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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for KLHL10
check button Gene summary
Basic gene informationGene symbolKLHL10
Gene namekelch-like family member 10
SynonymsSPGF11
CytomapUCSC genome browser: 17q21.2
Type of geneprotein-coding
RefGenesNM_152467.3,
Descriptionkelch-like 10kelch-like protein 10
Modification date20141207
dbXrefs MIM : 608778
HGNC : HGNC
Ensembl : ENSG00000161594
HPRD : 12296
Vega : OTTHUMG00000152510
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_KLHL10
BioGPS: 317719
PathwayNCI Pathway Interaction Database: KLHL10
KEGG: KLHL10
REACTOME: KLHL10
Pathway Commons: KLHL10
ContextiHOP: KLHL10
ligand binding site mutation search in PubMed: KLHL10
UCL Cancer Institute: KLHL10
Assigned class in TissGDB*B
Included tissue-specific gene expression resources
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Testis
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)TGCT
Reference showing the relevant tissue of KLHL10
Description by TissGene annotations
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


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TissGeneExp for KLHL10

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
THCA0.2726418981.39150461-1.1188627124.45E-123.54E-11
BRCA-0.6795647480.701419463-1.3809842116.02E-371.30E-35
STAD-1.031346820.39789068-1.42923750.0001330.000997057
BLCA-0.9386673790.648916831-1.5875842113.50E-050.000495473


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TissGene-miRNA for KLHL10

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for KLHL10
TissGeneSNV for KLHL10

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.D552NUCEC2
p.M245IBLCA1
p.S252NCOAD1
p.D489HBLCA1
p.D559YESCA1
p.V572EACC1
p.Y389HCOAD1
p.D425NPRAD1
p.G487DUCEC1
p.P511RBRCA1
p.E130KLUSC1
p.R329STHCA1
p.W299CSTAD1
p.D88VLUAD1
p.V369ALGG1
p.G345ESKCM1
p.A417TSTAD1
p.S380GUCS1
p.D201YUCEC1
p.A307DCOAD1
p.E580XESCA1
p.S568RLIHC1
p.N519ILGG1
p.R493QUCEC1
p.G490RLUAD1
p.E523QSKCM1
p.D193GLIHC1
p.M271TPRAD1
p.G433WKIRC1
p.E76KSKCM1
p.S62CCESC1
p.A236VPRAD1
p.T551ISKCM1
p.S277PSTAD1
p.V41MCESC1
p.D559HLUSC1
p.R376HLUAD1
p.R508CACC1
p.A576TCOAD1
p.P106LLIHC1
p.C255YUCEC1
p.E180DESCA1
p.D107NSTAD1
p.R287CSTAD1
p.S252NUCEC1
p.G36DPAAD1
p.D268HOV1
p.L112QLUAD1
p.A23VHNSC1
p.A428TPAAD1
p.A307VTHYM1
p.D348GSTAD1
p.A428TLGG1
p.D526NSKCM1
p.A23VPRAD1
p.D193HLUSC1
p.E237XESCA1
p.M1TLUAD1
p.R470SBLCA1


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TissGeneCNV for KLHL10

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for KLHL10

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNABE162856KLHL10-GNPDA1chr17:40001339chr5:141380648


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TissGeneNet for KLHL10

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)


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TissGeneProg for KLHL10

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for KLHL10
TissGeneDrug for KLHL10

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for KLHL10

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0004509Azoospermia1GAD
umls:C0021364Male infertility1BeFree
umls:C0028960Oligospermia1GAD
umls:C0403823Asthenozoospermia1GAD
umls:C3554453SPERMATOGENIC FAILURE 111CLINVAR,UNIPROT