3, PRKCB, PRKCQ, RGS12, HOMER1, GRASP (normal) |
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| KICH (tumor) | KICH (normal) |
| GRM5, PRKCG, PRKCA, FLNA, EFNB2, CALM1, PRKCE, GPRASP1, PRKCZ, PRKCD, HOMER3, PRKCB, PRKCQ, RGS12, HOMER1, GRASP (tumor) | GRM5, PRKCG, PRKCA, FLNA, EFNB2, CALM1, PRKCE, GPRASP1, PRKCZ, PRKCD, HOMER3, PRKCB, PRKCQ, RGS12, HOMER1, GRASP (normal) |
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| KIRC (tumor) | KIRC (normal) |
| GRM5, PRKCG, PRKCA, FLNA, EFNB2, CALM1, PRKCE, GPRASP1, PRKCZ, PRKCD, HOMER3, PRKCB, PRKCQ, RGS12, HOMER1, GRASP (tumor) | GRM5, PRKCG, PRKCA, FLNA, EFNB2, CALM1, PRKCE, GPRASP1, PRKCZ, PRKCD, HOMER3, PRKCB, PRKCQ, RGS12, HOMER1, GRASP (normal) |
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| KIRP (tumor) | KIRP (normal) |
| GRM5, PRKCG, PRKCA, FLNA, EFNB2, CALM1, PRKCE, GPRASP1, PRKCZ, PRKCD, HOMER3, PRKCB, PRKCQ, RGS12, HOMER1, GRASP (tumor) | GRM5, PRKCG, PRKCA, FLNA, EFNB2, CALM1, PRKCE, GPRASP1, PRKCZ, PRKCD, HOMER3, PRKCB, PRKCQ, RGS12, HOMER1, GRASP (normal) |
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| LIHC (tumor) | LIHC (normal) |
| GRM5, PRKCG, PRKCA, FLNA, EFNB2, CALM1, PRKCE, GPRASP1, PRKCZ, PRKCD, HOMER3, PRKCB, PRKCQ, RGS12, HOMER1, GRASP (tumor) | GRM5, PRKCG, PRKCA, FLNA, EFNB2, CALM1, PRKCE, GPRASP1, PRKCZ, PRKCD, HOMER3, PRKCB, PRKCQ, RGS12, HOMER1, GRASP (normal) |
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| LUAD (tumor) | LUAD (normal) |
| GRM5, PRKCG, PRKCA, FLNA, EFNB2, CALM1, PRKCE, GPRASP1, PRKCZ, PRKCD, HOMER3, PRKCB, PRKCQ, RGS12, HOMER1, GRASP (tumor) | GRM5, PRKCG, PRKCA, FLNA, EFNB2, CALM1, PRKCE, GPRASP1, PRKCZ, PRKCD, HOMER3, PRKCB, PRKCQ, RGS12, HOMER1, GRASP (normal) |
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| LUSC (tumor) | LUSC (normal) |
| GRM5, PRKCG, PRKCA, FLNA, EFNB2, CALM1, PRKCE, GPRASP1, PRKCZ, PRKCD, HOMER3, PRKCB, PRKCQ, RGS12, HOMER1, GRASP (tumor) | GRM5, PRKCG, PRKCA, FLNA, EFNB2, CALM1, PRKCE, GPRASP1, PRKCZ, PRKCD, HOMER3, PRKCB, PRKCQ, RGS12, HOMER1, GRASP (normal) |
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| PRAD (tumor) | PRAD (normal) |
| GRM5, PRKCG, PRKCA, FLNA, EFNB2, CALM1, PRKCE, GPRASP1, PRKCZ, PRKCD, HOMER3, PRKCB, PRKCQ, RGS12, HOMER1, GRASP (tumor) | GRM5, PRKCG, PRKCA, FLNA, EFNB2, CALM1, PRKCE, GPRASP1, PRKCZ, PRKCD, HOMER3, PRKCB, PRKCQ, RGS12, HOMER1, GRASP (normal) |
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| STAD (tumor) | STAD (normal) |
| GRM5, PRKCG, PRKCA, FLNA, EFNB2, CALM1, PRKCE, GPRASP1, PRKCZ, PRKCD, HOMER3, PRKCB, PRKCQ, RGS12, HOMER1, GRASP (tumor) | GRM5, PRKCG, PRKCA, FLNA, EFNB2, CALM1, PRKCE, GPRASP1, PRKCZ, PRKCD, HOMER3, PRKCB, PRKCQ, RGS12, HOMER1, GRASP (normal) |
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| THCA (tumor) | THCA (normal) |
| GRM5, PRKCG, PRKCA, FLNA, EFNB2, CALM1, PRKCE, GPRASP1, PRKCZ, PRKCD, HOMER3, PRKCB, PRKCQ, RGS12, HOMER1, GRASP (tumor) | GRM5, PRKCG, PRKCA, FLNA, EFNB2, CALM1, PRKCE, GPRASP1, PRKCZ, PRKCD, HOMER3, PRKCB, PRKCQ, RGS12, HOMER1, GRASP (normal) |
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| TissGeneProg for GRM5 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for GRM5 |
| TissGeneDrug for GRM5 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| DB06201 | Rufinamide | Inhibitor | Small molecule | Approved |
| DB00659 | Acamprosate | Antagonist | Small molecule | Approved|Investigational |
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| TissGeneDisease for GRM5 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0036341 | Schizophrenia | 12 | BeFree,GAD |
| umls:C0016667 | Fragile X Syndrome | 7 | BeFree |
| umls:C0004936 | Mental disorders | 4 | BeFree,GAD |
| umls:C0036572 | Seizures | 4 | BeFree |
| umls:C1263846 | Attention deficit hyperactivity disorder | 4 | BeFree,CTD_human,GAD,GWASCAT |
| umls:C0033975 | Psychotic Disorders | 3 | BeFree |
| umls:C0002736 | Amyotrophic Lateral Sclerosis | 2 | BeFree |
| umls:C0011570 | Mental Depression | 2 | BeFree |
| umls:C0011581 | Depressive disorder | 2 | BeFree |
| umls:C0014072 | Experimental Autoimmune Encephalomyelitis | 2 | BeFree |
| umls:C0018817 | Atrial Septal Defects | 2 | BeFree |
| umls:C0038220 | Status Epilepticus | 2 | CTD_human |
| umls:C0041696 | Unipolar Depression | 2 | BeFree |
| umls:C0349204 | Nonorganic psychosis | 2 | BeFree |
| umls:C0752347 | Lewy Body Disease | 2 | BeFree |
| umls:C1269683 | Major Depressive Disorder | 2 | BeFree |
| umls:C0001973 | Alcoholic Intoxication, Chronic | 1 | GAD |
| umls:C0002395 | Alzheimer's Disease | 1 | BeFree |
| umls:C0003469 | Anxiety Disorders | 1 | BeFree |
| umls:C0004114 | Astrocytoma | 1 | BeFree |
| umls:C0004352 | Autistic Disorder | 1 | BeFree |
| umls:C0005586 | Bipolar Disorder | 1 | BeFree |
| umls:C0011882 | Diabetic Neuropathies | 1 | CTD_human |
| umls:C0013146 | Drug abuse | 1 | BeFree |
| umls:C0013421 | Dystonia | 1 | BeFree |
| umls:C0014556 | Epilepsy, Temporal Lobe | 1 | CTD_human |
| umls:C0019829 | Hodgkin Disease | 1 | BeFree |
| umls:C0020179 | Huntington Disease | 1 | BeFree |
| umls:C0026269 | Mitral Valve Stenosis | 1 | BeFree |
| umls:C0026769 | Multiple Sclerosis | 1 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 1 | BeFree |
| umls:C0027796 | Neuralgia | 1 | CTD_human |
| umls:C0027819 | Neuroblastoma | 1 | BeFree |
| umls:C0029463 | Osteosarcoma | 1 | BeFree |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
| umls:C0043094 | Weight Gain | 1 | GAD |
| umls:C0153381 | Malignant neoplasm of mouth | 1 | BeFree |
| umls:C0220641 | Lip and Oral Cavity Carcinoma | 1 | BeFree |
| umls:C0236736 | Cocaine-Related Disorders | 1 | CTD_human |
| umls:C0236969 | Substance-Related Disorders | 1 | CTD_human |
| umls:C0338430 | Limbic Encephalitis | 1 | BeFree |
| umls:C0393593 | Dystonia Disorders | 1 | BeFree |
| umls:C0585442 | Osteosarcoma of bone | 1 | BeFree |
| umls:C0700095 | Central neuroblastoma | 1 | BeFree |
| umls:C1510586 | Autism Spectrum Disorders | 1 | BeFree |
| umls:C1851945 | DYSTONIA 1, TORSION, AUTOSOMAL DOMINANT | 1 | BeFree |
| umls:C2911647 | Weight Gain Adverse Event | 1 | GAD |
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