TissGeneSummary for HSPA1L |
Gene summary |
Basic gene information | Gene symbol | HSPA1L |
Gene name | heat shock 70kDa protein 1-like | |
Synonyms | HSP70-1L|HSP70-HOM|HSP70T|hum70t | |
Cytomap | UCSC genome browser: 6p21.3 | |
Type of gene | protein-coding | |
RefGenes | NM_005527.3, | |
Description | heat shock 10kDa protein 1-likeheat shock 70 kDa protein 1-Homheat shock 70 kDa protein 1-likeheat shock 70 kDa protein 1Lheat shock 70kD protein-like 1 | |
Modification date | 20141207 | |
dbXrefs | MIM : 140559 | |
HGNC : HGNC | ||
Ensembl : ENSG00000204390 | ||
HPRD : 00776 | ||
Vega : OTTHUMG00000031208 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_HSPA1L | |
BioGPS: 3305 | ||
Pathway | NCI Pathway Interaction Database: HSPA1L | |
KEGG: HSPA1L | ||
REACTOME: HSPA1L | ||
Pathway Commons: HSPA1L | ||
Context | iHOP: HSPA1L | |
ligand binding site mutation search in PubMed: HSPA1L | ||
UCL Cancer Institute: HSPA1L | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of HSPA1L | ||
Description by TissGene annotations | Cancer gene TissgsLTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0042026 | protein refolding | 21231916 | GO:0042026 | protein refolding | 21231916 |
Top |
TissGeneExp for HSPA1L |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
Top |
TissGene-miRNA for HSPA1L |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
Top |
TissGeneMut for HSPA1L |
TissGeneSNV for HSPA1L |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.K389N | CESC | 3 |
p.S241N | CESC | 2 |
p.E516K | BLCA | 1 |
p.H25R | STAD | 1 |
p.T132I | CESC | 1 |
p.E99K | LUAD | 1 |
p.N64H | LGG | 1 |
p.D481N | BLCA | 1 |
p.R249K | SKCM | 1 |
p.L239V | COAD | 1 |
p.G138S | SKCM | 1 |
p.T633I | LUAD | 1 |
p.L126F | HNSC | 1 |
p.R535W | LUSC | 1 |
p.L458Q | LUAD | 1 |
p.G409E | LIHC | 1 |
p.E602D | LUAD | 1 |
p.P620A | SKCM | 1 |
p.V262M | COAD | 1 |
p.E320K | HNSC | 1 |
p.G191C | READ | 1 |
p.G26R | LUAD | 1 |
p.G510S | SKCM | 1 |
p.P607L | LUAD | 1 |
p.V84D | HNSC | 1 |
p.Q603H | HNSC | 1 |
p.R324W | LUAD | 1 |
p.S277L | SKCM | 1 |
p.E99D | CESC | 1 |
p.A181V | THCA | 1 |
p.E119* | LIHC | 1 |
p.R350Q | CESC | 1 |
p.G232E | SKCM | 1 |
p.Y445H | LIHC | 1 |
p.R303Q | LIHC | 1 |
p.E246Q | OV | 1 |
p.D595H | BLCA | 1 |
p.L13P | STAD | 1 |
p.A182S | LUAD | 1 |
p.E578Q | BRCA | 1 |
p.G623R | LUSC | 1 |
p.D236N | LUAD | 1 |
p.G193R | SKCM | 1 |
p.G623R | COAD | 1 |
p.Q475E | BLCA | 1 |
p.V262M | SKCM | 1 |
p.R324Q | SKCM | 1 |
p.L457P | SKCM | 1 |
p.A375D | LGG | 1 |
p.E99K | SKCM | 1 |
p.V473I | COAD | 1 |
p.R418H | PRAD | 1 |
p.R511H | PRAD | 1 |
p.N283S | CESC | 1 |
p.S123L | BLCA | 1 |
p.G472R | SKCM | 1 |
p.Q614H | SKCM | 1 |
p.S581L | COAD | 1 |
p.A408S | LUAD | 1 |
p.P467S | SKCM | 1 |
p.S277L | DLBC | 1 |
p.A414D | HNSC | 1 |
p.P149S | STAD | 1 |
p.K389R | HNSC | 1 |
p.I255S | LIHC | 1 |
p.G634D | LUAD | 1 |
p.E532K | BLCA | 1 |
p.E545X | COAD | 1 |
p.S420C | BLCA | 1 |
p.G77D | BLCA | 1 |
p.T40I | KIRC | 1 |
p.D215E | SKCM | 1 |
p.M328I | SKCM | 1 |
p.K541N | UCEC | 1 |
p.P178R | OV | 1 |
p.D12N | UCEC | 1 |
p.G341D | LUAD | 1 |
p.S123L | UCEC | 1 |
p.T424N | LGG | 1 |
p.D325N | BLCA | 1 |
p.G186D | UCEC | 1 |
p.R263G | READ | 1 |
p.H139Y | CESC | 1 |
p.D595N | BLCA | 1 |
p.R359C | ESCA | 1 |
p.S581L | SKCM | 1 |
p.V500A | CESC | 1 |
p.Q281H | GBM | 1 |
p.P400S | BLCA | 1 |
p.D531H | CESC | 1 |
p.G619V | LUAD | 1 |
p.D494N | COAD | 1 |
p.M328I | HNSC | 1 |
p.Y355F | CESC | 1 |
Top |
TissGeneCNV for HSPA1L |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
Top |
TissGeneFusions for HSPA1L |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | FusionScan | BRCA | TCGA-A2-A0YK-01A | SLC44A4-HSPA1L | 5'UTR-5'UTR | chr6:31846717 | chr6:31779762 |
Chimerdb3.0 | FusionScan | BRCA | TCGA-BH-A18L-01A | TNS3-HSPA1L | CDS-5'UTR | chr7:47319761 | chr6:31779762 |
TCGAfusionPortal | PRADA | BRCA | TCGA-BH-A18L-01A | TNS3-HSPA1L | CDS-5UTR | Chr7:47319762 | Chr6:31779762 |
Top |
TissGeneNet for HSPA1L |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
Top |
TissGeneProg for HSPA1L |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Top |
TissGeneClin for HSPA1L |
TissGeneDrug for HSPA1L |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
TissGeneDisease for HSPA1L |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0036341 | Schizophrenia | 4 | BeFree,GAD |
umls:C0011854 | Diabetes Mellitus, Insulin-Dependent | 3 | BeFree,GAD |
umls:C0018133 | Graft-vs-Host Disease | 3 | BeFree,GAD,LHGDN |
umls:C0003873 | Rheumatoid Arthritis | 2 | BeFree,GAD |
umls:C0013182 | Drug Allergy | 2 | CTD_human,GAD |
umls:C0018781 | Noise-induced hearing loss | 2 | GAD |
umls:C0021368 | Inflammation | 2 | GAD |
umls:C0024141 | Lupus Erythematosus, Systemic | 2 | BeFree,GAD |
umls:C0024623 | Malignant neoplasm of stomach | 2 | BeFree,GAD |
umls:C0036202 | Sarcoidosis | 2 | BeFree,GAD,LHGDN |
umls:C0038013 | Ankylosing spondylitis | 2 | BeFree |
umls:C0151526 | Premature Birth | 2 | GAD |
umls:C0376358 | Malignant neoplasm of prostate | 2 | BeFree,GAD |
umls:C0600139 | Prostate carcinoma | 2 | BeFree |
umls:C0948008 | Ischemic stroke | 2 | BeFree,GAD |
umls:C0000786 | Spontaneous abortion | 1 | GAD |
umls:C0004238 | Atrial Fibrillation | 1 | GAD |
umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
umls:C0009782 | Connective Tissue Diseases | 1 | GAD |
umls:C0010068 | Coronary heart disease | 1 | GAD |
umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | GAD |
umls:C0015929 | Fetal Diseases | 1 | GAD |
umls:C0017605 | Angle Closure Glaucoma | 1 | GAD |
umls:C0017612 | Glaucoma, Open-Angle | 1 | GAD |
umls:C0019189 | Hepatitis, Chronic | 1 | BeFree |
umls:C0019693 | HIV Infections | 1 | BeFree |
umls:C0020538 | Hypertensive disease | 1 | GAD |
umls:C0020676 | Hypothyroidism | 1 | GAD |
umls:C0023418 | leukemia | 1 | GAD |
umls:C0023452 | Leukemia, Lymphocytic, Acute, L1 | 1 | BeFree |
umls:C0024299 | Lymphoma | 1 | BeFree |
umls:C0024517 | Single major depressive episode | 1 | BeFree |
umls:C0026857 | Musculoskeletal Diseases | 1 | GAD |
umls:C0029453 | Osteopenia | 1 | GAD |
umls:C0029456 | Osteoporosis | 1 | GAD |
umls:C0030567 | Parkinson Disease | 1 | GAD |
umls:C0032787 | Postoperative Complications | 1 | GAD |
umls:C0032914 | Pre-Eclampsia | 1 | GAD |
umls:C0032964 | Pregnancy Complications, Hematologic | 1 | GAD |
umls:C0034063 | Pulmonary Edema | 1 | GAD |
umls:C0036349 | Paranoid Schizophrenia | 1 | BeFree |
umls:C0036983 | Septic Shock | 1 | GAD |
umls:C0037274 | Dermatologic disorders | 1 | GAD |
umls:C0038454 | Cerebrovascular accident | 1 | BeFree |
umls:C0041696 | Unipolar Depression | 1 | BeFree |
umls:C0042164 | Uveitis | 1 | BeFree |
umls:C0085580 | Essential Hypertension | 1 | BeFree |
umls:C0085605 | Liver Failure | 1 | BeFree |
umls:C0086543 | Cataract | 1 | BeFree |
umls:C0162526 | AIDS-Related Opportunistic Infections | 1 | GAD |
umls:C0206172 | Diabetic Foot | 1 | GAD |
umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree,GAD |
umls:C0263313 | Pemphigus Foliaceus | 1 | BeFree |
umls:C0333186 | Restenosis | 1 | GAD |
umls:C0340100 | High altitude pulmonary edema | 1 | BeFree |
umls:C0376545 | Hematologic Neoplasms | 1 | GAD |
umls:C0524909 | Hepatitis B, Chronic | 1 | BeFree |
umls:C0678222 | Breast Carcinoma | 1 | BeFree |
umls:C0684249 | Carcinoma of lung | 1 | BeFree |
umls:C0856774 | High altitude illness | 1 | GAD |
umls:C0856825 | Acute GVH disease | 1 | BeFree |
umls:C0949691 | Spondylarthropathies | 1 | BeFree,GAD |
umls:C1269683 | Major Depressive Disorder | 1 | BeFree,GAD |
umls:C1532790 | Sarcoid uveitis | 1 | BeFree |
umls:C1535939 | Pneumocystis jiroveci pneumonia | 1 | GAD |
umls:C1719672 | Severe Sepsis | 1 | BeFree |
umls:C2239176 | Liver carcinoma | 1 | BeFree |
umls:C3714514 | Infection | 1 | GAD |