TissGeneSummary for HIST1H1T |
Gene summary |
Basic gene information | Gene symbol | HIST1H1T |
Gene name | histone cluster 1, H1t | |
Synonyms | H1.6|H1FT|H1t|dJ221C16.2 | |
Cytomap | UCSC genome browser: 6p21.3 | |
Type of gene | protein-coding | |
RefGenes | NM_005323.3, | |
Description | H1 histone family, member T (testis-specific)histone 1, H1thistone H1ttesticular H1 histone | |
Modification date | 20141215 | |
dbXrefs | MIM : 142712 | |
HGNC : HGNC | ||
Ensembl : ENSG00000187475 | ||
HPRD : 00822 | ||
Vega : OTTHUMG00000014430 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_HIST1H1T | |
BioGPS: 3010 | ||
Pathway | NCI Pathway Interaction Database: HIST1H1T | |
KEGG: HIST1H1T | ||
REACTOME: HIST1H1T | ||
Pathway Commons: HIST1H1T | ||
Context | iHOP: HIST1H1T | |
ligand binding site mutation search in PubMed: HIST1H1T | ||
UCL Cancer Institute: HIST1H1T | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of HIST1H1T | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for HIST1H1T |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for HIST1H1T |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for HIST1H1T |
TissGeneSNV for HIST1H1T |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R168I | UCEC | 2 |
p.N41S | UCEC | 1 |
p.H196Y | SKCM | 1 |
p.R37C | LUSC | 1 |
p.A158V | BRCA | 1 |
p.P156L | PRAD | 1 |
p.T103A | COAD | 1 |
p.T4I | UCEC | 1 |
p.S2F | SKCM | 1 |
p.K145N | LUAD | 1 |
p.L52F | COAD | 1 |
p.S188L | COAD | 1 |
p.A71G | STAD | 1 |
p.N199I | GBM | 1 |
p.D140N | SKCM | 1 |
p.A187V | HNSC | 1 |
p.R165K | LUAD | 1 |
p.K67N | LUAD | 1 |
p.L66F | COAD | 1 |
p.R168I | CESC | 1 |
p.A105S | LUAD | 1 |
p.R58Q | LIHC | 1 |
p.G95V | BLCA | 1 |
p.R25* | UCEC | 1 |
p.V5M | STAD | 1 |
p.A170T | UCEC | 1 |
p.S45F | SKCM | 1 |
p.T149N | HNSC | 1 |
p.T4A | COAD | 1 |
p.S2P | BRCA | 1 |
p.P182Q | THYM | 1 |
p.R25Q | STAD | 1 |
p.V164L | HNSC | 1 |
p.G172R | LGG | 1 |
p.V14L | COAD | 1 |
p.G167E | SKCM | 1 |
p.R25Q | BRCA | 1 |
p.S112T | OV | 1 |
p.P117T | BLCA | 1 |
p.K131R | HNSC | 1 |
p.G107S | PAAD | 1 |
p.R83H | KICH | 1 |
p.S181N | SKCM | 1 |
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TissGeneCNV for HIST1H1T |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for HIST1H1T |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for HIST1H1T |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for HIST1H1T |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for HIST1H1T |
TissGeneDrug for HIST1H1T |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for HIST1H1T |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0000786 | Spontaneous abortion | 1 | GAD |
umls:C0023418 | leukemia | 1 | GAD |
umls:C1271104 | Blood pressure finding | 1 | GAD,GWASCAT |
umls:C1272641 | Systemic arterial pressure | 1 | GAD,GWASCAT |
umls:C2239101 | Hemoglobin Adverse Event | 1 | GWASCAT |