TissGeneSummary for HMX2 |
Gene summary |
Basic gene information | Gene symbol | HMX2 |
Gene name | H6 family homeobox 2 | |
Synonyms | H6L|Nkx5-2 | |
Cytomap | UCSC genome browser: 10q26.13 | |
Type of gene | protein-coding | |
RefGenes | NM_005519.1, | |
Description | homeo box (H6 family) 2homeobox protein H6 family member 2homeobox protein HMX2 | |
Modification date | 20141207 | |
dbXrefs | MIM : 600647 | |
HGNC : HGNC | ||
Ensembl : ENSG00000188816 | ||
HPRD : 18780 | ||
Vega : OTTHUMG00000019198 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_HMX2 | |
BioGPS: 3167 | ||
Pathway | NCI Pathway Interaction Database: HMX2 | |
KEGG: HMX2 | ||
REACTOME: HMX2 | ||
Pathway Commons: HMX2 | ||
Context | iHOP: HMX2 | |
ligand binding site mutation search in PubMed: HMX2 | ||
UCL Cancer Institute: HMX2 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Kidney | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICH | |
Reference showing the relevant tissue of HMX2 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for HMX2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KICH | -2.926203501 | 0.189268499 | -3.115472 | 1.93E-06 | 6.96E-06 |
COAD | -2.637822578 | -0.395168731 | -2.242653846 | 1.23E-13 | 4.08E-12 |
LUSC | -1.675083814 | -2.897852442 | 1.222768627 | 1.19E-05 | 2.68E-05 |
KIRC | -2.813396723 | 0.192462999 | -3.005859722 | 2.84E-18 | 1.90E-17 |
KIRP | -2.825171376 | 1.554216124 | -4.3793875 | 1.35E-11 | 1.83E-10 |
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TissGene-miRNA for HMX2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for HMX2 |
TissGeneSNV for HMX2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.P12L | STAD | 1 |
p.S209L | COAD | 1 |
p.P87S | SKCM | 1 |
p.F66V | STAD | 1 |
p.S221L | BLCA | 1 |
p.E142K | HNSC | 1 |
p.R179H | STAD | 1 |
p.G96R | LUAD | 1 |
p.P229L | COAD | 1 |
p.G16C | ACC | 1 |
p.S184C | BLCA | 1 |
p.V226M | COAD | 1 |
p.Y173H | LIHC | 1 |
p.P131L | SARC | 1 |
p.R35W | UCEC | 1 |
p.S227I | LUAD | 1 |
p.G16V | ACC | 1 |
p.R201H | LGG | 1 |
p.S110Y | UCEC | 1 |
p.K93E | PAAD | 1 |
p.S260L | ACC | 1 |
p.R200C | BLCA | 1 |
p.P73L | BLCA | 1 |
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TissGeneCNV for HMX2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for HMX2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for HMX2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for HMX2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for HMX2 |
TissGeneDrug for HMX2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for HMX2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |