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| TissGeneSummary for SOX8 |
 Gene summary |
| Basic gene information | Gene symbol | SOX8 |
| Gene name | SRY (sex determining region Y)-box 8 | |
| Synonyms | - | |
| Cytomap | UCSC genome browser: 16p13.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_014587.4, | |
| Description | transcription factor SOX-8 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 605923 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000005513 | ||
| HPRD : 16175 | ||
| Vega : OTTHUMG00000122101 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_SOX8 | |
| BioGPS: 30812 | ||
| Pathway | NCI Pathway Interaction Database: SOX8 | |
| KEGG: SOX8 | ||
| REACTOME: SOX8 | ||
| Pathway Commons: SOX8 | ||
| Context | iHOP: SOX8 | |
| ligand binding site mutation search in PubMed: SOX8 | ||
| UCL Cancer Institute: SOX8 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,TiGER | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Brain | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGG | |
| Reference showing the relevant tissue of SOX8 | ||
| Description by TissGene annotations | Protective TissGene in RFS Have significant anti-correlated miRNA | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | 10662550 | GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | 10662550 |
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| TissGeneExp for SOX8 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| BLCA | -1.829708255 | 0.412775956 | -2.242484211 | 1.65E-07 | 8.74E-06 |
| THCA | 0.851231799 | -0.368139388 | 1.219371186 | 2.18E-06 | 7.94E-06 |
| BRCA | -0.786873167 | 1.516654903 | -2.30352807 | 1.62E-20 | 1.21E-19 |
| COAD | -0.21842283 | 1.143511786 | -1.361934615 | 0.00428 | 0.010465938 |
| KIRP | 1.068335824 | -0.812723551 | 1.881059375 | 0.000741 | 0.002110956 |
| HNSC | -1.519067373 | -0.116327839 | -1.402739535 | 3.30E-05 | 0.000166107 |
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| TissGene-miRNA for SOX8 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| LUAD | hsa-miR-27b-3p | MIMAT0000419 | 0.028 | -0.29 | 60 |
| LUAD | hsa-miR-27a-3p | MIMAT0000084 | 0.017 | -0.31 | 60 |
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| TissGeneMut for SOX8 |
| TissGeneSNV for SOX8 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.N421S | LUSC | 1 |
| p.A190T | COAD | 1 |
| p.P227L | BLCA | 1 |
| p.H409Y | HNSC | 1 |
| p.W316C | PAAD | 1 |
| p.R256S | LUSC | 1 |
| p.K164R | LUAD | 1 |
| p.S186F | SKCM | 1 |
| p.H183Q | SKCM | 1 |
| p.T226S | LUAD | 1 |
| p.E272K | STAD | 1 |
| p.G384S | BLCA | 1 |
| p.G378D | LUAD | 1 |
| p.P426S | COAD | 1 |
| p.G92V | THYM | 1 |
| p.P314T | LUAD | 1 |
| p.P426Q | LUAD | 1 |
| p.P322R | SKCM | 1 |
| p.E284K | KIRC | 1 |
| p.V273I | PAAD | 1 |
| p.Y169D | PRAD | 1 |
| p.R353Q | STAD | 1 |
| p.M106V | LUAD | 1 |
| p.R174W | UCS | 1 |
| p.R157H | SKCM | 1 |
| p.R412H | PAAD | 1 |
| p.A295T | LUSC | 1 |
| p.R149Q | BLCA | 1 |
| p.R174W | HNSC | 1 |
| p.E284A | STAD | 1 |
| p.P369L | SKCM | 1 |
| p.G199S | LUAD | 1 |
| p.D260N | SKCM | 1 |
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| TissGeneCNV for SOX8 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for SOX8 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | AA242792 | RPL3-SOX8 | chr22:39711526 | chr16:1036443 |
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| TissGeneNet for SOX8 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| SOX8, SP1, OLIG2, PAX3, CEBPA, MMP1, SOX2, POU3F3, EGR2, NOD1, JAM2, POU5F1, HOXC11, UTF1, HHEX, NR5A1, TCF12, DLX5 (tumor) | SOX8, SP1, OLIG2, PAX3, CEBPA, MMP1, SOX2, POU3F3, EGR2, NOD1, JAM2, POU5F1, HOXC11, UTF1, HHEX, NR5A1, TCF12, DLX5 (normal) |
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| COAD (tumor) | COAD (normal) |
| SOX8, SP1, OLIG2, PAX3, CEBPA, MMP1, SOX2, POU3F3, EGR2, NOD1, JAM2, POU5F1, HOXC11, UTF1, HHEX, NR5A1, TCF12, DLX5 (tumor) | SOX8, SP1, OLIG2, PAX3, CEBPA, MMP1, SOX2, POU3F3, EGR2, NOD1, JAM2, POU5F1, HOXC11, UTF1, HHEX, NR5A1, TCF12, DLX5 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| SOX8, SP1, OLIG2, PAX3, CEBPA, MMP1, SOX2, POU3F3, EGR2, NOD1, JAM2, POU5F1, HOXC11, UTF1, HHEX, NR5A1, TCF12, DLX5 (tumor) | SOX8, SP1, OLIG2, PAX3, CEBPA, MMP1, SOX2, POU3F3, EGR2, NOD1, JAM2, POU5F1, HOXC11, UTF1, HHEX, NR5A1, TCF12, DLX5 (normal) |
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| KICH (tumor) | KICH (normal) |
| SOX8, SP1, OLIG2, PAX3, CEBPA, MMP1, SOX2, POU3F3, EGR2, NOD1, JAM2, POU5F1, HOXC11, UTF1, HHEX, NR5A1, TCF12, DLX5 (tumor) | SOX8, SP1, OLIG2, PAX3, CEBPA, MMP1, SOX2, POU3F3, EGR2, NOD1, JAM2, POU5F1, HOXC11, UTF1, HHEX, NR5A1, TCF12, DLX5 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| SOX8, SP1, OLIG2, PAX3, CEBPA, MMP1, SOX2, POU3F3, EGR2, NOD1, JAM2, POU5F1, HOXC11, UTF1, HHEX, NR5A1, TCF12, DLX5 (tumor) | SOX8, SP1, OLIG2, PAX3, CEBPA, MMP1, SOX2, POU3F3, EGR2, NOD1, JAM2, POU5F1, HOXC11, UTF1, HHEX, NR5A1, TCF12, DLX5 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| SOX8, SP1, OLIG2, PAX3, CEBPA, MMP1, SOX2, POU3F3, EGR2, NOD1, JAM2, POU5F1, HOXC11, UTF1, HHEX, NR5A1, TCF12, DLX5 (tumor) | SOX8, SP1, OLIG2, PAX3, CEBPA, MMP1, SOX2, POU3F3, EGR2, NOD1, JAM2, POU5F1, HOXC11, UTF1, HHEX, NR5A1, TCF12, DLX5 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| SOX8, SP1, OLIG2, PAX3, CEBPA, MMP1, SOX2, POU3F3, EGR2, NOD1, JAM2, POU5F1, HOXC11, UTF1, HHEX, NR5A1, TCF12, DLX5 (tumor) | SOX8, SP1, OLIG2, PAX3, CEBPA, MMP1, SOX2, POU3F3, EGR2, NOD1, JAM2, POU5F1, HOXC11, UTF1, HHEX, NR5A1, TCF12, DLX5 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| SOX8, SP1, OLIG2, PAX3, CEBPA, MMP1, SOX2, POU3F3, EGR2, NOD1, JAM2, POU5F1, HOXC11, UTF1, HHEX, NR5A1, TCF12, DLX5 (tumor) | SOX8, SP1, OLIG2, PAX3, CEBPA, MMP1, SOX2, POU3F3, EGR2, NOD1, JAM2, POU5F1, HOXC11, UTF1, HHEX, NR5A1, TCF12, DLX5 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| SOX8, SP1, OLIG2, PAX3, CEBPA, MMP1, SOX2, POU3F3, EGR2, NOD1, JAM2, POU5F1, HOXC11, UTF1, HHEX, NR5A1, TCF12, DLX5 (tumor) | SOX8, SP1, OLIG2, PAX3, CEBPA, MMP1, SOX2, POU3F3, EGR2, NOD1, JAM2, POU5F1, HOXC11, UTF1, HHEX, NR5A1, TCF12, DLX5 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| SOX8, SP1, OLIG2, PAX3, CEBPA, MMP1, SOX2, POU3F3, EGR2, NOD1, JAM2, POU5F1, HOXC11, UTF1, HHEX, NR5A1, TCF12, DLX5 (tumor) | SOX8, SP1, OLIG2, PAX3, CEBPA, MMP1, SOX2, POU3F3, EGR2, NOD1, JAM2, POU5F1, HOXC11, UTF1, HHEX, NR5A1, TCF12, DLX5 (normal) |
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| STAD (tumor) | STAD (normal) |
| SOX8, SP1, OLIG2, PAX3, CEBPA, MMP1, SOX2, POU3F3, EGR2, NOD1, JAM2, POU5F1, HOXC11, UTF1, HHEX, NR5A1, TCF12, DLX5 (tumor) | SOX8, SP1, OLIG2, PAX3, CEBPA, MMP1, SOX2, POU3F3, EGR2, NOD1, JAM2, POU5F1, HOXC11, UTF1, HHEX, NR5A1, TCF12, DLX5 (normal) |
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| THCA (tumor) | THCA (normal) |
| SOX8, SP1, OLIG2, PAX3, CEBPA, MMP1, SOX2, POU3F3, EGR2, NOD1, JAM2, POU5F1, HOXC11, UTF1, HHEX, NR5A1, TCF12, DLX5 (tumor) | SOX8, SP1, OLIG2, PAX3, CEBPA, MMP1, SOX2, POU3F3, EGR2, NOD1, JAM2, POU5F1, HOXC11, UTF1, HHEX, NR5A1, TCF12, DLX5 (normal) |
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| TissGeneProg for SOX8 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for SOX8 |
| TissGeneDrug for SOX8 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for SOX8 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 2 | BeFree |
| umls:C0026769 | Multiple Sclerosis | 2 | BeFree,GAD |
| umls:C0686619 | Secondary malignant neoplasm of lymph node | 2 | BeFree |
| umls:C0026010 | Microphthalmos | 1 | BeFree |
| umls:C0026764 | Multiple Myeloma | 1 | BeFree |
| umls:C0031117 | Peripheral Neuropathy | 1 | BeFree,CTD_human |
| umls:C0086543 | Cataract | 1 | BeFree |
| umls:C0266295 | Congenital hypoplasia of kidney | 1 | BeFree |
| umls:C0475813 | Alpha thalassemia-mental retardation syndrome | 1 | BeFree |
| umls:C0542519 | Congenital absence of kidney | 1 | BeFree |
| umls:C1609433 | Congenital absence of kidneys syndrome | 1 | BeFree |
| umls:C1861922 | CAMPOMELIC DYSPLASIA | 1 | BeFree |
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