TissGeneSummary for GUCA1A |
Gene summary |
Basic gene information | Gene symbol | GUCA1A |
Gene name | guanylate cyclase activator 1A (retina) | |
Synonyms | C6orf131|COD3|CORD14|GCAP|GCAP1|GUCA|GUCA1|dJ139D8.6 | |
Cytomap | UCSC genome browser: 6p21.1 | |
Type of gene | protein-coding | |
RefGenes | NM_000409.3, | |
Description | GCAP 1cone dystrophy 3guanylate cyclase-activating protein, photoreceptor 1guanylin 1, retinaguanylyl cyclase-activating protein 1 | |
Modification date | 20141222 | |
dbXrefs | MIM : 600364 | |
HGNC : HGNC | ||
Ensembl : ENSG00000048545 | ||
HPRD : 02648 | ||
Vega : OTTHUMG00000014696 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_GUCA1A | |
BioGPS: 2978 | ||
Pathway | NCI Pathway Interaction Database: GUCA1A | |
KEGG: GUCA1A | ||
REACTOME: GUCA1A | ||
Pathway Commons: GUCA1A | ||
Context | iHOP: GUCA1A | |
ligand binding site mutation search in PubMed: GUCA1A | ||
UCL Cancer Institute: GUCA1A | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | TestisEye | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCTUVM | |
Reference showing the relevant tissue of GUCA1A | ||
Description by TissGene annotations | TissgsKTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for GUCA1A |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUSC | 2.374546918 | -0.5924472 | 2.966994118 | 1.62E-12 | 7.30E-12 |
LUAD | 1.017422307 | -0.888181141 | 1.905603448 | 7.93E-11 | 4.80E-10 |
HNSC | 1.261926717 | -0.051536073 | 1.313462791 | 2.90E-07 | 2.52E-06 |
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TissGene-miRNA for GUCA1A |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for GUCA1A |
TissGeneSNV for GUCA1A |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R93H | STAD | 2 |
p.I157V | UCEC | 1 |
p.R120C | LGG | 1 |
p.R120C | LUAD | 1 |
p.R172Q | BRCA | 1 |
p.R120C | SKCM | 1 |
p.T171A | UCEC | 1 |
p.T121M | UCEC | 1 |
p.Q20R | SARC | 1 |
p.F42L | UCEC | 1 |
p.E38* | LUSC | 1 |
p.S53N | LUAD | 1 |
p.T35P | LUSC | 1 |
p.R172Q | SKCM | 1 |
p.F96L | LUAD | 1 |
p.R40H | BRCA | 1 |
p.R120H | PRAD | 1 |
p.D110N | PAAD | 1 |
p.V180M | LUAD | 1 |
p.K23N | READ | 1 |
p.E17K | STAD | 1 |
p.E190K | SKCM | 1 |
p.F42L | KIRC | 1 |
p.D137Y | SKCM | 1 |
p.A196V | SKCM | 1 |
p.E57K | SKCM | 1 |
p.R181H | LIHC | 1 |
p.G32D | LUAD | 1 |
p.L34P | ESCA | 1 |
p.A197V | COAD | 1 |
p.G7E | SKCM | 1 |
p.M130I | LUAD | 1 |
p.G105S | LUAD | 1 |
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TissGeneCNV for GUCA1A |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for GUCA1A |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for GUCA1A |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for GUCA1A |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for GUCA1A |
TissGeneDrug for GUCA1A |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for GUCA1A |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0035334 | Retinitis Pigmentosa | 12 | BeFree |
umls:C1867326 | RETINAL CONE DYSTROPHY 1 | 10 | BeFree |
umls:C0730290 | Cone dystrophy | 7 | BeFree |
umls:C0035304 | Retinal Degeneration | 5 | BeFree |
umls:C0339527 | Leber Congenital Amaurosis | 5 | BeFree |
umls:C0035309 | Retinal Diseases | 4 | BeFree,GAD |
umls:C1865869 | CONE DYSTROPHY 3 (disorder) | 4 | BeFree,CLINVAR,CTD_human,MGD,UNIPROT |
umls:C0008497 | Choriocarcinoma | 2 | BeFree |
umls:C0242383 | Age related macular degeneration | 2 | BeFree |
umls:C0339508 | Hereditary macular dystrophy | 2 | BeFree |
umls:C0730292 | Macular dystrophy | 2 | BeFree |
umls:C0036631 | Seminoma | 1 | BeFree |
umls:C0270814 | Spastic syndrome | 1 | BeFree |
umls:C0339530 | Progressive cone-rod dystrophy | 1 | BeFree |
umls:C0854723 | Retinal Dystrophies | 1 | BeFree |
umls:C0271092 | Progressive cone dystrophy (without rod involvement) | 0 | ORPHANET |