TissGeneSummary for TRIML1 |
Gene summary |
Basic gene information | Gene symbol | TRIML1 |
Gene name | tripartite motif family-like 1 | |
Synonyms | RNF209 | |
Cytomap | UCSC genome browser: 4q35.2 | |
Type of gene | protein-coding | |
RefGenes | NM_178556.3, | |
Description | RING finger protein 209probable E3 ubiquitin-protein ligase TRIML1tripartite motif family-like protein 1 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000184108 | ||
HPRD : 08774 | ||
Vega : OTTHUMG00000160237 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_TRIML1 | |
BioGPS: 339976 | ||
Pathway | NCI Pathway Interaction Database: TRIML1 | |
KEGG: TRIML1 | ||
REACTOME: TRIML1 | ||
Pathway Commons: TRIML1 | ||
Context | iHOP: TRIML1 | |
ligand binding site mutation search in PubMed: TRIML1 | ||
UCL Cancer Institute: TRIML1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of TRIML1 | ||
Description by TissGene annotations | Risk TissGene in RFS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for TRIML1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
HNSC | -0.204308793 | -1.609776235 | 1.405467442 | 4.53E-05 | 0.000221576 |
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TissGene-miRNA for TRIML1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for TRIML1 |
TissGeneSNV for TRIML1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.S446F | SKCM | 5 |
p.R282K | SKCM | 2 |
p.S76R | LUAD | 2 |
p.E141K | SKCM | 2 |
p.E89K | SKCM | 2 |
p.H399Q | LUAD | 2 |
p.A131T | STAD | 1 |
p.R253_splice | LUSC | 1 |
p.E141K | UCS | 1 |
p.D319N | STAD | 1 |
p.Y298N | LIHC | 1 |
p.P321L | LUAD | 1 |
p.P450Q | LUAD | 1 |
p.S466C | SKCM | 1 |
p.V177I | LUAD | 1 |
p.Q220H | UCEC | 1 |
p.D374N | SKCM | 1 |
p.E192D | GBM | 1 |
p.S234F | BLCA | 1 |
p.A114T | LGG | 1 |
p.G373W | HNSC | 1 |
p.D385N | SKCM | 1 |
p.F445I | OV | 1 |
p.R150K | SKCM | 1 |
p.P63L | UCEC | 1 |
p.L258* | LIHC | 1 |
p.G423E | STAD | 1 |
p.L81H | SKCM | 1 |
p.R150G | LIHC | 1 |
p.T289M | ESCA | 1 |
p.R340G | UCEC | 1 |
p.A250T | SKCM | 1 |
p.E452K | SKCM | 1 |
p.P50A | LUAD | 1 |
p.Y342C | COAD | 1 |
p.Q260X | SKCM | 1 |
p.E242K | READ | 1 |
p.E152* | UCEC | 1 |
p.R147C | LUAD | 1 |
p.W57* | CESC | 1 |
p.A328V | LGG | 1 |
p.K184N | ESCA | 1 |
p.E91K | STAD | 1 |
p.P403H | HNSC | 1 |
p.V468I | KIRP | 1 |
p.E30K | UCEC | 1 |
p.G62D | SKCM | 1 |
p.E89* | LUAD | 1 |
p.M183I | SKCM | 1 |
p.C358F | LUAD | 1 |
p.Q438* | OV | 1 |
p.D360E | STAD | 1 |
p.R70H | PRAD | 1 |
p.G111C | LUAD | 1 |
p.G93V | LGG | 1 |
p.G348E | SKCM | 1 |
p.R70C | STAD | 1 |
p.C462Y | LUAD | 1 |
p.V468I | STAD | 1 |
p.H341Q | LUAD | 1 |
p.H186N | LUAD | 1 |
p.T286_splice | LUSC | 1 |
p.E132K | COAD | 1 |
p.P321Q | HNSC | 1 |
p.S302L | BRCA | 1 |
p.E206D | LGG | 1 |
p.E252Q | PAAD | 1 |
p.A104V | PRAD | 1 |
p.S52Y | BLCA | 1 |
p.R82L | HNSC | 1 |
p.E61D | LUSC | 1 |
p.R124K | SKCM | 1 |
p.Y387* | BLCA | 1 |
p.L145V | CESC | 1 |
p.G121D | COAD | 1 |
p.T171I | STAD | 1 |
p.R70S | LUAD | 1 |
p.V400F | LUAD | 1 |
p.T173N | PCPG | 1 |
p.A250S | LUAD | 1 |
p.D108V | BRCA | 1 |
p.C272* | LUSC | 1 |
p.T275M | GBM | 1 |
p.S83Y | HNSC | 1 |
p.G332R | LUAD | 1 |
p.D325N | LIHC | 1 |
p.P433L | GBM | 1 |
p.A102D | READ | 1 |
p.T100A | DLBC | 1 |
p.P256A | UCEC | 1 |
p.S34R | PRAD | 1 |
p.L375M | UCEC | 1 |
p.L459H | ESCA | 1 |
p.V38L | LUAD | 1 |
p.E204* | SARC | 1 |
p.T29I | LGG | 1 |
p.W390C | GBM | 1 |
p.E137K | SKCM | 1 |
p.T286M | THYM | 1 |
p.W343R | BLCA | 1 |
p.G356S | SKCM | 1 |
p.N465Y | LUAD | 1 |
p.A328V | GBM | 1 |
p.R124K | LUSC | 1 |
p.W343L | HNSC | 1 |
p.I229M | LUAD | 1 |
p.E287* | UCEC | 1 |
p.S446Y | THCA | 1 |
p.S239L | UCEC | 1 |
p.Q260* | SKCM | 1 |
p.Q92K | PAAD | 1 |
p.L145V | BLCA | 1 |
p.A104V | STAD | 1 |
p.E242K | SKCM | 1 |
p.T286M | LUAD | 1 |
p.E193D | UCEC | 1 |
p.C167F | LUAD | 1 |
p.G339W | LUAD | 1 |
p.R79S | UCEC | 1 |
p.D325H | UCEC | 1 |
p.S83T | UCEC | 1 |
p.P292T | LUSC | 1 |
p.E252K | SKCM | 1 |
p.R253K | SKCM | 1 |
p.V468I | LGG | 1 |
p.L127I | LUAD | 1 |
p.C261R | LUAD | 1 |
p.K406T | STAD | 1 |
p.C261F | LUSC | 1 |
p.E354G | UCEC | 1 |
p.E13K | SKCM | 1 |
p.A295T | SKCM | 1 |
p.C462* | LUAD | 1 |
p.L41F | SKCM | 1 |
p.S302L | UCEC | 1 |
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TissGeneCNV for TRIML1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for TRIML1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for TRIML1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for TRIML1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for TRIML1 |
TissGeneDrug for TRIML1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for TRIML1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |