TissGeneSummary for KRT79 |
Gene summary |
Basic gene information | Gene symbol | KRT79 |
Gene name | keratin 79 | |
Synonyms | K6L|KRT6L | |
Cytomap | UCSC genome browser: 12q13.13 | |
Type of gene | protein-coding | |
RefGenes | NM_175834.2, | |
Description | CK-79K79cytokeratin-79keratin 6Lkeratin, type II cytoskeletal 79keratin-6Lkeratin-79type-II keratin Kb38 | |
Modification date | 20141207 | |
dbXrefs | MIM : 611160 | |
HGNC : HGNC | ||
Ensembl : ENSG00000185640 | ||
HPRD : 11183 | ||
Vega : OTTHUMG00000169878 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_KRT79 | |
BioGPS: 338785 | ||
Pathway | NCI Pathway Interaction Database: KRT79 | |
KEGG: KRT79 | ||
REACTOME: KRT79 | ||
Pathway Commons: KRT79 | ||
Context | iHOP: KRT79 | |
ligand binding site mutation search in PubMed: KRT79 | ||
UCL Cancer Institute: KRT79 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Skin | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | SKCM | |
Reference showing the relevant tissue of KRT79 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for KRT79 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
BRCA | -0.164838476 | 1.511462401 | -1.676300877 | 1.01E-09 | 3.60E-09 |
LUAD | -0.430805324 | 2.366663641 | -2.797468966 | 2.56E-17 | 3.26E-16 |
BLCA | 1.659579068 | -0.788215669 | 2.447794737 | 0.00753 | 0.036170022 |
LUSC | 0.688880409 | 2.163164723 | -1.474284314 | 5.61E-05 | 0.000119186 |
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TissGene-miRNA for KRT79 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for KRT79 |
TissGeneSNV for KRT79 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.Q274P | LIHC | 1 |
p.E237K | SKCM | 1 |
p.A175S | THYM | 1 |
p.V38A | LIHC | 1 |
p.V117I | STAD | 1 |
p.F105L | OV | 1 |
p.G374E | SKCM | 1 |
p.K511N | BLCA | 1 |
p.A94T | STAD | 1 |
p.R2M | UCEC | 1 |
p.R424Q | SKCM | 1 |
p.A393V | COAD | 1 |
p.L324M | LUAD | 1 |
p.Y341* | SKCM | 1 |
p.Q405H | BLCA | 1 |
p.A94V | UCEC | 1 |
p.R139C | LIHC | 1 |
p.Q28H | LUAD | 1 |
p.Y446* | LUAD | 1 |
p.K268E | LUAD | 1 |
p.E245D | READ | 1 |
p.Q387* | PRAD | 1 |
p.G66R | BLCA | 1 |
p.V5I | KIRC | 1 |
p.H49R | LUSC | 1 |
p.E361K | SKCM | 1 |
p.R424W | COAD | 1 |
p.L194P | STAD | 1 |
p.D304E | BRCA | 1 |
p.G352E | HNSC | 1 |
p.E142G | BRCA | 1 |
p.S63C | CESC | 1 |
p.S4F | SKCM | 1 |
p.R367L | LUAD | 1 |
p.T205M | STAD | 1 |
p.L415M | LUAD | 1 |
p.E361D | UCEC | 1 |
p.R30H | CESC | 1 |
p.A244T | SARC | 1 |
p.G214E | LIHC | 1 |
p.G267D | ESCA | 1 |
p.R424W | PRAD | 1 |
p.R203W | STAD | 1 |
p.S489F | SKCM | 1 |
p.R7W | SARC | 1 |
p.M263I | HNSC | 1 |
p.R30S | HNSC | 1 |
p.L372P | GBM | 1 |
p.G106R | LUSC | 1 |
p.G86E | UCEC | 1 |
p.N305K | GBM | 1 |
p.G495E | LAML | 1 |
p.R396P | UCEC | 1 |
p.D217Y | BLCA | 1 |
p.T527M | DLBC | 1 |
p.E375G | TGCT | 1 |
p.S3P | BLCA | 1 |
p.T530M | LUAD | 1 |
p.R427H | UVM | 1 |
p.K498N | LUAD | 1 |
p.S302F | BLCA | 1 |
p.R139P | LGG | 1 |
p.E275D | UCEC | 1 |
p.N305K | OV | 1 |
p.A258T | LUAD | 1 |
p.R427H | COAD | 1 |
p.V294M | LGG | 1 |
p.H68N | LUAD | 1 |
p.R161W | LUAD | 1 |
p.S61N | SKCM | 1 |
p.D225E | STAD | 1 |
p.G494E | SKCM | 1 |
p.G14E | SKCM | 1 |
p.L355M | LIHC | 1 |
p.P126S | SKCM | 1 |
p.L425P | STAD | 1 |
p.W174R | LIHC | 1 |
p.A404D | UCEC | 1 |
p.G471D | COAD | 1 |
p.A348P | STAD | 1 |
p.A154T | PAAD | 1 |
p.Q321K | ESCA | 1 |
p.S313N | THYM | 1 |
p.T358I | SKCM | 1 |
p.V5I | COAD | 1 |
p.T366I | GBM | 1 |
p.S25R | SKCM | 1 |
p.S39F | LUAD | 1 |
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TissGeneCNV for KRT79 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for KRT79 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | TopHat-Fusion | SARC | TCGA-DX-A3LY-01B | KRT79-CDK4 | CDS-3'UTR | chr12:53223028 | chr12:58142183 |
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TissGeneNet for KRT79 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for KRT79 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for KRT79 |
TissGeneDrug for KRT79 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for KRT79 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |