TissGeneSummary for NANOS3 |
Gene summary |
Basic gene information | Gene symbol | NANOS3 |
Gene name | nanos homolog 3 (Drosophila) | |
Synonyms | NANOS1L|NOS3 | |
Cytomap | UCSC genome browser: 19p13.13 | |
Type of gene | protein-coding | |
RefGenes | NM_001098622.2, | |
Description | nanos homolog 3 | |
Modification date | 20141207 | |
dbXrefs | MIM : 608229 | |
HGNC : HGNC | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_NANOS3 | |
BioGPS: 342977 | ||
Pathway | NCI Pathway Interaction Database: NANOS3 | |
KEGG: NANOS3 | ||
REACTOME: NANOS3 | ||
Pathway Commons: NANOS3 | ||
Context | iHOP: NANOS3 | |
ligand binding site mutation search in PubMed: NANOS3 | ||
UCL Cancer Institute: NANOS3 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of NANOS3 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for NANOS3 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
THCA | 1.405390458 | 0.343541305 | 1.061849153 | 8.58E-09 | 4.32E-08 |
COAD | 1.835864187 | -0.858635813 | 2.6945 | 7.22E-07 | 4.18E-06 |
KICH | -1.432629814 | 0.007766187 | -1.440396 | 2.11E-09 | 1.24E-08 |
ESCA | 0.769814187 | -1.149194904 | 1.919009091 | 0.00317 | 0.03000034 |
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TissGene-miRNA for NANOS3 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for NANOS3 |
TissGeneSNV for NANOS3 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R121C | STAD | 1 |
p.E24K | SKCM | 1 |
p.P26S | STAD | 1 |
p.R165L | BLCA | 1 |
p.Q33K | SKCM | 1 |
p.S59F | SKCM | 1 |
p.R166L | ESCA | 1 |
p.S183L | HNSC | 1 |
p.E27K | SKCM | 1 |
p.C112Y | BLCA | 1 |
p.H104Y | BLCA | 1 |
p.R146L | BLCA | 1 |
p.R147* | LUAD | 1 |
p.R65H | UCEC | 1 |
p.H123Y | BLCA | 1 |
p.C93Y | BLCA | 1 |
p.R87L | COAD | 1 |
p.A103T | BLCA | 1 |
p.R119C | STAD | 1 |
p.E98K | SKCM | 1 |
p.P26S | SKCM | 1 |
p.S164L | HNSC | 1 |
p.R106* | SKCM | 1 |
p.Y135N | LIHC | 1 |
p.S164L | BLCA | 1 |
p.Y116N | LIHC | 1 |
p.D136N | BLCA | 1 |
p.E79K | SKCM | 1 |
p.P163S | THCA | 1 |
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TissGeneCNV for NANOS3 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for NANOS3 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for NANOS3 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for NANOS3 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for NANOS3 |
TissGeneDrug for NANOS3 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for NANOS3 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0020538 | Hypertensive disease | 20 | BeFree |
umls:C0038454 | Cerebrovascular accident | 9 | BeFree |
umls:C0856169 | Endothelial dysfunction | 9 | BeFree |
umls:C0003850 | Arteriosclerosis | 8 | BeFree |
umls:C0004153 | Atherosclerosis | 8 | BeFree |
umls:C0948008 | Ischemic stroke | 8 | BeFree |
umls:C1956346 | Coronary Artery Disease | 8 | BeFree |
umls:C3272363 | Ischemic Cerebrovascular Accident | 8 | BeFree |
umls:C0006142 | Malignant neoplasm of breast | 7 | BeFree |
umls:C0007222 | Cardiovascular Diseases | 7 | BeFree |
umls:C0028754 | Obesity | 7 | BeFree |
umls:C0678222 | Breast Carcinoma | 7 | BeFree |
umls:C0004096 | Asthma | 6 | BeFree |
umls:C0524620 | Metabolic Syndrome X | 6 | BeFree |
umls:C0010054 | Coronary Arteriosclerosis | 5 | BeFree |
umls:C0027051 | Myocardial Infarction | 5 | BeFree |
umls:C0010068 | Coronary heart disease | 4 | BeFree |
umls:C0011854 | Diabetes Mellitus, Insulin-Dependent | 4 | BeFree |
umls:C0022658 | Kidney Diseases | 4 | BeFree |
umls:C0085580 | Essential Hypertension | 4 | BeFree |
umls:C0339573 | Glaucoma, Primary Open Angle | 4 | BeFree |
umls:C0376358 | Malignant neoplasm of prostate | 4 | BeFree |
umls:C0600139 | Prostate carcinoma | 4 | BeFree |
umls:C0011881 | Diabetic Nephropathy | 3 | BeFree |
umls:C0022661 | Kidney Failure, Chronic | 3 | BeFree |
umls:C0035078 | Kidney Failure | 3 | BeFree |
umls:C0085215 | Ovarian Failure, Premature | 3 | BeFree,GAD,LHGDN |
umls:C0002895 | Anemia, Sickle Cell | 2 | BeFree |
umls:C0003873 | Rheumatoid Arthritis | 2 | BeFree |
umls:C0004943 | Behcet Syndrome | 2 | BeFree |
umls:C0005684 | Malignant neoplasm of urinary bladder | 2 | BeFree |
umls:C0011265 | Presenile dementia | 2 | BeFree |
umls:C0011849 | Diabetes Mellitus | 2 | BeFree |
umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 2 | BeFree |
umls:C0017601 | Glaucoma | 2 | BeFree |
umls:C0020542 | Pulmonary Hypertension | 2 | BeFree |
umls:C0021364 | Male infertility | 2 | BeFree |
umls:C0027627 | Neoplasm Metastasis | 2 | BeFree |
umls:C0041408 | Turner Syndrome | 2 | BeFree |
umls:C0042373 | Vascular Diseases | 2 | BeFree |
umls:C0085413 | Polycystic Kidney, Autosomal Dominant | 2 | BeFree |
umls:C0149871 | Deep Vein Thrombosis | 2 | BeFree |
umls:C0149931 | Migraine Disorders | 2 | BeFree |
umls:C0238421 | Selenium deficiency | 2 | BeFree |
umls:C0242339 | Dyslipidemias | 2 | BeFree |
umls:C0340100 | High altitude pulmonary edema | 2 | BeFree |
umls:C0340708 | Deep vein thrombosis of lower limb | 2 | BeFree |
umls:C0497327 | Dementia | 2 | BeFree |
umls:C0524851 | Neurodegenerative Disorders | 2 | BeFree |
umls:C0598608 | Hyperhomocysteinemia | 2 | BeFree |
umls:C0699885 | Carcinoma of bladder | 2 | BeFree |
umls:C0752304 | Hypoxic-Ischemic Encephalopathy | 2 | BeFree |
umls:C0948089 | Acute Coronary Syndrome | 2 | BeFree |
umls:C3495426 | Homocysteinemia | 2 | BeFree |
umls:C0001815 | Primary Myelofibrosis | 1 | BeFree |
umls:C0002453 | Amenorrhea | 1 | BeFree |
umls:C0002875 | Cooley's anemia | 1 | BeFree |
umls:C0002949 | Aneurysm, Dissecting | 1 | BeFree |
umls:C0005586 | Bipolar Disorder | 1 | BeFree |
umls:C0006012 | Borderline Personality Disorder | 1 | BeFree |
umls:C0006287 | Bronchopulmonary Dysplasia | 1 | BeFree |
umls:C0007131 | Non-Small Cell Lung Carcinoma | 1 | BeFree |
umls:C0007193 | Cardiomyopathy, Dilated | 1 | BeFree |
umls:C0011570 | Mental Depression | 1 | BeFree |
umls:C0011581 | Depressive disorder | 1 | BeFree |
umls:C0011847 | Diabetes | 1 | BeFree |
umls:C0011875 | Diabetic Angiopathies | 1 | BeFree |
umls:C0011884 | Diabetic Retinopathy | 1 | BeFree |
umls:C0013537 | Eclampsia | 1 | BeFree |
umls:C0018681 | Headache | 1 | BeFree |
umls:C0018784 | Sensorineural Hearing Loss (disorder) | 1 | BeFree |
umls:C0018801 | Heart failure | 1 | BeFree |
umls:C0018802 | Congestive heart failure | 1 | BeFree |
umls:C0020473 | Hyperlipidemia | 1 | BeFree |
umls:C0023449 | Acute lymphocytic leukemia | 1 | BeFree |
umls:C0024121 | Lung Neoplasms | 1 | BeFree |
umls:C0025286 | Meningioma | 1 | BeFree |
umls:C0025322 | Premature Menopause | 1 | BeFree |
umls:C0026946 | Mycoses | 1 | BeFree |
umls:C0029400 | Osteitis | 1 | BeFree |
umls:C0029443 | Osteomyelitis | 1 | BeFree |
umls:C0032285 | Pneumonia | 1 | BeFree |
umls:C0033117 | Priapism | 1 | BeFree |
umls:C0036421 | Systemic Scleroderma | 1 | BeFree |
umls:C0039538 | Teratoma | 1 | BeFree |
umls:C0040028 | Thrombocythemia, Essential | 1 | BeFree |
umls:C0041107 | Trisomy | 1 | BeFree |
umls:C0041696 | Unipolar Depression | 1 | BeFree |
umls:C0086132 | Depressive Symptoms | 1 | BeFree |
umls:C0149721 | Left Ventricular Hypertrophy | 1 | BeFree |
umls:C0150063 | Feeling powerless | 1 | BeFree |
umls:C0151950 | Deep thrombophlebitis | 1 | BeFree |
umls:C0152171 | Idiopathic pulmonary hypertension | 1 | BeFree |
umls:C0154723 | Migraine with Aura | 1 | BeFree |
umls:C0155626 | Acute myocardial infarction | 1 | BeFree |
umls:C0178874 | Tumor Progression | 1 | BeFree |
umls:C0232939 | Primary physiologic amenorrhea | 1 | BeFree |
umls:C0238463 | Papillary thyroid carcinoma | 1 | BeFree |
umls:C0279628 | Adenocarcinoma Of Esophagus | 1 | BeFree |
umls:C0338480 | Common Migraine | 1 | BeFree |
umls:C0340293 | Anterior myocardial infarction | 1 | BeFree |
umls:C0403447 | Chronic Kidney Insufficiency | 1 | BeFree |
umls:C0525045 | Mood Disorders | 1 | BeFree |
umls:C0596263 | Carcinogenesis | 1 | BeFree |
umls:C0683322 | Mental impairment | 1 | BeFree |
umls:C0694539 | Chronic atrial fibrillation | 1 | BeFree |
umls:C0747102 | Ovarian failure | 1 | BeFree |
umls:C0853879 | Invasive breast carcinoma | 1 | BeFree |
umls:C1269683 | Major Depressive Disorder | 1 | BeFree |
umls:C1281300 | Vascular degeneration | 1 | BeFree |
umls:C1401084 | Ovarian Insufficiency | 1 | BeFree |
umls:C1561643 | Chronic Kidney Diseases | 1 | BeFree |
umls:C1568272 | Tendinopathy | 1 | BeFree |
umls:C1704272 | Benign Prostatic Hyperplasia | 1 | BeFree |
umls:C1961102 | Precursor Cell Lymphoblastic Leukemia Lymphoma | 1 | BeFree |
umls:C2362324 | Pediatric Obesity | 1 | BeFree |
umls:C2931822 | Nasopharyngeal carcinoma | 1 | BeFree |
umls:C2973725 | Pulmonary arterial hypertension | 1 | BeFree |
umls:C3714636 | Pneumonitis | 1 | BeFree |
umls:C3714844 | Pulmonary Hypertension, Primary, 1, With Hereditary Hemorrhagic Telangiectasia | 1 | BeFree |
umls:C3840085 | Disorder of Achilles tendon | 1 | BeFree |