TissGeneSummary for HYAL1 |
Gene summary |
Basic gene information | Gene symbol | HYAL1 |
Gene name | hyaluronoglucosaminidase 1 | |
Synonyms | HYAL-1|LUCA1|NAT6 | |
Cytomap | UCSC genome browser: 3p21.31 | |
Type of gene | protein-coding | |
RefGenes | NM_033159.3, NM_153281.1,NM_153282.2,NM_153283.2,NM_153285.2, NR_047690.1,NM_153284.1,NM_153286.1, | |
Description | hyaluronidase-1luCa-1lung carcinoma protein 1plasma hyaluronidasetumor suppressor LUCA-1 | |
Modification date | 20141207 | |
dbXrefs | MIM : 607071 | |
HGNC : HGNC | ||
Ensembl : ENSG00000114378 | ||
HPRD : 06146 | ||
Vega : OTTHUMG00000156941 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_HYAL1 | |
BioGPS: 3373 | ||
Pathway | NCI Pathway Interaction Database: HYAL1 | |
KEGG: HYAL1 | ||
REACTOME: HYAL1 | ||
Pathway Commons: HYAL1 | ||
Context | iHOP: HYAL1 | |
ligand binding site mutation search in PubMed: HYAL1 | ||
UCL Cancer Institute: HYAL1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | CervixLiver | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | CESCLIHC | |
Reference showing the relevant tissue of HYAL1 | ||
Description by TissGene annotations | Cancer gene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0000302 | response to reactive oxygen species | 20554532 | GO:0006954 | inflammatory response | 18390475 | GO:0009615 | response to virus | 11296287 | GO:0010634 | positive regulation of epithelial cell migration | 21829529 | GO:0030212 | hyaluronan metabolic process | 19478093 | GO:0030213 | hyaluronan biosynthetic process | 21829529 | GO:0030214 | hyaluronan catabolic process | 11296287 | GO:0030308 | negative regulation of cell growth | 18725949 | GO:0036120 | cellular response to platelet-derived growth factor stimulus | 17324121 | GO:0044344 | cellular response to fibroblast growth factor stimulus | 19577615 | GO:0045766 | positive regulation of angiogenesis | 21829529 | GO:0045927 | positive regulation of growth | 21829529 | GO:0046677 | response to antibiotic | 11944887 | GO:0050679 | positive regulation of epithelial cell proliferation | 21829529 | GO:0071347 | cellular response to interleukin-1 | 18390475 | GO:0071467 | cellular response to pH | 19478093 | GO:0071493 | cellular response to UV-B | 21699545 | GO:1900106 | positive regulation of hyaluranon cable assembly | 16900089 | GO:0000302 | response to reactive oxygen species | 20554532 | GO:0006954 | inflammatory response | 18390475 | GO:0009615 | response to virus | 11296287 | GO:0010634 | positive regulation of epithelial cell migration | 21829529 | GO:0030212 | hyaluronan metabolic process | 19478093 | GO:0030213 | hyaluronan biosynthetic process | 21829529 | GO:0030214 | hyaluronan catabolic process | 11296287 | GO:0030308 | negative regulation of cell growth | 18725949 | GO:0036120 | cellular response to platelet-derived growth factor stimulus | 17324121 | GO:0044344 | cellular response to fibroblast growth factor stimulus | 19577615 | GO:0045766 | positive regulation of angiogenesis | 21829529 | GO:0045927 | positive regulation of growth | 21829529 | GO:0046677 | response to antibiotic | 11944887 | GO:0050679 | positive regulation of epithelial cell proliferation | 21829529 | GO:0071347 | cellular response to interleukin-1 | 18390475 | GO:0071467 | cellular response to pH | 19478093 | GO:0071493 | cellular response to UV-B | 21699545 | GO:1900106 | positive regulation of hyaluranon cable assembly | 16900089 |
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TissGeneExp for HYAL1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRP | 3.384008871 | 5.368024496 | -1.984015625 | 1.17E-06 | 5.83E-06 |
BRCA | -0.586801984 | 1.591697138 | -2.178499123 | 1.25E-38 | 3.35E-37 |
LUAD | 1.830295293 | 4.823915983 | -2.99362069 | 1.76E-18 | 2.58E-17 |
LUSC | 1.38376267 | 4.786497964 | -3.402735294 | 8.84E-25 | 1.84E-23 |
KIRC | 3.843767899 | 4.98491651 | -1.141148611 | 2.07E-17 | 1.28E-16 |
BLCA | -0.7601783 | 1.341258542 | -2.101436842 | 5.04E-06 | 0.000115019 |
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TissGene-miRNA for HYAL1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for HYAL1 |
TissGeneSNV for HYAL1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.V287D | LUSC | 1 |
p.W324* | LUSC | 1 |
p.S239I | PAAD | 1 |
p.A311V | LGG | 1 |
p.I8M | KIRP | 1 |
p.R191W | UCEC | 1 |
p.S123* | LUAD | 1 |
p.C43R | STAD | 1 |
p.G185D | LUAD | 1 |
p.E268D | LIHC | 1 |
p.A60V | COAD | 1 |
p.M1V | LUSC | 1 |
p.A227V | STAD | 1 |
p.R180Q | STAD | 1 |
p.R371H | STAD | 1 |
p.A311V | HNSC | 1 |
p.G124E | SKCM | 1 |
p.R226C | SKCM | 1 |
p.R240H | ESCA | 1 |
p.G256R | COAD | 1 |
p.L213I | UCEC | 1 |
p.F387L | STAD | 1 |
p.R431W | PAAD | 1 |
p.A132T | UCEC | 1 |
p.E45G | COAD | 1 |
p.Q411H | CESC | 1 |
p.A116V | STAD | 1 |
p.G365S | LUAD | 1 |
p.G124R | SKCM | 1 |
p.G256R | BRCA | 1 |
p.I246V | HNSC | 1 |
p.D142N | SKCM | 1 |
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TissGeneCNV for HYAL1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for HYAL1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for HYAL1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for HYAL1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for HYAL1 |
TissGeneDrug for HYAL1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for HYAL1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0005684 | Malignant neoplasm of urinary bladder | 6 | BeFree |
umls:C0699885 | Carcinoma of bladder | 6 | BeFree |
umls:C0006142 | Malignant neoplasm of breast | 4 | BeFree |
umls:C0027627 | Neoplasm Metastasis | 4 | BeFree |
umls:C0149925 | Small cell carcinoma of lung | 3 | BeFree,LHGDN |
umls:C0376358 | Malignant neoplasm of prostate | 3 | BeFree |
umls:C0600139 | Prostate carcinoma | 3 | BeFree |
umls:C0678222 | Breast Carcinoma | 3 | BeFree |
umls:C1291490 | Hyaluronidase Deficiency | 3 | BeFree,CLINVAR,CTD_human,MGD,ORPHANET,UNIPROT |
umls:C0005695 | Bladder Neoplasm | 1 | BeFree |
umls:C0007137 | Squamous cell carcinoma | 1 | BeFree |
umls:C0017638 | Glioma | 1 | BeFree,LHGDN |
umls:C0020542 | Pulmonary Hypertension | 1 | RGD |
umls:C0022548 | Keloid | 1 | GAD |
umls:C0024121 | Lung Neoplasms | 1 | LHGDN |
umls:C0027533 | Neck Neoplasms | 1 | BeFree |
umls:C0029408 | Degenerative polyarthritis | 1 | BeFree |
umls:C0029925 | Ovarian Carcinoma | 1 | BeFree |
umls:C0033578 | Prostatic Neoplasms | 1 | LHGDN |
umls:C0036323 | Schistosomiasis | 1 | BeFree |
umls:C0085078 | Lysosomal Storage Diseases | 1 | BeFree |
umls:C0086692 | Benign Neoplasm | 1 | BeFree |
umls:C0178874 | Tumor Progression | 1 | BeFree |
umls:C0476089 | Endometrial Carcinoma | 1 | BeFree |
umls:C0677886 | Epithelial ovarian cancer | 1 | BeFree |
umls:C0919267 | ovarian neoplasm | 1 | BeFree |
umls:C0936223 | Metastatic Prostate Carcinoma | 1 | BeFree |
umls:C1140680 | Malignant neoplasm of ovary | 1 | BeFree |
umls:C1168401 | Squamous cell carcinoma of the head and neck | 1 | BeFree |
umls:C1458155 | Mammary Neoplasms | 1 | LHGDN |
umls:C2931852 | Clear-cell metastatic renal cell carcinoma | 1 | BeFree |
umls:C3495559 | Juvenile arthritis | 1 | BeFree |
umls:C3662483 | Allergic sensitization | 1 | BeFree |
umls:C3714757 | Juvenile rheumatoid arthritis | 1 | BeFree |