TissGeneSummary for C14orf39 |
Gene summary |
Basic gene information | Gene symbol | C14orf39 |
Gene name | chromosome 14 open reading frame 39 | |
Synonyms | Six6os1 | |
Cytomap | UCSC genome browser: 14q23.1 | |
Type of gene | protein-coding | |
RefGenes | NM_174978.2, | |
Description | protein SIX6OS1six6 opposite strand transcript 1 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000179008 | ||
HPRD : 08504 | ||
Vega : OTTHUMG00000140332 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_C14orf39 | |
BioGPS: 317761 | ||
Pathway | NCI Pathway Interaction Database: C14orf39 | |
KEGG: C14orf39 | ||
REACTOME: C14orf39 | ||
Pathway Commons: C14orf39 | ||
Context | iHOP: C14orf39 | |
ligand binding site mutation search in PubMed: C14orf39 | ||
UCL Cancer Institute: C14orf39 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of C14orf39 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for C14orf39 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
STAD | -2.079676046 | -0.351141671 | -1.728534375 | 0.000183 | 0.001302427 |
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TissGene-miRNA for C14orf39 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for C14orf39 |
TissGeneSNV for C14orf39 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E452K | SKCM | 3 |
p.D74G | SARC | 2 |
p.D322N | SKCM | 2 |
p.I566T | LUAD | 2 |
p.V463L | LIHC | 2 |
p.A459T | BLCA | 1 |
p.E416K | BLCA | 1 |
p.E219X | COAD | 1 |
p.N486H | UCEC | 1 |
p.Y92C | DLBC | 1 |
p.N75T | COAD | 1 |
p.L277F | CESC | 1 |
p.E303K | KIRC | 1 |
p.E468K | SKCM | 1 |
p.D107H | CESC | 1 |
p.D378N | SKCM | 1 |
p.E120X | READ | 1 |
p.Q94E | LIHC | 1 |
p.F97V | READ | 1 |
p.K289Q | UCEC | 1 |
p.F400V | UCEC | 1 |
p.E387* | BLCA | 1 |
p.E61K | SKCM | 1 |
p.E387K | UCEC | 1 |
p.H112Y | SKCM | 1 |
p.I497V | STAD | 1 |
p.N44K | SARC | 1 |
p.R170* | GBM | 1 |
p.P470L | SKCM | 1 |
p.R286K | UVM | 1 |
p.E53K | STAD | 1 |
p.E28K | GBM | 1 |
p.T58I | LIHC | 1 |
p.G532C | LUAD | 1 |
p.R386K | BLCA | 1 |
p.R353G | STAD | 1 |
p.R136H | STAD | 1 |
p.R87C | READ | 1 |
p.Y125F | KIRC | 1 |
p.K80N | GBM | 1 |
p.E60K | BLCA | 1 |
p.D552A | STAD | 1 |
p.E28* | UCEC | 1 |
p.Q358R | KIRC | 1 |
p.P425L | SKCM | 1 |
p.S206* | ESCA | 1 |
p.A298E | ACC | 1 |
p.R136C | SARC | 1 |
p.D407N | SKCM | 1 |
p.G529E | SKCM | 1 |
p.R87H | PAAD | 1 |
p.E219* | UCEC | 1 |
p.V99I | COAD | 1 |
p.Q501K | LUSC | 1 |
p.V382I | UCEC | 1 |
p.P437L | SKCM | 1 |
p.R455I | HNSC | 1 |
p.L236I | READ | 1 |
p.S469F | SKCM | 1 |
p.D540G | LUAD | 1 |
p.D63N | SKCM | 1 |
p.S469C | CESC | 1 |
p.E423K | HNSC | 1 |
p.D194Y | UCEC | 1 |
p.Q561R | HNSC | 1 |
p.W79* | SARC | 1 |
p.F502L | UCEC | 1 |
p.V404A | BLCA | 1 |
p.S565L | SKCM | 1 |
p.R143I | UCEC | 1 |
p.D194H | BLCA | 1 |
p.F574Y | SKCM | 1 |
p.S206X | ESCA | 1 |
p.E109X | COAD | 1 |
p.T82I | SARC | 1 |
p.E252K | UCEC | 1 |
p.R87C | CESC | 1 |
p.E452K | UCEC | 1 |
p.S367L | COAD | 1 |
p.S206L | SKCM | 1 |
p.T545I | OV | 1 |
p.M167I | SKCM | 1 |
p.F502_splice | UCEC | 1 |
p.L178P | LUAD | 1 |
p.D378H | SKCM | 1 |
p.Q101* | BLCA | 1 |
p.G529* | STAD | 1 |
p.N35T | UCEC | 1 |
p.K141N | COAD | 1 |
p.I520L | BRCA | 1 |
p.G562D | SKCM | 1 |
p.R414T | LIHC | 1 |
p.D489G | PAAD | 1 |
p.R455K | READ | 1 |
p.P174L | SKCM | 1 |
p.L354F | LUSC | 1 |
p.R77I | ESCA | 1 |
p.R455I | READ | 1 |
p.F557Y | STAD | 1 |
p.P556S | SKCM | 1 |
p.D10N | SKCM | 1 |
p.R87C | SKCM | 1 |
p.E412Q | BLCA | 1 |
p.T421M | READ | 1 |
p.S575L | SKCM | 1 |
p.E466V | HNSC | 1 |
p.Q561E | OV | 1 |
p.G370E | SKCM | 1 |
p.E252* | UCEC | 1 |
p.S558L | SKCM | 1 |
p.C116R | LUAD | 1 |
p.E466K | SKCM | 1 |
p.R170* | BRCA | 1 |
p.P470S | SKCM | 1 |
p.L475I | READ | 1 |
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TissGeneCNV for C14orf39 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for C14orf39 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
TCGAfusionPortal | PRADA | LUAD | TCGA-78-7143-01A | DCAF5-C14orf39 | Out-of-frame | Chr14:69558391 | Chr14:60938457 |
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TissGeneNet for C14orf39 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for C14orf39 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for C14orf39 |
TissGeneDrug for C14orf39 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for C14orf39 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0034951 | Refractive Errors | 1 | GWASCAT |