TissGDB
Tissglogo

Home

Download

 Statistics

 Landscape

Help

Contact

Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

bullet point

TissGeneSummary

bullet point

TissGeneExp

bullet point

TissGene-miRNA

bullet point

TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

bullet point

TissGeneNet

bullet point

TissGeneProg

bullet point

TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for SOX8
check button Gene summary
Basic gene informationGene symbolSOX8
Gene nameSRY (sex determining region Y)-box 8
Synonyms-
CytomapUCSC genome browser: 16p13.3
Type of geneprotein-coding
RefGenesNM_014587.4,
Descriptiontranscription factor SOX-8
Modification date20141207
dbXrefs MIM : 605923
HGNC : HGNC
Ensembl : ENSG00000005513
HPRD : 16175
Vega : OTTHUMG00000122101
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_SOX8
BioGPS: 30812
PathwayNCI Pathway Interaction Database: SOX8
KEGG: SOX8
REACTOME: SOX8
Pathway Commons: SOX8
ContextiHOP: SOX8
ligand binding site mutation search in PubMed: SOX8
UCL Cancer Institute: SOX8
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesHPA,TiGER
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Brain
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)GBM,LGG
Reference showing the relevant tissue of SOX8
Description by TissGene annotationsProtective TissGene in RFS
Have significant anti-correlated miRNA
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID
GO:0045944positive regulation of transcription from RNA polymerase II promoter10662550
GO:0045944positive regulation of transcription from RNA polymerase II promoter10662550


Top
TissGeneExp for SOX8

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
BLCA-1.8297082550.412775956-2.2424842111.65E-078.74E-06
THCA0.851231799-0.3681393881.2193711862.18E-067.94E-06
BRCA-0.7868731671.516654903-2.303528071.62E-201.21E-19
COAD-0.218422831.143511786-1.3619346150.004280.010465938
KIRP1.068335824-0.8127235511.8810593750.0007410.002110956
HNSC-1.519067373-0.116327839-1.4027395353.30E-050.000166107


Top
TissGene-miRNA for SOX8

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples
LUADhsa-miR-27b-3pMIMAT00004190.028-0.2960
LUADhsa-miR-27a-3pMIMAT00000840.017-0.3160


Top
TissGeneMut for SOX8
TissGeneSNV for SOX8

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
bullet point


check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.N421SLUSC1
p.A190TCOAD1
p.P227LBLCA1
p.H409YHNSC1
p.W316CPAAD1
p.R256SLUSC1
p.K164RLUAD1
p.S186FSKCM1
p.H183QSKCM1
p.T226SLUAD1
p.E272KSTAD1
p.G384SBLCA1
p.G378DLUAD1
p.P426SCOAD1
p.G92VTHYM1
p.P314TLUAD1
p.P426QLUAD1
p.P322RSKCM1
p.E284KKIRC1
p.V273IPAAD1
p.Y169DPRAD1
p.R353QSTAD1
p.M106VLUAD1
p.R174WUCS1
p.R157HSKCM1
p.R412HPAAD1
p.A295TLUSC1
p.R149QBLCA1
p.R174WHNSC1
p.E284ASTAD1
p.P369LSKCM1
p.G199SLUAD1
p.D260NSKCM1


Top
TissGeneCNV for SOX8

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


Top
TissGeneFusions for SOX8

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNAAA242792RPL3-SOX8chr22:39711526chr16:1036443


Top
TissGeneNet for SOX8

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
SOX8, SP1, OLIG2, PAX3, CEBPA, MMP1, SOX2, POU3F3, EGR2, NOD1, JAM2, POU5F1, HOXC11, UTF1, HHEX, NR5A1, TCF12, DLX5 (tumor)SOX8, SP1, OLIG2, PAX3, CEBPA, MMP1, SOX2, POU3F3, EGR2, NOD1, JAM2, POU5F1, HOXC11, UTF1, HHEX, NR5A1, TCF12, DLX5 (normal)
bullet pointbullet point
COAD (tumor)COAD (normal)
SOX8, SP1, OLIG2, PAX3, CEBPA, MMP1, SOX2, POU3F3, EGR2, NOD1, JAM2, POU5F1, HOXC11, UTF1, HHEX, NR5A1, TCF12, DLX5 (tumor)SOX8, SP1, OLIG2, PAX3, CEBPA, MMP1, SOX2, POU3F3, EGR2, NOD1, JAM2, POU5F1, HOXC11, UTF1, HHEX, NR5A1, TCF12, DLX5 (normal)
bullet pointbullet point
HNSC (tumor)HNSC (normal)
SOX8, SP1, OLIG2, PAX3, CEBPA, MMP1, SOX2, POU3F3, EGR2, NOD1, JAM2, POU5F1, HOXC11, UTF1, HHEX, NR5A1, TCF12, DLX5 (tumor)SOX8, SP1, OLIG2, PAX3, CEBPA, MMP1, SOX2, POU3F3, EGR2, NOD1, JAM2, POU5F1, HOXC11, UTF1, HHEX, NR5A1, TCF12, DLX5 (normal)
bullet pointbullet point
KICH (tumor)KICH (normal)
SOX8, SP1, OLIG2, PAX3, CEBPA, MMP1, SOX2, POU3F3, EGR2, NOD1, JAM2, POU5F1, HOXC11, UTF1, HHEX, NR5A1, TCF12, DLX5 (tumor)SOX8, SP1, OLIG2, PAX3, CEBPA, MMP1, SOX2, POU3F3, EGR2, NOD1, JAM2, POU5F1, HOXC11, UTF1, HHEX, NR5A1, TCF12, DLX5 (normal)
bullet pointbullet point
KIRC (tumor)KIRC (normal)
SOX8, SP1, OLIG2, PAX3, CEBPA, MMP1, SOX2, POU3F3, EGR2, NOD1, JAM2, POU5F1, HOXC11, UTF1, HHEX, NR5A1, TCF12, DLX5 (tumor)SOX8, SP1, OLIG2, PAX3, CEBPA, MMP1, SOX2, POU3F3, EGR2, NOD1, JAM2, POU5F1, HOXC11, UTF1, HHEX, NR5A1, TCF12, DLX5 (normal)
bullet pointbullet point
KIRP (tumor)KIRP (normal)
SOX8, SP1, OLIG2, PAX3, CEBPA, MMP1, SOX2, POU3F3, EGR2, NOD1, JAM2, POU5F1, HOXC11, UTF1, HHEX, NR5A1, TCF12, DLX5 (tumor)SOX8, SP1, OLIG2, PAX3, CEBPA, MMP1, SOX2, POU3F3, EGR2, NOD1, JAM2, POU5F1, HOXC11, UTF1, HHEX, NR5A1, TCF12, DLX5 (normal)
bullet pointbullet point
LIHC (tumor)LIHC (normal)
SOX8, SP1, OLIG2, PAX3, CEBPA, MMP1, SOX2, POU3F3, EGR2, NOD1, JAM2, POU5F1, HOXC11, UTF1, HHEX, NR5A1, TCF12, DLX5 (tumor)SOX8, SP1, OLIG2, PAX3, CEBPA, MMP1, SOX2, POU3F3, EGR2, NOD1, JAM2, POU5F1, HOXC11, UTF1, HHEX, NR5A1, TCF12, DLX5 (normal)
bullet pointbullet point
LUAD (tumor)LUAD (normal)
SOX8, SP1, OLIG2, PAX3, CEBPA, MMP1, SOX2, POU3F3, EGR2, NOD1, JAM2, POU5F1, HOXC11, UTF1, HHEX, NR5A1, TCF12, DLX5 (tumor)SOX8, SP1, OLIG2, PAX3, CEBPA, MMP1, SOX2, POU3F3, EGR2, NOD1, JAM2, POU5F1, HOXC11, UTF1, HHEX, NR5A1, TCF12, DLX5 (normal)
bullet pointbullet point
LUSC (tumor)LUSC (normal)
SOX8, SP1, OLIG2, PAX3, CEBPA, MMP1, SOX2, POU3F3, EGR2, NOD1, JAM2, POU5F1, HOXC11, UTF1, HHEX, NR5A1, TCF12, DLX5 (tumor)SOX8, SP1, OLIG2, PAX3, CEBPA, MMP1, SOX2, POU3F3, EGR2, NOD1, JAM2, POU5F1, HOXC11, UTF1, HHEX, NR5A1, TCF12, DLX5 (normal)
bullet pointbullet point
PRAD (tumor)PRAD (normal)
SOX8, SP1, OLIG2, PAX3, CEBPA, MMP1, SOX2, POU3F3, EGR2, NOD1, JAM2, POU5F1, HOXC11, UTF1, HHEX, NR5A1, TCF12, DLX5 (tumor)SOX8, SP1, OLIG2, PAX3, CEBPA, MMP1, SOX2, POU3F3, EGR2, NOD1, JAM2, POU5F1, HOXC11, UTF1, HHEX, NR5A1, TCF12, DLX5 (normal)
bullet pointbullet point
STAD (tumor)STAD (normal)
SOX8, SP1, OLIG2, PAX3, CEBPA, MMP1, SOX2, POU3F3, EGR2, NOD1, JAM2, POU5F1, HOXC11, UTF1, HHEX, NR5A1, TCF12, DLX5 (tumor)SOX8, SP1, OLIG2, PAX3, CEBPA, MMP1, SOX2, POU3F3, EGR2, NOD1, JAM2, POU5F1, HOXC11, UTF1, HHEX, NR5A1, TCF12, DLX5 (normal)
bullet pointbullet point
THCA (tumor)THCA (normal)
SOX8, SP1, OLIG2, PAX3, CEBPA, MMP1, SOX2, POU3F3, EGR2, NOD1, JAM2, POU5F1, HOXC11, UTF1, HHEX, NR5A1, TCF12, DLX5 (tumor)SOX8, SP1, OLIG2, PAX3, CEBPA, MMP1, SOX2, POU3F3, EGR2, NOD1, JAM2, POU5F1, HOXC11, UTF1, HHEX, NR5A1, TCF12, DLX5 (normal)
bullet pointbullet point


Top
TissGeneProg for SOX8

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

Top
TissGeneClin for SOX8
TissGeneDrug for SOX8

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


Top
TissGeneDisease for SOX8

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0007131Non-Small Cell Lung Carcinoma2BeFree
umls:C0026769Multiple Sclerosis2BeFree,GAD
umls:C0686619Secondary malignant neoplasm of lymph node2BeFree
umls:C0026010Microphthalmos1BeFree
umls:C0026764Multiple Myeloma1BeFree
umls:C0031117Peripheral Neuropathy1BeFree,CTD_human
umls:C0086543Cataract1BeFree
umls:C0266295Congenital hypoplasia of kidney1BeFree
umls:C0475813Alpha thalassemia-mental retardation syndrome1BeFree
umls:C0542519Congenital absence of kidney1BeFree
umls:C1609433Congenital absence of kidneys syndrome1BeFree
umls:C1861922CAMPOMELIC DYSPLASIA1BeFree