TissGeneSummary for ACSM2B |
Gene summary |
Basic gene information | Gene symbol | ACSM2B |
Gene name | acyl-CoA synthetase medium-chain family member 2B | |
Synonyms | ACSM2|HXMA | |
Cytomap | UCSC genome browser: 16p12.3 | |
Type of gene | protein-coding | |
RefGenes | NM_001105069.1, NM_182617.3, | |
Description | acyl-CoA synthetase medium-chain family member 2acyl-coenzyme A synthetase ACSM2B, mitochondrialbutyrate--CoA ligase 2Bbutyryl-coenzyme A synthetase 2Bmiddle-chain acyl-CoA synthetase 2Bxenobiotic/medium-chain fatty acid-CoA ligase HXM-Axenobiotic/m | |
Modification date | 20141207 | |
dbXrefs | MIM : 614359 | |
HGNC : HGNC | ||
Ensembl : ENSG00000066813 | ||
HPRD : 17124 | ||
Vega : OTTHUMG00000131555 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ACSM2B | |
BioGPS: 348158 | ||
Pathway | NCI Pathway Interaction Database: ACSM2B | |
KEGG: ACSM2B | ||
REACTOME: ACSM2B | ||
Pathway Commons: ACSM2B | ||
Context | iHOP: ACSM2B | |
ligand binding site mutation search in PubMed: ACSM2B | ||
UCL Cancer Institute: ACSM2B | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | KidneyLiver | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICHLIHC | |
Reference showing the relevant tissue of ACSM2B | ||
Description by TissGene annotations | TissgsKTS CNV gained TissGeneKTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for ACSM2B |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KICH | -1.142323783 | 7.542112217 | -8.684436 | 2.78E-14 | 4.47E-13 |
THCA | -1.711343986 | -0.434893139 | -1.276450847 | 1.89E-13 | 1.91E-12 |
LIHC | 10.00583222 | 11.56432622 | -1.558494 | 8.11E-05 | 0.00028591 |
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TissGene-miRNA for ACSM2B |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for ACSM2B |
TissGeneSNV for ACSM2B |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.K195N | UCEC | 4 |
p.R5Q | SKCM | 3 |
p.E78K | SKCM | 3 |
p.M140I | SKCM | 3 |
p.W265X | SKCM | 3 |
p.D322N | SKCM | 3 |
p.D464N | SKCM | 3 |
p.W265* | SKCM | 3 |
p.R564* | SKCM | 3 |
p.D161N | SKCM | 2 |
p.E567K | SKCM | 2 |
p.E428K | SKCM | 2 |
p.S468F | SKCM | 2 |
p.R63Q | SKCM | 2 |
p.R560Q | SKCM | 2 |
p.G223E | SKCM | 2 |
p.R472W | ESCA | 1 |
p.L64P | GBM | 1 |
p.R358* | CESC | 1 |
p.Q8* | SKCM | 1 |
p.G223R | SKCM | 1 |
p.A507S | LUSC | 1 |
p.S236L | SKCM | 1 |
p.R447W | LUAD | 1 |
p.G421D | UCEC | 1 |
p.R564X | SKCM | 1 |
p.W81* | SKCM | 1 |
p.R5* | LGG | 1 |
p.I449M | HNSC | 1 |
p.R350K | SKCM | 1 |
p.R438Q | UCEC | 1 |
p.G102D | COAD | 1 |
p.R5Q | UCEC | 1 |
p.R447W | SARC | 1 |
p.D498Y | UCEC | 1 |
p.G190W | SKCM | 1 |
p.K539* | LUSC | 1 |
p.S495R | HNSC | 1 |
p.S424F | SKCM | 1 |
p.P486S | PRAD | 1 |
p.D440N | SKCM | 1 |
p.F546L | STAD | 1 |
p.E477D | LUAD | 1 |
p.G354R | SKCM | 1 |
p.G264V | LUSC | 1 |
p.Q332H | UCEC | 1 |
p.S571F | SKCM | 1 |
p.L287V | LUAD | 1 |
p.R461W | LIHC | 1 |
p.Q332X | KIRP | 1 |
p.Q332H | STAD | 1 |
p.S324F | SKCM | 1 |
p.D451Y | COAD | 1 |
p.E452K | SKCM | 1 |
p.R560* | GBM | 1 |
p.Q332* | KIRP | 1 |
p.T524N | SKCM | 1 |
p.G572R | SKCM | 1 |
p.E359* | UCEC | 1 |
p.M140I | SARC | 1 |
p.M244I | LUSC | 1 |
p.A576V | LUSC | 1 |
p.G460E | CHOL | 1 |
p.E479D | COAD | 1 |
p.A93V | PAAD | 1 |
p.M112V | PRAD | 1 |
p.R413S | TGCT | 1 |
p.R5Q | LUSC | 1 |
p.G556W | SKCM | 1 |
p.I123V | THCA | 1 |
p.E58K | SKCM | 1 |
p.R108H | UCEC | 1 |
p.E185A | ESCA | 1 |
p.G337R | SKCM | 1 |
p.R108C | COAD | 1 |
p.R108C | SKCM | 1 |
p.K398N | ESCA | 1 |
p.G190W | LUAD | 1 |
p.Q8X | SKCM | 1 |
p.E477K | SKCM | 1 |
p.W54* | UCEC | 1 |
p.A93T | GBM | 1 |
p.S476W | BLCA | 1 |
p.A60_splice | LUSC | 1 |
p.G572V | LUAD | 1 |
p.D397N | SKCM | 1 |
p.R5* | BRCA | 1 |
p.M134I | COAD | 1 |
p.G271D | UCEC | 1 |
p.A201V | HNSC | 1 |
p.R560Q | BLCA | 1 |
p.K557N | LUAD | 1 |
p.G337* | STAD | 1 |
p.A536T | SKCM | 1 |
p.D451Y | LUAD | 1 |
p.E85X | READ | 1 |
p.M112V | KIRC | 1 |
p.A386T | UCEC | 1 |
p.L64P | KIRP | 1 |
p.R358Q | SKCM | 1 |
p.L4M | ESCA | 1 |
p.S237I | LUAD | 1 |
p.R560X | COAD | 1 |
p.R542G | SKCM | 1 |
p.H53Q | LUAD | 1 |
p.Q139H | LUAD | 1 |
p.S571F | BLCA | 1 |
p.R105C | HNSC | 1 |
p.C101R | KIRP | 1 |
p.G474R | LUAD | 1 |
p.L64P | SARC | 1 |
p.E490D | HNSC | 1 |
p.A42S | LUAD | 1 |
p.R564* | LUSC | 1 |
p.P541R | LUAD | 1 |
p.A242S | BLCA | 1 |
p.A231G | LIHC | 1 |
p.R438* | UCS | 1 |
p.T491M | GBM | 1 |
p.A434V | HNSC | 1 |
p.G106R | LUSC | 1 |
p.N400K | LGG | 1 |
p.E490A | OV | 1 |
p.R542K | SKCM | 1 |
p.A231E | SKCM | 1 |
p.W70C | HNSC | 1 |
p.N82K | LGG | 1 |
p.T12N | BRCA | 1 |
p.G572R | ESCA | 1 |
p.G250C | LUAD | 1 |
p.A311D | LUSC | 1 |
p.Q559R | GBM | 1 |
p.G445E | SKCM | 1 |
p.E39G | UCEC | 1 |
p.G337X | STAD | 1 |
p.G15D | SKCM | 1 |
p.L64P | UCEC | 1 |
p.I494M | LUAD | 1 |
p.S236* | LUAD | 1 |
p.P175L | SKCM | 1 |
p.D56N | SKCM | 1 |
p.L444I | LUAD | 1 |
p.E526K | SKCM | 1 |
p.D446N | SKCM | 1 |
p.E545Q | CESC | 1 |
p.Q559* | CESC | 1 |
p.G405S | UCEC | 1 |
p.G211E | SKCM | 1 |
p.K525N | LUAD | 1 |
p.L323H | SKCM | 1 |
p.L342F | SKCM | 1 |
p.T143N | LUAD | 1 |
p.D464N | LUSC | 1 |
p.S517F | SKCM | 1 |
p.K243N | UCEC | 1 |
p.P304S | LUAD | 1 |
p.Q352K | LUAD | 1 |
p.E209D | LUSC | 1 |
p.E39K | SKCM | 1 |
p.G250S | SKCM | 1 |
p.I510T | UCEC | 1 |
p.S513* | BLCA | 1 |
p.A311T | STAD | 1 |
p.R447P | STAD | 1 |
p.G338R | UCEC | 1 |
p.L33Q | HNSC | 1 |
p.A253D | LUAD | 1 |
p.I123T | HNSC | 1 |
p.A574T | SKCM | 1 |
p.K241N | BLCA | 1 |
p.I179F | SKCM | 1 |
p.E545* | LUSC | 1 |
p.A242T | SKCM | 1 |
p.L227F | PCPG | 1 |
p.K141N | SKCM | 1 |
p.F220L | HNSC | 1 |
p.G338E | SKCM | 1 |
p.E365K | SKCM | 1 |
p.A231T | THCA | 1 |
p.R5* | BLCA | 1 |
p.G448E | SKCM | 1 |
p.T491M | ESCA | 1 |
p.R5Q | HNSC | 1 |
p.R575H | KIRC | 1 |
p.L10R | STAD | 1 |
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TissGeneCNV for ACSM2B |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for ACSM2B |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | CB162303 | ACSM2B-CYP3A4 | chr16:20548553 | chr7:99358595 |
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TissGeneNet for ACSM2B |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for ACSM2B |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for ACSM2B |
TissGeneDrug for ACSM2B |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for ACSM2B |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0524620 | Metabolic Syndrome X | 1 | GAD |