TissGeneSummary for OTOG |
Gene summary |
Basic gene information | Gene symbol | OTOG |
Gene name | otogelin | |
Synonyms | DFNB18B|MLEMP|OTGN | |
Cytomap | UCSC genome browser: 11p15.1 | |
Type of gene | protein-coding | |
RefGenes | NM_001277269.1, NM_001292063.1,NM_198497.1, | |
Description | - | |
Modification date | 20141207 | |
dbXrefs | MIM : 604487 | |
HGNC : HGNC | ||
Ensembl : ENSG00000188162 | ||
Vega : OTTHUMG00000149905 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_OTOG | |
BioGPS: 340990 | ||
Pathway | NCI Pathway Interaction Database: OTOG | |
KEGG: OTOG | ||
REACTOME: OTOG | ||
Pathway Commons: OTOG | ||
Context | iHOP: OTOG | |
ligand binding site mutation search in PubMed: OTOG | ||
UCL Cancer Institute: OTOG | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of OTOG | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for OTOG |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for OTOG |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for OTOG |
TissGeneSNV for OTOG |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.A1759V | ACC | 2 |
p.Y1182N | LIHC | 1 |
p.R1352Q | SARC | 1 |
p.V2048M | ESCA | 1 |
p.R1165* | CESC | 1 |
p.P1574L | ACC | 1 |
p.P21S | MESO | 1 |
p.R1161Q | LIHC | 1 |
p.R992W | CESC | 1 |
p.E2362Q | CESC | 1 |
p.T1025I | ESCA | 1 |
p.T250P | KICH | 1 |
p.R1339C | ESCA | 1 |
p.D1792N | CESC | 1 |
p.D1078E | SARC | 1 |
p.T1556I | LIHC | 1 |
p.R2837C | BRCA | 1 |
p.T1874M | ACC | 1 |
p.V2055L | ACC | 1 |
p.R2262W | SARC | 1 |
p.L1220M | ESCA | 1 |
p.R1102W | KIRP | 1 |
p.R98S | BRCA | 1 |
p.M2140I | ESCA | 1 |
p.T1162P | ACC | 1 |
p.L1852M | CESC | 1 |
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TissGeneCNV for OTOG |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for OTOG |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for OTOG |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for OTOG |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for OTOG |
TissGeneDrug for OTOG |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for OTOG |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0018777 | Conductive hearing loss | 1 | BeFree |
umls:C0030567 | Parkinson Disease | 1 | GAD |
umls:C0038454 | Cerebrovascular accident | 1 | GAD |
umls:C0155552 | Hearing Loss, Mixed Conductive-Sensorineural | 1 | BeFree |
umls:C1862939 | AMYOTROPHIC LATERAL SCLEROSIS 1 | 1 | CTD_human |
umls:C3554163 | DEAFNESS, AUTOSOMAL RECESSIVE 18B | 1 | CLINVAR,UNIPROT |