TissGeneSummary for NANOS2 |
Gene summary |
Basic gene information | Gene symbol | NANOS2 |
Gene name | nanos homolog 2 (Drosophila) | |
Synonyms | NOS2 | |
Cytomap | UCSC genome browser: 19q13.32 | |
Type of gene | protein-coding | |
RefGenes | NM_001029861.2, | |
Description | NOS-2nanos homolog 2 | |
Modification date | 20141207 | |
dbXrefs | MIM : 608228 | |
HGNC : HGNC | ||
Ensembl : ENSG00000188425 | ||
HPRD : 18784 | ||
Vega : OTTHUMG00000182487 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_NANOS2 | |
BioGPS: 339345 | ||
Pathway | NCI Pathway Interaction Database: NANOS2 | |
KEGG: NANOS2 | ||
REACTOME: NANOS2 | ||
Pathway Commons: NANOS2 | ||
Context | iHOP: NANOS2 | |
ligand binding site mutation search in PubMed: NANOS2 | ||
UCL Cancer Institute: NANOS2 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of NANOS2 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for NANOS2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for NANOS2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for NANOS2 |
TissGeneSNV for NANOS2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.G45R | SKCM | 1 |
p.R26W | COAD | 1 |
p.T110M | CESC | 1 |
p.R26W | HNSC | 1 |
p.S122F | SKCM | 1 |
p.G118D | BLCA | 1 |
p.Q17L | LUAD | 1 |
p.V75I | LGG | 1 |
p.P40T | STAD | 1 |
p.G118D | SKCM | 1 |
p.V88G | SKCM | 1 |
p.V75A | STAD | 1 |
p.R125C | STAD | 1 |
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TissGeneCNV for NANOS2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for NANOS2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for NANOS2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for NANOS2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for NANOS2 |
TissGeneDrug for NANOS2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for NANOS2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0024530 | Malaria | 9 | BeFree |
umls:C0004096 | Asthma | 7 | BeFree |
umls:C0596263 | Carcinogenesis | 5 | BeFree |
umls:C0009402 | Colorectal Carcinoma | 3 | BeFree |
umls:C0010674 | Cystic Fibrosis | 3 | BeFree |
umls:C0041234 | Chagas Disease | 3 | BeFree |
umls:C0042769 | Virus Diseases | 3 | BeFree |
umls:C0242379 | Malignant neoplasm of lung | 3 | BeFree |
umls:C0376358 | Malignant neoplasm of prostate | 3 | BeFree |
umls:C0600139 | Prostate carcinoma | 3 | BeFree |
umls:C0684249 | Carcinoma of lung | 3 | BeFree |
umls:C0002395 | Alzheimer's Disease | 2 | BeFree |
umls:C0003864 | Arthritis | 2 | BeFree |
umls:C0005684 | Malignant neoplasm of urinary bladder | 2 | BeFree |
umls:C0006142 | Malignant neoplasm of breast | 2 | BeFree |
umls:C0021364 | Male infertility | 2 | BeFree,CTD_human |
umls:C0023903 | Liver neoplasms | 2 | BeFree |
umls:C0024534 | Malaria, Cerebral | 2 | BeFree |
umls:C0036323 | Schistosomiasis | 2 | BeFree |
umls:C0036421 | Systemic Scleroderma | 2 | BeFree |
umls:C0036690 | Septicemia | 2 | BeFree |
umls:C0037054 | Sickle Cell Trait | 2 | BeFree |
umls:C0243026 | Sepsis | 2 | BeFree |
umls:C0264716 | Chronic heart failure | 2 | BeFree |
umls:C0678222 | Breast Carcinoma | 2 | BeFree |
umls:C0699885 | Carcinoma of bladder | 2 | BeFree |
umls:C1458155 | Mammary Neoplasms | 2 | BeFree |
umls:C1527249 | Colorectal Cancer | 2 | BeFree |
umls:C1704272 | Benign Prostatic Hyperplasia | 2 | BeFree |
umls:C2239176 | Liver carcinoma | 2 | BeFree |
umls:C0002736 | Amyotrophic Lateral Sclerosis | 1 | BeFree |
umls:C0002871 | Anemia | 1 | BeFree |
umls:C0003850 | Arteriosclerosis | 1 | BeFree |
umls:C0003873 | Rheumatoid Arthritis | 1 | BeFree |
umls:C0004153 | Atherosclerosis | 1 | BeFree |
umls:C0007102 | Malignant tumor of colon | 1 | BeFree |
umls:C0009404 | Colorectal Neoplasms | 1 | BeFree |
umls:C0009443 | Common Cold | 1 | BeFree |
umls:C0011854 | Diabetes Mellitus, Insulin-Dependent | 1 | BeFree |
umls:C0013080 | Down Syndrome | 1 | BeFree |
umls:C0013595 | Eczema | 1 | BeFree |
umls:C0019196 | Hepatitis C | 1 | BeFree |
umls:C0023434 | Chronic Lymphocytic Leukemia | 1 | BeFree |
umls:C0023895 | Liver diseases | 1 | BeFree |
umls:C0024141 | Lupus Erythematosus, Systemic | 1 | BeFree |
umls:C0024535 | Malaria, Falciparum | 1 | BeFree |
umls:C0027765 | nervous system disorder | 1 | BeFree |
umls:C0028840 | Ocular Hypertension | 1 | BeFree |
umls:C0032580 | Adenomatous Polyposis Coli | 1 | BeFree |
umls:C0033575 | Prostatic Diseases | 1 | BeFree |
umls:C0033581 | prostatitis | 1 | BeFree |
umls:C0033860 | Psoriasis | 1 | BeFree |
umls:C0038454 | Cerebrovascular accident | 1 | BeFree |
umls:C0041296 | Tuberculosis | 1 | BeFree |
umls:C0042384 | Vasculitis | 1 | BeFree |
umls:C0152171 | Idiopathic pulmonary hypertension | 1 | BeFree |
umls:C0153452 | Malignant neoplasm of gallbladder | 1 | BeFree |
umls:C0221376 | Hydrosalpinx (disease) | 1 | BeFree |
umls:C0221500 | Effects of heat | 1 | BeFree |
umls:C0235782 | Gallbladder Carcinoma | 1 | BeFree |
umls:C0238463 | Papillary thyroid carcinoma | 1 | BeFree |
umls:C0272105 | Anemia due to infection | 1 | BeFree |
umls:C0276447 | Rhinovirus infection | 1 | BeFree |
umls:C0338451 | Frontotemporal dementia | 1 | BeFree |
umls:C0338656 | Impaired cognition | 1 | BeFree |
umls:C0426980 | Motor symptoms | 1 | BeFree |
umls:C0483368 | Human anaplasmosis due to Anaplasma phagocytophilum | 1 | BeFree |
umls:C0524910 | Hepatitis C, Chronic | 1 | BeFree |
umls:C0566602 | Primary sclerosing cholangitis | 1 | BeFree |
umls:C0595921 | Intraocular pressure disorder | 1 | BeFree |
umls:C0699790 | Colon Carcinoma | 1 | BeFree |
umls:C0729233 | Dissecting aneurysm of the thoracic aorta | 1 | BeFree |
umls:C0850572 | Adenomatous polyp of colon | 1 | BeFree |
umls:C2931822 | Nasopharyngeal carcinoma | 1 | BeFree |
umls:C2936349 | Plaque, Amyloid | 1 | BeFree |
umls:C2973725 | Pulmonary arterial hypertension | 1 | BeFree |
umls:C3714844 | Pulmonary Hypertension, Primary, 1, With Hereditary Hemorrhagic Telangiectasia | 1 | BeFree |