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| TissGeneSummary for TUBB2B |
 Gene summary |
| Basic gene information | Gene symbol | TUBB2B |
| Gene name | tubulin, beta 2B class IIb | |
| Synonyms | PMGYSA|bA506K6.1 | |
| Cytomap | UCSC genome browser: 6p25 | |
| Type of gene | protein-coding | |
| RefGenes | NM_178012.4, | |
| Description | class II beta-tubulin isotypeclass IIb beta-tubulintubulin beta-2B chaintubulin, beta polypeptide paralog | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 612850 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000137285 | ||
| HPRD : 14707 | ||
| Vega : OTTHUMG00000014143 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_TUBB2B | |
| BioGPS: 347733 | ||
| Pathway | NCI Pathway Interaction Database: TUBB2B | |
| KEGG: TUBB2B | ||
| REACTOME: TUBB2B | ||
| Pathway Commons: TUBB2B | ||
| Context | iHOP: TUBB2B | |
| ligand binding site mutation search in PubMed: TUBB2B | ||
| UCL Cancer Institute: TUBB2B | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,TiGER | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Brain | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGG | |
| Reference showing the relevant tissue of TUBB2B | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for TUBB2B |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUSC | -0.866275385 | -2.569994993 | 1.703719608 | 3.93E-05 | 8.46E-05 |
| KIRC | -1.882361578 | 1.678843977 | -3.561205556 | 4.69E-29 | 8.21E-28 |
| LUAD | -0.37002312 | -2.698626569 | 2.328603448 | 1.48E-07 | 5.65E-07 |
| BRCA | -1.74770361 | 1.344838495 | -3.092542105 | 1.86E-29 | 2.37E-28 |
| COAD | -1.579569805 | 0.420168657 | -1.999738462 | 2.67E-06 | 1.37E-05 |
| STAD | -2.041341439 | -0.886978939 | -1.1543625 | 0.0109 | 0.036918825 |
| THCA | -3.68756485 | -2.52687502 | -1.160689831 | 0.00021 | 0.000548926 |
| KIRP | 0.596727311 | 2.034055436 | -1.437328125 | 4.93E-05 | 0.000180311 |
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| TissGene-miRNA for TUBB2B |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| LUAD | hsa-miR-29a-3p | MIMAT0000086 | 0.042 | -0.27 | 60 |
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| TissGeneMut for TUBB2B |
| TissGeneSNV for TUBB2B |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.A9V | PAAD | 1 |
| p.F85L | THCA | 1 |
| p.S75L | BLCA | 1 |
| p.E432K | SKCM | 1 |
| p.V169I | KIRC | 1 |
| p.A97V | STAD | 1 |
| p.E442K | LUAD | 1 |
| p.V91M | LUAD | 1 |
| p.E435G | UCEC | 1 |
| p.S420F | ACC | 1 |
| p.G223R | ESCA | 1 |
| p.V23F | PRAD | 1 |
| p.G148S | UCEC | 1 |
| p.N14S | KIRC | 1 |
| p.C12G | BRCA | 1 |
| p.G13C | LIHC | 1 |
| p.P61S | STAD | 1 |
| p.E440K | LUAD | 1 |
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| TissGeneCNV for TUBB2B |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for TUBB2B |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | DA506064 | TUBB2B-DYRK2 | chr6:3227887 | chr12:68052307 | |
| Chimerdb3.0 | ChiTaRs | NA | AW498865 | NACA-TUBB2B | chr12:57112717 | chr6:3225938 |
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| TissGeneNet for TUBB2B |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| TUBB2B, TRAF6, C8orf33, NFKB2, RELA, NFKB1, RGS2, MAP3K1, IKBKB, MAP3K14, ANXA7, MAP3K3, RIPK3, PHYH, TRAF3IP1, TAB1, RPL35, BID, MDK, MLF1IP, NF2 (tumor) | TUBB2B, NFKB2, MAP3K7, TNFRSF1A, FOS, CUL3, RGS2, HDAC6, MAP3K14, ANXA7, MAP3K3, RIPK3, CACNA1A, TNFRSF1B, HSP90AA1, TRAF3IP1, TAB1, RPL35, BID, MDK, MLF1IP (normal) |
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| COAD (tumor) | COAD (normal) |
| TUBB2B, TRAF6, C8orf33, NFKB2, CDKN1A, RELA, NFKB1, CUL3, RGS2, MAP3K1, HDAC6, MAP3K14, MAP3K3, RIPK3, RIPK2, CSNK2B, PHYH, TRAF3IP1, TAB1, BID, MLF1IP (tumor) | TUBB2B, TRAF6, NFKB2, MAP3K7, CDKN1A, RELA, TNFRSF1A, NFKB1, RGS2, MAP3K1, SUMO1, MAP3K14, MAP3K3, RIPK3, CACNA1A, CSNK2B, PHYH, RPL35, BID, MDK, MLF1IP (normal) |
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| HNSC (tumor) | HNSC (normal) |
| TUBB2B, TRAF6, C8orf33, CDKN1A, NFKB1, CUL3, MAP3K1, HDAC6, IKBKB, MAP3K14, MAP3K3, RIPK3, RIPK2, CACNA1A, TNFRSF1B, PHYH, TRAF3IP1, TAB1, MDK, MLF1IP, NF2 (tumor) | TUBB2B, C8orf33, NFKB2, CDKN1A, RELA, TNFRSF1A, NFKB1, HDAC6, IKBKB, MAP3K14, MAP3K3, CACNA1A, TNFRSF1B, HSP90AA1, CSNK2B, PHYH, TRAF3IP1, TAB1, RPL35, MDK, NF2 (normal) |
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| KICH (tumor) | KICH (normal) |
| TUBB2B, C8orf33, NFKB2, MAP3K7, TNFRSF1A, FOS, CUL3, RGS2, MAP3K1, HDAC6, IKBKB, SUMO1, MAP3K14, ANXA7, RIPK3, CACNA1A, HSP90AA1, PHYH, TRAF3IP1, RPL35, MLF1IP (tumor) | TUBB2B, C8orf33, NFKB2, CDKN1A, RELA, TNFRSF1A, MAP3K1, SUMO1, MAP3K14, MAP3K3, RIPK3, CACNA1A, TNFRSF1B, HSP90AA1, CSNK2B, PHYH, TRAF3IP1, BID, MDK, MLF1IP, NF2 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| TUBB2B, MAP3K7, CDKN1A, RELA, NFKB1, CUL3, RGS2, MAP3K1, HDAC6, IKBKB, SUMO1, RIPK3, RIPK2, CACNA1A, TNFRSF1B, CSNK2B, PHYH, TAB1, BID, MLF1IP, NF2 (tumor) | TUBB2B, C8orf33, NFKB2, TNFRSF1A, NFKB1, CUL3, RGS2, MAP3K1, HDAC6, SUMO1, MAP3K14, MAP3K3, RIPK3, TNFRSF1B, HSP90AA1, PHYH, TRAF3IP1, TAB1, BID, MDK, NF2 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| TUBB2B, TRAF6, CDKN1A, RELA, TNFRSF1A, FOS, CUL3, RGS2, MAP3K1, HDAC6, IKBKB, SUMO1, ANXA7, RIPK3, TNFRSF1B, HSP90AA1, PHYH, TRAF3IP1, TAB1, BID, MLF1IP (tumor) | TUBB2B, TRAF6, C8orf33, MAP3K7, CDKN1A, RELA, FOS, CUL3, RGS2, HDAC6, MAP3K14, RIPK3, RIPK2, TNFRSF1B, PHYH, TRAF3IP1, TAB1, BID, MDK, MLF1IP, NF2 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| TUBB2B, TRAF6, NFKB2, MAP3K7, CDKN1A, TNFRSF1A, NFKB1, RGS2, MAP3K1, IKBKB, MAP3K14, MAP3K3, RIPK3, RIPK2, CACNA1A, TNFRSF1B, HSP90AA1, PHYH, TAB1, BID, MDK (tumor) | TUBB2B, CDKN1A, RELA, NFKB1, CUL3, MAP3K1, HDAC6, IKBKB, SUMO1, ANXA7, RIPK3, RIPK2, CACNA1A, TNFRSF1B, HSP90AA1, CSNK2B, PHYH, RPL35, MDK, MLF1IP, NF2 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| TUBB2B, NFKB2, CDKN1A, RELA, TNFRSF1A, FOS, NFKB1, RGS2, MAP3K1, IKBKB, SUMO1, MAP3K14, MAP3K3, CACNA1A, TNFRSF1B, HSP90AA1, CSNK2B, PHYH, MDK, MLF1IP, NF2 (tumor) | TUBB2B, TRAF6, C8orf33, NFKB2, MAP3K7, RELA, TNFRSF1A, FOS, NFKB1, MAP3K1, HDAC6, MAP3K14, RIPK3, RIPK2, CACNA1A, TNFRSF1B, HSP90AA1, RPL35, MDK, MLF1IP, NF2 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| TUBB2B, NFKB2, MAP3K7, CDKN1A, TNFRSF1A, CUL3, RGS2, MAP3K1, HDAC6, IKBKB, SUMO1, MAP3K14, MAP3K3, CACNA1A, TNFRSF1B, PHYH, TRAF3IP1, TAB1, BID, MDK, MLF1IP (tumor) | TUBB2B, TRAF6, C8orf33, NFKB2, MAP3K7, CDKN1A, RELA, TNFRSF1A, NFKB1, RGS2, MAP3K1, HDAC6, ANXA7, RIPK3, CACNA1A, PHYH, TRAF3IP1, RPL35, BID, MDK, NF2 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| TUBB2B, MAP3K7, CDKN1A, CUL3, RGS2, HDAC6, IKBKB, SUMO1, ANXA7, MAP3K3, RIPK3, RIPK2, CACNA1A, HSP90AA1, PHYH, TRAF3IP1, TAB1, BID, MDK, MLF1IP, NF2 (tumor) | TUBB2B, C8orf33, NFKB2, CDKN1A, TNFRSF1A, FOS, NFKB1, CUL3, RGS2, MAP3K1, MAP3K14, MAP3K3, RIPK3, RIPK2, CACNA1A, TNFRSF1B, HSP90AA1, BID, MDK, MLF1IP, NF2 (normal) |
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| STAD (tumor) | STAD (normal) |
| TUBB2B, TRAF6, C8orf33, NFKB2, MAP3K7, RELA, FOS, CUL3, RGS2, MAP3K1, HDAC6, MAP3K14, ANXA7, MAP3K3, RIPK3, RIPK2, CSNK2B, TRAF3IP1, BID, MLF1IP, NF2 (tumor) | TUBB2B, TRAF6, NFKB2, MAP3K7, CDKN1A, RELA, TNFRSF1A, FOS, NFKB1, RGS2, HDAC6, MAP3K14, MAP3K3, RIPK3, RIPK2, CACNA1A, TNFRSF1B, HSP90AA1, PHYH, BID, MLF1IP (normal) |
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| THCA (tumor) | THCA (normal) |
| TUBB2B, TRAF6, C8orf33, NFKB2, CDKN1A, RELA, TNFRSF1A, NFKB1, HDAC6, MAP3K14, MAP3K3, RIPK2, CACNA1A, TNFRSF1B, PHYH, TRAF3IP1, RPL35, BID, MDK, MLF1IP, NF2 (tumor) | TUBB2B, TRAF6, C8orf33, NFKB2, CDKN1A, TNFRSF1A, FOS, CUL3, RGS2, MAP3K1, IKBKB, MAP3K14, ANXA7, MAP3K3, RIPK2, CACNA1A, TNFRSF1B, PHYH, TRAF3IP1, TAB1, MLF1IP (normal) |
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| TissGeneProg for TUBB2B |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for TUBB2B |
| TissGeneDrug for TUBB2B |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for TUBB2B |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0266464 | Polymicrogyria | 6 | BeFree |
| umls:C1955869 | Malformations of Cortical Development | 3 | BeFree,CTD_human |
| umls:C0000768 | Congenital Abnormality | 2 | BeFree |
| umls:C0025958 | Microcephaly | 2 | BeFree |
| umls:C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
| umls:C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
| umls:C0028850 | Ocular Motility Disorders | 1 | BeFree |
| umls:C0036341 | Schizophrenia | 1 | LHGDN |
| umls:C0036439 | Scoliosis, unspecified | 1 | BeFree |
| umls:C0175754 | Agenesis of corpus callosum | 1 | BeFree |
| umls:C0266449 | Congenital anomaly of brain | 1 | BeFree |
| umls:C0266463 | Lissencephaly | 1 | BeFree |
| umls:C0559260 | Congenital scoliosis | 1 | BeFree |
| umls:C0700208 | Acquired scoliosis | 1 | BeFree |
| umls:C1302995 | Congenital Fibrosis of the Extraocular Muscles | 1 | BeFree |
| umls:C1458155 | Mammary Neoplasms | 1 | LHGDN |
| umls:C3552236 | POLYMICROGYRIA, SYMMETRIC OR ASYMMETRIC | 1 | CTD_human,MGD,ORPHANET,UNIPROT |
| umls:C2750247 | Polymicrogyria, Asymmetric | 0 | CLINVAR |
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