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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for HYAL1
check button Gene summary
Basic gene informationGene symbolHYAL1
Gene namehyaluronoglucosaminidase 1
SynonymsHYAL-1|LUCA1|NAT6
CytomapUCSC genome browser: 3p21.31
Type of geneprotein-coding
RefGenesNM_033159.3,
NM_153281.1,NM_153282.2,NM_153283.2,NM_153285.2,
NR_047690.1,NM_153284.1,NM_153286.1,
Descriptionhyaluronidase-1luCa-1lung carcinoma protein 1plasma hyaluronidasetumor suppressor LUCA-1
Modification date20141207
dbXrefs MIM : 607071
HGNC : HGNC
Ensembl : ENSG00000114378
HPRD : 06146
Vega : OTTHUMG00000156941
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_HYAL1
BioGPS: 3373
PathwayNCI Pathway Interaction Database: HYAL1
KEGG: HYAL1
REACTOME: HYAL1
Pathway Commons: HYAL1
ContextiHOP: HYAL1
ligand binding site mutation search in PubMed: HYAL1
UCL Cancer Institute: HYAL1
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)CervixLiver
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)CESCLIHC
Reference showing the relevant tissue of HYAL1
Description by TissGene annotationsCancer gene
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID
GO:0000302response to reactive oxygen species20554532
GO:0006954inflammatory response18390475
GO:0009615response to virus11296287
GO:0010634positive regulation of epithelial cell migration21829529
GO:0030212hyaluronan metabolic process19478093
GO:0030213hyaluronan biosynthetic process21829529
GO:0030214hyaluronan catabolic process11296287
GO:0030308negative regulation of cell growth18725949
GO:0036120cellular response to platelet-derived growth factor stimulus17324121
GO:0044344cellular response to fibroblast growth factor stimulus19577615
GO:0045766positive regulation of angiogenesis21829529
GO:0045927positive regulation of growth21829529
GO:0046677response to antibiotic11944887
GO:0050679positive regulation of epithelial cell proliferation21829529
GO:0071347cellular response to interleukin-118390475
GO:0071467cellular response to pH19478093
GO:0071493cellular response to UV-B21699545
GO:1900106positive regulation of hyaluranon cable assembly16900089
GO:0000302response to reactive oxygen species20554532
GO:0006954inflammatory response18390475
GO:0009615response to virus11296287
GO:0010634positive regulation of epithelial cell migration21829529
GO:0030212hyaluronan metabolic process19478093
GO:0030213hyaluronan biosynthetic process21829529
GO:0030214hyaluronan catabolic process11296287
GO:0030308negative regulation of cell growth18725949
GO:0036120cellular response to platelet-derived growth factor stimulus17324121
GO:0044344cellular response to fibroblast growth factor stimulus19577615
GO:0045766positive regulation of angiogenesis21829529
GO:0045927positive regulation of growth21829529
GO:0046677response to antibiotic11944887
GO:0050679positive regulation of epithelial cell proliferation21829529
GO:0071347cellular response to interleukin-118390475
GO:0071467cellular response to pH19478093
GO:0071493cellular response to UV-B21699545
GO:1900106positive regulation of hyaluranon cable assembly16900089


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TissGeneExp for HYAL1

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
KIRP3.3840088715.368024496-1.9840156251.17E-065.83E-06
BRCA-0.5868019841.591697138-2.1784991231.25E-383.35E-37
LUAD1.8302952934.823915983-2.993620691.76E-182.58E-17
LUSC1.383762674.786497964-3.4027352948.84E-251.84E-23
KIRC3.8437678994.98491651-1.1411486112.07E-171.28E-16
BLCA-0.76017831.341258542-2.1014368425.04E-060.000115019


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TissGene-miRNA for HYAL1

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for HYAL1
TissGeneSNV for HYAL1

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.V287DLUSC1
p.W324*LUSC1
p.S239IPAAD1
p.A311VLGG1
p.I8MKIRP1
p.R191WUCEC1
p.S123*LUAD1
p.C43RSTAD1
p.G185DLUAD1
p.E268DLIHC1
p.A60VCOAD1
p.M1VLUSC1
p.A227VSTAD1
p.R180QSTAD1
p.R371HSTAD1
p.A311VHNSC1
p.G124ESKCM1
p.R226CSKCM1
p.R240HESCA1
p.G256RCOAD1
p.L213IUCEC1
p.F387LSTAD1
p.R431WPAAD1
p.A132TUCEC1
p.E45GCOAD1
p.Q411HCESC1
p.A116VSTAD1
p.G365SLUAD1
p.G124RSKCM1
p.G256RBRCA1
p.I246VHNSC1
p.D142NSKCM1


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TissGeneCNV for HYAL1

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for HYAL1

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP


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TissGeneNet for HYAL1

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
HYAL1, COL2A1 (tumor)HYAL1, COL2A1 (normal)
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COAD (tumor)COAD (normal)
HYAL1, COL2A1 (tumor)HYAL1, COL2A1 (normal)
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HNSC (tumor)HNSC (normal)
HYAL1, COL2A1 (tumor)HYAL1, COL2A1 (normal)
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KICH (tumor)KICH (normal)
HYAL1, COL2A1 (tumor)HYAL1, COL2A1 (normal)
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KIRC (tumor)KIRC (normal)
HYAL1, COL2A1 (tumor)HYAL1, COL2A1 (normal)
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KIRP (tumor)KIRP (normal)
HYAL1, COL2A1 (tumor)HYAL1, COL2A1 (normal)
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LIHC (tumor)LIHC (normal)
HYAL1, COL2A1 (tumor)HYAL1, COL2A1 (normal)
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LUAD (tumor)LUAD (normal)
HYAL1, COL2A1 (tumor)HYAL1, COL2A1 (normal)
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LUSC (tumor)LUSC (normal)
HYAL1, COL2A1 (tumor)HYAL1, COL2A1 (normal)
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PRAD (tumor)PRAD (normal)
HYAL1, COL2A1 (tumor)HYAL1, COL2A1 (normal)
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STAD (tumor)STAD (normal)
HYAL1, COL2A1 (tumor)HYAL1, COL2A1 (normal)
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THCA (tumor)THCA (normal)
HYAL1, COL2A1 (tumor)HYAL1, COL2A1 (normal)
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TissGeneProg for HYAL1

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for HYAL1
TissGeneDrug for HYAL1

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for HYAL1

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0005684Malignant neoplasm of urinary bladder6BeFree
umls:C0699885Carcinoma of bladder6BeFree
umls:C0006142Malignant neoplasm of breast4BeFree
umls:C0027627Neoplasm Metastasis4BeFree
umls:C0149925Small cell carcinoma of lung3BeFree,LHGDN
umls:C0376358Malignant neoplasm of prostate3BeFree
umls:C0600139Prostate carcinoma3BeFree
umls:C0678222Breast Carcinoma3BeFree
umls:C1291490Hyaluronidase Deficiency3BeFree,CLINVAR,CTD_human,MGD,ORPHANET,UNIPROT
umls:C0005695Bladder Neoplasm1BeFree
umls:C0007137Squamous cell carcinoma1BeFree
umls:C0017638Glioma1BeFree,LHGDN
umls:C0020542Pulmonary Hypertension1RGD
umls:C0022548Keloid1GAD
umls:C0024121Lung Neoplasms1LHGDN
umls:C0027533Neck Neoplasms1BeFree
umls:C0029408Degenerative polyarthritis1BeFree
umls:C0029925Ovarian Carcinoma1BeFree
umls:C0033578Prostatic Neoplasms1LHGDN
umls:C0036323Schistosomiasis1BeFree
umls:C0085078Lysosomal Storage Diseases1BeFree
umls:C0086692Benign Neoplasm1BeFree
umls:C0178874Tumor Progression1BeFree
umls:C0476089Endometrial Carcinoma1BeFree
umls:C0677886Epithelial ovarian cancer1BeFree
umls:C0919267ovarian neoplasm1BeFree
umls:C0936223Metastatic Prostate Carcinoma1BeFree
umls:C1140680Malignant neoplasm of ovary1BeFree
umls:C1168401Squamous cell carcinoma of the head and neck1BeFree
umls:C1458155Mammary Neoplasms1LHGDN
umls:C2931852Clear-cell metastatic renal cell carcinoma1BeFree
umls:C3495559Juvenile arthritis1BeFree
umls:C3662483Allergic sensitization1BeFree
umls:C3714757Juvenile rheumatoid arthritis1BeFree