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| TissGeneSummary for HSPA2 |
 Gene summary |
| Basic gene information | Gene symbol | HSPA2 |
| Gene name | heat shock 70kDa protein 2 | |
| Synonyms | HSP70-2|HSP70-3 | |
| Cytomap | UCSC genome browser: 14q24.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_021979.3, | |
| Description | heat shock 70kD protein 2heat shock-related 70 kDa protein 2 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 140560 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000126803 | ||
| HPRD : 07174 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_HSPA2 | |
| BioGPS: 3306 | ||
| Pathway | NCI Pathway Interaction Database: HSPA2 | |
| KEGG: HSPA2 | ||
| REACTOME: HSPA2 | ||
| Pathway Commons: HSPA2 | ||
| Context | iHOP: HSPA2 | |
| ligand binding site mutation search in PubMed: HSPA2 | ||
| UCL Cancer Institute: HSPA2 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
| Reference showing the relevant tissue of HSPA2 | ||
| Description by TissGene annotations | Cancer gene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0042026 | protein refolding | 21231916 | GO:0090084 | negative regulation of inclusion body assembly | 21231916 | GO:0042026 | protein refolding | 21231916 | GO:0090084 | negative regulation of inclusion body assembly | 21231916 |
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| TissGeneExp for HSPA2 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRC | 0.497763476 | 4.252805142 | -3.755041667 | 2.70E-37 | 9.31E-36 |
| KIRP | 0.373667989 | 4.021024239 | -3.64735625 | 2.10E-16 | 7.85E-15 |
| COAD | 1.121790826 | 2.849083134 | -1.727292308 | 1.14E-05 | 5.15E-05 |
| KICH | 1.288042364 | 4.858262364 | -3.57022 | 9.84E-13 | 1.18E-11 |
| BLCA | 0.39364447 | 2.654007628 | -2.260363158 | 2.10E-05 | 0.0003336 |
| STAD | 0.411274239 | 2.276396114 | -1.865121875 | 2.94E-05 | 0.000276655 |
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| TissGene-miRNA for HSPA2 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for HSPA2 |
| TissGeneSNV for HSPA2 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E389D | UCEC | 2 |
| p.S17X | SKCM | 1 |
| p.Q354L | LUSC | 1 |
| p.D532Y | LUAD | 1 |
| p.S278R | LUAD | 1 |
| p.G20W | BRCA | 1 |
| p.S279L | STAD | 1 |
| p.T166M | CHOL | 1 |
| p.E591K | CESC | 1 |
| p.S388P | KIRC | 1 |
| p.A179V | BLCA | 1 |
| p.A183S | LUSC | 1 |
| p.D639G | ACC | 1 |
| p.A269T | READ | 1 |
| p.A31T | COAD | 1 |
| p.A540T | COAD | 1 |
| p.A56T | COAD | 1 |
| p.A245T | LUAD | 1 |
| p.C18Y | BRCA | 1 |
| p.E306Q | HNSC | 1 |
| p.R538Q | ESCA | 1 |
| p.T166M | DLBC | 1 |
| p.V638M | STAD | 1 |
| p.D202E | KIRP | 1 |
| p.S224F | STAD | 1 |
| p.I145M | SARC | 1 |
| p.A327S | LUAD | 1 |
| p.G341V | LUAD | 1 |
| p.D393Y | LUAD | 1 |
| p.D398N | STAD | 1 |
| p.Q476* | SARC | 1 |
| p.E361Q | BLCA | 1 |
| p.G185S | BLCA | 1 |
| p.R304C | STAD | 1 |
| p.S622G | STAD | 1 |
| p.D228V | LUAD | 1 |
| p.A55T | LGG | 1 |
| p.S622G | COAD | 1 |
| p.S622G | UCEC | 1 |
| p.T38S | LUAD | 1 |
| p.P468S | CESC | 1 |
| p.P424T | LUSC | 1 |
| p.R472C | SKCM | 1 |
| p.V522L | UCEC | 1 |
| p.A262T | COAD | 1 |
| p.V210M | STAD | 1 |
| p.P618T | KIRP | 1 |
| p.D311N | COAD | 1 |
| p.S289L | SKCM | 1 |
| p.G620D | STAD | 1 |
| p.E596K | BLCA | 1 |
| p.A55T | COAD | 1 |
| p.E389K | LUAD | 1 |
| p.D482N | BLCA | 1 |
| p.A376T | UCEC | 1 |
| p.D398N | BRCA | 1 |
| p.N457Y | SARC | 1 |
| p.R172H | COAD | 1 |
| p.K600E | SKCM | 1 |
| p.V399M | STAD | 1 |
| p.T555M | PRAD | 1 |
| p.K598M | COAD | 1 |
| p.N486T | SKCM | 1 |
| p.R172S | CESC | 1 |
| p.A71T | PAAD | 1 |
| p.A525V | ACC | 1 |
| p.T166M | UCEC | 1 |
| p.D575G | LUAD | 1 |
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| TissGeneCNV for HSPA2 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for HSPA2 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | AI371755 | EIF4A1-HSPA2 | chr17:7482031 | chr14:65009163 |
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| TissGeneNet for HSPA2 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| HSPA2, SIRT7, UBC, CFTR, SRC, HNRNPA1, CDK1, MAP3K3, MEPCE, RIPK2, NCOA2, EWSR1, PSMA3, BAP1, PARP1, SCHIP1, TAB2, PARP2, MEOX2, RFWD2, HSPBP1 (tumor) | HSPA2, SIRT7, UBC, CFTR, SRC, CDK9, HNRNPA1, CDK1, MEPCE, RIPK2, NCOA2, EWSR1, PSMA3, BAP1, PARP1, SCHIP1, TAB2, PARP2, MEOX2, RFWD2, HSPBP1 (normal) |
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| COAD (tumor) | COAD (normal) |
| HSPA2, SIRT7, UBC, CFTR, SRC, CDK9, HNRNPA1, CDK1, MAP3K3, MEPCE, RIPK2, NCOA2, EWSR1, BAP1, PARP1, SCHIP1, TAB2, PARP2, MEOX2, RFWD2, HSPBP1 (tumor) | HSPA2, SIRT7, UBC, CFTR, SRC, CDK9, HNRNPA1, CDK1, MAP3K3, RIPK2, NCOA2, EWSR1, PSMA3, BAP1, PARP1, SCHIP1, TAB2, PARP2, MEOX2, RFWD2, HSPBP1 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| HSPA2, SIRT7, UBC, CFTR, SRC, CDK9, HNRNPA1, MAP3K3, MEPCE, RIPK2, NCOA2, EWSR1, PSMA3, BAP1, PARP1, SCHIP1, TAB2, PARP2, MEOX2, RFWD2, HSPBP1 (tumor) | HSPA2, SIRT7, UBC, CFTR, CDK9, HNRNPA1, CDK1, MAP3K3, MEPCE, RIPK2, NCOA2, EWSR1, PSMA3, BAP1, PARP1, SCHIP1, TAB2, PARP2, MEOX2, RFWD2, HSPBP1 (normal) |
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| KICH (tumor) | KICH (normal) |
| HSPA2, SIRT7, UBC, CFTR, SRC, CDK9, HNRNPA1, CDK1, MAP3K3, MEPCE, RIPK2, NCOA2, EWSR1, PSMA3, BAP1, PARP1, TAB2, PARP2, MEOX2, RFWD2, HSPBP1 (tumor) | HSPA2, SIRT7, UBC, CFTR, SRC, CDK9, HNRNPA1, CDK1, MEPCE, RIPK2, NCOA2, EWSR1, PSMA3, BAP1, PARP1, SCHIP1, TAB2, PARP2, MEOX2, RFWD2, HSPBP1 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| HSPA2, SIRT7, UBC, CFTR, SRC, CDK9, HNRNPA1, CDK1, MAP3K3, MEPCE, RIPK2, NCOA2, EWSR1, PSMA3, BAP1, PARP1, TAB2, PARP2, MEOX2, RFWD2, HSPBP1 (tumor) | HSPA2, SIRT7, UBC, CFTR, SRC, CDK9, HNRNPA1, CDK1, MAP3K3, MEPCE, RIPK2, NCOA2, EWSR1, PSMA3, BAP1, PARP1, SCHIP1, PARP2, MEOX2, RFWD2, HSPBP1 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| HSPA2, UBC, CFTR, SRC, CDK9, HNRNPA1, CDK1, MAP3K3, MEPCE, RIPK2, NCOA2, EWSR1, PSMA3, BAP1, PARP1, SCHIP1, TAB2, PARP2, MEOX2, RFWD2, HSPBP1 (tumor) | HSPA2, SIRT7, UBC, CFTR, SRC, CDK9, HNRNPA1, CDK1, MAP3K3, MEPCE, RIPK2, NCOA2, EWSR1, PSMA3, BAP1, PARP1, SCHIP1, TAB2, PARP2, MEOX2, RFWD2 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| HSPA2, SIRT7, UBC, CFTR, SRC, CDK9, HNRNPA1, CDK1, MAP3K3, MEPCE, RIPK2, EWSR1, PSMA3, BAP1, PARP1, SCHIP1, TAB2, PARP2, MEOX2, RFWD2, HSPBP1 (tumor) | HSPA2, SIRT7, UBC, CFTR, SRC, CDK9, HNRNPA1, CDK1, MAP3K3, MEPCE, RIPK2, NCOA2, EWSR1, PSMA3, PARP1, SCHIP1, TAB2, PARP2, MEOX2, RFWD2, HSPBP1 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| HSPA2, SIRT7, UBC, CFTR, SRC, CDK9, HNRNPA1, CDK1, MAP3K3, MEPCE, RIPK2, EWSR1, PSMA3, BAP1, PARP1, SCHIP1, TAB2, PARP2, MEOX2, RFWD2, HSPBP1 (tumor) | HSPA2, SIRT7, UBC, CFTR, SRC, CDK9, HNRNPA1, CDK1, MAP3K3, RIPK2, NCOA2, EWSR1, PSMA3, BAP1, PARP1, SCHIP1, TAB2, PARP2, MEOX2, RFWD2, HSPBP1 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| HSPA2, SIRT7, UBC, CFTR, SRC, HNRNPA1, CDK1, MAP3K3, MEPCE, RIPK2, NCOA2, EWSR1, PSMA3, BAP1, PARP1, SCHIP1, TAB2, PARP2, MEOX2, RFWD2, HSPBP1 (tumor) | HSPA2, SIRT7, UBC, CFTR, SRC, CDK9, HNRNPA1, CDK1, MAP3K3, MEPCE, RIPK2, EWSR1, PSMA3, BAP1, PARP1, SCHIP1, TAB2, PARP2, MEOX2, RFWD2, HSPBP1 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| HSPA2, SIRT7, UBC, CFTR, SRC, CDK9, HNRNPA1, CDK1, MAP3K3, MEPCE, RIPK2, NCOA2, EWSR1, BAP1, PARP1, SCHIP1, TAB2, PARP2, MEOX2, RFWD2, HSPBP1 (tumor) | HSPA2, SIRT7, UBC, CFTR, SRC, CDK9, HNRNPA1, CDK1, MAP3K3, MEPCE, RIPK2, EWSR1, PSMA3, BAP1, PARP1, SCHIP1, TAB2, PARP2, MEOX2, RFWD2, HSPBP1 (normal) |
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| STAD (tumor) | STAD (normal) |
| HSPA2, SIRT7, UBC, CFTR, SRC, CDK9, CDK1, MAP3K3, MEPCE, RIPK2, NCOA2, EWSR1, PSMA3, BAP1, PARP1, SCHIP1, TAB2, PARP2, MEOX2, RFWD2, HSPBP1 (tumor) | HSPA2, SIRT7, UBC, CFTR, SRC, CDK9, HNRNPA1, CDK1, MAP3K3, MEPCE, RIPK2, NCOA2, EWSR1, PSMA3, PARP1, SCHIP1, TAB2, PARP2, MEOX2, RFWD2, HSPBP1 (normal) |
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| THCA (tumor) | THCA (normal) |
| HSPA2, SIRT7, UBC, CFTR, SRC, CDK9, HNRNPA1, CDK1, MAP3K3, MEPCE, RIPK2, NCOA2, EWSR1, PSMA3, BAP1, PARP1, SCHIP1, TAB2, MEOX2, RFWD2, HSPBP1 (tumor) | HSPA2, SIRT7, UBC, CFTR, SRC, CDK9, HNRNPA1, CDK1, MAP3K3, MEPCE, RIPK2, NCOA2, EWSR1, PSMA3, BAP1, PARP1, SCHIP1, PARP2, MEOX2, RFWD2, HSPBP1 (normal) |
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| TissGeneProg for HSPA2 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for HSPA2 |
| TissGeneDrug for HSPA2 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for HSPA2 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0010346 | Crohn Disease | 5 | BeFree,GAD |
| umls:C0001339 | Acute pancreatitis | 3 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 3 | BeFree |
| umls:C0024141 | Lupus Erythematosus, Systemic | 3 | BeFree |
| umls:C0678222 | Breast Carcinoma | 3 | BeFree |
| umls:C1956346 | Coronary Artery Disease | 3 | BeFree |
| umls:C0001824 | Agranulocytosis | 2 | BeFree |
| umls:C0004509 | Azoospermia | 2 | BeFree |
| umls:C0007134 | Renal Cell Carcinoma | 2 | BeFree |
| umls:C0007282 | Carotid Stenosis | 2 | BeFree |
| umls:C0010054 | Coronary Arteriosclerosis | 2 | BeFree |
| umls:C0010068 | Coronary heart disease | 2 | BeFree |
| umls:C0011854 | Diabetes Mellitus, Insulin-Dependent | 2 | BeFree |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 2 | BeFree |
| umls:C0013295 | Duodenal Ulcer | 2 | BeFree |
| umls:C0018781 | Noise-induced hearing loss | 2 | GAD |
| umls:C0021364 | Male infertility | 2 | BeFree,LHGDN |
| umls:C0024623 | Malignant neoplasm of stomach | 2 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 2 | BeFree |
| umls:C0028754 | Obesity | 2 | BeFree |
| umls:C0149521 | Pancreatitis, Chronic | 2 | BeFree,GAD |
| umls:C0243026 | Sepsis | 2 | GAD |
| umls:C0699791 | Stomach Carcinoma | 2 | BeFree |
| umls:C1516170 | Cancer Cell Growth | 2 | BeFree |
| umls:C2931822 | Nasopharyngeal carcinoma | 2 | BeFree |
| umls:C0002395 | Alzheimer's Disease | 1 | GAD |
| umls:C0003850 | Arteriosclerosis | 1 | BeFree |
| umls:C0004153 | Atherosclerosis | 1 | BeFree |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 1 | BeFree |
| umls:C0007787 | Transient Ischemic Attack | 1 | BeFree |
| umls:C0009324 | Ulcerative Colitis | 1 | BeFree |
| umls:C0009375 | Colonic Neoplasms | 1 | CTD_human |
| umls:C0011570 | Mental Depression | 1 | BeFree |
| umls:C0011581 | Depressive disorder | 1 | BeFree |
| umls:C0011847 | Diabetes | 1 | BeFree |
| umls:C0011849 | Diabetes Mellitus | 1 | BeFree |
| umls:C0017154 | Gastritis, Atrophic | 1 | GAD |
| umls:C0018213 | Graves Disease | 1 | BeFree |
| umls:C0018802 | Congestive heart failure | 1 | BeFree |
| umls:C0021390 | Inflammatory Bowel Diseases | 1 | BeFree |
| umls:C0021831 | Intestinal Diseases | 1 | GAD |
| umls:C0023290 | Leishmaniasis, Visceral | 1 | BeFree |
| umls:C0024299 | Lymphoma | 1 | BeFree |
| umls:C0025568 | Metaplasia | 1 | GAD |
| umls:C0029453 | Osteopenia | 1 | GAD |
| umls:C0030305 | Pancreatitis | 1 | BeFree |
| umls:C0032927 | Precancerous Conditions | 1 | BeFree,GAD |
| umls:C0036983 | Septic Shock | 1 | GAD |
| umls:C0038013 | Ankylosing spondylitis | 1 | BeFree |
| umls:C0038454 | Cerebrovascular accident | 1 | BeFree |
| umls:C0042341 | Varicocele | 1 | LHGDN |
| umls:C0079487 | Helicobacter Infections | 1 | GAD |
| umls:C0151744 | Myocardial Ischemia | 1 | CTD_human |
| umls:C0235950 | Zinc deficiency | 1 | BeFree |
| umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
| umls:C0341318 | Enterocutaneous Fistula | 1 | BeFree |
| umls:C0376358 | Malignant neoplasm of prostate | 1 | BeFree |
| umls:C0376670 | Pancreatitis, Alcoholic | 1 | GAD |
| umls:C0409974 | Lupus Erythematosus | 1 | GAD |
| umls:C0596263 | Carcinogenesis | 1 | BeFree |
| umls:C0600139 | Prostate carcinoma | 1 | BeFree |
| umls:C0684249 | Carcinoma of lung | 1 | BeFree |
| umls:C0694549 | Community acquired pneumonia | 1 | BeFree |
| umls:C0917798 | Cerebral Ischemia | 1 | BeFree |
| umls:C0949691 | Spondylarthropathies | 1 | BeFree |
| umls:C1719672 | Severe Sepsis | 1 | BeFree |
| umls:C2239176 | Liver carcinoma | 1 | BeFree |
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