TissGeneSummary for HPX |
Gene summary |
Basic gene information | Gene symbol | HPX |
Gene name | hemopexin | |
Synonyms | HX | |
Cytomap | UCSC genome browser: 11p15.5-p15.4 | |
Type of gene | protein-coding | |
RefGenes | NM_000613.2, | |
Description | beta-1B-glycoprotein | |
Modification date | 20141207 | |
dbXrefs | MIM : 142290 | |
HGNC : HGNC | ||
Ensembl : ENSG00000110169 | ||
HPRD : 00793 | ||
Vega : OTTHUMG00000133399 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_HPX | |
BioGPS: 3263 | ||
Pathway | NCI Pathway Interaction Database: HPX | |
KEGG: HPX | ||
REACTOME: HPX | ||
Pathway Commons: HPX | ||
Context | iHOP: HPX | |
ligand binding site mutation search in PubMed: HPX | ||
UCL Cancer Institute: HPX | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
Reference showing the relevant tissue of HPX | ||
Description by TissGene annotations | TissgsKTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for HPX |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LIHC | 10.43960979 | 12.85111779 | -2.411508 | 3.73E-08 | 2.91E-07 |
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TissGene-miRNA for HPX |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for HPX |
TissGeneSNV for HPX |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.G424S | STAD | 2 |
p.R239S | LUAD | 1 |
p.K332N | LUAD | 1 |
p.A99D | UCEC | 1 |
p.L285V | HNSC | 1 |
p.A362V | HNSC | 1 |
p.E125D | COAD | 1 |
p.A100T | PAAD | 1 |
p.E153K | LGG | 1 |
p.T47A | LUAD | 1 |
p.P28_splice | GBM | 1 |
p.S95N | STAD | 1 |
p.P8L | SKCM | 1 |
p.W301C | LUAD | 1 |
p.G33E | SKCM | 1 |
p.R256C | STAD | 1 |
p.D404N | UCS | 1 |
p.H238R | COAD | 1 |
p.A444S | LUAD | 1 |
p.T24S | LUAD | 1 |
p.R284H | UCEC | 1 |
p.S417L | LUAD | 1 |
p.F101Y | SKCM | 1 |
p.E135A | UCEC | 1 |
p.G424D | SKCM | 1 |
p.D290N | SKCM | 1 |
p.A362V | PAAD | 1 |
p.L457H | THCA | 1 |
p.C257Y | UCEC | 1 |
p.L61Q | LUAD | 1 |
p.G405R | PRAD | 1 |
p.P137L | SKCM | 1 |
p.D45G | UCEC | 1 |
p.R102C | STAD | 1 |
p.P342L | ESCA | 1 |
p.P142L | SKCM | 1 |
p.M409T | HNSC | 1 |
p.P28S | SKCM | 1 |
p.Y198C | LUAD | 1 |
p.H353Y | BLCA | 1 |
p.P27S | SKCM | 1 |
p.W90* | BLCA | 1 |
p.A363V | CESC | 1 |
p.L13F | LUSC | 1 |
p.G245E | SKCM | 1 |
p.A58V | UCEC | 1 |
p.E157K | ESCA | 1 |
p.W292L | LUAD | 1 |
p.R234I | LUAD | 1 |
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TissGeneCNV for HPX |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for HPX |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | H95581 | HPX-R3HDM1 | chr11:6452330 | chr2:136396526 |
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TissGeneNet for HPX |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for HPX |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for HPX |
TissGeneDrug for HPX |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for HPX |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0023903 | Liver neoplasms | 3 | BeFree |
umls:C2239176 | Liver carcinoma | 3 | BeFree |
umls:C0013264 | Muscular Dystrophy, Duchenne | 2 | BeFree |
umls:C0023434 | Chronic Lymphocytic Leukemia | 2 | BeFree |
umls:C0678222 | Breast Carcinoma | 2 | BeFree |
umls:C0002452 | Amelogenesis Imperfecta | 1 | BeFree |
umls:C0002895 | Anemia, Sickle Cell | 1 | BeFree |
umls:C0003864 | Arthritis | 1 | BeFree |
umls:C0004364 | Autoimmune Diseases | 1 | CTD_human |
umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
umls:C0007124 | Noninfiltrating Intraductal Carcinoma | 1 | BeFree |
umls:C0009492 | Compartment syndromes | 1 | CTD_human |
umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | CTD_human |
umls:C0014072 | Experimental Autoimmune Encephalomyelitis | 1 | BeFree |
umls:C0024535 | Malaria, Falciparum | 1 | BeFree |
umls:C0027721 | Lipoid nephrosis | 1 | LHGDN |
umls:C0027726 | Nephrotic Syndrome | 1 | LHGDN |
umls:C0029882 | Otitis Media | 1 | BeFree |
umls:C0033578 | Prostatic Neoplasms | 1 | BeFree |
umls:C0596263 | Carcinogenesis | 1 | BeFree |
umls:C0741916 | Cardiac defects | 1 | BeFree |
umls:C0742343 | Acute Chest Syndrome | 1 | BeFree |
umls:C0860207 | Drug-Induced Liver Injury | 1 | CTD_human |
umls:C0917715 | Hajdu-Cheney Syndrome | 1 | BeFree |
umls:C1704321 | Nephrotic Syndrome, Minimal Change | 1 | BeFree |
umls:C2827407 | Infectious Otitis Media | 1 | BeFree |