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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for NANOS2
check button Gene summary
Basic gene informationGene symbolNANOS2
Gene namenanos homolog 2 (Drosophila)
SynonymsNOS2
CytomapUCSC genome browser: 19q13.32
Type of geneprotein-coding
RefGenesNM_001029861.2,
DescriptionNOS-2nanos homolog 2
Modification date20141207
dbXrefs MIM : 608228
HGNC : HGNC
Ensembl : ENSG00000188425
HPRD : 18784
Vega : OTTHUMG00000182487
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_NANOS2
BioGPS: 339345
PathwayNCI Pathway Interaction Database: NANOS2
KEGG: NANOS2
REACTOME: NANOS2
Pathway Commons: NANOS2
ContextiHOP: NANOS2
ligand binding site mutation search in PubMed: NANOS2
UCL Cancer Institute: NANOS2
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesHPA,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Testis
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)TGCT
Reference showing the relevant tissue of NANOS2
Description by TissGene annotations
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


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TissGeneExp for NANOS2

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR


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TissGene-miRNA for NANOS2

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for NANOS2
TissGeneSNV for NANOS2

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.G45RSKCM1
p.R26WCOAD1
p.T110MCESC1
p.R26WHNSC1
p.S122FSKCM1
p.G118DBLCA1
p.Q17LLUAD1
p.V75ILGG1
p.P40TSTAD1
p.G118DSKCM1
p.V88GSKCM1
p.V75ASTAD1
p.R125CSTAD1


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TissGeneCNV for NANOS2

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for NANOS2

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP


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TissGeneNet for NANOS2

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)


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TissGeneProg for NANOS2

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for NANOS2
TissGeneDrug for NANOS2

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for NANOS2

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0024530Malaria9BeFree
umls:C0004096Asthma7BeFree
umls:C0596263Carcinogenesis5BeFree
umls:C0009402Colorectal Carcinoma3BeFree
umls:C0010674Cystic Fibrosis3BeFree
umls:C0041234Chagas Disease3BeFree
umls:C0042769Virus Diseases3BeFree
umls:C0242379Malignant neoplasm of lung3BeFree
umls:C0376358Malignant neoplasm of prostate3BeFree
umls:C0600139Prostate carcinoma3BeFree
umls:C0684249Carcinoma of lung3BeFree
umls:C0002395Alzheimer's Disease2BeFree
umls:C0003864Arthritis2BeFree
umls:C0005684Malignant neoplasm of urinary bladder2BeFree
umls:C0006142Malignant neoplasm of breast2BeFree
umls:C0021364Male infertility2BeFree,CTD_human
umls:C0023903Liver neoplasms2BeFree
umls:C0024534Malaria, Cerebral2BeFree
umls:C0036323Schistosomiasis2BeFree
umls:C0036421Systemic Scleroderma2BeFree
umls:C0036690Septicemia2BeFree
umls:C0037054Sickle Cell Trait2BeFree
umls:C0243026Sepsis2BeFree
umls:C0264716Chronic heart failure2BeFree
umls:C0678222Breast Carcinoma2BeFree
umls:C0699885Carcinoma of bladder2BeFree
umls:C1458155Mammary Neoplasms2BeFree
umls:C1527249Colorectal Cancer2BeFree
umls:C1704272Benign Prostatic Hyperplasia2BeFree
umls:C2239176Liver carcinoma2BeFree
umls:C0002736Amyotrophic Lateral Sclerosis1BeFree
umls:C0002871Anemia1BeFree
umls:C0003850Arteriosclerosis1BeFree
umls:C0003873Rheumatoid Arthritis1BeFree
umls:C0004153Atherosclerosis1BeFree
umls:C0007102Malignant tumor of colon1BeFree
umls:C0009404Colorectal Neoplasms1BeFree
umls:C0009443Common Cold1BeFree
umls:C0011854Diabetes Mellitus, Insulin-Dependent1BeFree
umls:C0013080Down Syndrome1BeFree
umls:C0013595Eczema1BeFree
umls:C0019196Hepatitis C1BeFree
umls:C0023434Chronic Lymphocytic Leukemia1BeFree
umls:C0023895Liver diseases1BeFree
umls:C0024141Lupus Erythematosus, Systemic1BeFree
umls:C0024535Malaria, Falciparum1BeFree
umls:C0027765nervous system disorder1BeFree
umls:C0028840Ocular Hypertension1BeFree
umls:C0032580Adenomatous Polyposis Coli1BeFree
umls:C0033575Prostatic Diseases1BeFree
umls:C0033581prostatitis1BeFree
umls:C0033860Psoriasis1BeFree
umls:C0038454Cerebrovascular accident1BeFree
umls:C0041296Tuberculosis1BeFree
umls:C0042384Vasculitis1BeFree
umls:C0152171Idiopathic pulmonary hypertension1BeFree
umls:C0153452Malignant neoplasm of gallbladder1BeFree
umls:C0221376Hydrosalpinx (disease)1BeFree
umls:C0221500Effects of heat1BeFree
umls:C0235782Gallbladder Carcinoma1BeFree
umls:C0238463Papillary thyroid carcinoma1BeFree
umls:C0272105Anemia due to infection1BeFree
umls:C0276447Rhinovirus infection1BeFree
umls:C0338451Frontotemporal dementia1BeFree
umls:C0338656Impaired cognition1BeFree
umls:C0426980Motor symptoms1BeFree
umls:C0483368Human anaplasmosis due to Anaplasma phagocytophilum1BeFree
umls:C0524910Hepatitis C, Chronic1BeFree
umls:C0566602Primary sclerosing cholangitis1BeFree
umls:C0595921Intraocular pressure disorder1BeFree
umls:C0699790Colon Carcinoma1BeFree
umls:C0729233Dissecting aneurysm of the thoracic aorta1BeFree
umls:C0850572Adenomatous polyp of colon1BeFree
umls:C2931822Nasopharyngeal carcinoma1BeFree
umls:C2936349Plaque, Amyloid1BeFree
umls:C2973725Pulmonary arterial hypertension1BeFree
umls:C3714844Pulmonary Hypertension, Primary, 1, With Hereditary Hemorrhagic Telangiectasia1BeFree