TissGeneSummary for CCDC158 |
Gene summary |
Basic gene information | Gene symbol | CCDC158 |
Gene name | coiled-coil domain containing 158 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 4q21.1 | |
Type of gene | protein-coding | |
RefGenes | NM_178555.3, NM_001042784.1, | |
Description | coiled-coil domain-containing protein 158 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000163749 | ||
HPRD : 13395 | ||
Vega : OTTHUMG00000160916 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CCDC158 | |
BioGPS: 339965 | ||
Pathway | NCI Pathway Interaction Database: CCDC158 | |
KEGG: CCDC158 | ||
REACTOME: CCDC158 | ||
Pathway Commons: CCDC158 | ||
Context | iHOP: CCDC158 | |
ligand binding site mutation search in PubMed: CCDC158 | ||
UCL Cancer Institute: CCDC158 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of CCDC158 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for CCDC158 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LIHC | 0.125961944 | 1.258565944 | -1.132604 | 7.75E-07 | 4.25E-06 |
BRCA | 0.252037593 | 2.505350751 | -2.253313158 | 1.44E-24 | 1.39E-23 |
KICH | -2.564844056 | 0.231991944 | -2.796836 | 1.52E-19 | 1.01E-17 |
PRAD | -0.740754748 | 0.306979867 | -1.047734615 | 1.09E-07 | 1.01E-06 |
KIRP | -0.769609556 | 0.283899819 | -1.053509375 | 0.000835 | 0.002348896 |
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TissGene-miRNA for CCDC158 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for CCDC158 |
TissGeneSNV for CCDC158 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R583Q | SKCM | 4 |
p.P52S | SKCM | 2 |
p.R338K | SKCM | 2 |
p.P990S | SKCM | 2 |
p.P52L | SKCM | 2 |
p.D377N | SKCM | 1 |
p.R35C | SKCM | 1 |
p.T1026A | LIHC | 1 |
p.E228* | UCEC | 1 |
p.S21Y | UCEC | 1 |
p.E7K | LIHC | 1 |
p.E248K | GBM | 1 |
p.R176Q | SKCM | 1 |
p.E102D | COAD | 1 |
p.S1091F | READ | 1 |
p.R862H | UCEC | 1 |
p.R957I | COAD | 1 |
p.S464Y | BLCA | 1 |
p.E7K | UCEC | 1 |
p.E598X | COAD | 1 |
p.L322V | BLCA | 1 |
p.R448Q | LGG | 1 |
p.E633* | HNSC | 1 |
p.D1106Y | PAAD | 1 |
p.E677K | LUSC | 1 |
p.M164I | STAD | 1 |
p.R291* | SKCM | 1 |
p.A517S | LUAD | 1 |
p.S33F | BLCA | 1 |
p.E799G | KIRC | 1 |
p.E551K | CESC | 1 |
p.D405N | SKCM | 1 |
p.R583Q | GBM | 1 |
p.R78H | STAD | 1 |
p.S111L | SKCM | 1 |
p.D142Y | LUSC | 1 |
p.K619N | GBM | 1 |
p.H1022L | SKCM | 1 |
p.V869A | UCEC | 1 |
p.S356* | BLCA | 1 |
p.S965Y | SKCM | 1 |
p.A384_splice | LUSC | 1 |
p.E596K | SKCM | 1 |
p.H1022Q | SKCM | 1 |
p.E689* | UCEC | 1 |
p.S971L | SKCM | 1 |
p.R801H | STAD | 1 |
p.E420K | SKCM | 1 |
p.R583* | GBM | 1 |
p.R621Q | STAD | 1 |
p.A867T | THYM | 1 |
p.E232* | LGG | 1 |
p.L353F | PRAD | 1 |
p.S499L | SKCM | 1 |
p.S1015C | LUAD | 1 |
p.L746I | PRAD | 1 |
p.D142N | SKCM | 1 |
p.S874F | UCEC | 1 |
p.L353F | BLCA | 1 |
p.D1082N | SKCM | 1 |
p.R836S | ESCA | 1 |
p.L379R | STAD | 1 |
p.S1075N | UCEC | 1 |
p.K560N | CESC | 1 |
p.E96K | SKCM | 1 |
p.E279K | UCEC | 1 |
p.R801C | HNSC | 1 |
p.K739E | LUAD | 1 |
p.E341K | SKCM | 1 |
p.E507K | SKCM | 1 |
p.L1083V | COAD | 1 |
p.V59M | STAD | 1 |
p.R362W | STAD | 1 |
p.S1050F | READ | 1 |
p.E831Q | CESC | 1 |
p.R603Q | SKCM | 1 |
p.K619N | HNSC | 1 |
p.S958N | STAD | 1 |
p.D12H | BLCA | 1 |
p.D650H | STAD | 1 |
p.S890F | SKCM | 1 |
p.L795M | COAD | 1 |
p.Q469E | BLCA | 1 |
p.E396* | BLCA | 1 |
p.E82Q | BLCA | 1 |
p.I113V | LUAD | 1 |
p.E173* | BLCA | 1 |
p.N310I | LIHC | 1 |
p.E677K | SKCM | 1 |
p.P1020S | SKCM | 1 |
p.R646H | STAD | 1 |
p.K554I | LUAD | 1 |
p.E7K | SKCM | 1 |
p.L609R | SKCM | 1 |
p.R424Q | COAD | 1 |
p.E482X | ESCA | 1 |
p.S1091Y | LUAD | 1 |
p.H152Y | SKCM | 1 |
p.D1106N | UCEC | 1 |
p.S887F | STAD | 1 |
p.E183D | UCEC | 1 |
p.K846T | LUAD | 1 |
p.R836C | COAD | 1 |
p.R478H | CESC | 1 |
p.R317C | STAD | 1 |
p.G1063E | SKCM | 1 |
p.E483Q | BLCA | 1 |
p.S887F | SKCM | 1 |
p.N682D | COAD | 1 |
p.K1043N | SARC | 1 |
p.P71L | SKCM | 1 |
p.R389K | SKCM | 1 |
p.S1019Y | UCEC | 1 |
p.E232D | READ | 1 |
p.E427K | SKCM | 1 |
p.L260V | BRCA | 1 |
p.K487N | UCEC | 1 |
p.Q380* | BLCA | 1 |
p.S890P | LIHC | 1 |
p.R373H | CESC | 1 |
p.P851S | SKCM | 1 |
p.Q370L | LUAD | 1 |
p.E754* | LUSC | 1 |
p.R418Q | UCEC | 1 |
p.E598X | READ | 1 |
p.E482K | DLBC | 1 |
p.A157D | ESCA | 1 |
p.D939N | SKCM | 1 |
p.I1059T | LGG | 1 |
p.R317S | BLCA | 1 |
p.S296I | HNSC | 1 |
p.R365C | UCEC | 1 |
p.R317C | COAD | 1 |
p.K815N | COAD | 1 |
p.N1013S | THCA | 1 |
p.K607N | STAD | 1 |
p.Q140K | SARC | 1 |
p.L484F | BLCA | 1 |
p.Q443* | LUSC | 1 |
p.R448W | LUAD | 1 |
p.M604L | SARC | 1 |
p.S1054A | COAD | 1 |
p.Q399H | COAD | 1 |
p.R133_splice | GBM | 1 |
p.S1001T | LUAD | 1 |
p.M726I | HNSC | 1 |
p.G23R | SKCM | 1 |
p.S464F | SKCM | 1 |
p.A249S | PAAD | 1 |
p.T37A | THYM | 1 |
p.D964N | SKCM | 1 |
p.L351F | KIRC | 1 |
p.H182N | SKCM | 1 |
p.E927X | READ | 1 |
p.R317S | ESCA | 1 |
p.R684Q | SKCM | 1 |
p.I132M | CESC | 1 |
p.S313F | HNSC | 1 |
p.E285Q | LUAD | 1 |
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TissGeneCNV for CCDC158 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for CCDC158 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for CCDC158 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for CCDC158 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for CCDC158 |
TissGeneDrug for CCDC158 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for CCDC158 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |