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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for NANOS3
check button Gene summary
Basic gene informationGene symbolNANOS3
Gene namenanos homolog 3 (Drosophila)
SynonymsNANOS1L|NOS3
CytomapUCSC genome browser: 19p13.13
Type of geneprotein-coding
RefGenesNM_001098622.2,
Descriptionnanos homolog 3
Modification date20141207
dbXrefs MIM : 608229
HGNC : HGNC
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_NANOS3
BioGPS: 342977
PathwayNCI Pathway Interaction Database: NANOS3
KEGG: NANOS3
REACTOME: NANOS3
Pathway Commons: NANOS3
ContextiHOP: NANOS3
ligand binding site mutation search in PubMed: NANOS3
UCL Cancer Institute: NANOS3
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesHPA,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Testis
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)TGCT
Reference showing the relevant tissue of NANOS3
Description by TissGene annotations
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


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TissGeneExp for NANOS3

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
THCA1.4053904580.3435413051.0618491538.58E-094.32E-08
COAD1.835864187-0.8586358132.69457.22E-074.18E-06
KICH-1.4326298140.007766187-1.4403962.11E-091.24E-08
ESCA0.769814187-1.1491949041.9190090910.003170.03000034


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TissGene-miRNA for NANOS3

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for NANOS3
TissGeneSNV for NANOS3

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.R121CSTAD1
p.E24KSKCM1
p.P26SSTAD1
p.R165LBLCA1
p.Q33KSKCM1
p.S59FSKCM1
p.R166LESCA1
p.S183LHNSC1
p.E27KSKCM1
p.C112YBLCA1
p.H104YBLCA1
p.R146LBLCA1
p.R147*LUAD1
p.R65HUCEC1
p.H123YBLCA1
p.C93YBLCA1
p.R87LCOAD1
p.A103TBLCA1
p.R119CSTAD1
p.E98KSKCM1
p.P26SSKCM1
p.S164LHNSC1
p.R106*SKCM1
p.Y135NLIHC1
p.S164LBLCA1
p.Y116NLIHC1
p.D136NBLCA1
p.E79KSKCM1
p.P163STHCA1


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TissGeneCNV for NANOS3

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for NANOS3

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP


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TissGeneNet for NANOS3

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)


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TissGeneProg for NANOS3

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for NANOS3
TissGeneDrug for NANOS3

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for NANOS3

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0020538Hypertensive disease20BeFree
umls:C0038454Cerebrovascular accident9BeFree
umls:C0856169Endothelial dysfunction9BeFree
umls:C0003850Arteriosclerosis8BeFree
umls:C0004153Atherosclerosis8BeFree
umls:C0948008Ischemic stroke8BeFree
umls:C1956346Coronary Artery Disease8BeFree
umls:C3272363Ischemic Cerebrovascular Accident8BeFree
umls:C0006142Malignant neoplasm of breast7BeFree
umls:C0007222Cardiovascular Diseases7BeFree
umls:C0028754Obesity7BeFree
umls:C0678222Breast Carcinoma7BeFree
umls:C0004096Asthma6BeFree
umls:C0524620Metabolic Syndrome X6BeFree
umls:C0010054Coronary Arteriosclerosis5BeFree
umls:C0027051Myocardial Infarction5BeFree
umls:C0010068Coronary heart disease4BeFree
umls:C0011854Diabetes Mellitus, Insulin-Dependent4BeFree
umls:C0022658Kidney Diseases4BeFree
umls:C0085580Essential Hypertension4BeFree
umls:C0339573Glaucoma, Primary Open Angle4BeFree
umls:C0376358Malignant neoplasm of prostate4BeFree
umls:C0600139Prostate carcinoma4BeFree
umls:C0011881Diabetic Nephropathy3BeFree
umls:C0022661Kidney Failure, Chronic3BeFree
umls:C0035078Kidney Failure3BeFree
umls:C0085215Ovarian Failure, Premature3BeFree,GAD,LHGDN
umls:C0002895Anemia, Sickle Cell2BeFree
umls:C0003873Rheumatoid Arthritis2BeFree
umls:C0004943Behcet Syndrome2BeFree
umls:C0005684Malignant neoplasm of urinary bladder2BeFree
umls:C0011265Presenile dementia2BeFree
umls:C0011849Diabetes Mellitus2BeFree
umls:C0011860Diabetes Mellitus, Non-Insulin-Dependent2BeFree
umls:C0017601Glaucoma2BeFree
umls:C0020542Pulmonary Hypertension2BeFree
umls:C0021364Male infertility2BeFree
umls:C0027627Neoplasm Metastasis2BeFree
umls:C0041408Turner Syndrome2BeFree
umls:C0042373Vascular Diseases2BeFree
umls:C0085413Polycystic Kidney, Autosomal Dominant2BeFree
umls:C0149871Deep Vein Thrombosis2BeFree
umls:C0149931Migraine Disorders2BeFree
umls:C0238421Selenium deficiency2BeFree
umls:C0242339Dyslipidemias2BeFree
umls:C0340100High altitude pulmonary edema2BeFree
umls:C0340708Deep vein thrombosis of lower limb2BeFree
umls:C0497327Dementia2BeFree
umls:C0524851Neurodegenerative Disorders2BeFree
umls:C0598608Hyperhomocysteinemia2BeFree
umls:C0699885Carcinoma of bladder2BeFree
umls:C0752304Hypoxic-Ischemic Encephalopathy2BeFree
umls:C0948089Acute Coronary Syndrome2BeFree
umls:C3495426Homocysteinemia2BeFree
umls:C0001815Primary Myelofibrosis1BeFree
umls:C0002453Amenorrhea1BeFree
umls:C0002875Cooley's anemia1BeFree
umls:C0002949Aneurysm, Dissecting1BeFree
umls:C0005586Bipolar Disorder1BeFree
umls:C0006012Borderline Personality Disorder1BeFree
umls:C0006287Bronchopulmonary Dysplasia1BeFree
umls:C0007131Non-Small Cell Lung Carcinoma1BeFree
umls:C0007193Cardiomyopathy, Dilated1BeFree
umls:C0011570Mental Depression1BeFree
umls:C0011581Depressive disorder1BeFree
umls:C0011847Diabetes1BeFree
umls:C0011875Diabetic Angiopathies1BeFree
umls:C0011884Diabetic Retinopathy1BeFree
umls:C0013537Eclampsia1BeFree
umls:C0018681Headache1BeFree
umls:C0018784Sensorineural Hearing Loss (disorder)1BeFree
umls:C0018801Heart failure1BeFree
umls:C0018802Congestive heart failure1BeFree
umls:C0020473Hyperlipidemia1BeFree
umls:C0023449Acute lymphocytic leukemia1BeFree
umls:C0024121Lung Neoplasms1BeFree
umls:C0025286Meningioma1BeFree
umls:C0025322Premature Menopause1BeFree
umls:C0026946Mycoses1BeFree
umls:C0029400Osteitis1BeFree
umls:C0029443Osteomyelitis1BeFree
umls:C0032285Pneumonia1BeFree
umls:C0033117Priapism1BeFree
umls:C0036421Systemic Scleroderma1BeFree
umls:C0039538Teratoma1BeFree
umls:C0040028Thrombocythemia, Essential1BeFree
umls:C0041107Trisomy1BeFree
umls:C0041696Unipolar Depression1BeFree
umls:C0086132Depressive Symptoms1BeFree
umls:C0149721Left Ventricular Hypertrophy1BeFree
umls:C0150063Feeling powerless1BeFree
umls:C0151950Deep thrombophlebitis1BeFree
umls:C0152171Idiopathic pulmonary hypertension1BeFree
umls:C0154723Migraine with Aura1BeFree
umls:C0155626Acute myocardial infarction1BeFree
umls:C0178874Tumor Progression1BeFree
umls:C0232939Primary physiologic amenorrhea1BeFree
umls:C0238463Papillary thyroid carcinoma1BeFree
umls:C0279628Adenocarcinoma Of Esophagus1BeFree
umls:C0338480Common Migraine1BeFree
umls:C0340293Anterior myocardial infarction1BeFree
umls:C0403447Chronic Kidney Insufficiency1BeFree
umls:C0525045Mood Disorders1BeFree
umls:C0596263Carcinogenesis1BeFree
umls:C0683322Mental impairment1BeFree
umls:C0694539Chronic atrial fibrillation1BeFree
umls:C0747102Ovarian failure1BeFree
umls:C0853879Invasive breast carcinoma1BeFree
umls:C1269683Major Depressive Disorder1BeFree
umls:C1281300Vascular degeneration1BeFree
umls:C1401084Ovarian Insufficiency1BeFree
umls:C1561643Chronic Kidney Diseases1BeFree
umls:C1568272Tendinopathy1BeFree
umls:C1704272Benign Prostatic Hyperplasia1BeFree
umls:C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1BeFree
umls:C2362324Pediatric Obesity1BeFree
umls:C2931822Nasopharyngeal carcinoma1BeFree
umls:C2973725Pulmonary arterial hypertension1BeFree
umls:C3714636Pneumonitis1BeFree
umls:C3714844Pulmonary Hypertension, Primary, 1, With Hereditary Hemorrhagic Telangiectasia1BeFree
umls:C3840085Disorder of Achilles tendon1BeFree