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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for HSPA1L
check button Gene summary
Basic gene informationGene symbolHSPA1L
Gene nameheat shock 70kDa protein 1-like
SynonymsHSP70-1L|HSP70-HOM|HSP70T|hum70t
CytomapUCSC genome browser: 6p21.3
Type of geneprotein-coding
RefGenesNM_005527.3,
Descriptionheat shock 10kDa protein 1-likeheat shock 70 kDa protein 1-Homheat shock 70 kDa protein 1-likeheat shock 70 kDa protein 1Lheat shock 70kD protein-like 1
Modification date20141207
dbXrefs MIM : 140559
HGNC : HGNC
Ensembl : ENSG00000204390
HPRD : 00776
Vega : OTTHUMG00000031208
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_HSPA1L
BioGPS: 3305
PathwayNCI Pathway Interaction Database: HSPA1L
KEGG: HSPA1L
REACTOME: HSPA1L
Pathway Commons: HSPA1L
ContextiHOP: HSPA1L
ligand binding site mutation search in PubMed: HSPA1L
UCL Cancer Institute: HSPA1L
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesHPA,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Testis
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)TGCT
Reference showing the relevant tissue of HSPA1L
Description by TissGene annotationsCancer gene
TissgsLTS
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID
GO:0042026protein refolding21231916
GO:0042026protein refolding21231916


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TissGeneExp for HSPA1L

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR


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TissGene-miRNA for HSPA1L

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for HSPA1L
TissGeneSNV for HSPA1L

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.K389NCESC3
p.S241NCESC2
p.E516KBLCA1
p.H25RSTAD1
p.T132ICESC1
p.E99KLUAD1
p.N64HLGG1
p.D481NBLCA1
p.R249KSKCM1
p.L239VCOAD1
p.G138SSKCM1
p.T633ILUAD1
p.L126FHNSC1
p.R535WLUSC1
p.L458QLUAD1
p.G409ELIHC1
p.E602DLUAD1
p.P620ASKCM1
p.V262MCOAD1
p.E320KHNSC1
p.G191CREAD1
p.G26RLUAD1
p.G510SSKCM1
p.P607LLUAD1
p.V84DHNSC1
p.Q603HHNSC1
p.R324WLUAD1
p.S277LSKCM1
p.E99DCESC1
p.A181VTHCA1
p.E119*LIHC1
p.R350QCESC1
p.G232ESKCM1
p.Y445HLIHC1
p.R303QLIHC1
p.E246QOV1
p.D595HBLCA1
p.L13PSTAD1
p.A182SLUAD1
p.E578QBRCA1
p.G623RLUSC1
p.D236NLUAD1
p.G193RSKCM1
p.G623RCOAD1
p.Q475EBLCA1
p.V262MSKCM1
p.R324QSKCM1
p.L457PSKCM1
p.A375DLGG1
p.E99KSKCM1
p.V473ICOAD1
p.R418HPRAD1
p.R511HPRAD1
p.N283SCESC1
p.S123LBLCA1
p.G472RSKCM1
p.Q614HSKCM1
p.S581LCOAD1
p.A408SLUAD1
p.P467SSKCM1
p.S277LDLBC1
p.A414DHNSC1
p.P149SSTAD1
p.K389RHNSC1
p.I255SLIHC1
p.G634DLUAD1
p.E532KBLCA1
p.E545XCOAD1
p.S420CBLCA1
p.G77DBLCA1
p.T40IKIRC1
p.D215ESKCM1
p.M328ISKCM1
p.K541NUCEC1
p.P178ROV1
p.D12NUCEC1
p.G341DLUAD1
p.S123LUCEC1
p.T424NLGG1
p.D325NBLCA1
p.G186DUCEC1
p.R263GREAD1
p.H139YCESC1
p.D595NBLCA1
p.R359CESCA1
p.S581LSKCM1
p.V500ACESC1
p.Q281HGBM1
p.P400SBLCA1
p.D531HCESC1
p.G619VLUAD1
p.D494NCOAD1
p.M328IHNSC1
p.Y355FCESC1


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TissGeneCNV for HSPA1L

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for HSPA1L

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0FusionScanBRCATCGA-A2-A0YK-01ASLC44A4-HSPA1L5'UTR-5'UTRchr6:31846717chr6:31779762
Chimerdb3.0FusionScanBRCATCGA-BH-A18L-01ATNS3-HSPA1LCDS-5'UTRchr7:47319761chr6:31779762
TCGAfusionPortalPRADABRCATCGA-BH-A18L-01ATNS3-HSPA1LCDS-5UTRChr7:47319762Chr6:31779762


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TissGeneNet for HSPA1L

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
HSPA1L, TP53, COPS6, CAND1, UBC, MAP3K7, KIAA0101, SIRT3, NFKB1, RELB, MAP3K1, CUL1, COPS5, RIPK3, RIPK2, IL7R, NEDD8, CUL4A, MED10, MYD88, OLR1 (tumor)HSPA1L, CFTR, NFKB2, TNFRSF1A, SIRT3, RELB, CUL3, MAP3K1, RIPK1, IKBKB, RIPK3, RIPK2, TNFRSF1B, SIRT1, MED29, TRAF3IP1, MED26, MED10, NFKBIB, H2AFX, DCP1B (normal)
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COAD (tumor)COAD (normal)
HSPA1L, COPS6, YWHAZ, CFTR, NFKB2, KIAA0101, CUL4B, RELB, CUL3, CUL1, MAP3K3, RIPK3, MED29, TRAF3IP1, TAB1, MED26, NFKBIB, H2AFX, NFKBIE, DCP1B, MYD88 (tumor)HSPA1L, CAND1, TRAF6, YWHAZ, RUVBL2, MAP3K7, IKBKG, KIAA0101, CUL4B, TRAF1, RIPK1, COPS5, MAP3K3, RIPK2, TANK, PSMA3, RUVBL1, MED29, TRADD, H2AFX, DCP1B (normal)
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HNSC (tumor)HNSC (normal)
HSPA1L, CAND1, CUL5, YWHAZ, MED9, IKBKG, KIAA0101, RELA, SIRT3, RIPK1, MAP3K14, MAP3K3, RIPK3, CUL4A, TAB1, TRADD, MED10, NFKBIB, H2AFX, DCP1B, MYD88 (tumor)HSPA1L, TP53, UBC, YWHAZ, MED9, RELA, TNFRSF1A, CUL4B, TRAF1, IKBKB, MAP3K14, MAP3K3, ARRB2, TRAF2, RIPK2, TNFRSF1B, SIRT1, NEDD8, TAB1, PCK1, DCP1B (normal)
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KICH (tumor)KICH (normal)
HSPA1L, CUL5, TRAF6, CFTR, RUVBL2, MED9, TNFRSF1A, SIRT3, CUL4B, CUL3, MAP3K1, IKBKB, COPS5, MAP3K3, ARRB2, PSMA3, NEDD8, TRADD, NFKBIB, MYD88, OLR1 (tumor)HSPA1L, COPS6, CFTR, NFKB2, IKBKG, RELB, CUL3, MAP3K14, REL, NFKBIA, RIPK2, TANK, TNFRSF1B, SIRT1, IL7R, RUVBL1, MED29, TRAF3IP1, TAB1, NFKBIE, MYD88 (normal)
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KIRC (tumor)KIRC (normal)
HSPA1L, CFTR, MED9, KIAA0101, TNFRSF1A, SIRT3, RELB, TRAF1, CUL3, RIPK1, MAP3K3, ARRB2, DCUN1D1, PSMA3, IL7R, RUVBL1, MED29, CUL4A, TRADD, MYD88, OLR1 (tumor)HSPA1L, CUL2, TRAF6, YWHAZ, KIAA0101, TNFRSF1A, NFKB1, CUL3, RIPK1, CUL1, COPS5, NFKBIA, RIPK2, SIRT1, DCUN1D1, PSMA3, MED29, TRADD, PCK1, H2AFX, MAP3K8 (normal)
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KIRP (tumor)KIRP (normal)
HSPA1L, COPS6, CFTR, MAP3K7, MED9, TNFRSF1A, SIRT3, RELB, TRAF1, RIPK1, MAP3K3, ARRB2, MED19, IL7R, RUVBL1, TRAF3IP1, TAB1, PCK1, H2AFX, MYD88, OLR1 (tumor)HSPA1L, COPS6, CAND1, CFTR, MED9, IKBKG, KIAA0101, SIRT3, RELB, TRAF1, MAP3K1, RIPK1, IKBKB, CUL1, MAP3K3, MED19, RIPK3, RIPK2, TAB1, MED26, MAP3K8 (normal)
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LIHC (tumor)LIHC (normal)
HSPA1L, CAND1, CUL5, YWHAZ, CFTR, NFKB2, RUVBL2, MAP3K7, MED9, SIRT3, NFKB1, RELB, RIPK1, REL, RIPK2, TNFRSF1B, SIRT1, TAB1, MED26, PCK1, DCP1B (tumor)HSPA1L, CUL2, TRAF6, YWHAZ, RUVBL2, MED9, TNFRSF1A, CUL4B, RELB, CUL3, MAP3K1, RIPK1, MAP3K3, RIPK2, TNFRSF1B, SIRT1, PSMA3, TAB1, NFKBIB, DCP1B, MAP3K8 (normal)
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LUAD (tumor)LUAD (normal)
HSPA1L, CUL5, UBC, CFTR, RUVBL2, MAP3K7, KIAA0101, RELA, TNFRSF1A, RELB, MAP3K1, ARRB2, NFKBIA, RIPK2, PSMA3, RUVBL1, CUL4A, TRAF3IP1, DCP1B, MAP3K8, MYD88 (tumor)HSPA1L, TRAF6, YWHAZ, NFKB2, RUVBL2, IKBKG, KIAA0101, SIRT3, TRAF1, RIPK1, COPS5, MAP3K14, MAP3K3, NFKBIA, RIPK2, NEDD8, TRAF3IP1, TAB1, MED26, H2AFX, DCP1B (normal)
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LUSC (tumor)LUSC (normal)
HSPA1L, UBC, YWHAZ, RUVBL2, RELA, TNFRSF1A, SIRT3, NFKB1, RELB, MAP3K1, RIPK1, REL, NFKBIA, RIPK2, TNFRSF1B, RUVBL1, TRAF3IP1, TAB1, H2AFX, DCP1B, MAP3K8 (tumor)HSPA1L, YWHAZ, RUVBL2, TNFRSF1A, SIRT3, TRAF1, RIPK1, COPS5, MAP3K14, MAP3K3, NFKBIA, SIRT1, PSMA3, NEDD8, MED29, TRAF3IP1, TRADD, MED10, PCK1, H2AFX, DCP1B (normal)
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PRAD (tumor)PRAD (normal)
HSPA1L, CAND1, CUL5, UBC, CFTR, MAP3K7, MED9, IKBKG, KIAA0101, RELA, SIRT3, TNFRSF1B, DCUN1D1, IL7R, MED29, TRAF3IP1, MED26, TRADD, NFKBIB, MYD88, OLR1 (tumor)HSPA1L, COPS6, CAND1, CUL5, YWHAZ, MED9, KIAA0101, RELA, SIRT3, RELB, TRAF1, REL, TRAF2, RIPK2, NEDD8, CUL4A, TAB1, MED26, DCP1B, MYD88, OLR1 (normal)
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STAD (tumor)STAD (normal)
HSPA1L, TP53, YWHAZ, CFTR, NFKB2, KIAA0101, SIRT3, CUL1, MAP3K14, MAP3K3, MED19, RIPK3, SIRT1, MED29, CUL4A, TRAF3IP1, TAB1, NFKBIB, H2AFX, DCP1B, MYD88 (tumor)HSPA1L, TP53, COPS6, CAND1, UBC, YWHAZ, RUVBL2, IKBKG, KIAA0101, CUL4B, NFKB1, TRAF1, COPS5, MAP3K14, MAP3K3, NFKBIA, RIPK2, RUVBL1, MED29, H2AFX, DCP1B (normal)
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THCA (tumor)THCA (normal)
HSPA1L, TRAF6, NFKB2, KIAA0101, RELA, TNFRSF1A, RELB, TRAF1, MAP3K14, ARRB2, NFKBIA, RIPK2, TNFRSF1B, MED29, CUL4A, TRAF3IP1, TRADD, PCK1, NFKBIE, DCP1B, MYD88 (tumor)HSPA1L, CAND1, TRAF6, YWHAZ, CFTR, NFKB2, KIAA0101, RELA, SIRT3, RELB, RIPK1, IKBKB, ARRB2, RIPK2, IL7R, MED29, TRAF3IP1, NFKBIE, DCP1B, MYD88, OLR1 (normal)
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TissGeneProg for HSPA1L

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for HSPA1L
TissGeneDrug for HSPA1L

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for HSPA1L

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0036341Schizophrenia4BeFree,GAD
umls:C0011854Diabetes Mellitus, Insulin-Dependent3BeFree,GAD
umls:C0018133Graft-vs-Host Disease3BeFree,GAD,LHGDN
umls:C0003873Rheumatoid Arthritis2BeFree,GAD
umls:C0013182Drug Allergy2CTD_human,GAD
umls:C0018781Noise-induced hearing loss2GAD
umls:C0021368Inflammation2GAD
umls:C0024141Lupus Erythematosus, Systemic2BeFree,GAD
umls:C0024623Malignant neoplasm of stomach2BeFree,GAD
umls:C0036202Sarcoidosis2BeFree,GAD,LHGDN
umls:C0038013Ankylosing spondylitis2BeFree
umls:C0151526Premature Birth2GAD
umls:C0376358Malignant neoplasm of prostate2BeFree,GAD
umls:C0600139Prostate carcinoma2BeFree
umls:C0948008Ischemic stroke2BeFree,GAD
umls:C0000786Spontaneous abortion1GAD
umls:C0004238Atrial Fibrillation1GAD
umls:C0006142Malignant neoplasm of breast1BeFree
umls:C0009782Connective Tissue Diseases1GAD
umls:C0010068Coronary heart disease1GAD
umls:C0011860Diabetes Mellitus, Non-Insulin-Dependent1GAD
umls:C0015929Fetal Diseases1GAD
umls:C0017605Angle Closure Glaucoma1GAD
umls:C0017612Glaucoma, Open-Angle1GAD
umls:C0019189Hepatitis, Chronic1BeFree
umls:C0019693HIV Infections1BeFree
umls:C0020538Hypertensive disease1GAD
umls:C0020676Hypothyroidism1GAD
umls:C0023418leukemia1GAD
umls:C0023452Leukemia, Lymphocytic, Acute, L11BeFree
umls:C0024299Lymphoma1BeFree
umls:C0024517Single major depressive episode1BeFree
umls:C0026857Musculoskeletal Diseases1GAD
umls:C0029453Osteopenia1GAD
umls:C0029456Osteoporosis1GAD
umls:C0030567Parkinson Disease1GAD
umls:C0032787Postoperative Complications1GAD
umls:C0032914Pre-Eclampsia1GAD
umls:C0032964Pregnancy Complications, Hematologic1GAD
umls:C0034063Pulmonary Edema1GAD
umls:C0036349Paranoid Schizophrenia1BeFree
umls:C0036983Septic Shock1GAD
umls:C0037274Dermatologic disorders1GAD
umls:C0038454Cerebrovascular accident1BeFree
umls:C0041696Unipolar Depression1BeFree
umls:C0042164Uveitis1BeFree
umls:C0085580Essential Hypertension1BeFree
umls:C0085605Liver Failure1BeFree
umls:C0086543Cataract1BeFree
umls:C0162526AIDS-Related Opportunistic Infections1GAD
umls:C0206172Diabetic Foot1GAD
umls:C0242379Malignant neoplasm of lung1BeFree,GAD
umls:C0263313Pemphigus Foliaceus1BeFree
umls:C0333186Restenosis1GAD
umls:C0340100High altitude pulmonary edema1BeFree
umls:C0376545Hematologic Neoplasms1GAD
umls:C0524909Hepatitis B, Chronic1BeFree
umls:C0678222Breast Carcinoma1BeFree
umls:C0684249Carcinoma of lung1BeFree
umls:C0856774High altitude illness1GAD
umls:C0856825Acute GVH disease1BeFree
umls:C0949691Spondylarthropathies1BeFree,GAD
umls:C1269683Major Depressive Disorder1BeFree,GAD
umls:C1532790Sarcoid uveitis1BeFree
umls:C1535939Pneumocystis jiroveci pneumonia1GAD
umls:C1719672Severe Sepsis1BeFree
umls:C2239176Liver carcinoma1BeFree
umls:C3714514Infection1GAD