TissGeneSummary for KLHL10 |
Gene summary |
Basic gene information | Gene symbol | KLHL10 |
Gene name | kelch-like family member 10 | |
Synonyms | SPGF11 | |
Cytomap | UCSC genome browser: 17q21.2 | |
Type of gene | protein-coding | |
RefGenes | NM_152467.3, | |
Description | kelch-like 10kelch-like protein 10 | |
Modification date | 20141207 | |
dbXrefs | MIM : 608778 | |
HGNC : HGNC | ||
Ensembl : ENSG00000161594 | ||
HPRD : 12296 | ||
Vega : OTTHUMG00000152510 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_KLHL10 | |
BioGPS: 317719 | ||
Pathway | NCI Pathway Interaction Database: KLHL10 | |
KEGG: KLHL10 | ||
REACTOME: KLHL10 | ||
Pathway Commons: KLHL10 | ||
Context | iHOP: KLHL10 | |
ligand binding site mutation search in PubMed: KLHL10 | ||
UCL Cancer Institute: KLHL10 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | ||
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of KLHL10 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for KLHL10 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
THCA | 0.272641898 | 1.39150461 | -1.118862712 | 4.45E-12 | 3.54E-11 |
BRCA | -0.679564748 | 0.701419463 | -1.380984211 | 6.02E-37 | 1.30E-35 |
STAD | -1.03134682 | 0.39789068 | -1.4292375 | 0.000133 | 0.000997057 |
BLCA | -0.938667379 | 0.648916831 | -1.587584211 | 3.50E-05 | 0.000495473 |
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TissGene-miRNA for KLHL10 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for KLHL10 |
TissGeneSNV for KLHL10 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.D552N | UCEC | 2 |
p.M245I | BLCA | 1 |
p.S252N | COAD | 1 |
p.D489H | BLCA | 1 |
p.D559Y | ESCA | 1 |
p.V572E | ACC | 1 |
p.Y389H | COAD | 1 |
p.D425N | PRAD | 1 |
p.G487D | UCEC | 1 |
p.P511R | BRCA | 1 |
p.E130K | LUSC | 1 |
p.R329S | THCA | 1 |
p.W299C | STAD | 1 |
p.D88V | LUAD | 1 |
p.V369A | LGG | 1 |
p.G345E | SKCM | 1 |
p.A417T | STAD | 1 |
p.S380G | UCS | 1 |
p.D201Y | UCEC | 1 |
p.A307D | COAD | 1 |
p.E580X | ESCA | 1 |
p.S568R | LIHC | 1 |
p.N519I | LGG | 1 |
p.R493Q | UCEC | 1 |
p.G490R | LUAD | 1 |
p.E523Q | SKCM | 1 |
p.D193G | LIHC | 1 |
p.M271T | PRAD | 1 |
p.G433W | KIRC | 1 |
p.E76K | SKCM | 1 |
p.S62C | CESC | 1 |
p.A236V | PRAD | 1 |
p.T551I | SKCM | 1 |
p.S277P | STAD | 1 |
p.V41M | CESC | 1 |
p.D559H | LUSC | 1 |
p.R376H | LUAD | 1 |
p.R508C | ACC | 1 |
p.A576T | COAD | 1 |
p.P106L | LIHC | 1 |
p.C255Y | UCEC | 1 |
p.E180D | ESCA | 1 |
p.D107N | STAD | 1 |
p.R287C | STAD | 1 |
p.S252N | UCEC | 1 |
p.G36D | PAAD | 1 |
p.D268H | OV | 1 |
p.L112Q | LUAD | 1 |
p.A23V | HNSC | 1 |
p.A428T | PAAD | 1 |
p.A307V | THYM | 1 |
p.D348G | STAD | 1 |
p.A428T | LGG | 1 |
p.D526N | SKCM | 1 |
p.A23V | PRAD | 1 |
p.D193H | LUSC | 1 |
p.E237X | ESCA | 1 |
p.M1T | LUAD | 1 |
p.R470S | BLCA | 1 |
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TissGeneCNV for KLHL10 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for KLHL10 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BE162856 | KLHL10-GNPDA1 | chr17:40001339 | chr5:141380648 |
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TissGeneNet for KLHL10 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for KLHL10 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for KLHL10 |
TissGeneDrug for KLHL10 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for KLHL10 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0004509 | Azoospermia | 1 | GAD |
umls:C0021364 | Male infertility | 1 | BeFree |
umls:C0028960 | Oligospermia | 1 | GAD |
umls:C0403823 | Asthenozoospermia | 1 | GAD |
umls:C3554453 | SPERMATOGENIC FAILURE 11 | 1 | CLINVAR,UNIPROT |