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| TissGeneSummary for HOXB6 |
 Gene summary |
| Basic gene information | Gene symbol | HOXB6 |
| Gene name | homeobox B6 | |
| Synonyms | HOX2|HOX2B|HU-2|Hox-2.2 | |
| Cytomap | UCSC genome browser: 17q21.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_018952.4, NM_156036.1,NM_156037.1, | |
| Description | homeo box 2Bhomeo box B6homeobox protein Hox-2.2homeobox protein Hox-2Bhomeobox protein Hox-B6homeobox protein Hu-2 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 142961 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000108511 | ||
| HPRD : 00849 | ||
| Vega : OTTHUMG00000159912 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_HOXB6 | |
| BioGPS: 3216 | ||
| Pathway | NCI Pathway Interaction Database: HOXB6 | |
| KEGG: HOXB6 | ||
| REACTOME: HOXB6 | ||
| Pathway Commons: HOXB6 | ||
| Context | iHOP: HOXB6 | |
| ligand binding site mutation search in PubMed: HOXB6 | ||
| UCL Cancer Institute: HOXB6 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | ColonKidney | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | COADKIRC,KIRP,KICH | |
| Reference showing the relevant tissue of HOXB6 | ||
| Description by TissGene annotations | Protective TissGene in OS Risk TissGene in RFS Protective TissGene in RFS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for HOXB6 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRP | 1.934273881 | 3.496148881 | -1.561875 | 1.95E-05 | 7.70E-05 |
| KIRC | 0.814220408 | 3.39141902 | -2.577198611 | 2.15E-35 | 5.95E-34 |
| HNSC | -1.909016962 | -3.817516962 | 1.9085 | 2.10E-08 | 2.34E-07 |
| KICH | 2.969503131 | 4.062259131 | -1.092756 | 6.14E-06 | 2.02E-05 |
| ESCA | 1.155755131 | -1.809981233 | 2.965736364 | 0.00648 | 0.046943062 |
| BLCA | 0.594944604 | -0.876476448 | 1.471421053 | 0.00453 | 0.024632567 |
| STAD | 1.715798881 | 0.143811381 | 1.5719875 | 0.00313 | 0.013207073 |
| PRAD | -3.210391023 | -1.747981408 | -1.462409615 | 0.00149 | 0.004549169 |
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| TissGene-miRNA for HOXB6 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for HOXB6 |
| TissGeneSNV for HOXB6 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.G143V | LUAD | 1 |
| p.R176C | THYM | 1 |
| p.S106P | LUAD | 1 |
| p.S3T | LIHC | 1 |
| p.W201* | HNSC | 1 |
| p.E178K | SKCM | 1 |
| p.E187* | SKCM | 1 |
| p.E216K | STAD | 1 |
| p.D107Y | LUAD | 1 |
| p.R176L | LUSC | 1 |
| p.S140F | HNSC | 1 |
| p.E117K | BLCA | 1 |
| p.K163E | LIHC | 1 |
| p.S91F | BLCA | 1 |
| p.R150C | STAD | 1 |
| p.T13P | BLCA | 1 |
| p.Q212* | HNSC | 1 |
| p.R148L | LUAD | 1 |
| p.R148Q | BLCA | 1 |
| p.E216K | BLCA | 1 |
| p.S141F | CESC | 1 |
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| TissGeneCNV for HOXB6 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for HOXB6 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | FusionScan | BRCA | TCGA-BH-A0AW-01A | HOXB6-LYRM1 | 5'UTR-CDS | chr17:46681841 | chr16:20931443 |
| Chimerdb3.0 | FusionScan | OV | TCGA-VG-A8LO-01A | HOXB6-TEC | 5'UTR-5'UTR | chr17:46681841 | chr4:48230676 |
| Chimerdb3.0 | FusionScan | DLBC | TCGA-FF-8047-01A | HOXB6-PITPNC1 | 5'UTR-CDS | chr17:46681841 | chr17:65528917 |
| Chimerdb3.0 | TopHat-Fusion | LGG | TCGA-P5-A5EV-01A | MAPT-HOXB6 | 5'UTR-5'UTR | chr17:44096095 | chr17:46677808 |
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| TissGeneNet for HOXB6 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| HOXB6, PLSCR1, CREBBP, EP300, RAB3GAP2, CSNK2B, HOXB7, SAT1, KRT15, TCEAL1, TCF21, ALX4, PKNOX1 (tumor) | HOXB6, PLSCR1, CREBBP, EP300, RAB3GAP2, CSNK2B, HOXB7, SAT1, KRT15, TCEAL1, TCF21, ALX4, PKNOX1 (normal) |
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| COAD (tumor) | COAD (normal) |
| HOXB6, PLSCR1, CREBBP, EP300, RAB3GAP2, CSNK2B, HOXB7, SAT1, KRT15, TCEAL1, TCF21, ALX4, PKNOX1 (tumor) | HOXB6, PLSCR1, CREBBP, EP300, RAB3GAP2, CSNK2B, HOXB7, SAT1, KRT15, TCEAL1, TCF21, ALX4, PKNOX1 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| HOXB6, PLSCR1, CREBBP, EP300, RAB3GAP2, CSNK2B, HOXB7, SAT1, KRT15, TCEAL1, TCF21, ALX4, PKNOX1 (tumor) | HOXB6, PLSCR1, CREBBP, EP300, RAB3GAP2, CSNK2B, HOXB7, SAT1, KRT15, TCEAL1, TCF21, ALX4, PKNOX1 (normal) |
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| KICH (tumor) | KICH (normal) |
| HOXB6, PLSCR1, CREBBP, EP300, RAB3GAP2, CSNK2B, HOXB7, SAT1, KRT15, TCEAL1, TCF21, ALX4, PKNOX1 (tumor) | HOXB6, PLSCR1, CREBBP, EP300, RAB3GAP2, CSNK2B, HOXB7, SAT1, KRT15, TCEAL1, TCF21, ALX4, PKNOX1 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| HOXB6, PLSCR1, CREBBP, EP300, RAB3GAP2, CSNK2B, HOXB7, SAT1, KRT15, TCEAL1, TCF21, ALX4, PKNOX1 (tumor) | HOXB6, PLSCR1, CREBBP, EP300, RAB3GAP2, CSNK2B, HOXB7, SAT1, KRT15, TCEAL1, TCF21, ALX4, PKNOX1 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| HOXB6, PLSCR1, CREBBP, EP300, RAB3GAP2, CSNK2B, HOXB7, SAT1, KRT15, TCEAL1, TCF21, ALX4, PKNOX1 (tumor) | HOXB6, PLSCR1, CREBBP, EP300, RAB3GAP2, CSNK2B, HOXB7, SAT1, KRT15, TCEAL1, TCF21, ALX4, PKNOX1 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| HOXB6, PLSCR1, CREBBP, EP300, RAB3GAP2, CSNK2B, HOXB7, SAT1, KRT15, TCEAL1, TCF21, ALX4, PKNOX1 (tumor) | HOXB6, PLSCR1, CREBBP, EP300, RAB3GAP2, CSNK2B, HOXB7, SAT1, KRT15, TCEAL1, TCF21, ALX4, PKNOX1 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| HOXB6, PLSCR1, CREBBP, EP300, RAB3GAP2, CSNK2B, HOXB7, SAT1, KRT15, TCEAL1, TCF21, ALX4, PKNOX1 (tumor) | HOXB6, PLSCR1, CREBBP, EP300, RAB3GAP2, CSNK2B, HOXB7, SAT1, KRT15, TCEAL1, TCF21, ALX4, PKNOX1 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| HOXB6, PLSCR1, CREBBP, EP300, RAB3GAP2, CSNK2B, HOXB7, SAT1, KRT15, TCEAL1, TCF21, ALX4, PKNOX1 (tumor) | HOXB6, PLSCR1, CREBBP, EP300, RAB3GAP2, CSNK2B, HOXB7, SAT1, KRT15, TCEAL1, TCF21, ALX4, PKNOX1 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| HOXB6, PLSCR1, CREBBP, EP300, RAB3GAP2, CSNK2B, HOXB7, SAT1, KRT15, TCEAL1, TCF21, ALX4, PKNOX1 (tumor) | HOXB6, PLSCR1, CREBBP, EP300, RAB3GAP2, CSNK2B, HOXB7, SAT1, KRT15, TCEAL1, TCF21, ALX4, PKNOX1 (normal) |
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| STAD (tumor) | STAD (normal) |
| HOXB6, PLSCR1, CREBBP, EP300, RAB3GAP2, CSNK2B, HOXB7, SAT1, KRT15, TCEAL1, TCF21, ALX4, PKNOX1 (tumor) | HOXB6, PLSCR1, CREBBP, EP300, RAB3GAP2, CSNK2B, HOXB7, SAT1, KRT15, TCEAL1, TCF21, ALX4, PKNOX1 (normal) |
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| THCA (tumor) | THCA (normal) |
| HOXB6, PLSCR1, CREBBP, EP300, RAB3GAP2, CSNK2B, HOXB7, SAT1, KRT15, TCEAL1, TCF21, ALX4, PKNOX1 (tumor) | HOXB6, PLSCR1, CREBBP, EP300, RAB3GAP2, CSNK2B, HOXB7, SAT1, KRT15, TCEAL1, TCF21, ALX4, PKNOX1 (normal) |
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| TissGeneProg for HOXB6 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for HOXB6 |
| TissGeneDrug for HOXB6 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for HOXB6 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0009402 | Colorectal Carcinoma | 2 | BeFree |
| umls:C0023467 | Leukemia, Myelocytic, Acute | 2 | BeFree |
| umls:C0206659 | Embryonal Carcinoma | 2 | BeFree |
| umls:C1527249 | Colorectal Cancer | 2 | BeFree |
| umls:C1861922 | CAMPOMELIC DYSPLASIA | 2 | BeFree |
| umls:C0007134 | Renal Cell Carcinoma | 1 | BeFree |
| umls:C0023440 | Acute Erythroblastic Leukemia | 1 | BeFree |
| umls:C0027831 | Neurofibromatosis 1 | 1 | BeFree |
| umls:C0035412 | Rhabdomyosarcoma | 1 | BeFree |
| umls:C0848558 | Hypospadias | 1 | BeFree,GAD |
| umls:C0878500 | Intraepithelial Neoplasia | 1 | BeFree |
| umls:C0919267 | ovarian neoplasm | 1 | BeFree |
| umls:C1378703 | Renal carcinoma | 1 | BeFree |
| umls:C1691215 | Penile hypospadias | 1 | BeFree |
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